Theoretical and Experimental Analysis of Stability Limits of Non-Axisymmetric Liquid Bridges under Microgravity Conditions

The stability of nonaxisymmetric liquid bridges under microgravity conditions is investigated. The influence on the stability of an almost cylindrical liquid bridge of axisymmetric effects like its volume, a small axial acceleration acting on it, and unequal-diameter supporting disks, as well as that of nonaxisymmetric perturbations like small lateral acceleration and noncoaxial supporting disks, has been analyzed by using standard bifurcation techniques. An expression for the maximum length of a liquid bridge, including all the above-mentioned effects, has been obtained. In addition, the effect on the stability of liquid bridges having noncoaxial supporting disks has been experimentally studied within the constraints of an Earth laboratory by using millimetric liquid bridges. Analytical and experimental results show that each one of the nonaxisymmetric perturbations like the ones here considered (lateral acceleration and eccentricity) can be, from the point of view of stability, as critical as axisymmetric perturbations. In addition, it is demonstrated that when both nonaxisymmetric perturbations are not negligible, the coupling of both perturbations can be a stabilizing effect on the liquid bridg

Design and Manufacturing of an APTF to Test Fluid Behaviour in Microgravity Environment

The present paper deals with the design and manufacturing of an APTF (Advanced Plateau Tank Facility) in order to carrying out earth experiments, previous to space experiments, of fluid behaviour in microgravity environment. This work has been done in collaboration between Manufacturing and Microgravity Laboratories in the Polytechnic University of Madrid, and analyses the requirements and restrictions that must be considered for an APTF design and manufacture. Mechanism employed in each part of the prototype are described in detail, emphasising those that suppose new solutions rather previous designs

Effect of rotation on the equilibrium shapes and stability of liquid bridges in a lateral gravitational field

A cylindrical liquid bridge supported between two circular-shaped disks in isorotation is considered. The effect of a lateral gravitational field on the stability of the liquid bridge is investigated. A numerical method is used to find stable and unstable shapes and to determine the stability limit for different values of lateral gravity

A Plateau Tank Facility (PTF) for Liquid Bridge Experimentation by Using Buoyancy Technique for Microgravity Simulation

Plateau tank is just a reservoir filled with a liquid inside of which there is another immiscible liquid of the same density. The behaviour of the inner liquid can be studied in some respects as in weightlessness. Several Plateau tank facilities have been built-up in the last decade at Lamf/ETSIA. In this paper a new apparatus for liquid bridge experimentation in simulated microgravity conditions is presented. Such equipment allows to impose to the experimental configuration a wide range of controlled mechanical disturbances and incorporates appropriate diagnosis means. The apparatus' may be operated either manually or from a desktop computer to which a remote controller can be linked for telescience operation

A methodology to select suppliers to increase sustainability within supply chains

[EN] Sustainability practice within supply chains remains in an early development phase. Enterprises still need tools that support the integration of sustainability strategy into their activity, and to align their sustainability strategy with the supplier selection process. This paper proposes a methodology using a multi-criteria technique to support supplier selection decisions by taking two groups of inputs that integrate sustainability performance: supply chain performance and supplier assessment criteria. With the proposed methodology, organisations will have a tool to select suppliers based on their development towards sustainability and on their alignment with the supply chain strategy towards sustainability. The methodology is applied to an agri-food supply chain to assess sustainability in the supplier selection process.The authors of this publication acknowledge the contribution of Project GV/2017/065 'Development of a decision support tool for the management and improvement of sustainability in supply chains', funded by the Regional Valencian Government. Also, the authors acknowledge Project 691249, RUC-APS: Enhancing and implementing knowledge-based ICT solutions within high risk and uncertain conditions for agriculture production systems (www.ruc-aps.eu), funded by the European Union according to funding scheme H2020-MSCA-RISE-2015.Verdecho Sáez, MJ.; Alarcón Valero, F.; Pérez Perales, D.; Alfaro Saiz, JJ.; Rodríguez Rodríguez, R. (2021). A methodology to select suppliers to increase sustainability within supply chains. 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Caracterización del comportamiento y gestión de interrupciones en sistemas empotrados Linux sobre arquitecturas ARM

El objetivo de este TFM es caracterizar el comportamiento de lasinterrupciones sobre SoCs con núcleo ARM orientado a aplicaciones,gestionados mediante Linux. Para ello se parte del estudio de todoslos posibles mecanismos hardware disponibles en ARM para gestionary disminuir la latencia de interrupción. Se estudia el tratamiento delas excepciones en el núcleo de Linux, prestando especial atención ala influencia de los diferentes modos de expulsión, incluyendo la ex-pulsión total para tiempo real estricto, en condiciones de carga y sincarga. Sobre dos placas (Beaglebone y Raspberry Pi) con diferentesmicroprocesadores ARM, en ambos casos orientados a aplicación, secaracterizan las latencias en diferentes niveles y condiciones, desde lageneración /retorno de la señal hasta los handlers y rutinas de serviciode niveles más altos del núcleo. Se estudian las diferencias en los tiem-pos de respuesta de las dos placas analizadas en diferentes condicio-nes. Se muestra que la programaciónbaremetalsin sistema operativo,recurriendo a librerías optimizadas por el fabricante, puede ser másestable pero poco eficiente, proporcionando una latencia de respuestaen torno a 1.5 ms, en relación a Linux/ARM que proporciona laten-cias de respuesta medias en torno a 10 us. Se estudian las variacionesen la latencia de interrupción que aparecen en Linux/ARM y se con-cluye por exclusión que puede deberse a la gestión de los gpios y elsistema de entrada/salida de las placas, y no con los controladores deinterrupciones del SoC o con los mecanismos de gestión de Linux

Eficacia de la metodología basada en problemas sobre el aprendizaje por competencias comparada con la metodología tradicional

Objetivo: Comprobar que la aplicación de la metodología aprendizaje basado en problemas mejora el aprendizaje por competencias de matemática II en estudiantes del pregrado. Métodos: Estudio cuasiexperimental que incluyó 40 estudiantes del II ciclo de la Facultad de Ciencias Administrativas y Turismo de la Universidad Nacional De Educación “Enrique Guzmán y Valle”. Lima. Perú. Se introdujo 12 sesiones de la metodología aprendizaje basado en problemas al grupo experimental (n=20) y la metodología tradicional al grupo control (n=20). Se evaluaron las competencias de aprendizaje a través de tres dimensiones: competencias conceptuales, operacionales y actitudinales antes y después de la intervención. Resultados: Respecto a la competencia conceptual la diferencia en el puntaje del grupo experimental y el control fue de 4 ± 0,5 (p<0,01); en la competencia procedimental fue de 31,65 ± 2,29 (p<0,01) mientras que en la competencia actitudinal fue de 10,8 ± 0,92 (p<0,01). Conclusiones: Se encontró que existen diferencias significativas entre la metodología aprendizaje por competencias de los conocimientos conceptuales, procedimentales y actitudinales de matemática II, comparada con la metodología tradicional. La dinámica de aplicación de la metodología aprendizaje basado en problemas, mediante el trabajo colaborativo, cooperativo, solidario y autónomo permitió el cambio de actitud favorable, mejorando significativamente el aprendizaje por competencias de matemática II en comparación con la metodología tradicional de los estudiantes al participar activamente, haciendo habilidades y estilos de aprendizaje independiente y durante las sesiones del grupo experimental.Revisión por pare

Dibenzylxanthines as PPEPCK-M inhibitors for cancer therapy

Phosphoenolpyruvate carboxykinase (PEPCK) is the key enzyme in gluconeogenesis/glyceroneogenesis, which catalyzes the decarboxylation of oxaloacetate to phosphoenolpyruvate. In eukaryotes, there are two isozymes present either in the cytosol (PEPCKC, PCK1) or the mitochondria (PEPCK-M, PCK2). While PCK1 is found in gluconeogenic tissues and has a very clear metabolic function, PCK2 is expressed in non-gluconeogenic cell types, where its role remains largely unknown. For example, PCK2 is highly expressed in most cancer cells, where it provides a growth advantage to cancer cells in nutrient-poor environments