Stochastic vs. deterministic magnetic coding in designed cylindrical nanowires for 3D magnetic networks

[EN] Advances in cylindrical nanowires for 3D information technologies profit from intrinsic curvature that introduces significant differences with regards to planar systems. A model is proposed to control the stochastic and deterministic coding of remanent 3D complex vortex configurations in designed multilayered (magnetic/non-magnetic) cylindrical nanowires. This concept, introduced by micromagnetic simulations, is experimentally confirmed by magnetic imaging in FeCo/Cu multilayered nanowires. The control over the random/deterministic vortex states configurations is achieved by a suitable geometrical interface tilting of almost non-interacting FeCo segments with respect to the nanowire axis, together with the relative orientation of the perpendicular magnetic field. The proper design of the segments' geometry (e.g. tilting) in cylindrical nanowires opens multiple opportunities for advanced nanotechnologies in 3D magnetic networks.Spanish Ministry of Science and Innovation under Projects MAT2016-76824-C3-1-R, PID2019-108075RB-C31/ AEI / 10.13039/501100011033 and PGC2018-097789-B-I00 and the Regional Government of Madrid under Project S2018/NMT-4321 NANOMAGCOST-CM. LA and MF acknowledge project RTI2018-095303-B-C53.Peer reviewe

Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019

Altres ajuts: Spanish AIDS Research Network; European Funding for Regional Development (FEDER).Objectives: We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018. Methods: The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation. Results: The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001). Conclusions: In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial

More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369

Volviéndonos mejores: necesidad de acción inmediata ante el reto de la obesidad. Una postura de profesionales de la salud.

La creciente epidemia de obesidad ha sido uno de los retos más importantes de salud pública en México durante los últimos años. Con apoyo de la Federación Mundial de Obesidad, en 2021 formamos un grupo de profesionales para identificar y resumir las acciones prioritarias en las que puede enfocarse nuestro país para hacer frente a esta epidemia. Al proceso de desarrollo y discusión de este grupo se sumaron más de 1 000 profesionales de la salud para retomar recomendaciones de documentos y guías de alto nivel previamente publicados. En conmemoración del Día Mundial de la Obesidad, en este 2022 se presenta esta postura como insumo para el desarrollo de acciones en el ámbito profesional y de los diferentes sectores, en la que se incluyen 10 recomendaciones de acción, desde la perspectiva poblacional hasta la atención individualizada, y se enfatiza en la importancia de la participación social, de las intervenciones integrales con visión centrada en la persona y de la sostenibilidad planetaria, además de mejorar la educación y las campañas de difusión, propiciar un ambiente promotor de entornos activos y blindar de conflictos de interés los esfuerzos de prevención y control. La postura hace un llamado para abordar la obesidad de manera seria, con base en la evidencia científica, oportuna e integral, con enfoque de curso de vida, de forma ética y sensible, y sin perpetuar las barreras del estigma de peso en la sociedad

First report of Polyphagotarsonemus latus (Banks) in Apaxtleco chili (Capsicum annuum L.) cultivated in greenhouse

Objectives: To generate information on a new host of the Polyphagotarsonemus latus (Banks) mite, and to know the damage caused to the Apaxtleco chili (Capsicum annuum L.) crop in the northern region of the state of Guerrero. Design / methodology: The identification of the mite was carried out by means of taxonomic keys and the damages caused in vegetative shoots, mature leaves and flower shoots were described. Results: The P. latus mite was identified causing significant damage to the Aplaxtleco chili crop grown in the greenhouse in the state of Guerrero, Mexico, and the first report of this mite in the greenhouse-grown Aplaxtleco chilli crop in the state is released. from Guerrero, Mexico. Findings / conclusions. The cultivation of Aplaxtleco chili is a characteristic crop of the municipality of Aplaxtla, in the North zone and from which economic income is obtained, for this reason knowing the identity of the P. latus mite in the cultivation of Aplaxtleco chili will help to propose effective control methods for higher performance.Objectives: To generate information about a new host of the Polyphagotarsonemuslatus (Banks) mite, and to understand the damages caused by the cultivation ofApatlexco chili pepper (Capsicum annuum L.) in the northern region of the state ofGuerrero.Design/Methodology/Approach: The identification of the mite was carried out throughtaxonomic keys and the damages caused in vegetative shoots, mature leaves andflower buds were described.Results: The P. latus mite was identified as causing important damage to the crops ofAplaxtleco chili pepper grown in greenhouses in the state of Guerrero, Mexico, and thisis the first report of this mite in the Aplaxtleco chili pepper crop grown in greenhouses inthe state of Guerrero, Mexico.Findings/Conclusions: Economic income is obtained from the cultivation of Aplaxtlecochili peppers, a characteristic crop of the municipality of Aplaxtla, in the northern zone of Guerrero; therefore, knowing the identity of the P. latus mite in the Aplaxtleco chili cropwill help to suggest effective control methods to obtain higher yields

Morphological characterization of Hirsutella citriformis Speare Mexican isolates and evaluation against Diaphorina citri Kuwayama (Hemiptera: Psyllidae)

Diaphorina citri, the vector of the pathogen causing Huanglongbing, has been found infected by the entomopathogenic fungus Hirsutella citriformis Speare in the Mexican citrus industry.&nbsp; The objective of this study was to characterize morphologically eight H. citriformis isolates and evaluate their potential for the control of D. citri adults. The fungal isolates were obtained from citrus groves located in the Mexican states of Campeche, Chiapas, Colima, Quintana Roo, San Luis Potosí, Tabasco, Veracruz, and Yucatán.&nbsp; The fungi showed mycelium composed by delicate hyphae measuring 1.18-1.88 µm in diameter; phialides 30.7-40.9 µm in lenght and neck length of 24.7-35.8 µm.&nbsp; Conidia measured 5.83-5.92 µm in length and 1.43-1.99 in diameter.&nbsp; The mucilaginous layer was 7.83-8.12 X 5.86-5.99 µm.&nbsp; The morphological characterization indicated that the isolates were related to H. citriformis.&nbsp; The experiments for the evaluation of pathogenicity were conducted under controlled conditions (25±2°C, 76±4% RH and 16:8 h L:D).&nbsp; Insects were inoculated by contact with sporulated cultures of the isolates.&nbsp; For each H. citriformis isolate, 15 adults of D. citri received the spores of the fungus.&nbsp; The results showed that mortality of the psyllids by the fungus began six days after inoculation; occurrence of the first H. citriformis sinnemata in the D. citri specimens was observed 10 days after inoculation.&nbsp; In the first bioassay, the final record of survivorship was performed 27 days after the beginning of the experiments; the mean rate of mortality was 98 and 70% for the Tabasco, and San Luis Potosi H. citriformis isolates, respectively

Morphological characterization of Hirsutella citriformis Speare Mexican isolates and evaluation against Diaphorina citri Kuwayama (Hemiptera: Psyllidae)

Diaphorina citri, the vector of the pathogen causing Huanglongbing, has been found infected by the entomopathogenic fungus Hirsutella citriformis Speare in the Mexican citrus industry.&nbsp; The objective of this study was to characterize morphologically eight H. citriformis isolates and evaluate their potential for the control of D. citri adults. The fungal isolates were obtained from citrus groves located in the Mexican states of Campeche, Chiapas, Colima, Quintana Roo, San Luis Potosí, Tabasco, Veracruz, and Yucatán.&nbsp; The fungi showed mycelium composed by delicate hyphae measuring 1.18-1.88 µm in diameter; phialides 30.7-40.9 µm in lenght and neck length of 24.7-35.8 µm.&nbsp; Conidia measured 5.83-5.92 µm in length and 1.43-1.99 in diameter.&nbsp; The mucilaginous layer was 7.83-8.12 X 5.86-5.99 µm.&nbsp; The morphological characterization indicated that the isolates were related to H. citriformis.&nbsp; The experiments for the evaluation of pathogenicity were conducted under controlled conditions (25±2°C, 76±4% RH and 16:8 h L:D).&nbsp; Insects were inoculated by contact with sporulated cultures of the isolates.&nbsp; For each H. citriformis isolate, 15 adults of D. citri received the spores of the fungus.&nbsp; The results showed that mortality of the psyllids by the fungus began six days after inoculation; occurrence of the first H. citriformis sinnemata in the D. citri specimens was observed 10 days after inoculation.&nbsp; In the first bioassay, the final record of survivorship was performed 27 days after the beginning of the experiments; the mean rate of mortality was 98 and 70% for the Tabasco, and San Luis Potosi H. citriformis isolates, respectively

Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice : A multicentre cohort study

Background: The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegravir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment-experienced patients from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). Methods: Treatment-experienced patients starting treatment with EVG/COB/TFV/FTC + DRV during the years 2014-2018 and with more than 24 weeks of follow-up were included. TFV could be administered either as tenofovir disoproxil fumarate or tenofovir alafenamide. We evaluated virological response, defined as viral load (VL) < 50 copies/ml and < 200 copies/ml at 24 and 48 weeks after starting this regimen, stratified by baseline VL (< 50 or ≥ 50 copies/ml at the start of the regimen). Results: We included 39 patients (12.8% women). At baseline, 10 (25.6%) patients had VL < 50 copies/ml and 29 (74.4%) had ≥ 50 copies/ml. Among patients with baseline VL < 50 copies/ml, 85.7% and 80.0% had VL < 50 copies/ml at 24 and 48 weeks, respectively, and 100% had VL < 200 copies/ml at 24 and 48 weeks. Among patients with baseline VL ≥ 50 copies/ml, 42.3% and 40.9% had VL < 50 copies/ml and 69.2% and 68.2% had VL < 200 copies/ml at 24 and 48 weeks. During the first 48 weeks, no patients changed their treatment due to toxicity, and 4 patients (all with baseline VL ≥ 50 copies/ml) changed due to virological failure. Conclusions: EVG/COB/TFV/FTC + DRV was well tolerated and effective in treatment-experienced patients with undetectable viral load as a simplification strategy, allowing once-daily, two-pill regimen with three antiretroviral drug classes. Effectiveness was low in patients with detectable viral loads