Web 2.0 en el proceso de enseñanza-aprendizaje. Aplicación a la enseñanza de Economía de la Empresa

El uso de Internet y su evolución acelerada en el tiempo no afecta exclusivamente a las empresas, sino que su ritmo viene marcado precisamente por los que se han de considerar nuevos productores de contenido en la Red. La Universidad no puede quedarse atrás en el uso de las TIC pero tampoco puede centrarse exclusivamente en plataformas de aprendizaje on-line de sofisticación elevada –OCW, Moodle, entre otros-, pero sin otorgar poder para modificar y generar contenidos a los usuarios. La Unidad Docente de Organización de Empresas del Departamento de Economía y Gestión Forestal de la Escuela Técnica Superior de Ingenieros de Montes de la Universidad Politécnica de Madrid propone el uso de plataformas Web 2.0 con el objeto de desarrollar competencias tradicionales y competencias 2.0. Estas plataformas tienen una gran acogida entre el alumnado, presentan utilidad tanto en el presente como en el futuro, y se puede utilizar como plataforma de Learning 2.0 de la Economía y Organización de Empresa

GlobTherm, a global database on thermal tolerances for aquatic and terrestrial organisms

CITATION: Bennett, J. M., et al. 2018. GlobTherm, a global database on thermal tolerances for aquatic and terrestrial organisms. Scientific Data, 5:180022, doi:10.1038/sdata.2018.22.The original publication is available at https://www.nature.comHow climate affects species distributions is a longstanding question receiving renewed interest owing to the need to predict the impacts of global warming on biodiversity. Is climate change forcing species to live near their critical thermal limits? Are these limits likely to change through natural selection? These and other important questions can be addressed with models relating geographical distributions of species with climate data, but inferences made with these models are highly contingent on non-climatic factors such as biotic interactions. Improved understanding of climate change effects on species will require extensive analysis of thermal physiological traits, but such data are both scarce and scattered. To overcome current limitations, we created the GlobTherm database. The database contains experimentally derived species’ thermal tolerance data currently comprising over 2,000 species of terrestrial, freshwater, intertidal and marine multicellular algae, plants, fungi, and animals. The GlobTherm database will be maintained and curated by iDiv with the aim to keep expanding it, and enable further investigations on the effects of climate on the distribution of life on Earth.https://www.nature.com/articles/sdata201822Publisher's versio

Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study

Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels and low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT dysfunction through measurements of the adiponectin/leptin ratio (ALR), the adipo-insulin resistance index (Adipo-IRi), fasting/postprandial (F/P) immunometabolic phenotyping and direct F/P differential gene expression in AT biopsies obtained from symptom-free adults from the GEMM family study. AT dysfunction was evaluated through associations of the ALR with F/P insulin-glucose axis, lipid-lipoprotein metabolism, and inflammatory markers. A relevant pattern of negative associations between decreased ALR and markers of systemic low-grade metaflammation, HOMA, and postprandial cardiovascular risk hyperinsulinemic, triglyceride and GLP-1 curves was found. We also analysed their plasma non-coding microRNAs and shotgun lipidomics profiles finding trends that may reflect a pattern of adipose tissue dysfunction in the fed and fasted state. Direct gene differential expression data showed initial patterns of AT molecular signatures of key immunometabolic genes involved in AT expansion, angiogenic remodelling and immune cell migration. These data reinforce the central, early role of AT dysfunction at the molecular and systemic level in the pathogenesis of IR and immunometabolic disorders

Choice of the initial antiretroviral treatment for HIV-positive individuals in the era of integrase inhibitors

BACKGROUND: We aimed to describe the most frequently prescribed initial antiretroviral therapy (ART) regimens in recent years in HIV-positive persons in the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) and to investigate factors associated with the choice of each regimen. METHODS: We analyzed initial ART regimens prescribed in adults participating in CoRIS from 2014 to 2017. Only regimens prescribed in >5% of patients were considered. We used multivariable multinomial regression to estimate Relative Risk Ratios (RRRs) for the association between sociodemographic and clinical characteristics and the choice of the initial regimen. RESULTS: Among 2874 participants, abacavir(ABC)/lamivudine(3TC)/dolutegavir(DTG) was the most frequently prescribed regimen (32.1%), followed by tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC)/elvitegravir(EVG)/cobicistat(COBI) (14.9%), TDF/FTC/rilpivirine (RPV) (14.0%), tenofovir alafenamide (TAF)/FTC/EVG/COBI (13.7%), TDF/FTC+DTG (10.0%), TDF/FTC+darunavir/ritonavir or darunavir/cobicistat (bDRV) (9.8%) and TDF/FTC+raltegravir (RAL) (5.6%). Compared with ABC/3TC/DTG, starting TDF/FTC/RPV was less likely in patients with CD4100.000 copies/mL. TDF/FTC+DTG was more frequent in those with CD4100.000 copies/mL. TDF/FTC+RAL and TDF/FTC+bDRV were also more frequent among patients with CD4<200 cells//muL and with transmission categories other than men who have sex with men. Compared with ABC/3TC/DTG, the prescription of other initial ART regimens decreased from 2014-2015 to 2016-2017 with the exception of TDF/FTC+DTG. Differences in the choice of the initial ART regimen were observed by hospitals' location. CONCLUSIONS: The choice of initial ART regimens is consistent with Spanish guidelines' recommendations, but is also clearly influenced by physician's perception based on patient's clinical and sociodemographic variables and by the prescribing hospital location

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase&nbsp;1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation&nbsp;disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age&nbsp; 6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score&nbsp; 652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc&nbsp;= 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N&nbsp;= 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in&nbsp;Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in&nbsp;Asia&nbsp;and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Broad-scale patterns of body size in squamate reptiles of Europe and North America

Aim To document geographical interspecific patterns of body size of European and North American squamate reptile assemblages and explore the relationship between body size patterns and environmental gradients. Location North America and western Europe. Methods We processed distribution maps for native species of squamate reptiles to document interspecific spatial variation of body size at a grain size of 110 x 110 km. We also examined seven environmental variables linked to four hypotheses possibly influencing body size gradients. We used simple and multiple regression, evaluated using information theory, to identify the set of models best supported by the data. Results Europe is characterized by clear latitudinal trends in body size, whereas geographical variation in body size in North America is complex. There is a consistent association of mean body size with measures of ambient energy in both regions, although lizards increase in size northwards whereas snakes show the opposite pattern. Our best models accounted for almost 60% of the variation in body size of lizards and snakes within Europe, but the proportions of variance explained in North America were less than 20%. Main conclusions Although body size influences the energy balance of thermoregulating ectotherms, inconsistent biogeographical patterns and contrasting associations with energy in lizards and snakes suggest that no single mechanism can explain variation of reptile body size in the northern temperate zone

Translation competence acquisition. Design and results of the PACTE group\u2019s experimental research

This issue provides a study on translation competence acquisition (TCA). The study consisted of an TCA experiment involving 129 first to fourth year trainee translators and recent graduates. The experiment was conducted in November 2011, when the first-year subjects had just begun their degree course; the graduates had completed their studies in June 2011. Firstly, the conceptual and methodological framework of the research is described. Then the study's measurements and results beginning with translation acceptability (a cross-cutting indicator whose results are brought together with those of most of the other indicators) are presented, and followed by the different study variables: knowledge of translation; translation project; identification and solution of translation problems; decision-making; efficacy of the translation process; and use of instrumental resources. Finally, the study's conclusions, defining features of TCA, are presented. The publication also includes six online appendices containing the hypotheses, the main instruments used, the statistical test results and a glossary of key terms from the research

Competence levels in translation: working towards a European framework

This paper presents the research project the PACTE group is carrying out on \u2018Establishing Competence Levels in the Acquisition of Translation Competence in Written Translation\u2019. A continuation of PACTE\u2019s previous experimental research on translation competence and its acquisition, the project aims to propose level descriptors as a first step towards developing a common European framework of reference for translation\u2019s academic and professional arenas, both of which are represented among its participants. The project is organized into three stages, the first of which involved the production of a first level descriptor proposal, including a three-level scale with sub-levels and five descriptive categories (language competence; cultural, world knowledge and thematic competence; instrumental competence; translation service provision competence; and translation problem solving competence). In the second stage, the proposal produced is to be evaluated by experts from the academic and professional arenas. In the third stage, the data obtained through the expert judgement process will be analysed and the proposal revised. This paper sets out the project\u2019s objectives, our grounds for undertaking it, its conceptual framework and its methodology, as well as the results obtained in the first stage and the future direction of the research

Establishing levels of competence in translation: First results of the nact project

This paper presents the research project the PACTE group is carrying out on "Establishing Competence Levels in the Acquisition of Translation Competence in Written Translation". The project aims to propose level descriptors as a first step towards developing a common European framework of reference for translation's academic and professional arenas. The project is a continuation of PACTE's previous experimental research on translation competence and its acquisition. Representatives of both academic and professional arenas participate in the project. It is organized into three stages, the first of which involved the production of a first level descriptor proposal, including a three-level scale with sub-levels and five descriptive categories (language competence; cultural, world knowledge, and thematic competence; instrumental competence; translation service provision competence; and translation problem solving competence). This proposal produced is to be evaluated by experts from the academic and professional arenas. This paper sets out the project, as well as the first level descriptor proposal

Evolution of the efficacy of the translation process in translation competence acquisition

The aim of this paper is to present PACTE's measurement of and results for the variable "efficacy of the Translation Process" in its experiment on Translation Competence Acquisition (TCA). This is one of the variables that provide information about the acquisition of the strategic sub-competence. We define this variable as the relationship between the time taken to complete a translation task, its distribution in stages, and solution acceptability. We consider translation process efficacy to be based on an optimal relationship between solution acceptability and time, i.e. achieving maximum acceptability in minimum time. In that respect, our initial premise was that finding acceptable solutions should take less time as the TCA process advances. Our aim as regards this variable was to investigate whether, as Translation Competence is acquired, differences occur in terms of: (1) the time taken to carry out a translation task; (2) the distribution of the time spent on a translation task between stages; (3) the relationship between the time spent on a translation task and solution acceptability