PENGARUH FAKTOR·FAKTOR PERILAKU KEPEMIMPINAN TERHADAP PENINGKATAN KINERJA KARYAWAN PADA PERUSAHAAN TRANSPORTASI CV SATRIA HARAPAN

Seorang pemimpin bertanggung jawab terhadap segala sesuatu yang dilakukan bawahannya, dan ia bertanggung jawab terhadap pembinaan dan pengemban bawahannya, memotivasi dan meningkatkan semangat keIja serta berusaha menyelaraskan kebutuhan bawahan dengan kepentingan perusahaan. Peran informatif yang dilakukan oleh seseorang pemimpin adalah menerima dan mengirim informasi dalam rangka hubungan yang dijalankan dengan lingkungan sekitamya. Peran selaku pengambil keputusan adaIah seorang pemimpin mempunyai kewajiban melakukan pengambilan keputusan untuk kelancaran mekanisme unit keIjanya. Keputusan yang diambil tentu saja berdasarkan informasi 8tau masukan (input) yang ada atau yang dimiliki selaku pemegang peran informatif

169pselective induction of pd l1 expression in plasma derived exosomes by gemcitabine nab paclitaxel vs folfirinox in pancreas cancer

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Integrating Liquid Biopsy and Radiomics to Monitor Clonal Heterogeneity of EGFR-Positive Non-Small Cell Lung Cancer

Background: EGFR-positive Non-small Cell Lung Cancer (NSCLC) is a dynamic entity and tumor progression and resistance to tyrosine kinase inhibitors (TKIs) arise from the accumulation, over time and across different disease sites, of subclonal genetic mutations. For instance, the occurrence of EGFR T790M is associated with resistance to gefitinib, erlotinib, and afatinib, while EGFR C797S causes osimertinib to lose activity. Sensitive technologies as radiomics and liquid biopsy have great potential to monitor tumor heterogeneity since they are both minimally invasive, easy to perform, and can be repeated over patient’s follow-up, enabling the extraction of valuable information. Yet, to date, there are no reported cases associating liquid biopsy and radiomics during treatment. Case presentation: In this case series, seven patients with metastatic EGFR-positive NSCLC have been monitored during target therapy. Plasma-derived cell free DNA (cfDNA) was analyzed by a digital droplet PCR (ddPCR), while radiomic analyses were performed using the validated LifeX® software on computed tomography (CT)-images. The dynamics of EGFR mutations in cfDNA was compared with that of radiomic features. Then, for each EGFR mutation, a radiomic signature was defines as the sum of the most predictive features, weighted by their corresponding regression coefficients for the least absolute shrinkage and selection operator (LASSO) model. The receiver operating characteristic (ROC) curves were computed to estimate their diagnostic performance. The signatures achieved promising performance on predicting the presence of EGFR mutations (R2 = 0.447, p <0.001 EGFR activating mutations R2 = 0.301, p = 0.003 for T790M; and R2 = 0.354, p = 0.001 for activating plus resistance mutations), confirmed by ROC analysis. Conclusion: To our knowledge, these are the first cases to highlight a potentially promising strategy to detect clonal heterogeneity and ultimately identify patients at risk of progression during treatment. Together, radiomics and liquid biopsy could detect the appearance of new mutations and therefore suggest new therapeutic management

expression of tk1 and cdk9 in plasma derived exosomes is associated with clinical response to cdk4 6 inhibitors in breast cancer

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Motivating antibiotic stewardship in Bangladesh:identifying audiences and target behaviours using the behaviour change wheel

BACKGROUND: South Asia is a hotspot for antimicrobial resistance due largely to over-the-counter antibiotic sales for humans and animals and from a lack of policy compliance among healthcare providers. Additionally, there is high population density and high infectious disease burden. This paper describes the development of social and behavioural change communication (SBCC) to increase the appropriate use of antibiotics.METHODS: We used formative research to explore contextual drivers of antibiotic sales, purchase, consumption/use and promotion among four groups: 1) households, 2) drug shop staff, 3) registered physicians and 4) pharmaceutical companies/medical sales representatives. We used formative research findings and an intervention design workshop with stakeholders to select target behaviours, prioritise audiences and develop SBCC messages, in consultation with a creative agency, and through pilots and feedback. The behaviour change wheel was used to summarise findings.RESULTS: Workshop participants identified behaviours considered amenable to change for all four groups. Household members and drug shop staff were prioritised as target audiences, both of which could be reached at drug shops. Among household members, there were two behaviours to change: suboptimal health seeking and ceasing antibiotic courses early. Thus, SBCC target behaviours included: seek registered physician consultations; ask whether the medicine provided is an antibiotic; ask for instructions on use and timing. Among drug shop staff, important antibiotic dispensing practices needed to change. SBCC target behaviours included: asking customers for prescriptions, referring them to registered physicians and increasing customer awareness by instructing that they were receiving antibiotics to take as a full course.CONCLUSIONS: We prioritised drug shops for intervention delivery to all drug shop staff and their customers to improve antibiotic stewardship. Knowledge deficits among these groups were notable and considered amenable to change using a SBCC intervention addressing improved health seeking behaviours, improved health literacy on antibiotic use, and provision of information on policy governing shops. Further intervention refinement should consider using participatory methods and address the impact on profit and livelihoods for drug shop staff for optimal compliance.</p

Lipoxin A4 and interleukin-8 levels in cystic fibrosis sputum after antibiotherapy

AbstractAntibiotics are largely prescribed for cystic fibrosis (CF) respiratory exacerbations. Effects of antibiotics on the inflammatory profile of the patients have been shown but remain controversial. Lipoxin A4 (LXA4) is a lipid mediator, reported to play a central role in resolving airway inflammation. The aim of the study was to investigate the consequences of antibiotherapy on LXA4 and IL-8 levels in CF patients' airways.MethodsEighteen CF patients (7 females, median age 20, range 8 to 47 years) consecutively admitted at the CF center of Montpellier for antibiotics during pulmonary exacerbation, were enrolled. Before and after antibiotics, all patients underwent spirometry (FEV1 and FVC), bacterial cultures and cell counts in sputa. IL-8 and LXA4 concentrations were determined in sputum samples by the median of immunometric assays.ResultsAs previously reported, after antibiotics therapy, FEV1 and FVC significantly improved. While neutrophil cell counts and IL-8 levels decreased, the LXA4 levels significantly increased after antibiotics therapy and were inversely correlated with IL-8 levels.In conclusion, we reported a correlation between antibiotics treatments and inflammatory markers in CF sputum. Our data provide evidences for a novel effect of antibiotics increasing the concentration of the anti-inflammatory lipid mediator LXA4

KOMUNIKASI POLITIK PARTAI KEADILAN SEJAHTERA (PKS) DALAM PEMENANGAN PASANGAN ATBAH ROMIN SUHAILI DAN HAIRIAH PADA PEMILIHAN UMUM KEPALA DAERAH KABUPATEN SAMBAS TAHUN 2015

Penelitian ini mendeskripsikan dan mengkaji secara mendalam strategi komunikasi politik PKS dalam memenangkan pasangan Atbah Romin Suhaili dan Hairiah pada pemilukada Kabupaten Sambas tahun 2015. Dalam penelitian ini ditemukan bahwa strategi komunikasi politik PKS meliputi merawat ketokohan dan memantapkan kelembagaan, menciptakan kebersamaan dengan khalayak, serta dengan membangun konsensus. Atbah dikenal sebagai sosok tokoh agama yang sangat friendly, menerima keberagaman, dan berbudaya. Selain itu, Atbah mampu menciptakan suasana yang homofili yakni dengan membangun persamaan keyakinan, kepentingan, dan motivasi dengan masyarakat. Atbah adalah seorang orator ulung sehingga dapat dengan mudah mempengaruhi khalayak melalui pesan - pesan politik yang persuasif. Kemenangan Atbah - Hairiah pada pemilukada Kabupaten Sambas tahun 2015 lalu adalah kemenangan yang tak terduga, perolehan suara mereka jauh melampaui perolehan suara pasangan lainnya yakni Tony - Eka dan Juliarti - Hasanusi. Pasangan Juliarti - Hasanusi awalnya diprediksi dapat mendulang suara terbanyak, posisinya sebagai petahana menguntungkan dari tingkat popularitas, jaringan atau relasi yang lebih luas, serta dukungan politik yang sangat kuat karena diusung oleh partai besar pemenang pemilu tahun 2014. Atbah yang tidak memiliki track record dalam birokrasi mampu unggul dengan perolehan suara yang signifikan. Kemenangan pasangan ini adalah hasil kerja kolektif dari para partai pengusung lainnya yang tergabung dalam koalisi. PKS sebagai partai pengusung utama memegang andil yang sangat besar. Komunikasi politik yang dibangun PKS salah satunya menjadi faktor yang membuat unggul pasangan ini