Sistematización de la metodología de validación e interpretación de resultados para medidas clínicas de la enfermedad de Parkinson

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina Preventiva y Salud Pública y Microbiología. Fecha de lectura: 12-03-201

Activated char from the co-pyrolysis of polystyrene and olive stone mixtures for the adsorption of CO2

Yogurt plastic containers made of polystyrene (PS), olive stone, and mixtures of both have been converted into activated carbon materials transforming them firstly into char via pyrolysis and secondly with activation using either KOH or H2SO4. The pyrolysis of the olive stone gave a higher yield of material than the plastic PS. However, the activation of the PS char with KOH was more effective, reaching surface areas of 508 vs 194 m2 g−1 of the corresponding prepared with olive stone. The prepared materials were tested as CO2 adsorbent in thermobalance and fixed-be column assays. The materials activated with H2SO4 slightly enhanced the adsorption ability of the original char but were far from the performance obtained with KOH activation. The CO2 isotherms showed high synergy of CO2 uptake and selectivity when using activated chars prepared with the char from the mixture of raw materials, specially at a 1:1 mass ratio. The isosteric heat of adsorption values were those expected for a physisorption process. Further experiments in a fixed-bed column were also studied at atmospheric pressure at different inlet CO2 concentrations (10–50%). The CO2 retention increased as the partial CO2 pressure rose. Besides, a very similar performance of the material prepared with plastic and olive stones was obtained at 50%, i.e. 220 and 197 mg g−1 respectively. At low CO2 concentrations, the materials enriched with plastic displayed better performance than those prepared with olive stone. Cycles of adsorption-desorption were carried out in the column to assess the stability of the materials. The curves obtained did not display any substantial change, demonstrating the lack of adsorption retention

Calmodulin Supports TRPA1 Channel Association with Opioid Receptors and Glutamate NMDA Receptors in the Nervous Tissue

Supplementary Materials: The following are available online at https://www.mdpi.com/1422-006 7/22/1/229/s1, Figure S1: TRPA1 association with MORs in spinal cord in HINT1-/- and 1R-/- mice. Figure S2: The HINT1 protein or 1R does not support the MOR association with the Nt or Ct regions of TRPA1 channels. Figure S3: CaM mediates the TRPA1 Ct association with MOR in the absence of Ca2+. Figure S4: Pharmacological modulation of TRPA1 associations with MORs and glutamate NMDARs. Figure S5: Formalin-induced inflammatory pain alters TRPA1 associations with MORs and NMDARs. Figure S6: TRPA1 associations with opioid receptors and NMDARs in the CCI model of neuropathic pain.We would like to thank Gabriela de Alba and María José López for their excellent technical assistanceTransient receptor potential ankyrin member 1 (TRPA1) belongs to the family of thermo TRP cation channels that detect harmful temperatures, acids and numerous chemical pollutants. TRPA1 is expressed in nervous tissue, where it participates in the genesis of nociceptive signals in response to noxious stimuli and mediates mechanical hyperalgesia and allodynia associated with different neuropathies. The glutamate N-methyl-d-aspartate receptor (NMDAR), which plays a relevant role in allodynia to mechanical stimuli, is connected via histidine triad nucleotide-binding protein 1 (HINT1) and type 1 sigma receptor (σ1R) to mu-opioid receptors (MORs), which mediate the most potent pain relief. Notably, neuropathic pain causes a reduction in MOR antinociceptive efficacy, which can be reversed by blocking spinal NMDARs and TRPA1 channels. Thus, we studied whether TRPA1 channels form complexes with MORs and NMDARs that may be implicated in the aforementioned nociceptive signals. Our data suggest that TRPA1 channels functionally associate with MORs, delta opioid receptors and NMDARs in the dorsal root ganglia, the spinal cord and brain areas. These associations were altered in response to pharmacological interventions and the induction of inflammatory and also neuropathic pain. The MOR-TRPA1 and NMDAR-TRPA1 associations do not require HINT1 or σ1R but appear to be mediated by calcium-activated calmodulin. Thus, TRPA1 channels may associate with NMDARs to promote ascending acute and chronic pain signals and to control MOR antinociception.MICINN Plan Nacional I+D+i RT 2018-093677B-100University of Granada PPJIB2019.11MECD FPU 15/02356 FPU16/0321

Innovando en la Gestión académica: La incorporación de protocolos y herramientas digitales en los Grados de la Facultad de Ciencias Políticas y Sociología

Proyecto de Innovación en la Gestión Académica que tiene como objetivos principales incorporar protocolos y herramientas para la mejora en la Calidad de la gestión académica de los Grados. Principalmente aplicables a la coordinación docente de los Grados, la organización académica de los Trabajos Fin de Grado, la difusión e información de los estudios de Grado, el mantenimiento de la información web de los Grados, el reconocimiento de Créditos, y, la acogida, tutela y asesoramiento de los estudiantes de los Grados

Recensiones

RESEÑA 1 de : Perea Yébenes, Sabino. El sello de Dios (E(papyig úeov) Nueve estudios sobre magia y creencias populares greco-romanas. Madrid : Signifier libros, 2000. RESEÑA 2 de : Nogales Basarrate, Trinidad. Espacios, imágenes y protagonistas del ocio y espectáculo en la sociedad romana emeritense. Monografías emeritenses, n.° 5. Badajoz : Fundación de Estudios, 2000. RESEÑA 3 de : Blázquez Martínez, J.M. Los pueblos en el Mediterráneo en Antigüedad. Madrid : Ediciones Cátedra SA, 2000. RESEÑA 4 de : Hornung, E. Estado, métodos, tareas. Trotta. Barcelona : Edicions de la Universitat de Barcelona, 2000. RESEÑA 5 de : López Pardo, Fernando. El empeño de Heracles (La exposición del Atlántico en la Antigüedad). Arcos, Libros, SL. Cuadernos de Historia, 13, 2000. RESEÑA 6 de : Montero, Santiago. Trajano y la adivinación. Prodigios, oráculos y apocalíptica en el Imperio Romano (98-117 d.C). Gerión : Anejos, IV, 2000. RESEÑA 7 de : Sánchez Moreno, Eduardo. Velones : historia y arqueología de un pueblo prerromano. Madrid : Ed. Universidad Autónoma, 2000. RESEÑA 8 de : Saquete, José Carlos. Las vírgenes Vestales (Un sacerdocio femenino en la religión pública romana). Madrid : CSIC. Instituto de Historia, 2000. RESEÑA 9 de : Maier, J. Jorge Bonsor (1855-1930). Un académico correspondiente de la Real Academia de la Historia y la Arqueología españolas. Madrid : Real Academia de la Historia, 1999

Patients’ Opinions about Knowing Their Risk for Depression and What to Do about It. The PredictD-Qualitative Study

[Background] The predictD study developed and validated a risk algorithm for predicting the onset of major depression in primary care. We aimed to explore the opinion of patients about knowing their risk for depression and the values and criteria upon which these opinions are based. [Methods] A maximum variation sample of patients was taken, stratified by city, age, gender, immigrant status, socio-economic status and lifetime depression. The study participants were 52 patients belonging to 13 urban health centres in seven different cities around Spain. Seven Focus Groups (FGs) were given held with primary care patients, one for each of the seven participating cities. [Results] The results showed that patients generally welcomed knowing their risk for depression. Furthermore, in light of available evidence several patients proposed potential changes in their lifestyles to prevent depression. Patients generally preferred to ask their General Practitioners (GPs) for advice, though mental health specialists were also mentioned. They suggested that GPs undertake interventions tailored to each patient, from a “patient-centred” approach, with certain communication skills, and giving advice to help patients cope with the knowledge that they are at risk of becoming depressed. [Conclusions] Patients are pleased to be informed about their risk for depression. We detected certain beliefs, attitudes, values, expectations and behaviour among the patients that were potentially useful for future primary prevention programmes on depression.This work was supported by grants from the Andalusian Council of Health [grant reference: 2008/0195][www.juntadeandalucia.es/fundacionprogres​oysalud]; the Department of Health of the Basque Government [grant reference: 2008/111021][www.osakidetza.euskadi.net]; the Spanish Network of Primary Care Research “redIAPP” (RD06/0018), the “Aragón group” (RD06/0018/0020), the “Sant Joan de Deu group” (RD07/0018/0017), “Bizkaya group” (RD07/0018/0018), “Castilla-León group” (RD07/0018/0027) and the “SAMSERAP group” (RD06/0018/0039 and CTS-587) [www.rediapp.org]

Los alumnos de nuevo ingreso de origen asiático en la Facultad de Ciencias Políticas y Sociología. Análisis, estudio y propuestas de acción II. Hacia un protocolo de actuación

El Proyecto es la continuación del ya desarrollado en la convocatoria del curso pasado PIE 2017/222 en el que constatábamos que la Facultad de Ciencias Políticas y Sociología recibe cada curso académico un mayor número de alumnos de origen asiático que sufren fuertes dificultades en su proceso de adaptación e integración en los diferentes Grados que se imparten en dicha Facultad (Ciencias Políticas, Sociología, Gestión y Administración Pública, Antropología Social y Cultural, Relaciones Internacionales y los Dobles Grados de Derecho y Ciencias Políticas, Relaciones Internacionales y Sociología, Gestión y Administración Pública y Económicas, y Ciencias Políticas y Filosofía). El alumnado chino constituye uno de los mayores retos que tiene la Universidad Complutense en el esfuerzo por la mejora de la institución en su conjunto y el servicio que da a la sociedad en el proceso de internacionalización de la UCM

Coordinación y promoción del grado en estudios franceses: taller de teatro en lengua francesa

Memoria ID-301. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2013-2014

High Antipredatory Efficiency of Insular Lizards: A Warning Signal of Excessive Specimen Collection?

We live-captured lizards on islands in the Gulf of California and the Baja California peninsula mainland, and compared their ability to escape predation. Contrary to expectations, endemic lizard species from uninhabited islands fled from humans earlier and more efficiently than those from peninsular mainland areas. In fact, 58.2% (n = 146) of the lizards we tried to capture on the various islands escaped successfully, while this percentage was only 14.4% (n = 160) on the peninsular mainland. Separate evidence (e.g., proportion of regenerated tails, low human population at the collection areas, etc.) challenges several potential explanations for the higher antipredatory efficiency of insular lizards (e.g., more predation pressure on islands, habituation to humans on the peninsula, etc.). Instead, we suggest that the ability of insular lizards to avoid predators may be related to harvesting by humans, perhaps due to the value of endemic species as rare taxonomic entities. If this hypothesis is correct, predation-related behavioral changes in rare species could provide early warning signals of their over-exploitation, thus encouraging the adoption of conservation measures