Contratación de personas con discapacidad y determinación del impuesto a la renta en Servicios Chan Chan S.A., Trujillo, 2018

El presente trabajo de investigación tiene por objetivo determinar el efecto de la contratación de personas con discapacidad en la determinación del impuesto a la renta en la empresa de Servicios Chan Chan S.A., Distrito de Trujillo, año 2018. Para ello se usó el tipo de investigación de nivel descriptivo y el diseño de la investigación no experimental, siendo la muestra la empresa de Servicios Chan Chan S.A., año 2018. Haciendo uso de la técnica de entrevista y análisis documentario para la recolección de información. Se concluye que la contratación de personas con discapacidad tiene un efecto positivo en la determinación del impuesto a la renta en la empresa de Servicios Chan Chan S.A., Año 2018, ya que al término del ejercicio económico 2018 en la determinación del impuesto a la renta anual fue de 153,334 soles, este monto es sin considerar la aplicación de la deducción adicional y el crédito frente al impuesto a la renta anual; sin embargo, al aplicar estos beneficios el resultado fue de 148,753 soles, el cual beneficia a la empresa

New Electrocardiographic Algorithm for the Diagnosis of Acute Myocardial Infarction in Patients With Left Bundle Branch Block

Background Current electrocardiographic algorithms lack sensitivity to diagnose acute myocardial infarction (AMI) in the presence of left bundle branch block. Methods and Results A multicenter retrospective cohort study including consecutive patients with suspected AMI and left bundle branch block, referred for primary percutaneous coronary intervention between 2009 and 2018. Pre-2015 patients formed the derivation cohort (n=163, 61 with AMI); patients between 2015 and 2018 formed the validation cohort (n=107, 40 with AMI). A control group of patients without suspected AMI was also studied (n=214). Different electrocardiographic criteria were tested. A total of 484 patients were studied. A new electrocardiographic algorithm (BARCELONA algorithm) was derived and validated. The algorithm is positive in the presence of ST deviation ≥1 mm (0.1 mV) concordant with QRS polarity, in any lead, or ST deviation ≥1 mm (0.1 mV) discordant with the QRS, in leads with max (R|S) voltage (the voltage of the largest deflection of the QRS, ie, R or S wave) ≤6 mm (0.6 mV). In both the derivation and the validation cohort, the BARCELONA algorithm achieved the highest sensitivity (93%-95%), negative predictive value (96%-97%), efficiency (91%-94%) and area under the receiver operating characteristic curve (0.92-0.93), significantly higher than previous electrocardiographic rules (P<0.01); the specificity was good in both groups (89%-94%) as well as the control group (90%). Conclusions In patients with left bundle branch block referred for primary percutaneous coronary intervention, the BARCELONA algorithm was specific and highly sensitive for the diagnosis of AMI, leading to a diagnostic accuracy comparable to that obtained by ECG in patients without left bundle branch block

Estudio bibliométrico sobre extensión agraria de cultivos hortí­colas en revistas cientí­ficas agrí­colas de Cuba

La producción y consumo de hortalizas está en pleno crecimiento en el mundo, los consumidores están modificando sus hábitos de consumo, influenciados por una mayor conciencia sobre la salud (Ferratto y Mondino, 2008), esto va acompañado por la labor de los actores que intervienen en la Extensión agraria donde son capaces de trasmitir el avance de la ciencia, y que se mide a partir de sus producciones cientí­ficas. El presente estudio tiene como objetivo analizar los artí­culos sobre extensión agraria en las revistas cientí­ficas agrí­colas con interés hortí­cola durante el perí­odo 2005-2015. Se utilizaron indicadores bibliométricos para determinar la producción cientí­fica anual, la de las revistas, institucional, así­ como, la autoral. Los trabajos nacionales y originales fueron los de mayor representación distribuida en las revistas: Agrotecnia de Cuba, Centro Agrí­cola, Cultivos Tropicales, Fitosanidad y Protección Vegetal. La revista Cultivos Tropicales, es la que más difunde la Extensión agraria en los cultivos de hortalizas y el Instituto Nacional de Ciencia Agrí­cola es la institución con mayor visibilidad en el tema. Los resultados, por sí­ solo, expresan que no existe un impacto en el quehacer cientí­fico en las revistas de ciencia agrí­colas sobre el trabajo de extensión agraria en estos cultivos, de igual forma, estos solo reflejan una realidad y no se corresponde con el desarrollo cultural existente en el paí­s en las hortalizas

Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha

Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch their core metabolism from oxidative phosphorylation to glycolysis1. Here we show that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macrophages. A comprehensive metabolic map of lipopolysaccharide-activated macrophages shows upregulation of glycolytic and downregulation of mitochondrial genes, which correlates directly with the expression profiles of altered metabolites. Lipopolysaccharide strongly increases the levels of the tricarboxylic-acid cycle intermediate succinate. Glutamine-dependent anerplerosis is the principal source of succinate, although the ‘GABA (γ-aminobutyric acid) shunt’ pathway also has a role. Lipopolysaccharide-induced succinate stabilizes hypoxia-inducible factor-1α, an effect that is inhibited by 2-deoxyglucose, with interleukin-1β as an important target. Lipopolysaccharide also increases succinylation of several proteins. We therefore identify succinate as a metabolite in innate immune signalling, which enhances interleukin-1β production during inflammation

Mycobacterium “habana” TMC 5135 as a vaccine candidate against tuberculosis: In vitro studies

Background: Tuberculosis (TB) is one of the biggest problems of global health, at present. Bacillus–Calmette–Guérin is the only vaccine available against this disease. It protects only against the severe forms of TB in the childhood, which is a challenge in the search of new vaccine candidates. Taking into account the protective history of Mycobacterium “habana” against experimental TB, we proposed to provide the elements that support the use of M. “habana” TMC 5135 as a vaccine candidate against TB by infection studies in murine macrophages cell cultures. Methods: The production of microbicidal compounds dependent on oxygen metabolism as nitric oxide and hydrogen peroxide by murine peritoneal macrophages was detected. The invasive and toxigenic capacity of M. “habana” to infect this cell type was also evaluated through the quantification of intracellular alive bacillus and 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay, respectively. Results: The results suggest that M. “habana” TMC 5135 is able to persist into peritoneal macrophages, to resist the effectors mechanisms of respiratory burst, and to keep the viability of the target cell. The demonstration of these effector mechanisms and the survival capacity of M. “habana” in this niche are relevant aspects of this research assuring the continuity of this candidate to next phases of preclinical development. Conclusion: The present investigation contributes to the characterization of the infection by this mycobacteria in its main target cells of innate immunity and it suggest future investigations to evaluate the activation of effector mechanisms of the innate immunity against this candidate

Towards contact integration for III-V/Silicon heterogeneous photonics devices

International audienceSilicon photonics is of great interest as it opens the way to large bandwidth and high data rates. A pioneer Silicon photonics scheme consists in integrating III-V lasers on the SOI substrates containing the passive components. However, key developments are necessary to co-integrate III-V devices with CMOS very large scale integration (VLSI). In this paper we propose a CMOS-compatible integration scheme of contacts (i.e. semiconductor metallization and plug) on III-V surfaces taking into account the limitations fixed by the operating laser device. Based on metallurgical, morphological, optical and electrical studies, processes are submitted and reviewed for the purpose of forming stable and reproducible contacts with low resistivity in a 200 millimeters fab line

Metallurgical studies of integrable Ni-based contacts for their use in III–V/Si heterogeneous photonics devices

International audienceOpening the way to large bandwidths and high data rates Silicon Photonics is of great interest. In the scope of co-integrating III-V devices with CMOS very large scale integration (VLSI), innovative contacts to III-V materials have to be developed. In this paper we study the metallurgical and electrical properties of Ni-based metallizations to n-InP and p-InGaAs. It appears that the integration of both metallizations must be realized at temperatures lower than or equal to 340 °C starting with that on n-InP