Keystroke Biometrics in Response to Fake News Propagation in a Global Pandemic

This work proposes and analyzes the use of keystroke biometrics for content de-anonymization. Fake news have become a powerful tool to manipulate public opinion, especially during major events. In particular, the massive spread of fake news during the COVID-19 pandemic has forced governments and companies to fight against missinformation. In this context, the ability to link multiple accounts or profiles that spread such malicious content on the Internet while hiding in anonymity would enable proactive identification and blacklisting. Behavioral biometrics can be powerful tools in this fight. In this work, we have analyzed how the latest advances in keystroke biometric recognition can help to link behavioral typing patterns in experiments involving 100,000 users and more than 1 million typed sequences. Our proposed system is based on Recurrent Neural Networks adapted to the context of content de-anonymization. Assuming the challenge to link the typed content of a target user in a pool of candidate profiles, our results show that keystroke recognition can be used to reduce the list of candidate profiles by more than 90%. In addition, when keystroke is combined with auxiliary data (such as location), our system achieves a Rank-1 identification performance equal to 52.6% and 10.9% for a background candidate list composed of 1K and 100K profiles, respectively.Comment: arXiv admin note: text overlap with arXiv:2004.0362

Hybrid Analog-Digital Precoding Revisited Under Realistic RF Modeling

In this letter, we revisit hybrid analog-digital precoding systems with emphasis on the modeling of their radio-frequency (RF) losses, to realistically evaluate their benefits in 5G system implementations. We focus on fully-connected analog beamforming networks (FC-ABFNs) and on discrete Fourier transform implementations, and decompose these as a bank of commonly used RF components. We then model their losses based on their S-parameters. Our results reveal that the performance and energy efficiency of hybrid precoding systems are severely affected once these, commonly ignored, losses are considered in the overall design. In this context, we also show that hybrid precoder designs similar to Butler matrices are capable of providing better performances than FC-ABFN for systems with a large number of RF chains

Metamagnetic transition in Tb2MnCoO6

The magnetic properties of the double perovskite Tb2MnCoO6 have been studied. The refinement of neutron pattern reveals antisite defects in the ordered array of Mn4+ and Co2+ cations. The temperature dependence of dc magnetization exhibits a magnetic transition at ~100 K with a strong irreversibility between ZFC and FC conditions. The ac magnetic susceptibility curve shows a strong peak at the same temperature whose position and intensity slightly depends on the field frequency. These features are typical of a spin-glasslike phase but neutron diffraction shows the onset of a ferromagnetic contribution at the same temperature. Ferromagnetism in this sample is associated to superexchange interaction between Mn4+ and Co2+ cations. The most striking property of Tb2MnCoO6 is the presence of field induced transitions. This is observed in the magnetic hysteresis loops below 100K. The metamagnetic transition was studied by powder neutron diffraction at different temperatures and magnetic fields. At low temperature, the magnetic field induces a long range magnetic ordering of Tb3+ moments in the ab-plane. The magnetic peaks of Tb moments at 30 kOe vanish at 60 K. Above this temperature, the metamagnetic transition is ascribed to the field induced transition from short to long range ferromagnetic ordering in the Mn-Co sublattice

Tenofovir Inhibits Wound Healing of Epithelial Cells and Fibroblasts from the Upper and Lower Human Female Reproductive Tract

Disruption of the epithelium in the female reproductive tract (FRT) is hypothesized to increase HIV infection risk by interfering with barrier protection and facilitating HIV-target cell recruitment. Here we determined whether Tenofovir (TFV), used vaginally in HIV prevention trials, and Tenofovir alafenamide (TAF), an improved prodrug of TFV, interfere with wound healing in the human FRT. TFV treatment of primary epithelial cells and fibroblasts from the endometrium (EM), endocervix (CX) and ectocervix (ECX) significantly delayed wound closure. Reestablishment of tight junctions was compromised in EM and CX epithelial cells even after wound closure occurred. In contrast, TAF had no inhibitory effect on wound closure or tight junction formation following injury. TAF accumulated inside genital epithelial cells as TFV-DP, the active drug form. At elevated levels of TAF treatment to match TFV intracellular TFV-DP concentrations, both equally impaired barrier function, while wound closure was more sensitive to TFV. Furthermore, TFV but not TAF increased elafin and MIP3a secretion following injury, molecules known to be chemotactic for HIV-target cells. Our results highlight the need of evaluating antiretroviral effects on genital wound healing in future clinical trials. A possible link between delayed wound healing and increased risk of HIV acquisition deserves further investigation

GOLLUM: a next-generation simulation tool for electron, thermal and spin transport

We have developed an efficient simulation tool 'GOLLUM' for the computation of electrical, spin and thermal transport characteristics of complex nanostructures. The new multi-scale, multi-terminal tool addresses a number of new challenges and functionalities that have emerged in nanoscale-scale transport over the past few years. To illustrate the flexibility and functionality of GOLLUM, we present a range of demonstrator calculations encompassing charge, spin and thermal transport, corrections to density functional theory such as LDA+U and spectral adjustments, transport in the presence of non-collinear magnetism, the quantum-Hall effect, Kondo and Coulomb blockade effects, finite-voltage transport, multi-terminal transport, quantum pumps, superconducting nanostructures, environmental effects and pulling curves and conductance histograms for mechanically-controlled-break-junction experiments.Comment: 66 journal pages, 57 figure

Predictors of diabetes risk in urban and rural areas in Colombia

Background: Nutritional habits low in fruits and vegetables and sedentary lifestyle are associated with a higher risk of developing Type 2 Diabetes (T2D). However, it is important to assess differences between urban and rural areas. This study aimed to analyze the associations between the risk of developing T2D and setting in the Colombian north coast in 2017. Methods: This cross-sectional study included 1,005 subjects. Data was collected by interviewing self-identified members of an urban community and a rural-indigenous population. The interaction terms were evaluated as well as the confounders. Then, adjusted binary logistic regressions were used to estimate the odds ratio (OR) and 95% Confidence Intervals (CI). Results: subjects with a high risk of T2D are more likely to belong to the urban setting (OR = 1.908; 95%CI = 1.201-2.01) compared with those with lower T2D after adjusting for age, Body Mass Index (BMI), physical activity, history of high levels of glycemia, and diabetes in relatives. Conclusions: Urban communities are more likely to have T2D compared with rural-indigenous populations. These populations have differences from the cultural context, including personal, and lifestyle factors.Peer reviewe

Sex Hormones Regulate Tenofovir-Diphosphate in Female Reproductive Tract Cells in Culture

The conflicting results of recent pre-exposure prophylaxis (PrEP) trials utilizing tenofovir (TFV) to prevent HIV infection in women led us to evaluate the accumulation of intracellular TFV-diphosphate (TFV-DP) in cells from the female reproductive tract (FRT) and whether sex hormones influence the presence of TFV-DP in these cells. Following incubation with TFV, isolated epithelial cells, fibroblasts, CD4+ T cells and CD14+ cells from the FRT as well as blood CD4+ T cells and monocyte-derived macrophages convert TFV to TFV-DP. Unexpectedly, we found that TFV-DP concentrations (fmol/million cells) vary significantly with the cell type analyzed and the site within the FRT. Epithelial cells had 5-fold higher TFV-DP concentrations than fibroblasts; endometrial epithelial cells had higher TFV-DP concentrations than cells from the ectocervix. Epithelial cells had 125-fold higher TFV-DP concentrations than FRT CD4+ T cells, which were comparable to that measured in peripheral blood CD4+ T cells. These findings suggest the existence of a TFV-DP gradient in the FRT where epithelial cells \u3e fibroblasts \u3e CD4+ T cells and macrophages. In other studies, estradiol increased TFV-DP concentrations in endometrial and endocervical/ectocervical epithelial cells, but had no effect on fibroblasts or CD4+ T cells from FRT tissues. In contrast, progesterone alone and in combination with estradiol decreased TFV-DP concentrations in FRT CD4+ T cells. Our results suggest that epithelial cells and fibroblasts are a repository of TFV-DP that is under hormonal control. These cells might act either as a sink to decrease TFV availability to CD4+ T cells and macrophages in the FRT, or upon conversion of TFV-DP to TFV increase TFV availability to HIV-target cells. In summary, these results indicate that intracellular TFV-DP varies with cell type and location in the FRT and demonstrate that estradiol and/or progesterone regulate the intracellular concentrations of TFV-DP in FRT epithelial cells and CD4+ T cells

Multifunctional Eu-doped NaGd(MoO4)(2) nanoparticles functionalized with poly(L-lysine) for optical and MRI imaging

A method for the synthesis of non-aggregated and highly uniform Eu3+ doped NaGd(MoO4)(2) nanoparticles is reported for the first time. The obtained particles present tetragonal structure, ellipsoidal shape and their size can be varied by adjusting the experimental synthesis parameters. These nanoparticles, which were coated with citrate anions and functionalised with PLL, have also been developed in order to improve their colloidal stability in physiological medium (2-(N-morpholino) ethanesulfonic acid, MES). A study of the luminescent dynamics of the samples as a function of the Eu doping level has been conducted in order to find the optimum nanophosphors, whose magnetic relaxivity and cell viability have also been evaluated for the first time for this system, in order to assess their suitability as multifunctional probes for optical (in vitro) and magnetic bioimaging applications

Estradiol Reduces Susceptibility of CD4+ T Cells and Macrophages to HIV-Infection

The magnitude of the HIV epidemic in women requires urgent efforts to find effective preventive methods. Even though sex hormones have been described to influence HIV infection in epidemiological studies and regulate different immune responses that may affect HIV infection, the direct role that female sex hormones play in altering the susceptibility of target cells to HIV-infection is largely unknown. Here we evaluated the direct effect of 17-b-estradiol (E2) and ethinyl estradiol (EE) in HIV-infection of CD4+ T-cells and macrophages. Purified CD4+ T-cells and monocyte-derived macrophages were generated in vitro from peripheral blood and infected with R5 and X4 viruses. Treatment of CD4+ T-cells and macrophages with E2 prior to viral challenge reduced their susceptibility to HIV infection in a dose-dependent manner. Addition of E2 2h after viral challenge however did not result in reduced infection. In contrast, EE reduced infection in macrophages to a lesser extent than E2 and had no effect on CD4+ T-cell infection. Reduction of HIV-infection induced by E2 in CD4+ T-cells was not due to CCR5 down-regulation, but was an entry-mediated mechanism since infection with VSV-G pseudotyped HIV was not modified by E2. In macrophages, despite the lack of an effect of on CCR5 expression, E2 –treatment reduced viral entry 2 h after challenge and increased MIP-1 b secretion. These results demonstrate the direct effect of E2 on susceptibility of HIV-target cells to infection and indicate that inhibition of target cell infection involves cell-entry related mechanisms