Delitos informáticos y la evidencia digital en el proceso Peruano del distrito judicial de Junín, 2020

El tema de esta investigación fue Delitos Informáticos y La Evidencia Digital en el Proceso Peruano del Distrito Judicial de Junín, 2020, cuyo objetivo general fue Determinar la relación entre los delitos informáticos y la evidencia digital en el proceso peruano del Distrito Judicial de Junín, 2020. La metodología corresponde a un método científico, los métodos específicos son la observación y la experimentación, el tipo de investigación es básica, el nivel de investigación es: explorativa, descriptiva y correlacional; el diseño es el no experimental, con una muestra de 40 operadores de derecho del distrito judicial de Junín, 2020 Los resultados muestran que no existe una relación directa y significativa entre los delitos informáticos y la evidencia digital en el proceso peruano del Distrito Judicial de Junín, 2020. (p=0,952>0.05). Donde la mayoría de los operadores de derecho, consideran que el nivel en que se aplica la legislación para los delitos informáticos en el proceso peruano del distrito judicial de Junín, 2020 es medianamente suficiente (62.5%). Y la mayoría de los operadores de derecho, consideran que el nivel de evidencia digital en el proceso peruano del distrito judicial de Junín, 2020 es muy alto (40.0%)

Antiwear performance of ionic liquid+graphene dispersions with anomalous viscosity-temperature behavior

New dispersions of few-layers graphene (G) in 1-ethyl-3-methylimidazolium ([EMIM]) ionic liquids (ILs) with dicyanamide ([DCA]) or bis(trifluoromethylsulfonyl)imide ([TFSI]) anions have been obtained by mechanical mixing and sonication. IL+0.5 wt% G dispersions show constant viscosity values from 357K (for IL = [EMIM][DCA]) or from 385K (for IL = [EMIM][TFSI]) to 393K. IL + G dispersions with G > 0.5 wt% show linear viscosity increases with increasing temperature, from 306K (for [EMIM][DCA]+1 wt%G) and from 330K to 393K (for [EMIM][TFSI]+0.75 wt%G and [EMIM][TFSI]+1 wt%G). Addition of graphene improves the poor wear reducing performance of [EMIM][DCA], and prevents surface damage on steel when added to [EMIM][TFSI]. Graphene increases the load-carrying ability of ILs, forms a surface layer on the sliding path and retains wear debris, preventing the formation of large abrasive particles.Ministerio de Economía, Industria y Competitividad (MINECO, Spain), EU FEDER Program (Grant # MAT2017-85130-P) Este trabajo es resultado de la actividad desarrollada en el marco del Programa de Ayudas a Grupos de Excelencia de la Región de Murcia, de la Fundación Séneca, Agencia de Ciencia y Tecnología de la Región de Murcia (Grant # 19877/GERM/15) M.D. Avilés ha recibido una beca del MINECO (BES-2015-074836)

Determinants of image quality of rotational angiography for on-line assessment of frame geometry after transcatheter aortic valve implantation

To study the determinants of image quality of rotational angiography using dedicated research prototype software for motion compensation without rapid ventricular pacing after the implantation of four commercially available catheter-based valves. Prospective observational study including 179 consecutive patients who underwent transcatheter aortic valve implantation (TAVI) with either the Medtronic CoreValve (MCS), Edward-SAPIEN Valve (ESV), Boston Sadra Lotus (BSL) or Saint-Jude Portico Valve (SJP) in whom rotational angiography (R-angio) with motion compensation 3D image reconstruction was performed. Image quality was evaluated from grade 1 (excellent image quality) to grade 5 (strongly degraded). Distinction was made between good (grades 1, 2) and poor image quality (grades 3–5). Clinical (gender, body mass index, Agatston score, heart rate and rhythm, artifacts), procedural (valve type) and technical variables (isocentricity) were related with the image quality assessment. Image quality was good in 128 (72 %) and poor in 51 (28 %) patients. By univariable analysis only valve type (BSL) and the presence of an artefact negatively affected image quality. By multivariate analysis (in which BMI was forced into the model) BSL valve (Odds 3.5, 95 % CI [1.3–9.6], p = 0.02), presence of an artifact (Odds 2.5, 95 % CI [1.2–5.4], p = 0.02) and BMI (Odds 1.1, 95 % CI [1.0–1.2], p = 0.04) were independent predictors of poor image quality. Rotational angiography with motion compensation 3D image reconstruction using a dedicated research prototype software offers good image quality for the evaluation of frame geometry after TAVI in the majority of patients. Valve type, presence of artifacts and higher BMI negatively affect image quality

Protocolo de intervención psicosocial en pacientes oncológicos sometidos a cirugía torácica

At present, lung cancer is the most common cause of death worldwide from cancer in men and the second among women. Moreover, lung cancer shows an increasing rate of incidence and mortality among the world’s population. Surgical resection, if feasible, is the treatment of choice. However, surgical treatment can cause a great amount stress, both for patients and their families. To reduce psychological and emotional distress and improving quality of life, psychosocial evaluation and intervention should begin prior to the surgical procedure and continue through the postsurgical period. In this paper, the psychosocial evaluation and intervention protocol developed in the Thoracic Surgery Unit of the Hospital Clínico San Carlos of Madrid is presented

Late onset of new conduction disturbances requiring permanent pacemaker implantation following TAVI

Background: The timing of onset and associated predictors of late new conduction disturbances (CDs) leading to permanent pacemaker implantation (PPI) following transcatheter aortic valve implantation (TAVI) are still unknown, however, essential for an early and safe discharge. This study aimed to investigate the timing of onset and associated predictors of late onset CDs in patients requiring PPI (LCP) following TAVI. Methods and results: We performed retrospective analysis of prospectively collected data from five large volume centres in Europe. Post-TAVI electrocardiograms and telemetry data were evaluated in patients with a PPI post-TAVI to identify the onset of new advanced CDs. Early onset CDs were defined as within 48 hours after procedure, and late onset CDs as after 48 hours. A total of 2804 patients were included for analysis. The PPI rate was 12%, of which 18% was due to late onset CDs (>48 hours). Independent predictors for LCP were pre-existing non-specific intraventricular conduction delay, pre-existing right bundle branch block, self-expandable valves and predilation. At least one of these risk factors was present in 98% of patients with LCP. Patients with a balloon-expandable valve without predilation did not develop CDs requiring PPI after 48 hours. Conclusions: Safe early discharge might be feasible in patients without CDs in the first 48 hours after TAVI if no risk factors for LCP are present

Protocolo de intervención psicosocial en pacientes oncológicos sometidos a cirugía torácica

At present, lung cancer is the most common cause of death worldwide from cancer in men and the second among women. Moreover, lung cancer shows an increasing rate of incidence and mortality among the world’s population. Surgical resection, if feasible, is the treatment of choice. However, surgical treatment can cause a great amount stress, both for patients and their families. To reduce psychological and emotional distress and improving quality of life, psychosocial evaluation and intervention should begin prior to the surgical procedure and continue through the postsurgical period. In this paper, the psychosocial evaluation and intervention protocol developed in the Thoracic Surgery Unit of the Hospital Clínico San Carlos of Madrid is presented

Discovery and validation of new potential biomarkers for early detection of colon cancer

Background: accurate detection of characteristic proteins secreted by colon cancer tumor cells in biological fluids could serve as a biomarker for the disease. The aim of the present study was to identify and validate new serum biomarkers and demonstrate their potential usefulness for early diagnosis of colon cancer. Methods: the study was organized in three sequential phases: 1) biomarker discovery, 2) technical and biological validation, and 3) proof of concept to test the potential clinical use of selected biomarkers. A prioritized subset of the differentially-expressed genes between tissue types (50 colon mucosa from cancer-free individuals and 100 normal-tumor pairs from colon cancer patients) was validated and further tested in a series of serum samples from 80 colon cancer cases, 23 patients with adenoma and 77 cancer-free controls.Results: in the discovery phase, 505 unique candidate biomarkers were identified, with highly significant results and high capacity to discriminate between the different tissue types. After a subsequent prioritization, all tested genes (N = 23) were successfully validated in tissue, and one of them, COL10A1, showed relevant differences in serum protein levels between controls, patients with adenoma (p = 0.0083) and colon cancer cases (p = 3.2e-6). Conclusion: we present a sequential process for the identification and further validation of biomarkers for early detection of colon cancer that identifies COL10A1 protein levels in serum as a potential diagnostic candidate to detect both adenoma lesions and tumor. Impact:the use of a cheap serum test for colon cancer screening should improve its participation rates and contribute to decrease the burden of this disease