1,580 research outputs found
Internet Media in Technological Risk Amplification: Plutonium on Board the Cassini-Huygens Spacecraft
The author discusses how the Cassini controversy demonstrates the power of the Internet, particularly listservs and Usenet groups, and how this resource offers political activists an opportunity to affect the agendas of risk management policy decision-makers
Spatial accessibility and social inclusion: The impact of Portugal's last health reform
Health policies seek to promote access to health care and should provide appropriate geographical accessibility to each demographical functional group. The dispersal demand of health‐careservices and the provision for such services atfixed locations contribute to the growth of inequality intheir access. Therefore, the optimal distribution of health facilities over the space/area can lead toaccessibility improvements and to the mitigation of the social exclusion of the groups considered mostvulnerable. Requiring for such, the use of planning practices joined with accessibility measures. However,the capacities of Geographic Information Systems in determining and evaluating spatial accessibility inhealth system planning have not yet been fully exploited. This paper focuses on health‐care services planningbased on accessibility measures grounded on the network analysis. The case study hinges on mainlandPortugal. Different scenarios were developed to measure and compare impact on the population'saccessibility. It distinguishes itself from other studies of accessibility measures by integrating network data ina spatial accessibility measure: the enhanced two‐stepfloating catchment area. The convenient location forhealth‐care facilities can increase the accessibility standards of the population and consequently reducethe economic and social costs incurred. Recently, the Portuguese government implemented a reform thataimed to improve, namely, the access and equity in meeting with the most urgent patients. It envisaged,in terms of equity, the allocation of 89 emergency network points that ensured more than 90% of thepopulation be within 30 min from any one point in the network. Consequently, several emergency serviceswere closed, namely, in rural areas. This reform highlighted the need to improve the quality of the emergencycare, accessibility to each care facility, and equity in their access. Hence, accessibility measures becomean efficient decision‐making tool, despite its absence in effective practice planning. According to anapplication of this type of measure, it was possible to verify which levels of accessibility were decreased,including the most disadvantaged people, with a larger time of dislocation of 12 min between 2001 and 2011
BDNF Val66Met Polymorphism Influences Age Differences in Microstructure of the Corpus Callosum
Brain-derived neurotrophic factor (BDNF) plays an important role in neuroplasticity and promotes axonal growth, but its secretion, regulated by a BDNF gene, declines with age. The low-activity (met) allele of common polymorphism BDNF val66met is associated with reduced production of BDNF. We examined whether age-related reduction in the integrity of cerebral white matter (WM) depends on the BDNF val66met genotype. Forty-one middle-aged and older adults participated in the study. Regional WM integrity was assessed by fractional anisotropy (FA) computed from manually drawn regions of interest in the genu and splenium of the corpus callosum on diffusion tensor imaging scans. After controlling for effects of sex and hypertension, we found that only the BDNF 66met carriers displayed age-related declines in the splenium FA, whereas no age-related declines were shown by BDNF val homozygotes. No genotype-related differences were observed in the genu of the corpus callosum. This finding is consistent with a view that genetic risk for reduced BDNF affects posterior regions that otherwise are considered relatively insensitive to normal aging. Those individuals with a genetic predisposition for decreased BDNF expression may not be able to fully benefit from BDNF-based plasticity and repair mechanisms
Adult Age Differences and the Role of Cognitive Resources in Perceptual-Motor Skill Acquisition: Application of a Multilevel Negative Exponential Model
The effects of advanced age and cognitive resources on the course of skill acquisition are unclear, and discrepancies among studies may reflect limitations of data analytic approaches. We applied a multilevel negative exponential model to skill acquisition data from 80 trials (four 20-trial blocks) of a pursuit rotor task administered to healthy adults (19-80 years old). The analyses conducted at the single-trial level indicated that the negative exponential function described performance well. Learning parameters correlated with measures of task-relevant cognitive resources on all blocks except the last and with age on all blocks after the second. Thus, age differences in motor skill acquisition may evolve in 2 phases: In the first, age differences are collinear with individual differences in task-relevant cognitive resources; in the second, age differences orthogonal to these resources emerg
The complex network of global cargo ship movements
Transportation networks play a crucial role in human mobility, the exchange
of goods, and the spread of invasive species. With 90% of world trade carried
by sea, the global network of merchant ships provides one of the most important
modes of transportation. Here we use information about the itineraries of
16,363 cargo ships during the year 2007 to construct a network of links between
ports. We show that the network has several features which set it apart from
other transportation networks. In particular, most ships can be classified in
three categories: bulk dry carriers, container ships and oil tankers. These
three categories do not only differ in the ships' physical characteristics, but
also in their mobility patterns and networks. Container ships follow regularly
repeating paths whereas bulk dry carriers and oil tankers move less predictably
between ports. The network of all ship movements possesses a heavy-tailed
distribution for the connectivity of ports and for the loads transported on the
links with systematic differences between ship types. The data analyzed in this
paper improve current assumptions based on gravity models of ship movements, an
important step towards understanding patterns of global trade and bioinvasion.Comment: 7 figures Accepted for publication by Journal of the Royal Society
Interface (2010) For supplementary information, see
http://www.icbm.de/~blasius/publications.htm
Lighting in the third dimension : laser scanning as an architectural survey and representation method
This paper proposes tridimensional (3D) laser scanning to architects and lighting designers as a lighting
enquiry and visualization method for existing built environments. The method constitutes a complement
to existing lighting methods by responding to limitations of photometric measurements, computer
simulation and HDR imagery in surveying and visualizing light in actual buildings. The research explores
advantages and limitations of 3D laser scanning in a case study addressing a vast, geometrically complex
and fragmented naturally and artificially lit space. Lighting patterns and geometry of the case study are
captured with a 3D laser scanner through a series of four scans. A single 3D model of the entire space is
produced from the aligned and fused scans. Lighting distribution patterns are showcased in relation to
the materiality, geometry and position of windows, walls, lighting fixtures and day lighting sources.
Results and presented through images similar to architectural presentation drawings. More specifically,
the lighting distribution patterns are illustrated in a floor plan, a reflected ceiling plan, an axonometry
and a cross-section. The point cloud model of the case study is also generated into a video format
representing the entire building as well as different viewpoints. The study shows that the proposed
method provides powerful visualization results due to the unlimited number of images that can be
generated from a point cloud and facilitates understanding of existing lighting conditions in spaces
First report of Sporolithon ptychoides (Sporolithales, Corallinophycidae, Rhodophyta) for the Atlantic Ocean
Samples corresponding to Sporolithon ptychoides Heydrich were collected in
the mesophotic zone (50 m depth) south of Espírito Santo State, Brazil. The
collected material presented features characteristic of the species namely:
tetrasporangia of 75-105 x 40-55 μm grouped into sori that are raised above the
surrounding vegetative thallus surface; presence of a basal layer of elongate cells
in areas where the tetrasporangia develop; presence of buried tetrasporangial
compartments deep in the thallus; and 3-5 cells in the tetrasporangial
paraphyses. These same features said to collectively characterise S. ptychoides,
were all observed in a representative specimen and the type specimen of
Sporolithon dimotum (Foslie & Howe) Yamaguishi-Tomita ex M.J Wynne.
2
This latter species is thus conspecific with S. ptychoides and is therefore
considered a heterotypic synonym thereof as S. ptychoides has nomenclatural
priority. This study expands the known geographical distribution of the species
and may give insight into the origin of the species into other geographical
regions.Web of Scienc
The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes.
Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome activation are not fully understood. Here, we report that the Parkinson\u27s disease-associated mitochondrial serine protease HtrA2 restricts the activation of ASC-dependent NLRP3 and AIM2 inflammasomes, in a protease activity-dependent manner. Consistently, disruption of the protease activity of HtrA2 results in exacerbated NLRP3 and AIM2 inflammasome responses in macrophages ex vivo and systemically in vivo. Mechanistically, we show that the HtrA2 protease activity regulates autophagy and controls the magnitude and duration of inflammasome signaling by preventing prolonged accumulation of the inflammasome adaptor ASC. Our findings identify HtrA2 as a non-redundant mitochondrial quality control effector that keeps NLRP3 and AIM2 inflammasomes in check
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