Narrador como pilar da estrutura narrativa na curta-metragem Bégan

Trabalho de projetoA escrita deste ensaio é o resultado de uma análise ao papel que um narrador ocupa na narrativa cinematográfica. Desenvolvendo teoricamente conceitos de narratologia e linguagem cinematográfica, a primeira parte argumenta como a personagem-narrador pode ser a base que sustenta uma narrativa e consolida pesquisa que sustenta a curta-metragem Bégan. Nesse sentido, a segunda parte caracteriza as etapas de desenvolvimento do projeto, desde a conceção da ideia à escrita do argumento, explicando como pode uma estrutura narrativa circunscrever-se a um narrador heterodiegético. A conclusão atingida apresenta como o projeto comprova a premissa do ensaio.The writing of this essay is the result of an analysis of the role that a narrator occupies in the cinematic narrative. By theoretically developing concepts of narratology and cinematic language, the first part argues how the narrator-character can be the basis that sustains a narrative and consolidates research that sustains the short film Bégan. In this sense, the second part characterizes the stages of development of the project, from the conception of the idea to the writing of the argument, explaining how a narrative structure can be limited to a heterodiegetic narrator. The conclusion reached shows how the project proves the premise of the essay

The academic incubation impact: a selection process evaluation

Among the main issues pointed out in the literature, much of the attention in the research has been related to impact evaluation of business incubation. Although the internal process is considered as a black box by several studies, the main components of incubation are already known. The focus of this work is an evaluation strategy of the first component - the selection process. The effectiveness of this stage was evaluated as the alignment between the incubator desired profile and the companies entrepreneurial orientation. Although innovativeness was perceived as the main characteristic, the survival-of-the-fittest strategy was more evident. The entrepreneurial orientation offers a set of relevant selection criteria because it expands the term weak-but-promise into better-defined concepts and relates to the existing incubation literature. Therefore, this analysis presents a more structured approach to effectiveness evaluation of selection process, opening the incubator black box. As future work, it is suggested to evaluate pre-incubation activities to verify their impact along with this approach

The Colors of a Bible and Three Gospels Produced in the Armenian Diaspora

Funding Information: This research was funded by the Portuguese Foundation for Science and Technology [Fundação para a Ciência e Tecnologia, Ministério da Educação e Ciência (FCT/MCTES)], through PhD grants awarded to Márcia Vieira [SFRH/BD/148729/2019] and to Hermine Grigoryan [PD/BD/142866/2018], CEEC junior contract awarded to Paula Nabais (2021.01344.CEECIND), UIDB/EAT/00729/2020, UIDP/00729/2020; Associate Laboratory for Green Chemistry- LAQV financed by FCT/MCTES (UID/QUI/50006/2019 and UIDB/50006/2020) and co-financed by the ERDF under the PT2020 Partnership Agreement (PO-CI-01-0145-FEDER-007265); Glass and Ceramic for the Arts—VICARTE financed by FCT/MCTES (UIDB/00729/2020 and UIDP/00729/2020); Laboratory for Instrumentation, Bio-medical Engineering and Radiation Physics—LIBPhys financed by FCT/MCTES (UIDB/04559/2020 and UIDP/04559/2020). Calouste Gulbenkian Foundation grant on Armenian Studies (No. 269685) awarded to Hermine Grigoryan. Publisher Copyright: © 2023 by the authors.The illuminated manuscripts at the Gulbenkian Museum were produced in the 17th century, in scriptoria of the Armenian diaspora. In this work, we selected analytical methods that can be used in situ to study the colors of the illuminations. Scientific analysis based on fiber-optics reflectance spectroscopy in the visible and Raman spectroscopy has shown the use of a medieval palette based on inorganic pigments such as lapis lazuli, minium, vermilion, orpiment, indigo, two different greens (vergaut and malachite), lead white and carbon black. More importantly, in this context, it showed that the very important reds and pinks are possibly based on carminic acid. The painting technique is, however, different, as are the ways of painting the faces, hands, and vestments. The range of colors in the Bible and the three Gospel Books, enhanced by lapis lazuli blue and organic reds and pinks, demonstrates a desire to create exceptional illuminated manuscripts.publishersversionpublishe

Aerococcus spp infective endocarditis following a prostate biopsy: a case report

We report a rare case of an infective endocarditis by Aerococcus spp in a bioprosthetic aortic valve following a prostate biopsy, in an asymptomatic adult with no additional risk factor for prostate cancer, excepting for age. The diagnosis was based on the presence of vegetations on the bioprosthesis seen on the echocardiogram, positive blood cultures and fever, and a favorable clinical outcome following the treatment with ceftriaxone and gentamicin

Antimicrobial resistance and class I integrons in Salmonella enterica isolates from wild boars and Bísaro pigs

The antibiotic resistance phenotype and genotype and the integron type were characterized in 58 Salmonellaenterica isolates recovered from Bísaro pigs and wild boars (20 S. Typhimurium, 17 S. Rissen, 14 S. Enteritidis and 7S. Havana). Most S. Typhimurium isolates (15/20 of Bísaro pigs and wild boars) showed ampicillin, chloramphenicol, streptomycin, tetracycline, sulfonamide, and amoxicillin-clavulanic acid resistances. Of the 17 S. Rissen isolates of both origins, 13 were resistant to ampicillin, tetracycline and trimethoprim-sulfamethoxazole. Among the S. Enteritidis isolates of Bísaro pigs, eight were nalidixic acid-resistant and three were sulfonamide-resistant. The tet(A) or tet(G) genes were detected in most tetracycline-resistant isolates. The intI1 gene was identified in 72.5% of S. enterica isolates in which the conserved region 3′ of class 1 integrons (qacEΔ1+sul1) was also amplified, whereas none had the intI2 gene. The dfrA12+orfF+aadA2 gene cassette arrangement was found in the variable region of class 1 integrons in 14 S. Rissen isolates. Fifteen S. Typhimurium isolates had two integrons with variable regions of 1000 and 1200 bp that harbored the aadA2 and blaPSE-1 gene cassettes, respectively. In these isolates the floR and tet(G) genes were also amplified, indicative of the genomic island 1 (SGI1). Salmonella Typhimurium and S. Rissen of animal origin frequently show a multi-antimicrobial resistant phenotype, which may have implications in public health. [Int Microbiol 2011; 14(1):19-24

9-Borafluoren-9-yl and diphenylboron tetracoordinate complexes of F- and Cl-substituted 8-quinolinolato ligands: synthesis, molecular and electronic structures, fluorescence and application in OLED devices

Six new four-coordinate tetrahedral boron complexes, containing 9-borafluoren-9-yl and diphenylboron cores attached to orthogonal fluorine- and chlorine-substituted 8-quinolinolato ligand chromophores, have been synthesised, characterised, and applied as emitters in organic light-emitting diodes (OLEDs). An extensive steady-state and time-resolved photophysical study, in solution and in the solid state, resulted in the first-time report of delayed fluorescence (DF) in solid films of 8-quinolinolato boron complexes. The DF intensity dependence on excitation dose suggests that this emission originates from triplet–triplet annihilation (TTA). Density functional theory (DFT) and time-dependent density functional theory (TDDFT) studies give insight into the ground and excited state geometries, electronic structures, absorption energies, and singlet–triplet gaps in these new organoboron luminophores. Finally, given their highly luminescent behaviour, organic light-emitting diode (OLED) devices were produced using the synthesised organoboron compounds as emissive fluorescent dopants. The best OLED displays green-blue (λmaxEL = 489 nm) electroluminescence with an external quantum efficiency (EQE) of 3.3% and a maximum luminance of 6300 cd m−2

Fatores Associados aos Triggers e Eventos Adversos em Pediatria

Highlights: This study evaluated triggers and adverse events in pediatric patients. More than 50% of patients had at least one trigger. The most common triggers included drops in hemoglobin and oxygen saturation. Risk management is crucial to the safety of pediatric patients. Introduction: The frequent occurrence of adverse events during hospital admission demands proactive means of risk management, including checking trackers/triggers. Objective: to verify the factors associated with triggers and adverse events in pediatric hospitalization. Material and Methods: Cross-sectional research based on the Institute for Healthcare Improvement (IHI) methodology, through the application of the Pediatric Trigger Tool (PTT) to a sample (n= 194) from medical records of pediatric patients from a hospital in the Center-West of Brazil. Descriptive, inferential statistical analysis and Poisson regression were performed. Results: More than half (n=107; 55.15%) of patients had at least one trigger upon admission. 204 triggers were identified, with the highest occurrence of a drop in hemoglobin/hematocrit (9.80%), a drop in oxygen saturation (9.80%) and an increase in kidney function markers (9.20%). Of the total triggers, 64 (31.37%) adverse events were confirmed, which were mostly classified as temporary damage requiring patient support (65.62%). The length of stay (p-value=0.004) and the nature of the hospitalization (p-value<0.001) were variables associated with the occurrence of triggers. Character of hospitalization and admissions from other institutions were predictors of the occurrence of triggers and adverse events.   Discussion: The study found 31.37% of triggers resulting in harm to the patient, early detection is essential in pediatric patient safety, prolonged hospitalizations are linked to infections and adverse events, patient transfers require rigorous and effective safety measures.   Conclusions:  Prolonged hospitalizations and children admitted via transfer deserve attention to triggers and/or adverse events. How to cite this article: Moraes, Rúbia Marcela Rodrigues; Jucá, Sileyde Cristiane Bernardino Matos Povoas; de Quadros, Deise Vacario; de Magalhães, Ana María Müller; Júnior, Gilmar Jorge de Oliveira; Barbosa, Welistânia Vieira Bispo; de Oliveira, João Lucas Campos.  Fatores Associados aos Triggers e Eventos Adversos em Pediatria. Revista Cuidarte. 2023;14(3):e3060. http://dx.doi.org/10.15649/cuidarte.3060Introducción: La frecuente aparición de eventos adversos durante el ingreso hospitalario exige medios proactivos de gestión de riesgos, incluida la verificación de rastreadores /disparadores.  Objetivo: verificar los factores asociados a desencadenantes y eventos adversos en la hospitalización pediátrica, Material y Métodos:  Investigación transversal basada en la metodología Institute for Healthcare Improvement  (IHI), mediante la aplicación del Pediatric Trigger Tool (PTT) a una muestra (n= 194) de historias clínicas de pacientes pediátricos de un hospital del Centro-Oeste de Brasil. Se realizaron análisis estadísticos descriptivos, inferenciales y regresión de Poisson. Resultados: Más de la mitad (n=107; 55,15%) de los pacientes presentaron al menos un desencadenante al ingreso. Se identificaron 204 desencadenantes, con mayor incidencia de descenso de la hemoglobina /hematocrito (9,80%), descenso de la saturación de oxígeno (9,80%) y aumento de los marcadores de función renal (9,20%). Del total de desencadenantes, se confirmaron 64 (31,37%) eventos adversos, los cuales en su mayoría fueron clasificados como daños temporales que requirieron apoyo del paciente (65,62%). La duración de la estancia (p-valor=0,004) y la naturaleza de la hospitalización (p-valor<0,001) fueron variables asociadas con la aparición de desencadenantes. El carácter de la hospitalización y los ingresos de otras instituciones fueron predictores de la aparición de desencadenantes y eventos adversos. Discusión: El estudio encontró que el 31,37% de los desencadenantes resultan en daño al paciente, la detección temprana es esencial en la seguridad del paciente pediátrico, las hospitalizaciones prolongadas están vinculadas a infecciones y eventos adversos, los traslados de pacientes requieren medidas de seguridad rigurosas y efectivas.   Conclusiones:  Las hospitalizaciones prolongadas y los niños ingresados ​​vía traslado merecen atención a los desencadenantes y/o eventos adversos. Como citar este artículo: Moraes, Rúbia Marcela Rodrigues; Jucá, Sileyde Cristiane Bernardino Matos Povoas; de Quadros, Deise Vacario; de Magalhães, Ana María Müller; Júnior, Gilmar Jorge de Oliveira; Barbosa, Welistânia Vieira Bispo; de Oliveira, João Lucas Campos.  Fatores Associados aos Triggers e Eventos Adversos em Pediatria. Revista Cuidarte. 2023;14(3):e3060. http://dx.doi.org/10.15649/cuidarte.3060Highlights: Este estudo avaliou triggers e eventos adversos em pacientes pediátricos. Mais de 50% dos pacientes apresentaram pelo menos um trigger. Os triggers mais comuns incluíam queda na hemoglobina e saturação de oxigênio. A gestão de riscos é crucial na segurança de pacientes pediátricos. Introdução: A ocorrência frequente de eventos adversos durante a internação hospitalar demanda meios proativos de gerenciamento de riscos, incluindo a verificação de rastreadores /triggers. Objetivo: verificar os fatores associados aos triggers e eventos adversos na internação pediátrica. Material e Métodos: Pesquisa transversal embasada na metodologia do Institute for Healthcare Improvement (IHI), por meio da aplicação do Paediatric Trigger Tool (PTT) a uma amostra (n=194) de prontuários de pacientes pediátricos de um hospital do Centro-Oeste do Brasil. Foi realizada análise estatística descritiva, inferencial e regressão de Poisson. Resultados: Mais da metade (n=107; 55,15%) dos pacientes apresentou pelo menos um trigger na internação. Foram identificados 204 triggers/gatilhos, com maior ocorrência de queda de hemoglobina /hematócrito (9,80%), queda de saturação de oxigênio (9,80%) e aumento de marcadores de funções renais (9,20%). Do total de gatilhos, 64 (31,37%) eventos adversos foram confirmados, os quais foram classificados majoritariamente como dano temporário com necessidade de suporte ao paciente (65,62%). O tempo de internação (p-valor=0,004) e o caráter da internação (p-valor<0,001) foram variáveis associadas à ocorrência de triggers. Caráter de internação e admissões provenientes de outras instituições foram preditores na ocorrência de triggers e eventos adversos. Discussão: O estudo encontrou 31,37% dos triggers resultando em danos ao paciente, a detecção precoce é essencial na segurança do paciente pediátrico, internações prolongadas estão ligadas a infecções e eventos adversos, transferências de pacientes exigem medidas de segurança rigorosas e eficazes.  Conclusões: internações prolongadas e crianças admitidas via transferência merecem atenção a triggers e/ou eventos adversos concretizados. Como citar este artigo: Moraes, Rúbia Marcela Rodrigues; Jucá, Sileyde Cristiane Bernardino Matos Povoas; de Quadros, Deise Vacario; de Magalhães, Ana María Müller; Júnior, Gilmar Jorge de Oliveira; Barbosa, Welistânia Vieira Bispo; de Oliveira, João Lucas Campos.  Fatores Associados aos Triggers e Eventos Adversos em Pediatria. Revista Cuidarte. 2023;14(3):e3060.  http://dx.doi.org/10.15649/cuidarte.306

Effects of collagen membranes enriched with in vitro-differentiated N1E-115 cells on rat sciatic nerve regeneration after end-to-end repair

Peripheral nerves possess the capacity of self-regeneration after traumatic injury but the extent of regeneration is often poor and may benefit from exogenous factors that enhance growth. The use of cellular systems is a rational approach for delivering neurotrophic factors at the nerve lesion site, and in the present study we investigated the effects of enwrapping the site of end-to-end rat sciatic nerve repair with an equine type III collagen membrane enriched or not with N1E-115 pre-differentiated neural cells. After neurotmesis, the sciatic nerve was repaired by end-to-end suture (End-to-End group), end-to-end suture enwrapped with an equine collagen type III membrane (End-to-EndMemb group); and end-to-end suture enwrapped with an equine collagen type III membrane previously covered with neural cells pre-differentiated in vitro from N1E-115 cells (End-to-EndMembCell group). Along the postoperative, motor and sensory functional recovery was evaluated using extensor postural thrust (EPT), withdrawal reflex latency (WRL) and ankle kinematics. After 20 weeks animals were sacrificed and the repaired sciatic nerves were processed for histological and stereological analysis. Results showed that enwrapment of the rapair site with a collagen membrane, with or without neural cell enrichment, did not lead to any significant improvement in most of functional and stereological predictors of nerve regeneration that we have assessed, with the exception of EPT which recovered significantly better after neural cell enriched membrane employment. It can thus be concluded that this particular type of nerve tissue engineering approach has very limited effects on nerve regeneration after sciatic end-to-end nerve reconstruction in the rat

Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder

Deregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. Increased HDAC3 levels were associated with improved patient survival. SiRNA experiments showed decrease cell viability and motility, and increased apoptosis. We concluded that class I HDACs play an important role in bladder carcinogenesis through deregulation of proliferation, migration and apoptosis, constituting putative therapeutic targets.info:eu-repo/semantics/publishedVersio