Low cost storage techniques and models applied to small and medium enterprises

Este artículo fue escrito con el objetivo de presentarle a aquellas pequeñas y medianas empresas creadas en Colombia, técnicas y modelos de almacenamiento como opción que permitan el crecimiento empresarial, la reducción de costos y reconocimiento en el sector al que pertenecen. Por medio de la investigación cualitativa se aglomeraron y se escogieron las mejores técnicas y modelos de bajo costo aplicables a este tipo de empresas, finalmente se realiza la caracterización por tamaño de empresa y tipo de producto almacenado obteniendo como resultado la consolidación de varias opciones de selección que permita a las pequeñas y medianas empresas lograr obtener un ahorro en el manejo de los inventarios, en el productos faltante por mermas o ventas perdidas por clientes insatisfechos, además de estos ahorros permiten a las empresas un crecimiento ordenado y eficiente.This article was written with the objective of presenting to those small and medium sized companies created in Colombia techniques and storage models as an option that allow business growth, cost reduction and recognition in the sector to which they belong, through qualitative research the best techniques and low-cost models applicable to this type of companies were agglomerated and chosen, finally the characterization by company size and type of stored product is carried out, resulting in the consolidation of several selection options that allow small and medium sized companies achieve savings in the management of inventories, in the missing products due to losses or sales lost by unsatisfied customers, in addition to these savings allow companies to orderly and efficiently grow.Especializació

Plan piloto estrategico de seleccion de personal a la empresa inversora san rafael en el area de personal

La Empresa SAN RAFAEL S.A.S. una empresa especializada en catering, donde se desarrolló un plan piloto estratégico de selección de personal para el recurso humano, está empresa desarrolla sus labores en el Departamento de Casanare, Colombia. Se evidencio que la empresa Inversora SAN RAFAEL S.A.S., presenta falencias organizacionales en el proceso de selección y rotación de personal, por tal motivo desarrollamos la presente investigación para proponer el plan estratégico más adecuado. Por tanto, desarrollar un plan estratégico que permita planificar, organizar, dirigir y evaluar la mejor intervención que pueda corregir exactamente los ejes delos dos ejes demuestra propuesta, que serán la selección de personal en todos sus procesos y, en segundo lugar, la rotación de personal. Lo anterior a través de una investigación cualitativa-descriptiva que nos permite a mediante una encuesta obtener directamente información dela población y obtener los resultados obtenidos en la metodología de investigación.The Company SAN RAFAEL S.A.S. a company specialized in catering, where I develop a strategic personnel selection pilot in the human area, is located in the Department of Casanare, Colombia. Themain objective of the selection is to adapt the area of modern Human Management within the company and achieve the business vision, improve its organizational culture, performance and performance of the people within the company of the company, which adapts to the descriptions and facades of the position. On the other hand, it is important to emphasize that when we talk about seeking to hire suitable staff, we mean a key process within macroprocesses, which aims to find the candidate for the best who adapts to the characteristics by the job and according to the profile of the position, through a series of stages that have to choose the applicant. Therefore, develop a strategic plan that allows to plan, organize, direct and evaluate the best intervention that can correct exactly the axes of the two axes of our proposal, which will be the selection of personnel in all its processes and secondly, the rotation of personnel. This is through qualitative comotiva research that allows us to form the extension of the questions or data obtained in the field investigated based on the bases of human resources management and the results obtained in the research methodology. It is evident that the company SAN RAFAEL S.A.S., presents organizational fallaciousness in the process of selection and rotation of personnel, this as a sequel to the research and implemented the plan this as a sequel to the strategic. If you get a clear resultanalysiss and to make decisions, in this way the company will achieve a desired organizational and external internal result within the business climate

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

XV International Congress of Control Electronics and Telecommunications: "The role of technology in times of pandemic and post-pandemic: innovation and development for strategic social and productive sectors"

La anterior selección, motivados por la aseveración de Manuel Castells -hace casi 20 años ya- que la innovación y la difusión de la tecnología parecía ser la herramienta apropiada para el desarrollo en la era de la información. Este 2020, sin embargo, ante la situación disruptiva que aquejó y aqueja a la sociedad red como una estructura social emergente de la Era de la Información basada en redes de producción, energizadas por el poder y la experiencia; falló y debe reencontrar su rumbo. Es así que los problemas acuciantes, ahora, fueron: la atención sanitaria y la superación de la epidemia de Sars Cov 2; tomó forma la, hasta entonces, visión irrealista de Castells que … no podemos avanzar con nuestros modelos de desarrollo actual, destruyendo nuestro entorno y excluyendo a la mayor parte de la humanidad de los beneficios de la revolución tecnológica más extraordinaria de la historia, sin sufrir una devastadora reacción por parte de la sociedad y la naturaleza. Fue así que el Cuarto Mundo, específicamente, donde la suficiencia de recurso humano, de capital, trabajo, información y mercado -vinculados todos a través de la tecnología- supuso que atendería eficazmente a través de la población que podía por su capacidad hacer uso racional y profesional del conocimiento, las necesidades de la mayoritaria población vulnerable y vulnerada. Por lo anterior, poner en el centro a las personas, en entornos de tarea y trabajo globales hiperconectados combinando espacios físicos, corrientes de información con canales de conexión expeditos, y formando profesionales del conocimiento que asuman y afronten los retos derivados de la transformación digital de empresas, universidades, y organizaciones, pero en condiciones de equidad y sujetos de prosperidad, será el desafío en los escenarios presentes y futuros inmediatos.The previous selection, motivated by the assertion of Manuel Castells -almost 20 years ago- that innovation and diffusion of technology seemed to be the appropriate tool for development in the information age. This 2020, however, in the face of the disruptive situation that afflicted and continues to afflict the network society as an emerging social structure of the Information Age based on production networks, energized by power and experience; He failed and must find his way again. Thus, the pressing problems now were: health care and overcoming the Sars Cov 2 epidemic; Castells' until then unrealistic vision took shape that... we cannot advance with our current development models, destroying our environment and excluding the majority of humanity from the benefits of the most extraordinary technological revolution in history, without suffering a devastating reaction from society and nature. It was thus that the Fourth World, specifically, where the sufficiency of human resources, capital, work, information and market - all linked through technology - meant that it would serve effectively through the population that could, due to its capacity, make rational use. and knowledge professional, the needs of the majority vulnerable and vulnerable population. Therefore, putting people at the center, in hyperconnected global task and work environments, combining physical spaces, information flows with expedited connection channels, and training knowledge professionals who assume and face the challenges derived from the digital transformation of companies, universities, and organizations, but in conditions of equality and subject to prosperity, will be the challenge in the present and immediate future scenarios.Bogot

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele