Towards Spatial Multiplexing in Wireless Networks within Computing Packages

Wireless Networks-on-Chip (WNoCs) are regarded as a disruptive alternative to conventional interconnection networks at the chip scale, yet limited by the relatively low aggregate bandwidth of such wireless networks. Hence, any method to increase the amount of concurrent channels in this scenario is of high value. In this direction, and since WNoC implies close integration of multiple antennas on a chip anyway, in this paper we present a feasibility study of compact monopole antenna arrays in a flip-chip environment at millimeter-wave and sub-terahertz frequencies. By means of a full-wave solver, we evaluate the feasibility to create, at will, concentrations of field in different spots of the chip. This way, we set the steps towards spatial multiplexing that enables concurrent multicast communications and also increases the aggregate bandwidth of the wireless network. Our results at 60 GHz show two clearly separable parallel channels that radiate simultaneously from two opposite corners of the chip, achieving a Signal-to-Interference Ratio (SIR) of around 40 dB, which proves that the channels are independent of each other even in such an enclosed environment. Further, we see potential to expand our approach to three or more concurrent channels, and to frequencies beyond 100 GHz

Collective Communication Patterns Using Time-Reversal Terahertz Links at the Chip Scale

Wireless communications in the terahertz band have been recently proposed as complement to conventional wired interconnects within computing packages. Such environments are typically highly reverberant, hence showing long channel impulse responses and severely limiting the achievable rates. Fortunately, this communications scenario is static and can be pre-characterized, which opens the door to techniques such as time reversal. Time reversal acts a spatial matched filter and has a spatiotemporal focusing effect, which allows not only to increase the achievable symbol rates, but also to create multiple spatial channels. In this paper, the multi-user capability of time reversal is explored in the context of wireless communications in the terahertz band within a computing package. Full-wave simulations are carried out to validate the approach, whereas modulation streams are simulated to evaluate the error rate as a function of the transmitted power, symbol rate, and number of simultaneous transmissions

Exploration of Time Reversal for Wireless Communications within Computing Packages

Wireless Network-on-Chip (WNoC) is a promising paradigm to overcome the versatility and scalability issues of conventional on-chip networks for current processor chips. However, the chip environment suffers from delay spread which leads to intense Inter-Symbol Interference (ISI). This degrades the signal when transmitting and makes it difficult to achieve the desired Bit Error Rate (BER) in this constraint-driven scenario. Time reversal (TR) is a technique that uses the multipath richness of the channel to overcome the undesired effects of the delay spread. As the flip-chip channel is static and can be characterized beforehand, in this paper we propose to apply TR to the wireless in-package channel. We evaluate the effects of this technique in time and space from an electromagnetic point of view. Furthermore, we study the effectiveness of TR in modulated data communications in terms of BER as a function of transmission rate and power. Our results show not only the spatiotemporal focusing effect of TR in a chip that could lead to multiple spatial channels, but also that transmissions using TR outperform, BER-wise, non-TR transmissions it by an order of magnitud

Synthesis of Degraded Limonoid Analogs as New Antibacterial Scaffolds againstStaphylococcus aureus

Staphylococcus aureusand methicillin-resistantStaphylococcus aureus(MRSA) have become serious infections in humans and ruminants.S. aureusstrains are showing rapid changes to develop resistance in traditional antibiotic-containing systems. In the continuous fierce fight against the emergent multi-drug resistant bacterial strains, straightforward and scalable synthetic procedures to produce new active molecules are in demand. Analysis of molecular properties points to degraded limonoids as promising candidates. In this article, we report a simple synthetic approach to obtain degraded limonoid analogs as scaffolds for new antibacterial molecules. The minimum inhibitory concentrations againstS. aureuswere evaluated for the stereoisomer mixtures by the broth microdilution method. Analysis of results showed that the acetylated derivatives were the most active of them all

ISG20L2: an RNA nuclease regulating T cell activation.

ISG20L2, a 3' to 5' exoribonuclease previously associated with ribosome biogenesis, is identified here in activated T cells as an enzyme with a preferential affinity for uridylated miRNA substrates. This enzyme is upregulated in T lymphocytes upon TCR and IFN type I stimulation and appears to be involved in regulating T cell function. ISG20L2 silencing leads to an increased basal expression of CD69 and induces greater IL2 secretion. However, ISG20L2 absence impairs CD25 upregulation, CD3 synaptic accumulation and MTOC translocation towards the antigen-presenting cell during immune synapsis. Remarkably, ISG20L2 controls the expression of immunoregulatory molecules, such as AHR, NKG2D, CTLA-4, CD137, TIM-3, PD-L1 or PD-1, which show increased levels in ISG20L2 knockout T cells. The dysregulation observed in these key molecules for T cell responses support a role for this exonuclease as a novel RNA-based regulator of T cell function.This study was supported by grant P2022/BMD7209- INTEGRAMUNE from the Comunidad de Madrid, a grant from “La Caixa” Banking Foundation (HR17-00016) to FS-M; the Spanish Ministerio de Ciencia e Innovación (PDC2021-121719-I00 and PID2020-120412RB-I00 to FS-M), grant from AECC, CIBER Cardiovascular (CB16/11/00272, Fondo de Investigación Sanitaria del Instituto de Salud Carlos III and co-funding by Fondo Europeo de Desarrollo Regional FEDER). The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015- 0505). Vaňáčová’s laboratory is supported by the Czech Science Foundation (20-19617S and 23-07372S to S.V.) and the institutional support CEITEC 2020 (LQ1601). ARG and SGD are supported by a grant from the Spanish Ministry of Universities. Funding agencies do not have intervened in the design of the studies, with no copyright over the study.S

Revisiting the epidemiology of bloodstream infections and healthcare-associated episodes: results from a multicentre prospective cohort in Spain (PRO-BAC Study)

PROBAC REIPI/GEIH-SEIMC/SAEI Group.The epidemiology of bloodstream infections (BSIs) is dynamic as it depends on microbiological, host and healthcare system factors. The aim of this study was to update the information regarding the epidemiology of BSIs in Spain considering the type of acquisition. An observational, prospective cohort study in 26 Spanish hospitals from October 2016 through March 2017 including all episodes of BSI in adults was performed. Bivariate analyses stratified by type of acquisition were performed. Multivariate analyses were performed by logistic regression. Overall, 6345 BSI episodes were included; 2510 (39.8%) were community-acquired (CA), 1661 (26.3%) were healthcare-associated (HCA) and 2056 (32.6%) hospital-acquired (HA). The 30-day mortality rates were 11.6%, 19.5% and 22.0%, respectively. The median age of patients was 71 years (interquartile range 60–81 years) and 3656 (58.3%; 95% confidence interval 57.1–59.6%) occurred in males. The proportions according to patient sex varied according to age strata. Escherichia coli (43.8%), Klebsiella spp. (8.9%), Staphylococcus aureus (8.9%) and coagulase-negative staphylococci (7.4%) were the most frequent pathogens. Multivariate analyses confirmed important differences between CA and HCA episodes, but also between HCA and HA episodes, in demographics, underlying conditions and aetiology. In conclusion, we have updated the epidemiological information regarding patients’ profiles, underlying conditions, frequency of acquisition types and aetiological agents of BSI in Spain. HCA is confirmed as a distinct type of acquisition.This work was financed by grants from Plan Nacional de I+D+i 2013–2016, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades [PI16/01432] and the Spanish Network for Research in Infectious Diseases (REIPI) [RD16/0016/0001; RD16/0016/0008], co‐financed by the European Development Regional Fund ‘A way to achieve Europe’, Operative program Intelligent Growth 2014–2020

Risk Factors and Predictive Score for Bacteremic Biliary Tract Infections Due to Enterococcus faecalis and Enterococcus faecium: a Multicenter Cohort Study from the PROBAC Project

Biliary-tract bloodstream infections (BT-BSI) caused by Enterococcus faecalis and E. faecium are associated with inappropriate empirical treatment and worse outcomes compared to other etiologies. The objective of this study was to investigate the risk factors for enterococcal BT-BSI. Patients with BT-BSI from the PROBAC cohort, including consecutive patients with BSI in 26 Spanish hospitals between October 2016 and March 2017, were selected; episodes caused by E. faecalis or E. faecium and other causes were compared. Independent predictors for enterococci were identified by logistic regression, and a predictive score was developed. Eight hundred fifty episodes of BT-BSI were included; 73 (8.5%) were due to target Enterococcus spp. (48 [66%] were E. faecium and 25 [34%] E. faecalis). By multivariate analysis, the variables independently associated with Enterococcus spp. were (OR; 95% confidence interval): cholangiocarcinoma (4.48;1.32 to 15.25), hospital acquisition (3.58;2.11 to 6.07), use of carbapenems in the previous month (3.35;1.45 to 7.78), biliary prosthesis (2.19;1.24 to 3.90), and moderate or severe chronic kidney disease (1.55;1.07 to 2.26). The AUC of the model was 0.74 [95% CI0.67 to 0.80]. A score was developed, with 7, 6, 5, 4, and 2 points for these variables, respectively, with a negative predictive value of 95% for a score # 6. A model, including cholangiocarcinoma, biliary prosthesis, hospital acquisition, previous carbapenems, and chronic kidney disease showed moderate prediction ability for enterococcal BT-BSI. Although the score will need to be validated, this information may be useful for deciding empirical therapy in biliary tract infections when bacteremia is suspected. IMPORTANCE Biliary tract infections are frequent, and a significant cause of morbidity and mortality. Bacteremia is common in these infections, particularly in the elderly and patients with cancer. Inappropriate empirical treatment has been associated with increased risk of mortality in bacteremic cholangitis, and the probability of receiving inactive empirical treatment is higher in episodes caused by enterococci. This is because many of the antimicrobial agents recommended in guidelines for biliary tract infections lack activity against these organisms. To the best of our knowledge, this is the first study analyzing the predictive factors for enterococcal BT-BSI and deriving a predictive score.8 página

The CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018)

Introduction:Infections caused by carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa, including isolates producing acquired carbapenemases, constitute a prevalent health problem worldwide. The primary objective of this study was to determine the distribution of the different carbapenemases among carbapenemase-producing Enterobacterales (CPE, specifically Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex, and Klebsiella aerogenes) and carbapenemase-producing P. aeruginosa (CPPA) in Spain from January 2014 to December 2018.Methods: A national, retrospective, cross-sectional multicenter study was performed. The study included the first isolate per patient and year obtained from clinical samples and obtained for diagnosis of infection in hospitalized patients. A structured questionnaire was completed by the participating centers using the REDCap platform, and results were analyzed using IBM SPSS Statistics 29.0.0.Results: A total of 2,704 carbapenemase-producing microorganisms were included, for which the type of carbapenemase was determined in 2692 cases: 2280 CPE (84.7%) and 412 CPPA (15.3%), most often using molecular methods and immunochromatographic assays. Globally, the most frequent types of carbapenemase in Enterobacterales and P. aeruginosa were OXA-48-like, alone or in combination with other enzymes (1,523 cases, 66.8%) and VIM (365 cases, 88.6%), respectively. Among Enterobacterales, carbapenemase-producing K. pneumoniae was reported in 1821 cases (79.9%), followed by E. cloacae complex in 334 cases (14.6%). In Enterobacterales, KPC is mainly present in the South and South-East regions of Spain and OXA-48-like in the rest of the country. Regarding P. aeruginosa, VIM is widely distributed all over the country. Globally, an increasing percentage of OXA-48-like enzymes was observed from 2014 to 2017. KPC enzymes were more frequent in 2017–2018 compared to 2014–2016.Discussion: Data from this study help to understand the situation and evolution of the main species of CPE and CPPA in Spain, with practical implications for control and optimal treatment of infections caused by these multi-drug resistant organisms

Extremadura-Portugal: Una guía para la cooperación transfronteriza

El presente libro pretende servir de guía práctica para que los actores interesados en la cooperación transfronteriza entre Extremadura y Portugal puedan disponer de las herramientas concretas con las que llevarla a cabo. La obra analiza tanto el marco jurídico actual de la cooperación transfronteriza, con los instrumentos ya existentes, como los diferentes sectores de políticas públicas en los que se dan prácticas de intercambio entre Extremadura y las regiones portuguesas vecinas. Asimismo, intenta aclarar la asimetría institucional, administrativa y política existente a ambos lados de la frontera común, la Raya, pues las diferencias competenciales y de articulación interna en dichos ámbitos constituye, a día de hoy, uno de los obstáculos principales para profundizar en una cooperación transfronteriza cada vez más oportuna y necesaria.This book aims to serve as a practical guide so that stakeholders interested in cross-border cooperation between Extremadura and Portugal can have the specific tools with which to carry it out. The book analyzes both the current legal framework for cross-border cooperation, with existing instruments, and the different public policy sectors in which exchange practices take place between Extremadura and neighboring Portuguese regions. Likewise, it attempts to clarify the institutional, administrative and political asymmetry existing on both sides of the common border, La Raya, since the differences in competence and internal articulation in these areas constitute, today, one of the main obstacles to deepening a increasingly timely and necessary cross-border cooperation