Developing writing skills through educative social networks

The present dissertation approaches social networks and their use in Secondary Education, particularly in the English as a Second Language Subject. There is not a shade of doubt that social media are an important part of people’s lives nowadays, and, perhaps the extent of this importance is greater within teenagers, since personal relationships appear to gain significance during adolescence. On account of this fact, the incorporation of social networks in Education seems logical. However, even if there is a lot of investigation regarding the advantages and disadvantages of Information and Communication Technologies at school in general, the truth is that little research has been done as for their effects in the use of language. For that reason, this work seeks to study whether social networks help improve communicative skills in a foreign language, focusing on the writing competence in ESL.Departamento de Didáctica de la Lengua y LiteraturaMáster en Profesor de Educación Secundaria Obligatoria y Bachillerato, Formación Profesional y Enseñanzas de Idioma

Personal Anonycloud

Personal AnonyCloud es un proyecto que soluciona varios de los principales problemas en redes hoy en día. Por una parte, actualmente las herramientas VPN solo permiten conexiones punto a punto, es decir, cliente a servidor. Con PA podremos conseguir una red VPN compuesta por varios terminales de repetición y por otro lado aumentar la seguridad, debido a que los terminales son propios. Estas máquinas serán creadas bajo demanda en servicios cloud públicos generales, siendo reemplazadas en caso de cualquier tipo de intrusión. Además, PA ofrece una interfaz intuitiva y simple, permitiendo el uso de la herramienta a cualquier persona, sea cual sea su nivel de conocimiento sobre servicios VP

Tendencia de las precipitaciones de marzo en el sur de la Península Ibérica

La existencia de una tendencia decreciente de las precipitaciones de marzo, desde los años sesenta hasta los años noventa del siglo pasado, ha sido constatada por diversos autores para la vertiente occidental de la Península Ibérica. En este artículo ampliamos la dimensión temporal de este fenómeno, evaluando su magnitud desde una perspectiva histórica (desde comienzos del siglo XIX), y extendiéndolo hasta el año 2005. Además, asumimos como zona de estudio todo el sur peninsular y analizamos las variaciones espaciales que se registran en ella. El análisis del fenómeno a una escala plurisecular pone de manifiesto la singularidad de este comportamiento en las precipitaciones a lo largo de las últimas décadas del siglo XX. Por último, hemos puesto en relación los resultados obtenidos, con las previsiones de cambio climático y con estudios recientes sobre variaciones en los patrones de circulación atmosférica en el Atlántico norte.March monthly accumulated precipitation in the central and western regions of the Iberian Peninsula presents a clear continuous decline of 50% from the 60’s onwards documented by several authors. In this paper we describe this phenomenon up to 2005 evaluating on the one hand, its magnitude and evolution from a historical perspective and, on the other hand, the spatial variations in the study area. Despite the similarities with other periods when considering various centuries of data, these last decades of the 20th century present different characteristics. The results of this study are related to climate change predictions and to recent studies reporting atmospheric circulation changes in the North Atlantic area

Cómo experimentar con el sonido y sus características dentro de un aula de Educación Infantil

El presente proyecto de investigación se centra en el estudio del sonido y sus características a través de la música y la fabricación de instrumentos con materiales que la propia naturaleza nos brinda. Nuestra principal finalidad es investigar este fenómeno como medio para fomentar las ciencias experimentales en la Educación Infantil. En este trabajo pretendemos innovar recolectando materiales de origen natural (semillas, ramas de madera...) con los que poder fabricar a continuación los instrumentos musicales, favoreciendo la sostenibilidad del medio ambiente. Una vez elaborados todos los instrumentos, hemos analizado y observado sus cualidades y características propias, validando así cuáles son más adecuados según qué aspectos se desean trabajar dentro de un aula de Educación Infantil. Finalmente, creemos logrado nuestro objetivo principal, ya que con este TFG hemos introducido las ciencias experimentales en las aulas de Educación Infantil, trabajando el sonido de manera interdisciplinar gracias a la música, y favoreciendo, además, la sensibilización medioambiental.The present research project develops the study of sound and its characteristics through music and the manufacture of instruments with materials that nature itself gives us. Our main purpose is to investigate this phenomenon as a means to promote experimental sciences in Early Childhood Education. In this work we intend to innovate collecting materials of natural origin (seeds, branches of wood,...) with which we can then manufacture musical instruments, favoring the sustainability of the environment. Once all the instruments have been developed, we have analyzed and observed their own qualities and characteristics, thus validating which ones are most suitable according to what aspects to work for in an Early Childhood Education classroom. Finally, we believe that our main objective has been achieved, since with this TFG we have introduced experimental sciences in the Early Childhood Education classrooms, working the sound in an interdisciplinary way thanks to music, and also promoting environmental awareness

Resistance to 2-Hydroxy-Flutamide in Prostate Cancer Cells Is Associated with the Downregulation of Phosphatidylcholine Biosynthesis and Epigenetic Modifications

18 p.In this study, we examined the metabolic adaptations of a chemoresistant prostate cancer cell line in comparison to a sensitive cell line. We utilized prostate cancer LNCaP cells and subjected them to a stepwise increase in the antiandrogen 2-hydroxy-flutamide (FLU) concentration to generate a FLU-resistant cell line (LN-FLU). These LN-FLU cells displayed characteristics of cancer stem cells, exhibited drug resistance, and showed a significantly reduced expression of Cyclin D1, along with the overexpression of p16, pointing to a proliferation arrest. In comparing the cancer stem-like LN-FLU cells to the LNCaP cells, we observed a decrease in the expression of CTP-choline cytidylyl transferase ? (CCT?), as well as a decline in choline kinase, suggesting altogether a downregulation of the phosphatidylcholine biosynthetic pathway. In addition, we found decreased levels of the protein methyl transferase PRMT2 and the upregulation of the histone deacetylase Sirtuin1 (Sirt1). Analysis of the human prostate cancer samples revealed similar results in a population with high expressions of the stem cell markers Oct4 and ABCB1A1. Our findings suggest that the adaptation of prostate cancer cells to antiandrogens could induce reprogramming into stem cells that survive in a low phosphocholine metabolism and cell cycle arrest and display drug resistance.Instituto de Salud Carlos IIFundación Tatiana Pérez de Guzmán el BuenoComunidad de Madri

Evolution of lipid classes and fatty acid digestibility along the gastrointestinal tract of broiler chickens fed different fat sources at different ages

The aim of the present study is to evaluate the effect of the dietary fat saturation degree and age on the lipid class (TAG, DAG, MAG, and FFA) composition and fatty acid digestibility along the gastrointestinal tract (GIT) and excreta in broiler chickens. A total of 120 one-day-old female broiler chickens were randomly distributed in 2 dietary treatments (6 cages/treatment), which resulted from the supplementation of a basal diet with 6% of soybean oil or palm oil. Two digestibility balances were carried out at 14 and 35 d and fatty acid digestibility and lipid class composition were determined in the gizzard, duodenum, jejunum, ileum, and excreta. Along de GIT, both fatty acid digestibility and lipid class composition were influenced by the dietary fat source and the age of the chickens. The absorption of the unsaturated fat was more efficient and faster than it was for the saturated fat. The ability of adult chickens to absorb fat was higher than for young chickens. The results show that the duodenum is the main place of fat digestion (hydrolysis), and the jejunum the main place of fat absorption. The role of the ileum on fat absorption is very important, as it is the last segment of the GIT where the absorption of fatty acids has been described. Thus, it was the contribution of the ileum that was responsible for the higher fat utilization observed for animals fed the unsaturated diet than for those fed the saturated diet at 14 d, and it was also responsible for the improvement on the utilization of the saturated diet between 14 and 35 d. All the results suggest that the absorption of fatty acids is more limiting than is hydrolysis, because the main differences were observed in the jejunum and ileum, where the absorption of fatty acids takes place

Uso de nuevos anticoagulantes orales (NACO) en la prevención del ictus y la embolia sistémica en pacientes con fibrilación auricular no valvular (FANV)

Introducción: Las herramientas de ayuda para la toma de decisiones compartidas son materiales, con información fiable basada en estudios científicos, sobre una determinada enfermedad o problema de salud en cuestión. Las herramientas son utilizadas para ayudar a las personas a sentirse más informadas y cómodas, para tomar decisiones sobre un tema de salud como el expuesto en el trabajo, teniendo en cuenta sus preferencias y valores. Además, facilitan la relación de las personas afectadas por una enfermedad y los profesionales sanitarios con el objetivo de llegar a una toma de decisiones con junta. Metodología: En este artículo se ha creado una herramienta para la toma de decisiones compartidas, realizándose un análisis y una comparación de los distintos anticoagulantes presentes en la actualidad para la prevención del ictus y la embolia sistémica en pacientes con fibrilación auricular no valvular (FANV). Resultados: La presente herramienta, que consta de un tríptico para poder ser utilizado en Atención Primaria, quiere ser probado dentro de las prácticas que realicemos el próximo curso y de esta manera comprobar su utilidad.Introduction: Shared decision-support tools are materials, with reliable scientific based information, about a given disease or health problem. Tools are used to help people feel more informed and comfortable, Make decisions on a health issue such as the one exposed in the work, taking into account their preferences and values, and facilitate the relationship of people affected by a disease and health professionals with the goal of reaching joint decision-making. Methodology: This article has created a tool for shared decision making, with an analysis and comparison of the different anticoagulants present for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation (FVAC). Results: This tool, which consists of a triptych to be used in Primary Care, wants to be tested within the practices that we perform the next course and thus prove their usefulness

Enriching footsteps sounds in gait rehabilitation in chronic stroke patients: a pilot study

In the context of neurorehabilitation, sound is being increasingly applied for facilitating sensorimotor learning. In this study, we aimed to test the potential value of auditory stimulation for improving gait in chronic stroke patients by inducing alterations of the frequency spectra of walking sounds via a sound system that selectively amplifies and equalizes the signal in order to produce distorted auditory feedback. Twenty‐two patients with lower extremity paresis were exposed to real‐time alterations of their footstep sounds while walking. Changes in body perception, emotion, and gait were quantified. Our results suggest that by altering footsteps sounds, several gait parameters can be modified in terms of left–right foot asymmetry. We observed that augmenting low‐frequency bands or amplifying the natural walking sounds led to a reduction in the asymmetry index of stance and stride times, whereas it inverted the asymmetry pattern in heel–ground exerted force. By contrast, augmenting high‐frequency bands led to opposite results. These gait changes might be related to updating of internal forward models, signaling the need for adjustment of the motor system to reduce the perceived discrepancies between predicted–actual sensory feedbacks. Our findings may have the potential to enhance gait awareness in stroke patients and other clinical conditions, supporting gait rehabilitation.This study was supported by the Spanish Government with an MINECO grant (PSI2015‐69178‐P) awarded to A.R.F., two MINECO grants (RYC‐2014–15421 and PSI2016‐79004‐R, AEI/FEDER, UE) awarded to A.T.‐J., and a predoctoral FPI grant (BES‐2016‐078889) awarded to A.G.‐A

Comprehensive approach to peritoneal dialysis-related peritonitis by enteric microorganisms: comparison between single organism and polymicrobial infections

[Abstract] Background: Peritoneal infections of enteric origin (EntP) have been classically investigated using partial strategies, focused on particular subgroups of microorganisms. A more comprehensive approach may facilitate the definition of the nomenclature and clinical presentation of these infections. Objectives: To investigate the clinical presentation and outcomes of a full spectrum of EntP, with a particular interest in the comparison between single-organism and polymicrobial infections. Method: Following an observational design, we investigated 165 single-organism and 83 polymicrobial peritonitis episodes with isolation of at least 1 enteric bacteria (Enterobacteriaceae, Enterococcus spp. and/or intestinal anaerobics). We compared the risk of treatment failure for these 2 types of infection and explored the significance of the isolation of specific microorganisms and of their antibacterial susceptibility patterns. Results: Polymicrobial EntP was associated with higher rates of hospitalization, more changes to initial antibiotic therapy, more surgical explorations, and higher mortality and treatment failure rates than monobacterial EntP. However, stratified and multivariate analyses revealed that the burden of these differences rested on the isolation of intestinal anaerobics (odds ratio [OR] 12.05, 95% confidence interval [CI] 2.53–31.09, p < 0.001) and/or Enterococcus faecium (OR 3.37, 95% CI 1.02–11.30, p = 0.046), while other polymicrobial infections were more comparable with single-organism peritonitis, except for even higher mortality rates in the former group. Lower antibiotic susceptibility of the isolations (OR 1.18, 95% CI 0.51–2.70, p = 0.70) did not perform as a predictor of treatment failure. Conclusion: A comprehensive approach to peritoneal infections by intestinal microorganisms may provide a focused perspective of the clinical presentation and outcomes of these complications of peritoneal dialysis