A perspectiva de gênero nas opiniões e discursos das mulheres sobre o cuidado

Objetivo: Explorar el significado que las mujeres cuidadoras dan a sus prácticas de cuidado y analizar la relación de dichas prácticas con las trayectorias laborales. Método: Estudio de corte cualitativo con diseño fenomenológico, realizado en Sevilla, España con cuidadoras familiares. La estrategia de obtención de datos ha sido la entrevista semi-estructurada. Los datos fueron analizados mediante análisis de contenido, se utilizó el software informático Atlas-ti GmbH versión 5.0®. Las categorías definidas son: historia cuidadora e historia laboral y significado del cuidado en sus vidas. Resultados: Participaron del estudio veinte cuidadoras. Las mujeres cuidadoras narran unas historias de cuidados extensas, cuidan a distintas personas de la unidad familiar en distintos momentos temporales. Los cuidados que desempeñan son muy diversos, contemplando la dimensión física y social. Se observa una contradicción entre el trabajo de cuidado y la incorporación y/o mantenimiento en el mercado laboral. Conclusión: Las mujeres expresan un concepto de cuidados integral que contempla la responsabilidad, la disponibilidad, el acompañamiento, así como estados afectivos, que generan un gran impacto en su salud. Las mujeres entrevistadas ajustan la participación en el mercado laboral a las necesidades de cuidados de la familia. Así, la perspectiva de género debe ser incorporada por los profesionales sanitarios que atienden los problemas de salud de las cuidadoras.Objective: To investigate the meanings given by women caregivers to their care practices and to analyze the relationship between such practices and their work history. Method: This was a phenomenological qualitative cohort study conducted in Seville, Spain, with family caregivers. Data were collected using semi-structured interviews and submitted to content analysis, using Atlas-ti GmbH software version 5.0®. The following categories emerged: caregiving history and work history, and the meaning of care in their lives. Results: Twenty caregivers participated in the study. Women caregivers told stories of wide-ranging care, including several individuals in their family at different moments. They performed different forms of care, encompassing physical and social dimensions. Their discourse expressed the contradiction between their caregiving role and entering and/or maintaining their place in the labor market. Conclusion: The women expressed a concept of comprehensive care that includes responsibility, availability, and companionship, as well as emotional states, which greatly impact health. They tailored their participation in the labor market according to their family’s care needs. Thus, the gender perspective must be incorporated by health care providers who work with the health of caregivers.Objetivo: Explorar o significado que as mulheres cuidadoras dão às suas práticas de cuidado e analisar a relação dessas práticas com as trajetórias de trabalho. Método: Estudo qualitativo, com desenho fenomenológico de desígnio, realizado em Sevilha, Espanha com cuidadoras familiares. A estratégia de obtenção de dados foi a entrevista semiestruturada. Os dados foram analisados com a metodologia de análise de conteúdo, por meio do software Atlas-ti GmbH, versão 5.0®. As categorias definidas são: história de cuidados e história laboral e o significado do cuidado em suas vidas. Resultados: Participaram do estudo 20 cuidadoras. As mulheres cuidadoras narram algumas histórias de cuidados extensas e cuidam de diferentes pessoas da unidade familiar em diferentes momentos temporais. Os cuidados que desempenham são muito diversos, contemplando a dimensão física e social. Observa-se uma contradição entre o trabalho de cuidado e a incorporação e/ou manutenção no mercado de trabalho. Conclusão: As mulheres expressam um conceito integrante de cuidados que abarca a responsabilidade, a disponibilidade, o acompanhamento, como também estados afetivos que geram um grande impacto em sua saúde. As mulheres entrevistadas ajustam a participação no mercado de trabalho com as necessidades de cuidados da família. Deste modo, a perspectiva de gênero deve ser incorporada pelos profissionais da saúde que atendem aos problemas de saúde das cuidadoras

Implantación de nuevas actividades formativas complementarias para alumnos de posgrado en Fisiopatología y Farmacología

Memoria ID-0207. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2016-2017

Estrategias de mejora de la coordinación de las asignaturas del máster en fisiopatología y farmacología celular y molecular

Memoria ID-058. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2013-2014

Elaboración de asignaturas del Máster de Fisiopatología y Farmacología en el campus virtual

Memoria ID-0037. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2014-2015

Promoción del Máster en Fisiopatología Celular y Molecular

Memoria ID12-0097. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2012-2013

Role of drug transporters in the sensitivity of acute myeloid leukemia to sorafenib

[EN]Chemoresistance often limits the success of the pharmacological treatment in acute myeloid leukemia (AML) patients. Although positive results have been obtained with tyrosine kinase inhibitors (TKIs), such as sorafenib, especially in patients with Fms-like tyrosine kinase 3 (FLT3)-positive AML, the success of chemotherapy is very heterogeneous.The sensitivity to sorafenib-induced cell death (MTT test and anexin V/7-AAD method) was evaluated in five different cell lines: MOLM-13, OCI-AML2, HL-60, HEL and K-562. The transportome was characterized by measuring mRNA using RT-qPCR. Drug uptake/efflux was determined by flow cytometry using specific substrates and inhibitors. The cytostatic response to sorafenib was: MOLM-13»OCI-AML2>HL- 60>HEL≈K-562. Regarding efflux pumps, MDR1 was highly expressed in HEL>K- 562≈MOLM-13, but not in OCI-AML2 and HL-60. BCRP and MPR3 expression was low in all cell lines, whereas MRP4 and MRP5 expression was from moderate to high. Flow cytometry studies demonstrated that MRP4, but not MRP5, was functional

una mirada desde las Ciencias de la Conducta

Este libro es el resultado de los trabajos presentados en el 1er Congreso Internacional "Convivencia y bienestar con sentido humanista para una cultura de paz"

Elaboración de contenidos docentes sobre fisiología y fisiopatología para el uso en el campus virtual Studium

Memoria ID-039 Ayudas de la Universidad de Salamanca para la innovación docente, curso 2020-2021

The search for novel diagnostic and prognostic biomarkers in cholangiocarcinoma

[EN] The poor prognosis of cholangiocarcinoma (CCA) is in part due to late diagnosis, which is currently achieved by a combination of clinical, radiological and histological approaches. Available biomarkers determined in serum and biopsy samples to assist in CCA diagnosis are not sufficiently sensitive and specific. Therefore, the identification of new biomarkers, preferably those obtained by minimally invasive methods, such as liquid biopsy, is important. The development of innovative technologies has permitted to identify a significant number of genetic, epigenetic, proteomic and metabolomic CCA features with potential clinical usefulness in early diagnosis, prognosis or prediction of treatment response. Potential new candidates must be rigorously evaluated prior to entering routine clinical application. Unfortunately, to date, no such biomarker has achieved validation for these purposes. This review is an up-to-date of currently used biomarkers and the candidates with promising characteristics that could be included in the clinical practice in the next future. This article is part of a Special Issue entitled: Cholangiocytes in Health and Disease edited by Jesus Banales, Marco Marzioni, Nicholas LaRusso and Peter Jansen