Robust designs for Poisson regression models

We consider the problem of how to construct robust designs for Poisson regression models. An analytical expression is derived for robust designs for first-order Poisson regression models where uncertainty exists in the prior parameter estimates. Given certain constraints in the methodology, it may be necessary to extend the robust designs for implementation in practical experiments. With these extensions, our methodology constructs designs which perform similarly, in terms of estimation, to current techniques, and offers the solution in a more timely manner. We further apply this analytic result to cases where uncertainty exists in the linear predictor. The application of this methodology to practical design problems such as screening experiments is explored. Given the minimal prior knowledge that is usually available when conducting such experiments, it is recommended to derive designs robust across a variety of systems. However, incorporating such uncertainty into the design process can be a computationally intense exercise. Hence, our analytic approach is explored as an alternative

Overview of the TCV tokamak experimental programme

The tokamak a configuration variable (TCV) continues to leverage its unique shaping capabilities, flexible heating systems and modern control system to address critical issues in preparation for ITER and a fusion power plant. For the 2019-20 campaign its configurational flexibility has been enhanced with the installation of removable divertor gas baffles, its diagnostic capabilities with an extensive set of upgrades and its heating systems with new dual frequency gyrotrons. The gas baffles reduce coupling between the divertor and the main chamber and allow for detailed investigations on the role of fuelling in general and, together with upgraded boundary diagnostics, test divertor and edge models in particular. The increased heating capabilities broaden the operational regime to include T (e)/T (i) similar to 1 and have stimulated refocussing studies from L-mode to H-mode across a range of research topics. ITER baseline parameters were reached in type-I ELMy H-modes and alternative regimes with \u27small\u27 (or no) ELMs explored. Most prominently, negative triangularity was investigated in detail and confirmed as an attractive scenario with H-mode level core confinement but an L-mode edge. Emphasis was also placed on control, where an increased number of observers, actuators and control solutions became available and are now integrated into a generic control framework as will be needed in future devices. The quantity and quality of results of the 2019-20 TCV campaign are a testament to its successful integration within the European research effort alongside a vibrant domestic programme and international collaborations

DiseNo optimo de experimentos para modelos de regresion

Centro de Informacion y Documentacion Cientifica (CINDOC). C/Joaquin Costa, 22. 28002 Madrid. SPAIN / CINDOC - Centro de Informaciòn y Documentaciòn CientìficaSIGLEESSpai

Glucose-6-phosphate dehydrogenase deficiency in northern Mexico and description of a novel mutation

There are numerous species of gastropods of commercial importance; they are used for meat and for their shell, in addition to the potential use of their toxins for pharmaceutical use. There are few studies focused on the analysis of the importance and/or the economic potential of these organisms in the State of Guerrero, Mexico. This research was conducted at 7 sites, with the aim of determine the species of economic potential, the current use and possible commercial use, besides estimating the descriptive statistics of population sizes and geographic distribution. According to the regionalization of the National Commission for the Knowledge and Use of Biodiversity, the sampling sites are located in the Marine Region Priority 32. Species with economic potential were determined as a basis of the abundance of populations and the frequency of occurrence at the sampling sites. Forty species of economic potential were found, of which 14 are commercially exploited, one has biomedical potential and 25 of them no record was found indicating any commercial utilization. The species of greater size was Macrocypraea cervinetta. Sixty five percent of the species with economic potential are of wide distribution. The region is highly diverse and with potential for commercial use of a large number of species. To carry out a good fishery management of the species with economic potential, fishery-biology and ecological studies are required that allow for the development of measures and strategies for carrying out sound and sustainable use of these resources. " 2014 Universidad de Valparaiso. All rights reserved.",,,,,,,,,"http://hdl.handle.net/20.500.12104/41816","http://www.scopus.com/inward/record.url?eid=2-s2.0-84912134972&partnerID=40&md5=d7a289b2706f20ef4b80ab8cf200ee96",,,,,,"3",,"Revista de Biologia Marina y Oceanografia",,"54

Guerrero, México gastropods with economic potential associated with the rocky intertidal zone of the marine region priority 32, Mexico [Gasterópodos con potencial económico asociados al intermareal rocoso de la región marina prioritaria 32]

There are numerous species of gastropods of commercial importance; they are used for meat and for their shell, in addition to the potential use of their toxins for pharmaceutical use. There are few studies focused on the analysis of the importance and/or the economic potential of these organisms in the State of Guerrero, Mexico. This research was conducted at 7 sites, with the aim of determine the species of economic potential, the current use and possible commercial use, besides estimating the descriptive statistics of population sizes and geographic distribution. According to the regionalization of the National Commission for the Knowledge and Use of Biodiversity, the sampling sites are located in the Marine Region Priority 32. Species with economic potential were determined as a basis of the abundance of populations and the frequency of occurrence at the sampling sites. Forty species of economic potential were found, of which 14 are commercially exploited, one has biomedical potential and 25 of them no record was found indicating any commercial utilization. The species of greater size was Macrocypraea cervinetta. Sixty five percent of the species with economic potential are of wide distribution. The region is highly diverse and with potential for commercial use of a large number of species. To carry out a good fishery management of the species with economic potential, fishery-biology and ecological studies are required that allow for the development of measures and strategies for carrying out sound and sustainable use of these resources. © 2014 Universidad de Valparaiso. All rights reserved

Pyrethroid susceptibility reversal in Aedes aegypti: A longitudinal study in Tapachula, Mexico.

Pyrethroid resistance in Aedes aegypti has become widespread after almost two decades of frequent applications to reduce the transmission of mosquito-borne diseases. Because few insecticide classes are available for public health use, insecticide resistance management (IRM) is proposed as a strategy to retain their use. A key hypothesis of IRM assumes that negative fitness is associated with resistance, and when insecticides are removed from use, susceptibility is restored. In Tapachula, Mexico, pyrethroids (PYRs) were used exclusively by dengue control programs for 15 years, thereby contributing to selection for high PYR resistance in mosquitoes and failure in dengue control. In 2013, PYRs were replaced by organophosphates-insecticides from a class with a different mode of action. To test the hypothesis that PYR resistance is reversed in the absence of PYRs, we monitored Ae. aegypti's PYR resistance from 2016 to 2021 in Tapachula. We observed significant declining rates in the lethal concentration 50 (LC50), for permethrin and deltamethrin. For each month following the discontinuation of PYR use by vector control programs, we observed increases in the odds of mosquitoes dying by 1.5% and 8.4% for permethrin and deltamethrin, respectively. Also, knockdown-resistance mutations (kdr) in the voltage-gated sodium channel explained the variation in the permethrin LC50s, whereas variation in the deltamethrin LC50s was only explained by time. This trend was rapidly offset by application of a mixture of neonicotinoid and PYRs by vector control programs. Our results suggest that IRM strategies can be used to reverse PYR resistance in Ae. aegypti; however, long-term commitment by operational and community programs will be required for success