Fishing and the impact of marine reserves in a variable environment

We use discrete-time models to investigate the impact of marine reserve establishment on fishery catch and biomass levels in open-access and quota-regulated fisheries under conditions of recruitment variability and natural mortality events. We find that under the conditions of variability tested, reserves can increase the probability of achieving target levels of biomass (60%, 35%, and 5% of carrying capacity) and can reduce catch variability in neighbouring fisheries, making future planning in the fishery more efficient. The size of the reserve required to meet each objective will depend on the initial condition of the stock and the exploitation rate in the fishery. Reserve coverage of between 20% and 40% prevent stock collapse in most cases. In heavily exploited fisheries, reserves are also likely to enhance mean catches, particularly in highly variable systems. If the stock has previously been heavily exploited, large reserves (greater than or equal to60%) may be required to significantly increase the probability of achieving target biomass levels. However, once stocks have recovered, reserve coverage may be reduced without a reduction in this probability of success

The importance of habitat quality for marine reserve fishery linkages

We model marine reserve - fishery linkages to evaluate the potential contribution of habitat-quality improvements inside a marine reserve to fish productivity and fishery catches. Data from Mombasa Marine National Park, Kenya, and the adjacent fishery are used. Marine reserves increase total fish biomass directly by providing refuge from exploitation and indirectly by improving fish habitat in the reserve. As natural mortality of the fish stock decreases in response to habitat enhancement in the reserve, catches increase by up to 2.6 tonnes (t).km(-2).year(-1) and total fish biomass by up to 36 t.km(-2). However, if habitat-quality improvement reduces the propensity of fish to move out of the reserve, catches may fall by up to 0.9 t.km(-2).year(-1). Our results indicate that habitat protection in reserves can underpin fish productivity and, depending on its effects on fish movements, augment catches

A Multinational Analysis of Mutations and Heterogeneity in PZase, RpsA, and PanD Associated with Pyrazinamide Resistance in M/XDR Mycobacterium tuberculosis.

Pyrazinamide (PZA) is an important first-line drug in all existing and new tuberculosis (TB) treatment regimens. PZA-resistance in M. tuberculosis is increasing, especially among M/XDR cases. Noted issues with PZA Drug Susceptibility Testing (DST) have driven the search for alternative tests. This study provides a comprehensive assessment of PZA molecular diagnostics in M/XDR TB cases. A set of 296, mostly XDR, clinical M. tuberculosis isolates from four countries were subjected to DST for eight drugs, confirmatory Wayne's assay, and whole-genome sequencing. Three genes implicated in PZA resistance, pncA, rpsA, and panD were investigated. Assuming all non-synonymous mutations cause resistance, we report 90% sensitivity and 65% specificity for a pncA-based molecular test. The addition of rpsA and panD potentially provides 2% increase in sensitivity. Molecular heterogeneity in pncA was associated with resistance and should be evaluated as a diagnostic tool. Mutations near the N-terminus and C-terminus of PZase were associated with East-Asian and Euro-American lineages, respectively. Finally, Euro-American isolates are most likely to have a wild-type PZase and escape molecular detection. Overall, the 8-10% resistance without markers may point to alternative mechanisms of resistance. Confirmatory mutagenesis may improve the disconcertingly low specificity but reduce sensitivity since not all mutations may cause resistance

An evaluation framework to determine the impact of the Lyme Bay Fisheries and Conservation Reserve and the activities of the Lyme Bay Consultative Committee on ecosystem services and human wellbeing.

This research evaluates the social and economic impact of the management measures that form the Lyme Bay Reserve and the partnership activities of the Lyme Bay Consultative Committee (LBCC) on Lyme Bay resource users. For the purpose of this evaluation it is the combination of the 2008 Statutory Instrument (SI) closure and the more recently designated Site of Community Interest (SCI) that form the boundary of the Lyme Bay Fisheries and Conservation Reserve, termed as the Lyme Bay Reserve. Data is analysed between 2005 and 2015. The results show that the habitats and species of Lyme Bay interact to support the delivery of several ecosystem processes (e.g. primary and secondary production, formation of species habitat) and the realisation of ecosystem services (e.g. fish for food). Overall it is clear that the closure of the area to mobile fishing gear has benefitted static gear fishermen by separating spatial conflict between gear types. The closure has enabled reef habitats to recover which in turn has supported increased catches of some reef associated species e.g. scallops. Further management and support measures agreed through the LBCC have clearly been successful in improving the well-being for those fishermen directly involved in the project. This research represents collaboration between Plymouth University, Exeter University, The Blue Marine Foundation and CEFAS. Input into the evaluation was provided by the Devon and Severn Inshore Fisheries and Conservation Authority (IFCA), the Southern IFCA, local fishermen and fishery representatives

A face in a sea of faces: exploring university students’ reasons for non-attendance to teaching sessions

In the past twenty years, the landscape of Higher Education in the United Kingdom has changed considerably. With the prospect of tuition fees spiralling above £9,000 per year, per student, it is important to explore the impact this has upon the student experience. In spite of the vast financial investment current students make toward their education, student attendance and engagement remains low. The present study therefore adopted a qualitative approach using focus groups to explore reasons for non-attendance at university teaching sessions. Four key themes emerged; these surrounded issues about a sense of belonging to university, views of the teaching (material taught and the personality and method of the tutor), perceptions of being a consumer; and external pressures. This research suggests that universities should pay particular attention to the reasons why students do not attend and possibly change practice, providing more support where appropriate

High-Frequency Electrooptic Fabry-Perot Modulators

Electrooptic modulators built from GaAs/AlxGa1-xAs Fabry-Perot cavities operating up to 6.5 GHz are reported. The measured frequency response agrees well with the one predicted using an equivalent circuit model derived from high-speed electrical measurements. The parasitic capacitances have been reduced to approximately 30 fF by fabricating the devices on semi-insulating GaAs substrates and integrating them with on-wafer bound pads which have dimensions compatible with microwave coplanar probes

Transplanting the leafy liverwort Herbertus hutchinsiae : A suitable conservation tool to maintain oceanic-montane liverwort-rich heath?

Thanks to the relevant landowners and managers for permission to carry out the experiments, Chris Preston for helping to obtain the liverwort distribution records and the distribution map, Gordon Rothero and Dave Horsfield for advice on choosing experimental sites and Alex Douglas for statistical advice. Juliane Geyer’s help with fieldwork was greatly appreciated. This study was made possible by a NERC PhD studentship and financial support from the Royal Botanic Garden Edinburgh and Scottish Natural Heritage.Peer reviewedPostprin

High body mass index and pre-existing autoimmune disease are associated with an increased risk of immune-related adverse events in cancer patients treated with PD-(L)1 inhibitors across different solid tumors

BACKGROUND\nPATIENTS AND METHODS\nRESULTS\nCONCLUSION\nTreatment with anti-PD-(L)1 antibodies, approved for several oncology indications, can lead to immune-related adverse events (irAEs). We aimed to investigate risk factors associated with an increased reporting of irAEs in patients treated with PD-(L)1 inhibitors approved for solid tumor indications.\nA retrospective review was performed of individual data from patients in phase II/III registrational studies for PD-(L)1 inhibitors in solid tumors. Data on baseline characteristics and adverse events were extracted. Univariate and multivariable logistic regression models were used to identify risk factors.\nIn total, 5123 patients were included from 15 studies reporting on the use of four PD-(L)1 inhibitors for five solid tumor indications. Univariate analysis suggested that type of study drug (P 2 [odds ratio (OR) 1.5, 95% confidence interval (CI) 1.2-1.8] in comparison to normal BMI, having an autoimmune disease at baseline (OR 1.8, 95% CI 1.1-2.7), and use of a PD-L1 inhibitor (OR 1.6, 95% CI 1.2-2.0). The latter finding is probably biased due to the selection of the studies in the dataset with complete information on baseline characteristics.\nThis study was conducted using a large dataset of individual patient data from clinical trials comprising multiple solid tumor indications. We demonstrated that patients with obesity and concurrent autoimmune disease were at increased risk of developing irAEs.FWN – Publicaties zonder aanstelling Universiteit Leide