Factores que favorecen el reingreso en intensivos de pacientes con síndrome coronario agudo

Introduction: About 7% of patients admitted in Intensive Care Units (ICUs) due to acute coronary syndrome (ACS) in Spain, are readmitted again later. Objectives: Identify the possible causes and predisposing factors for returning to ICU because of ACS. Methodology: Retrospective, descriptive, comparative and longitudinal study of patients admitted for ACS in the ICU between January 2008 and December 2013.Demographic variables, number of admissions, admission risk factors (dyslipidemia, hypertension and diabetes) and non heart-healthy life habits (sedentary / obesity, smoking, alcoholism) of patients who come back were collected and were compared with control group (not readmitted patients). Pearson’s Chi 2 test and statistical significance were performed. Results: 2.506 patients were admitted by ACS. Readmissions were 140 (5,58%) after 12,93±16,41 months from their first admission. The ICU’s reentering patients stayed4.97± 3.3 days (4.03±1.8 control group) in their first admission. A table is attached with risk factors’ incidence and non heart–healthy life habits of both groups. Smoking and alcoholism habits are related with readmissions (χ²=5.67; p<0.01)Conclusions: The patients who are readmitted stay more days in ICU in their first admission, have less control about risk factors and less quitting index of nocive habits than control group. It seems to exist an adherence therapeutic problem in the sample studied.Introducción: Alrededor del 7% de los pacientes que ingresan en las Unidades de Cuidados Intensivos (UCI) por síndrome coronario agudo (SCA) en España, reingresan de nuevo tiempo después. Objetivos: Identificar posibles causas y factores predisponentes a reingresar en UCI por SCA.Metodología: Estudio retrospectivo, descriptivo, comparativo y longitudinal de pacientes ingresados por SCA en una UCI polivalente entre enero de 2008 y diciembre de 2013. Se recogen variables demográficas, número de ingresos, factores de riesgo al ingreso (dislipemias, hipertensión arterial y diabetes) y hábitos de vida no cardiosaludables (sedentarismo/obesidad, tabaquismo, enolismo) de pacientes que reingresan y se comparan con grupo de control (pacientes que no reingresan). Se realiza test Chi 2 de Pearson y significación estadística.Resultados: Ingresaron 2.506 pacientes por SCA. Reingresaron 140 (5,58%) a los 12,93±16,41 meses después del primer ingreso. Los que reingresan están en UCI 4.97± 3.3 días (4.03±1.8 grupo control) en su primer ingreso. Se adjunta tabla con incidencia de factores de riesgo y hábitos de vida no saludables de ambos grupos. El tabaquismo y enolismo se relacionan con los reingresos (χ²=5.67; p<0.01)Conclusiones: Los pacientes que reingresan, están más días en UCI en su primer ingreso, presentan un menor control de factores de riesgo y menor índice de abandono de hábitos nocivos que el grupo control. El tabaco y el alcohol son factores que favorecen el reingreso. Parece indicar que existe un problema de adherencia terapéutica en la muestra estudiada. &nbsp

Existence of extremal solutions for quadratic fuzzy equations

Some results on the existence of solution for certain fuzzy equations are revised and extended. In this paper, we establish the existence of a solution for the fuzzy equation , where , , , and are positive fuzzy numbers satisfying certain conditions. To this purpose, we use fixed point theory, applying results such as the well-known fixed point theorem of Tarski, presenting some results regarding the existence of extremal solutions to the above equation.Research partially supported by Ministerio de Educación y Ciencia and FEDER, Projects BFM2001 – 3884 – C02 – 01 and MTM2004 – 06652 – C03 – 01, and by Xunta de Galicia and FEDER, Project PGIDIT02PXIC20703PNS

Potential of bacteriophage K as an antimicrobial strategy against biofilms of Staphylococcus aureus in the food industry

1 poster presented at the 24th International ICFMH Conference, Food Micro 2014, 1-4 Septembre, Nantes, FranceThe potential of phage K in the removal and prevention of Staphylococcus aureus biofilms on stainless steel surfaces was examined. The host range of the phage was tested on 18 strains from the food industry. Two out of six sensitive strains were selected for study of biofilms. Immature 6-h-old biofilms were challenged wfth a wide range of multipticlties of infection {MOl, 0.01-500) for 18 h at 25ºc. A noticeable effect on cell number was appreciated at MOIs≥10, but no effect was detected at lower MOis. Subsequently, 24 h-old biofilms (with a higher cell density and a more dense extracellular matrix) were challenged too at MOIs between 0.01-3.0 for 24 hat 25ºc. Again, a significant effect was only found at MOls > 1. The effectiveness in the prevention of biofilm formation was examined by Infecting planktonlc cultures of S. aureus with sub-lethal and lethal doses of phage K (MOIs 1-10-7-10.0). A notable effect on cell number and biofilm biomass was observed from MOIs >1·10-5. The potential of phage K as a tool for biohygienization in the food Industry acting specifically against biofilms of S. aureus was thus shown. However, neither biofilm cells were completely removed nor biofilm formation was totally prevented, and a sub-population of live cells was left In both cases As a result, the effectiveness of two co-adjuvant-based strategies was subsequently assessed. Combining DNase (0,1-10 mg/ml) with phage K (MOl of 0.3-3.0) did not show an additional effect on the removal of 24 h-old-biofilms at 25°C. A 30 min pre-treatment at 37ºc aimed to enhance DNase activity also had not effect. DNase did not show any effects by itself either. In contrast, combining cis-2-decenoic acid {1 - 100 nM) with phage K (MOl of 0.03-0.3) seemed to show some effects on biofilmsN

Testing for alpha-1 antitrypsin in COPD in outpatient respiratory clinics in Spain: A multilevel, cross-sectional analysis of the EPOCONSUL study

Background Alpha-1 antitrypsin deficiency (AATD) is the most common hereditary disorder in adults, but is under-recognized. In Spain, the number of patients diagnosed with AATD is much lower than expected according to epidemiologic studies. The objectives of this study were to assess the frequency and determinants of testing serum α1-antitrypsin (AAT) levels in COPD patients, and to describe factors associated with testing. Methods EPOCONSUL is a cross-sectional clinical audit, recruiting consecutive COPD cases over one year. The study evaluated serum AAT level determination in COPD patients and associations between individual, disease-related, and hospital characteristics. Results A total of 4,405 clinical records for COPD patients from 57 Spanish hospitals were evaluated. Only 995 (22.5%) patients had serum AAT tested on some occasion. A number of patient characteristics (being male [OR 0.5, p < 0.001], ≤55 years old [OR 2.38, p<0.001], BMI≤21 kg/m2 [OR 1.71, p<0.001], FEV1(%)<50% [OR 1.35, p<0.001], chronic bronchitis [OR 0.79, p < 0.001], Charlson index ≥ 3 [OR 0.66, p < 0.001], or history or symptoms of asthma [OR 1.32, p<0.001]), and management at a specialized COPD outpatient clinic [OR 2.73,p<0.001] were identified as factors independently associated with ever testing COPD patients for AATD. Overall, 114 COPD patients (11.5% of those tested) had AATD. Of them, 26 (22.8%) patients had severe deficiency. Patients with AATD were younger, with a low pack-year index, and were more likely to have emphysema (p<0.05). Conclusion Testing of AAT blood levels in COPD patients treated at outpatient respiratory clinics in Spain is infrequent. However, when tested, AATD (based on the serum AAT levels ≤100 mg/dL) is detected in one in five COPD patients. Efforts to optimize AATD case detection in COPD are needed.SEPA

Existence of solutions to uncertain differential equations of nonlocal type via an extended Krasnosel’skii fixed point theorem

In the present study, we investigate the existence of the solutions to a type of uncertain differential equations subject to nonlocal derivatives. The approach is based on the application of an extended Krasnosel’skii fixed point theorem valid on fuzzy metric spaces. With this theorem, we deduce that the problem of interest has a fuzzy solution, which is defined on a certain interval. Our approach includes the consideration of a related integral problem, to which the above-mentioned tools are applicable. We finish with some physical motivationsWe are grateful to the Editor and the anonymous Referees for their comments and suggestions that helped to improve the paper. The research of J.J.N. and R.R.L. is supported by grant numbers PID2020-113275GB-I00 (AEI/FEDER, UE), MTM2016-75140-P (AEI/FEDER, UE), and ED431C 2019/02 (GRC Xunta de Galicia). The visit of A.K. to the University of Santiago de Compostela has been partially supported by the Agencia Estatal de Investigación (AEI) of Spain, co-financed by the European Fund for Regional Development (FEDER) corresponding to the 2014-2020 multiyear financial framework, project MTM2016-75140-P; and by Xunta de Galicia under grant ED431C 2019/02. Open Access funding provided thanks to the CRUE-CSIC agreement with Springer NatureS

Existence of Periodic Solution for a Nonlinear Fractional Differential Equation

We study the existence of solutions for a class of fractional differential equations. Due to the singularity of the possible solutions, we introduce a new and proper concept of periodic boundary value conditions. We present Green's function and give some existence results for the linear case and then we study the nonlinear problem.The research of J. J. Nieto and R. Rodríguez-López has been partially supported by Ministerio de Educacion y Ciencia and FEDER, project MTM2007-61724, and by Xunta de Galicia and FEDER, project PGIDIT06PXIB207023PRS