A la búsqueda de un modelo integrado de Orientación

El artículo constituye una reflexión sobre el Modelo Comprensivo de Gysbers, sus bases teóricas, su estructura organizativa y funcional. Su fundamentación en las teorías del Desarrollo de la Carrera; el carácter de comprensividad como seña de identidad y su integración en el proceso educativo propician; por un lado establecer un paralelismo con el modelo institucional de orientación de nuestro país; por otro retomarlo como inspiración para el modelo organizativo y funcional del Plan de Orientación y Acción Tutorial en nuestros centros de secundaria

Oxoperoxovanadium Complexes of Hetero Ligands: X-Ray Crystal Structure, Density Functional Theory, and Investigations on DNA/ BSA Interactions, Cytotoxic, and Molecular Docking Studies

Oxoperoxovanadium (V) complexes [VO (O)2 (nf ) (bp)] (1) and [VO (O)2 (ox) (bp)] (2) based on 5-nitro-2-furoic acid (nf ), oxine (ox) and 2, 2 bipyridine (bp) bidentate ligands have been synthesized and characterized by FT-IR, UV-visible, mass, and NMR spectroscopic techniques. e structure of complex 2 shows distorted pentagonal-bipyramidal geometry, as con rmed by a single-crystal XRD di raction study. e interactions of complexes with bovine serum albumin (BSA) and calf thymus DNA (CTDNA) are investigated using UV-visible and uorescence spectroscopic techniques. It has been observed that CT-DNA interacts with complexes through groove binding mode and the binding constants for complexes 1 and 2 are 8.7 ×103M−1 and 8.6 ×103M−1, respectively, and BSA quenching constants for complexes 1 and 2 are 0.0628 ×106M−1 and 0.0163 ×106M−1, respectively. e ability of complexes to cleave DNA is investigated using the gel electrophoresis method with pBR322 plasmid DNA. Furthermore, the cytotoxic e ect of the complexes is evaluated against the HeLa cell line using an MTT assay. e complexes are subjected to density functional theory calculations to gain insight into their molecular geometries and are in accordance with the results of docking studies. Furthermore, based on molecular docking studies, the intermolecular interactions responsible for the stronger binding a£nities between metal complexes and DNA are discussed

A Lamellar Zn-Based Coordination Polymer Showing Increasing Photoluminescence upon Dehydration

This research was funded by Gobierno Vasco/Eusko Jaurlaritza (IT1755-22, IT1722-22 and IT1500-22) and Junta de Andalucia (B-FQM-734-UGR20, ProyExcel_00386 and FQM-394).The present study reports on a 2D lamellar coordination polymer (CP) of {[Zn(& mu;(3)-pmdc)(H2O)]& BULL;H2O}(n) formula (pmdc = pyrimidine-4,6-dicarboxylate). This CP is synthesized under an appropriate acid-base reaction between the gently mortared reagents in the solid state through a solvent-free procedure that avoids the presence of concomitant byproducts. The X-ray crystal structure reveals the occurrence of Zn-2 entities connected through carboxylate groups of pmdc, which behave as triconnected nodes, giving rise to six-membered ring-based layers that are piled up through hydrogen bonding interactions. In addition to a routine physico-chemical characterization, the thermal evolution of the compound has been studied by combining thermogravimetric and thermodiffractometric data. The photoluminescence properties are characterized in the solid state and the processes governing the spectra are described using time-dependent density-functional theory (TD-DFT) with two different approaches employing different program packages. The emissive capacity of the material is further analyzed according to the dehydration and decreasing temperature of the polycrystalline sample.Basque Government IT1755-22, IT1722-22, IT1500-22Junta de Andalucia B-FQM-734-UGR20, ProyExcel_00386, FQM-39

Antibacterial Cu or Zn-MOFs Based on the 1,3,5-Tris-(styryl)benzene Tricarboxylate

This work was funded by the Marie Skłodowska-Curie Actions, HeatNMof ITN under Grant ID: 860942, Marie Sklodowska-Curie grant agreement No. 101061833 (BioPolyMOF). Universidad de Castilla-La Mancha project 2022-GRIN-34214.Supplementary Materials: The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/nano13162294/s1Metal–organic frameworks (MOFs) are highly versatile materials. Here, two novel MOFs, branded as IEF-23 and IEF-24 and based on an antibacterial tricarboxylate linker and zinc or copper cations, and holding antibacterial properties, are presented. The materials were synthesized by the solvothermal route and fully characterized. The antibacterial activity of IEF-23 and IEF-24 was investigated against Staphylococcus epidermidis and Escherichia coli via the agar diffusion method. These bacteria are some of the most broadly propagated pathogens and are more prone to the development of antibacterial resistance. As such, they represent an archetype to evaluate the efficiency of novel antibacterial treatments. MOFs were active against both strains, exhibiting higher activity against Staphylococcus epidermidis. Thus, the potential of the developed MOFs as antibacterial agents was proved.H2020 Marie Skłodowska-Curie Actions 101061833, 860942 MSCAUniversidad de Castilla-La Mancha 2022-GRIN-34214 UCL

Aproximación a la educación vocacional. Una perspectiva desde la Reforma Educativa

Múltiples y muy diversos han sido los factores que han condicionado la evolución que en las últimas décadas se percibe en la Orientación Vocacional: de un planteamiento estático y bastante determinista se ha pasado a una perspectiva evolutiva y de desarrollo que contempla los sucesivos roles y funciones que el individuo va asumiendo a lo largo de la vida. De un interés por la adecuación al puesto de trabajo se ha pasado a dar respuesta a la necesidad de formar al individuo para amplios sectores de la actividad laboral, teniendo en cuenta, no sólo la inteligencia y capacidades, sino también los valores, apetencias y convicciones. De una actuación concebida como subsidiaria y de apoyo a quienes abandonan la escolaridad ha pasado a ser concebida como procesual y plenamente implicada en la tarea educativa

A metal-organic framework based on Co(II) and 3-aminoisonicotinate showing specific and reversible colourimetric response to solvent exchange with variable magnet behaviour

Supplementary data to this article can be found online at https://doi.org/10.1016/j.mtchem.2022.100794.This work has been funded by the Spanish Ministry of Science, Innovation and Universities (MCIU/AEI/FEDER, UE; PGC2018- 102052-A-C22, PGC2018-102052-B-C21 and PID2019-108028GBC21), University of the Basque Country (GIU20/028), Gobierno Vasco/Eusko Jaurlaritza (IT1005-16, IT1291-19) and Junta de Andalucía (FQM-394, B-FQM-734-UGR20). O.P.C. thanks his predoctoral fellowship to UPV/EHU. The authors thank for technical and human support provided by SGIker of UPV/EHU and European funding (ERDF and ESF).A versatile metal-organic system consisting of Co-based compounds that show reversible transformations between a 3D metal-organic framework (MOF) of {[Co(μ-3isoani)2]·DMF}n (1) formula (where 3isoani = 3-aminoisonicotinato and DMF = dimethylformamide) and a 0D monomeric [Co(3isoani)2(H2O)4] (2) complex is reported. These 1 ↔ 2 transformations, triggered by the exposure of the MOF and the monomer-based compound to H2O and DMF, respectively, involve colour changes from purple (in MOF 1) to light brown (in monomeric complex 2), which imbues the system with colourimetric sensing capacity towards these solvents. Despite the high reactivity of the MOF in contact with water, it presents good thermal stability and permanent porosity with a remarkably high CO2 capture capacity at room temperature (3.35 mmol/g), which is further analysed by in situ single-crystal X-ray diffraction. Experimental magnetic properties and CASSCF/NEVPT2 calculations of all compounds reveal distinct slow magnetic relaxations for 3D and 0D compounds.Spanish Ministry of Science, Innovation and Universities (MCIU/AEI/FEDER, UE; PGC2018- 102052-A-C22, PGC2018-102052-B-C21 and PID2019-108028GBC21)University of the Basque Country (GIU20/028)Gobierno Vasco/Eusko Jaurlaritza (IT1005-16, IT1291-19)Junta de Andalucía (FQM-394, B-FQM-734-UGR20

Metal−Organic Frameworks in Agriculture

The work has been supported by the MOFSEIDON project (PID2019-104228RB-100) funded by MCI/AEI/10.13039/ 501100011033/FEDER “Una manera de hacer Europa”, ESENCE project (RTC2019-007254-5) funded by MCIN/ AEI/10.13039/501100011033), Junta de Andalucía (FQM- 394), and the Multifunctional Metallodrugs in Diagnosis and Therapy Network (MICIU, RED2018-102471-T). P.H. acknowledges the Spanish Ramón y Cajal Programme (grant agreement 2014-15039). S.R. acknowledges the Spanish Juan de la Cierva Incorporación Fellowship (grant agreement no. IJC2019-038894-I) funded by MCIN/AEI/10.13039/ 501100011033. Funding for open access charge: Universidad de Granada/CBUA.Agrochemicals, which are crucial to meet the world food qualitative and quantitative demand, are compounds used to kill pests (insects, fungi, rodents, or unwanted plants). Regrettably, there are some important issues associated with their widespread and extensive use (e.g., contamination, bioaccumulation, and development of pest resistance); thus, a reduced and more controlled use of agrochemicals and thorough detection in food, water, soil, and fields are necessary. In this regard, the development of new functional materials for the efficient application, detection, and removal of agrochemicals is a priority. Metal–organic frameworks (MOFs) with exceptional sorptive, recognition capabilities, and catalytical properties have very recently shown their potential in agriculture. This Review emphasizes the recent advances in the use of MOFs in agriculture through three main views: environmental remediation, controlled agrochemical release, and detection of agrochemicals.MOFSEIDON project (PID2019-104228RB-100) funded by MCI/AEI/10.13039/ 501100011033/FEDERESENCE project (RTC2019-007254-5) funded by MCIN/ AEI/10.13039/501100011033Junta de Andalucía (FQM- 394), and the Multifunctional Metallodrugs in Diagnosis and Therapy Network (MICIU, RED2018-102471-T)Spanish Ramón y Cajal Programme (grant agreement 2014-15039)Spanish Juan de la Cierva Incorporación Fellowship (grant agreement no. IJC2019-038894-I) funded by MCIN/AEI/10.13039/ 501100011033Funding for open access charge: Universidad de Granada/CBU

Catalytic activation of remote alkenes through silyl-rhodium(III) complexes

The tandem isomerization–hydrosilylation reaction is a highly valuable process able to transform mixtures of internal olefins into linear silanes. Unsaturated and cationic hydrido-silyl-Rh(III) complexes have proven to be effective catalysts for this reaction. Herein, three silicon-based bidentate ligands, 8-(dimethylsilyl) quinoline (L1), 8-(dimethylsilyl)-2-methylquinoline (L2) and 4-(dimethylsilyl)-9-phenylacridine (L3), have been used to synthesize three neutral [RhCl(H)(L)PPh3] (1-L1, 1-L2 and 1-L3) and three cationic [Rh(H)(L) (PPh3)2][BArF 4] (2-L1, 2-L2 and 2-L3) Rh(III) complexes. Among the neutral compounds, 1-L2 could be characterized in the solid state by X-ray diffraction showing a distorted trigonal bipyramidal structure. Neutral complexes (1-L1, 1-L2 and 1-L3) failed to catalyze the hydrosilylation of olefins. On the other hand, the cationic compound 2-L2 was also characterized by X-ray diffraction showing a square pyramidal structure. The unsaturated and cationic Rh(III) complexes 2-L1, 2-L2 and 2-L3 showed significant catalytic activity in the hydrosilylation of remote alkenes, with the most sterically hindered (2-L2) being the most active onePID2019-111281GB-I00MCIN/AEI/10.13039/501100011033IT1741-22 and IT1553-22Gobierno VascoSGiker for technical and human support. Universidad del País Vasco (UPV/EHU)IKERBASQU

Therapy and diagnosis of Alzheimer’s disease: from discrete metal complexes to metal–organic frameworks

Alzheimer’s disease (AD) is a neurodegenerative disorder affecting 44 million people worldwide. Although many issues (pathogenesis, genetics, clinical features, and pathological aspects) are still unknown, this disease is characterized by noticeable hallmarks such as the formation of b-amyloid plaques, hyperphosphorylation of tau proteins, the overproduction of reactive oxygen species, and the reduction of acetylcholine levels. There is still no cure for AD and the current treatments are aimed at regulating the cholinesterase levels, attenuating symptoms temporarily rather than preventing the AD progression. In this context, coordination compounds are regarded as a promissing tool in AD treatment and/or diagnosis. Coordination compounds (discrete or polymeric) possess several features that make them an interesting option for developing new drugs for AD (good biocompatibility, porosity, synergetic effects of ligand–metal, fluorescence, particle size, homogeneity, monodispersity, etc.). This review discusses the recent progress in the development of novel discrete metal complexes and metal–organic frameworks (MOFs) for the treatment, diagnosis and theragnosis of AD. These advanced therapies for AD treatment are organized according to the target: Ab peptides, hyperphosphorylated tau proteins, synaptic dysfunction, and mitochondrial failure with subsequent oxidative stressMOFSEIDON project (PID2019- 104228RB-100, MCI/AEI/FEDER)AgroMOFs project (TED2021-132440B-I00)MCIN/AEI/10.13039/50110 0011033NextGenerationEU/PRTRMargarita Salas contract 401Ministerio de Universidades and Next GenerationB- FQM-394, ProyExcel_00105ProyExcel_00386Consejería de Universidad, Investigación e Innovación de la Junta de AndalucíaGrant (RYC2021-032522-I)MCIN/AEI/10.13039/ 50110001103