6,720 research outputs found
Video games and Intellectual Disabilities: a literature review.
Los videojuegos son omnipresentes en la sociedad y esta tecnologĂa ha trascendido su lado lĂşdico inicial para convertirse tambiĂ©n en una herramienta educativa y de entrenamiento cognitivo. En este sentido, diferentes estudios han demostrado que los jugadores expertos obtener ventajas en diversos procesos cognitivos respecto a no-jugadores y jugar con juegos de video puede resultar en especial los beneficios que en algunos casos podrĂa generalizarse a otras tareas. En consecuencia, los juegos de video podrĂa ser utilizado como una herramienta de formaciĂłn para mejorar las capacidades cognitivas en poblaciones atĂpicas, como las relativas a las personas con discapacidad intelectual (DI). Sin embargo, la literatura sobre los videojuegos en personas con ID es escasa. En este trabajo se ejecutĂł una revisiĂłn narrativa de los estudios sobre el uso de los videojuegos en relaciĂłn a las personas con ID.Video games are ubiquitous in the society and this technology has transcended its initial playful side to become also an educational and cognitive training tool. In this sense, different studies have shown that expert game players gain advantages in various cognitive processes respect to non-players and that playing with video games can result in particular profits that in some cases could be generalized to other tasks. Accordingly, video games could be used as a training tool in order to improve cognitive abilities in atypical populations, such as relating to individuals with intellectual disabilities (ID). However, literature concerning video games in people with ID is sparse. In this paper we executed a narrative review of the studies about the use of video games in relation to people with ID.• FundaciĂłn Valhondo Calaff (Cáceres), para Marta RodrĂguez JimĂ©nez
• Università di Padova. Beca CPDA 127939, para Silvia LanfranchipeerReviewe
Model-based indicators of labour market rigidity
We derive indicators of labour market flexibility that are comparable across countries and time intervals. Our indicators build on a structural VAR model of real wages, output and unemployment dynamics. We compute our indicators for thirteen OECD countries and for two time periods, and we compare them with existing indicators of labour market flexibility in the literature . The main result of the paper is that we did not find evidence of a closing gap in terms of labour market flexibility between the United States and continental European countries, although our findings suggest that medium-sized and small countries have experienced greater improvements in this regard than the large countries since the mid-eighties. JEL Classification: J20, J21, J41
Estrategias artĂsticas en torno a la EscenografĂa: hacia una EscenografĂa Expandida
En esta comunicaciĂłn se reflexiona sobre la docencia de la asignatura “EscenografĂa” en la Facultad de Bellas Artes de la Universidad de Málaga. Esta asignatura enmarcada en el área de Escultura intenta cuestionar el proceso de creaciĂłn artĂstica de un espacio escenográfico facilitando una formaciĂłn activa y manteniendo unas propuestas que desarrollen el espĂritu investigador y experimental tanto a nivel formal como conceptual del alumnado, partiendo de la obra literaria “Historias de cronopios y famas” de Julio Cortázar. El planteamiento de esta asignatura busca generar un espacio formativo que motive la investigaciĂłn y creatividad del alumnado y promueva la bĂşsqueda de nuevas alternativas expresivas y simbĂłlicas en el diseño y creaciĂłn de espacios escenográficos.Universidad de Málaga. Campus de Excelencia Internacional AndalucĂa Tech
Using stakeholder dialogue as a source for new ideas. A dynamic capability underlying sustainable innovation
This paper attempts to gain a deeper understanding of the firm's ability for integrating stakeholder insights into the process of organisational innovation within the context of sustainable development. Given the early stage of empirical research on the topic, we used an exploratory case study method of two Spanish companies that have successfully learned from stakeholder dialogue and have generated innovations that are both beneficial for the company and for sustainable development in general. The evidence from the two case studies suggests the existence of two simple capabilities - stakeholder dialogue and stakeholder knowledge integration - for generating innovations in accordance with stakeholder needs. Whereas stakeholder dialogue leverages organisational resources that promote two-way communication, transparency and appropriate feedback to stakeholders, stakeholder knowledge integration relies on non-hierarchical structures, flexibility and openness to change. The paper sheds some light on the under-researched issue of linking stakeholder dialogue and sustainable innovation, and contributes to opening the 'black box' of dynamic capabilities and advancing in the understanding of this fundamental organisational concept.sustainable development; stakeholders; innovation; capabilities;
Social media, interactive tools that change business model dynamics
The aim of this research is two-folded. On the one hand, it attempts to assist
employers of Catalan micro-retailers in designing, implementing and developing their
Social Media strategy as a complementary channel of communication. On the other
hand, it attempts to contribute to the research community with a better understanding
on both which building block of the micro-retailerÂżs Business Model is more
influenced by the customer level of interaction by means of the Social Media and how
a transformation can be observed in the micro-retailersÂż Business Models as a result
of the Social Media implementation.
The research question to be answered in this paper is how the transformation of the
activity system of the micro-retailersÂż Business Model would allow the emergence of
a Participatory Business Model by means of Social Media. To carry out this research
the Participatory Action Research methodology was used, whose contribution has two
results: the one is more practitioner oriented and the other is more academic.
The incipient results of the research showed a scarce transformation of Catalan microretailerÂżs
business model as a consequence of the implementation of social media.
However, it is significant enough to be considered as more than just a simple adoption
of an alternative channel of communication.
One of the main contributions is related to how customer influences the activity
system of the micro-retailerÂżs business model beyond four levels of customer
interaction (communication, interaction, participation and collaboration) by means of
social media. On the one hand, the activity system of a business model is referred to
the eight building blocks of Osterwalder, Pigneur and Tucci (2005) research that
includes customer segment, customer relationship, distribution channel, capabilities,
partner, value configuration, value proposition, profit and cost. On the other hand, the
four defined levels of customer interaction are based on the literature of group
collaboration systems.
The results showed that not all the building blocks forming the business model are
influenced by consumer interaction. The only building blocks influenced by an initial
communication level in the current social media strategy implementation stage of our
sample (five micro-retailers) are the following: customer segment, customer
relationship, distribution channel, value proposition and cost. This incipient stage of
transformation can be justified by a lack of effort made due to the small size of the
business and a lack of team working inside the companies, easily adapting to changes.
It can also be justified by the fact it was carried out by the micro-retailers only during
a short period of time (14 month).
Another contribution of the paper shows that Social Media transformation drives a
BM innovation according to the following mediator elements: (1) the dynamic
capabilities, (2) the ability of learning, (3) the dedicated effort, (4) the implementation
time and (5) the level of customer participation
Multifunctional Scaffolds for Selective Protein-Protein Inhibition
Protein-protein interactions (PPIs) play an important role in numerous biological processes. Consequently, modulating PPIs is fundamental for understanding and manipulating mechanisms that govern many diseases. Among the wide range of topographies that PPIs display, the α-helix is the most common secondary structure in nature and thus represents a good generic template for inhibitor design.1 Some of the most relevant approaches in this field are the proteomimetic approach, which recapitulate the key binding residues of an α-helix on a non-peptidic scaffold; and the constrained peptides, which aim to reproduce the helical structure by stabilising a helical peptide. Both approaches have generated potent inhibitors of a great diversity of α-helix mediated PPIs. However, developing a better understanding of the key features that govern the modulation of protein recognition is necessary to further advance the field and fully exploit each class of foldamer.
In that context, we developed functionalised aromatic oligoamide backbones to mimic residues located on multiple faces of an -helix to target the ER/co-activator PPI. The novel scaffolds are based on bis-benzamide and N-(4-aminophenyl)terephthalamidic acid backbones functionalised with isobutyl groups to reproduce the key side chains of the co-activator α-helix. Conformational studies in combination with molecular modeling and docking analysis provide evidence that the new oligomers can adopt conformations that mimic the residues at i, i+3 and i+4 positions of the native co-activator α-helix.
In addition, the rules that govern molecular recognition of protein surfaces were further investigated through the optimisation of the oligobenzamide hybrid scaffold using a structure-activity relationship (SAR) study. A library of compound analogues has been synthesised incorporating five variable sites. The modifications focused on size, polarity and stereochemistry to obtain more potent and selective proteomimetic inhibitors of the p53/hDM2 and Mcl-1/NOXA B PPIs.
Finally, using existing methodologies a 3-O-alkylated proteomimetic scaffold and hydrocarbon stapling peptide strategy, have been used to design inhibitors of the Asf1/H3 interaction. The application of both approaches allowed the different inhibitor designs to be directly compared when targeting the same PPI
Maximizing stakeholders' interests: An empirical analysis of the stakeholder approach to corporate governance
The purpose of this paper is to build on the emerging stakeholder model of corporate governance by analyzing the CSR function at board level, board diversity, and stakeholder engagement, and how it relates to financial performance. Based on an empirical study of an international sample of large companies, we find board responsibility for CSR to be a key factor in promoting engagement with primary and secondary stakeholders of the firm. Depending on the legal tradition of the country in which the company is based, we find evidence that board diversity and stakeholder engagement are positively correlated with firm financial performance.Corporate governance; corporate social responsibility; board diversity; stakeholder engagement; firm performance;
Model-based indicators of labour market rigidity
We derive indicators of labour market flexibility that are comparable across countries and time intervals. Our indicators build on a structural VAR model of real wages, output and unemployment dynamics. We compute our indicators for thirteen OECD countries and for two time periods, and we compare them with existing indicators of labour market flexibility in the literature . The main result of the paper is that we did not find evidence of a closing gap in terms of labour market flexibility between the United States and continental European countries, although our findings suggest that medium-sized and small countries have experienced greater improvements in this regard than the large countries since the mid-eighties
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