Aula sin fronteras

El CEDID Ciudad Bolívar, que hizo parte de los cinco colegios que nacieron en el marco del Plan Ciudad Bolívar para el Distrito, consolida su jornada de fin de semana en un proyecto de Jóvenes y Adultos alrededor de 1998

Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study

: The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135-15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359-5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138-5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184-5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598-9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090-6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286-5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p < 0.001; 95% CI 1.912-7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138-0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143-0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990)

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery

La Señora de Matute : comedia en dos actos y en prosa / de Eduardo Navarro Gonzalvo y Pedro de Górriz

Estrenada en el Teatro de la Comedia el dia 20 de noviembre de 1886." Al v. de port. consta : "... El Teatro, de Don Florencio Fiscowich y de la Administración Lírico-Dramática de D. Eduardo Hidalgo..."H Ca. 102/02

Productividad y estructura vertical de un bosque templado con incidencia de incendios forestales

Se evaluaron las afectaciones ocasionadas por un incendio forestal, la estructura vertical y la asociación de las especies arbóreas y su relación con la productividad a través de variables dasométricas. Se trabajó en dos áreas, una incendiada y otra no incendiada, en las que se establecieron 36 sitios circulares de 11.28 m de radio y de 400 m2. Mediante el índice de Pretzsch, se hizo una clasificación de tres estratos: estrato I (80-100 %), estrato II (50-80 %) y estrato III (0-50 %). Se determinó la productividad utilizando datos dasométricos como densidad individual (ha-1), área basal (m2 ha-1), área de copa (m2 ha-1) y volumen (m3 ha-1). Se hizo un análisis estadístico en el programa r-Studio® (Ver. 3.1.1), mediante una comparación de medias entre grupos independientes de los parámetros dasométricos. El análisis de la estructura vertical se realizó mediante el índice A de Pretzsch, reveló que el área incendiada fue mayor con Amax de 2.71 contra 2.20 de la no incendiada. El estrato II fue el que concentró mayor número de individuos por hectárea, en las dos áreas (50 % y 33 %), con una altura máxima de 23.9 y 26 m, respectivamente. La productividad fue superior en el área incendiada, lo que se atribuye a la abundancia de Pinus pseudostrobus; mientras que la no incendiada registró menos individuos por hectárea, diferido a menor proporcionalidad en volumen (m3 ha-1). Se concluye que existen beneficios en la estructural y productividad en un bosque sometido a incendio

Calidad de planta en etapa de vivero de dos especies de pino en sistema Doble-Trasplante

El objetivo de esta investigación fue evaluar la calidad de planta producida en el sistema de Doble-Trasplante, con diferente volumen de contenedor y fertilización, en dos coníferas: Pinus douglasiana y Pinus devoniana, cuyas características e índices de calidad en vivero permitan estimar el éxito de su supervivencia en campo. Se seleccionaron 500 plantas por especie de 12 meses de edad (125 por tratamiento), producidas en charolas de poliestireno con un volumen por cavidad de 0.165 L., las cuales se trasplantaron y mantuvieron durante cinco meses en los contenedores de 1 y 5 L y con dos rutinas de fertilización (con y sin fertilizante). Se aplicó un diseño en bloques completamente al azar, con arreglo factorial 22 con cuatro tratamientos por taxon. El volumen del contenedor, en ambos taxa, tuvo un efecto positivo en las variables de crecimiento; sin embargo, solo Pinus devoniana registró una respuesta positiva a la fertilización adicional. Los contenidos foliares de N, Fe, Cu, Ca y Mn presentaron una relación con el crecimiento en los dos pinos bajo estudio. Para predecir el porcentaje de supervivencia en campo, el índice de Dickson (IQ) resultó ser el mejor indicador de calidad para P. douglasiana, mientras que para P. devoniana fue el índice de contenedor raíz (ICR). Por lo anterior, y por su facilidad de uso, el ICR se propone como un método práctico para determinar la calidad de planta en vivero

Di-d-fructose dianhydride-enriched caramels : effect on colon microbiota, inflammation, and tissue damage in trinitrobenzenesulfonic acid-induced colitic rats

9 páginas, 8 figuras, 3 tablas.In the present study we describe the preparation and chemical characterization of a caramel with a high (70%) content of difructose dianhydrides (DFAs) and glycosylated derivatives (DFAs). This product was obtained by thermal activation (90 °C) of highly concentrated (90% w/v) aqueous d-fructose solutions using the sulfonic acid ion-exchange resin Lewatit S2328 as caramelization catalyst. DFAs represent a unique family of cyclic fructans with prebiotic properties already present in low proportions (<15%) in commercial caramel. We report the antiinflammatory activity of the new DFA-enriched caramel in the trinitrobenzenesulfonic acid (TNBS) model of rat colitis, an experimental model that resembles human inflammatory bowel disease (IBD), and compare its effects with those obtained with a commercial sucrose caramel and with linear fructooligosaccharides (FOS). For this purpose, the effects on colon tissue damage, gut microbiota, short-chain fatty acid (SCFAs) production, and different inflammatory markers were evaluated. The administration of DFA-enriched caramel to colitic rats showed intestinal antiinflammatory effect, as evidenced macroscopically by a significant reduction in the extent of the colonic damage induced by TNBS. This effect was similar to that obtained with FOS in the same experimental settings, whereas commercial caramel was devoid of any significant antiinflammatory effect. The beneficial effect was associated with the inhibition of the colonic levels of the proinflammatory cytokines, tumor necrosis factor α (TNF α) and interleukin 1β (IL-1β), and the reduction in colonic myeloperoxidase (MPO) activity and inducible nitric oxide synthase (iNOS) expression. The DFA-enriched caramel also promoted a more favorable intestinal microbiota, increasing lactobacilli and bifidobacteria counts as well as inducing higher concentrations of SCFAs in the luminal colonic contents. These results reinforce the concept of DFAs and glycosyl-DFAs as dietary beneficial compounds with prebiotic properties and suggest that the novel DFA-enriched caramel here reported may be an interesting candidate to be explored for the dietary treatment of human IBD.We thank the Spanish Ministerio de Ciencia e Innovación (contract numbers CTQ2007-61180/PPQ, CTQ2006-15515-C02-01/BQU, and SAF2008-02616) and the Junta de Andalucía for financial support (CTS 164). E.S.-P. is a “Project of Excellence” Fellow (Junta de Andalucía; contract number P06-AGR-02150). CIBERehd is funded by the Instituto de Salud Carlos III.Peer reviewe