On the origin of the mitochondrial genetic code: Towards a unified mathematical framework for the management of genetic information

The origin of the genetic code represents one of the most challenging problems in molecular evolution. The genetic code is an important universal feature of extant organisms and indicates a common ancestry of different forms of life on earth. Known variants of the genetic code can be mainly divided in mitochondrial and nuclear classes. Here we provide a new insight on the origin of the mitochondrial genetic code: we found that its degeneracy distribution can be explained by using a mathematical approach recently developed for the description of the Euplotes nuclear variant of the genetic code. The results point to a primeval mitochondrial genetic code composed of four base codons, which we call tesserae, that, among other features, exhibit outstanding error detection capabilities. The theoretical description suggests also a formulation of a plausible biological theory about the origin of protein coding. Such theory is based on the symmetry properties of hypothetical primeval chemical adaptors between nucleic acids and amino acids (ancient tRNA’s). Our paper provides a unified mathematical framework for different hypotheses on the origin of genetic coding. Also, it contributes to revisit our present view about the evolutionary steps that led to extant genetic codes by giving a new first-principles perspective on the difficult problem of the origin of the genetic code, and consequently, on the origin of life on earth

Prediction in Photovoltaic Power by Neural Networks

The ability to forecast the power produced by renewable energy plants in the short and middle term is a key issue to allow a high-level penetration of the distributed generation into the grid infrastructure. Forecasting energy production is mandatory for dispatching and distribution issues, at the transmission system operator level, as well as the electrical distributor and power system operator levels. In this paper, we present three techniques based on neural and fuzzy neural networks, namely the radial basis function, the adaptive neuro-fuzzy inference system and the higher-order neuro-fuzzy inference system, which are well suited to predict data sequences stemming from real-world applications. The preliminary results concerning the prediction of the power generated by a large-scale photovoltaic plant in Italy confirm the reliability and accuracy of the proposed approaches

A Comparison of the SAO-Hipparcos reference frames

The reference systems defined by the SAO and Hipparcos catalogues are compared using vector spherical harmonic analysis. The differences between astrometric data in both catalogues have been grouped into different data sets and separate harmonic analysis performed on them. The Fourier coefficients yield estimates of systematic errors in SAO catalogue.Fil: Arias, E. F.. Universidad Nacional de la Plata. Facultad de Ciencias Astronómicas y Geofísicas; ArgentinaFil: Cionco, Rodolfo Gustavo. Universidad Nacional de la Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica la Plata; ArgentinaFil: Orellana, Rosa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica la Plata; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Astronómicas y Geofísicas; ArgentinaFil: Vucetich, Hector. Universidad Nacional de la Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentin

The banking crisis of 2007-2008, and contemporary responses

Until 2006, the financial system prospered and was stable, and Basel II rules were viewed as contributing to that stability. The financial crisis of 2007-2008 forced a change in those beliefs, as imbalances spread and risks materialized, affecting banks and other financial institutions, and impairing economic growth. We discuss the causes of the financial crisis, the response measures that were applied by governments, central banks and the changes in supervision and regulation that are being prepared under Basel III, to increase the resilience of banks, and to reduce the risks of future crisis.info:eu-repo/semantics/publishedVersio

Dynamical characterization of the last prolonged solar minima

The planetary hypothesis of the solar cycle is an old idea in which the gravitational influence of the planets has a non-negligible effect on the causes of the solar magnetic cycle. In this work we looked for a possible causal link in relation with solar barycentric dynamics and prolonged minima events. We searched for particular changes in the Sun's acceleration and concentrated on long-term variations of the solar cycle. We show how the orbital angular momentum of the Sun evolves and how the inclination of the solar barycentric orbit varies during the epochs of orbital retrogressions. In particular, at these moments, the radial component of the Sun's acceleration (i.e., in the barycentre-Sun direction) had an exceptional magnitude. These radial impulses occurred at the very beginning of the Maunder Minimum, during the Dalton Minimum and also at the maximum of cycle 22 before the present extended minimum. We also found a strong correlation between the planetary torque and the observed sunspots international number around that maximum. We apply our results in a novel theory of Sun-planets interaction that it is sensitive to Sun barycentric dynamics and found a very important effect on the Sun's capability of storing hypothetical reservoirs of potential energy that could be released by internal flows and might be related to the solar cycle. This process begins about 40 years before the solar angular momentum inversions, i.e., before Maunder Minimum, Dalton Minimum, and before the present extended minimum. Our conclusions suggest a dynamical characterization of peculiar prolonged solar minima. We discuss the possible implications of these results for the solar cycle including the present extended minimum. (Please read the complete Abstract in the paper)Comment: 17 pages, 6 figures, ACCEPTED in Advances in Space Researc

Modelación de una estructura de pavimento utilizando los módulos dinámicos obtenidos en laboratorio aplicando las metodologías Marshall y Superpave

El programa SHRP (Strategic Higway Research Program) a través del nuevo método de diseño de mezclas asfálticas en caliente 'Superpave', ha impulsado el desarrollo de investigaciones con el fin de obtener mezclas asfálticas más durables, resistentes y en general, que muestren un comportamiento superior como su nombre lo indica. Entonces, es importante conocer los estados de esfuerzos y deformaciones que se producen al modelar una estructura de pavimento con capas de rodadura, compuestas con mezclas asfálticas diseñadas por métodos distintos (Marshall y Superpave) y, por supuesto, con una caracterización dinámica diferente (leyes de fatiga, módulos dinámicos y respuesta al ahuellamiento). Esta modelación permite tener una idea general de la capacidad estructural para soportar el tránsito durante su vida útil representada en el valor de N (Número de ejes equivalentes de carga) y quizá obtener algunos indicios de posibles ahorros en costos de conservación de los pavimentos, razones fundamentales para apoyar e incentivar la implementación del método Superpave como nuevo diseño de las mezclas asfálticas en caliente

Comparación de módulos dinámicos de probetas elaboradas por el método Marshall y por el método Superpave

En el mundo se han emprendido grandes campañas para mejorar el comportamiento de las mezclas asfálticas; entre ellas, está la liderada por los Estados Unidos denominado 'Programa estratégico de investigación en carreteras (SHRP)' en la que se desarrollan nuevos ensayos para medir las propiedades de los materiales que constituyen las mezclas y para las mezclas como material de construcción. Uno de los productos finales de SHRP es el sistema Superpave (pavimentos asfálticos con comportamiento superior). En Colombia, en 1996, se modificaron las especificaciones de construcción de carreteras, introduciendo exigencias en el control de los procesos constructivos, pero sin modificar de manera apreciable lo que al diseño de mezclas en caliente se refiere. En este artículo se muestran los resultados de una investigación donde se pretendió profundizar en uno de los tantos aspectos que intervienen en el desempeño de las mezclas asfálticas que se fabrican en Colombia, y es precisamente el de diseño de la mezcla, porque se considera que en esta etapa se pueden analizar de forma más completa los materiales constitutivos y las mezclas mismas para predecir con mayor certeza el desempeño en obra, bajo unas condiciones determinadas de tránsito, clima y apoyo estructural. Es así como se realiza la comparación de los módulos dinámicos obtenidos de probetas de mezcla asfáltica elaborados por dos metodologías distintas, la Marshall y la Superpave; la primera, tradicional en Colombia, y la segunda, una propuesta innovadora en el mundo sin tener acogida aún en nuestro país

Twitter in Mexican Politics: Messages to People or Candidates?

Twitter has reached Mexican politics in the presidential election. Despite the fact candidates have a twitter account to send messages; we propose the question how they use it to communicate with citizens? This exploratory research provides evidence that Mexican presidential candidates are only sending messages for politicians and not for citizens. We collected and analyzed 618 tweets from the three most important political parties: PRI, PAN and PRD, from November 2011 to February 2012. Using a five category framework, we found that most candidates sent thank and regret messages, but very few messages to their militancy and citizens. We found that the lack of information about this technological tool has disabled Mexican politicians to take advantage of this tool. Finally we hope this research contributes to analyze the impact of social media in Mexican Politics in a more systematic way

Hunting wino and higgsino dark matter at the muon collider with disappearing tracks

We study the capabilities of a muon collider experiment to detect disappearing tracks originating when a heavy and electrically charged long-lived particle decays via $X^+ \to Y^+ Z^0$, where $X^+$ and $Z^0$ are two almost mass degenerate new states and $Y^+$ is a charged Standard Model particle. The backgrounds induced by the in-flight decays of the muon beams (BIB) can create detector hit combinations that mimic long-lived particle signatures, making the search a daunting task. We design a simple strategy to tame the BIB, based on a detector-hit-level selection exploiting timing information and hit-to-hit correlations, followed by simple requirements on the quality of reconstructed tracks. Our strategy allows us to reduce the number of tracks from BIB to an average of 0.08 per event, hence being able to design a cut-and-count analysis that shows that it is possible to cover weak doublets and triplets with masses close to $\sqrt{s}/2$ in the 0.1-10 ns range. In particular, this implies that a 10 TeV muon collider is able to probe thermal MSSM higgsinos and thermal MSSM winos, thus rivaling the FCC-hh in that respect, and further enlarging the physics program of the muon collider into the territory of WIMP dark matter and long-lived signatures. We also provide parton-to-reconstructed level efficiency maps, allowing an estimation of the coverage of disappearing tracks at muon colliders for arbitrary models.Comment: 32 pages, 17 figures, 3 table

On the origin of the mitochondrial genetic code: Towards a unified mathematical framework for the management of genetic information

The origin of the genetic code represents one of the most challenging problems in molecular evolution. The genetic code is an important universal feature of extant organisms and indicates a common ancestry of different forms of life on earth. Known variants of the genetic code can be mainly divided in mitochondrial and nuclear classes. Here we provide a new insight on the origin of the mitochondrial genetic code: we found that its degeneracy distribution can be explained by using a mathematical approach recently developed for the description of the Euplotes nuclear variant of the genetic code. The results point to a primeval mitochondrial genetic code composed of four base codons, which we call tesserae, that, among other features, exhibit outstanding error detection capabilities. The theoretical description suggests also a formulation of a plausible biological theory about the origin of protein coding. Such theory is based on the symmetry properties of hypothetical primeval chemical adaptors between nucleic acids and amino acids (ancient tRNA's). Our paper provides a unified mathematical framework for different hypotheses on the origin of genetic coding. Also, it contributes to revisit our present view about the evolutionary steps that led to extant genetic codes by giving a new first-principles perspective on the difficult problem of the origin of the genetic code, and consequently, on the origin of life on earth