USING SOCIAL MEDIA AS A MARKETING TOOL FOR TRAVELLERS

This research assessed the influence of social media in the information search and decision-making processes of local leisure travelers working in the BPO (Business Process Outsourcing) industry in Metro Manila. It synthesized existing researches, concepts and theories to understand how social media applications influence local travelers. It also presented a snapshot of how consumers gather information and make decisions regarding their travel purchases in this rapidly increasing, commercialized field. Specifically, the paper described the socio-demographic profile of the travelers. It determined the social media sites most frequently used by travelers, the factors and elements that help in making their travel decisions, and the problems and issues they encountered. A profile comparison between social media and non-social media users was also made to determine if there was a significant difference between the two sets of respondents

Development of a Carbonated Guyabano Juice

Soda is said to have “empty calories.” Thus, a healthier carbonated beverage was produced using guyabano, which is rich in vitamins, minerals, and flavonoids. Guyabano syrup was prepared with sugar, water, guyabano juice, and calamansi juice. To optimize the final product, guyabano syrup was mixed with carbonated water in three ratios, namely, 2:17, 3:17, and 4:17. From a preference ranking test, formulations with 3:17 and 4:17 ratio were not significantly different, but the latter was chosen for the succeeding tests based on its low rank sum. A consumer acceptability test showed that panelists “moderately liked” the appearance, taste, and sweetness of the product. On the other hand, aroma, carbonation, and the overall acceptability were “liked very much.” Physicochemical properties of guyabano juice, guyabano syrup, and carbonated guyabano juice were determined. The pure guyabano juice had 4.21 pH, 0.94% malic acid, and 15 °Bx while the guyabano syrup had a pH of 3.97, 0.69% malic acid, and 46.26 °Bx. The pH, TTA (total titratable acidity), and TSS (total soluble solids) of the finished product were 3.80, 0.21%, and 10.37 °Bx, respectively. An antioxidant capacity assay showed that the carbonated guyabano juice had 0.131 mg ascorbic acid equivalent-mL-1. There was no significant change in pH and TTA after one week storage at ambient temperature. However, yeast and mold count significantly increased and TSS significantly decreased. Thus, it is recommended that the developed carbonated guyabano juice be stored at refrigerated temperature or added with a suitable preservative

Abstract TMP39: Paucity of Evidence-Based Patent Foramen Ovale Severity Ratings in Transesophageal Echocardiogram Clinical Reports

Introduction: The presence of a large physiologic shunt, defined as >20 left atrial microbubbles within 3 cardiac cycles on transesophageal echocardiography (TEE), is a key, randomized controlled trial-validated, indication for patent foramen ovale (PFO) with a closure device in patients with otherwise cryptogenic ischemic stroke. The frequency with which this information is available to treating physicians from clinical TEE reports has not been well delineated. Methods: Among consecutive ischemic stroke patients admitted to an academic medical center undergoing TEE between January-June 2023, TEE reports were reviewed to determine frequency with which formal, clinical-trial definition-adherent characterization of PFO shunt size was provided, frequency of informal PFO shunt size descriptions, and correlations with transcranial Doppler (TCD) formal shunt grades (Spencer Grades 1-5). Results: Among the 50 patients, median age was 64 (IQR 58-74.5), and 20 (40%) were female. On TEE, shunt presence was assessed by bubble study in 38 (76%), direct Doppler alone in 6 (12%), and neither in 6 (12%). Among patients with bubble study, a right-to-left shunt (RLS) potentially due to PFO was present 15 (39%). RLS severity was quantified in 27% (4/15) of PFO patients, all with formally small (<20) shunts. For the remaining 11, reports informally characterized shunt severity with various descriptive terms, including “mild” (7 cases), “mild/trace” (1), “moderate” (2), and “large” (1). TCD bubble studies were performed in 67% (10/15) of the TEE RLS PFO patients. Shunt severity correlation between TEE and TCD was 100% (3/3) for the formally quantified TEE shunts, but poor for the 7 informally assessed TEE shunts, with 60% (3/5) of shunts deemed “mild” on TEE quantified as intermediate-large on TCD, 1/1 deemed “moderate” on TEE quantified as intermediate on TCD, and 1/1 deemed “large” on TEE quantified as miniscule on TCD. Conclusions: Quantified, evidence-based ratings of PFO shunt severity were present in less than 3 of every 10 TEE reports, and unquantified, informal size estimates correlated poorly with TCD quantification of shunt severity. Patient management would be aided by inclusion of formal PFO shunt size quantification in all clinical stroke patient TEE reports

A LiDAR-based flood modelling approach for mapping rice cultivation areas in Apalit, Pampanga

Majority of rice cultivation areas in the Philippines are susceptible to excessive flooding owing to intense rainfall events. The study introduces the use of fine scale flood inundation modelling to map cultivation areas in Apalit, a rice-producing municipality located in the province of Pampanga in the Philippines. The study used a LiDAR-based digital elevation model (DEM), river discharge and rainfall data to generate flood inundation maps using LISFLOOD-FP. By applying spatial analysis, rice cultivation zone maps were derived and four cultivation zones are proposed. In areas where both depth and duration exceed threshold values set in this study, varieties tolerant to stagnant flooding and submergence are highly recommended in Zone 1, where flood conditions are least favorable for any existing traditional lowland irrigation varieties. The study emphasizes that a decline in yield is likely as increasing flood extents and longer submergence periods may cause cultivation areas for traditional irrigated lowland varieties to decrease over time. This decrease in yield may be prevented by using varieties most suitable to the flooding conditions as prescribed in the rice zone classification. The method introduced in this study could facilitate appropriate rice cultivation in flood-prone areas

Spatiotemporal pattern of global forest change over the past 60 years and the forest transition theory

Forest ecosystems play an indispensable role in addressing various pressing sustainability and social-ecological challenges such as climate change and biodiversity loss. However, global forest loss has been, and still is today, an important issue. Here, based on spatially explicit data, we show that over the past 60 years (1960–2019), the global forest area has declined by 81.7 million ha (i.e. 10% more than the size of the entire Borneo island), with forest loss (437.3 million ha) outweighing forest gain (355.6 million ha). With this forest decline and the population increase (4.68 billion) over the period, the global forest per capita has decreased by over 60%, from 1.4 ha in 1960 to 0.5 ha in 2019. The spatiotemporal pattern of forest change supports the forest transition theory, with forest losses occurring primarily in the lower income countries in the tropics and forest gains in the higher income countries in the extratropics. Furthermore, economic growth has a stronger association with net forest gain than with net forest loss. Our results highlight the need to strengthen the support given to lower income countries, especially in the tropics, to help improve their capacity to minimize or end their forest losses. To help address the displacement of forest losses to the lower income countries in the tropics, higher income nations need to reduce their dependence on imported tropical forest products

Plasma lensing of a laser wakefield accelerated electron bunch

We report on the first all-optical demonstration of plasma lensing using laser wakefield accelerated elec-trons in a two-stage setup. The LWFA electron bunch was focused by a second plasma stage without any ex-ternal fields applied..

Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response

Mycobacterium tuberculosis (Mtb) bacilli readily aggregate. We previously reported that Mtb aggregates lead to phagocyte death and subsequent efficient replication in the dead infected cells. Here, we examined the transcriptional response of human monocyte derived macrophages to phagocytosis of aggregated Mtb relative to phagocytosis of non-aggregated single or multiple bacilli. Infection with aggregated Mtb led to an early upregulation of pro-inflammatory associated genes and enhanced TNFα signaling via the NFκB pathway. These pathways were significantly more upregulated relative to infection with single or multiple non-aggregated bacilli per cell. Phagocytosis of aggregates led to a decreased phagosome acidification on a per bacillus basis and increased phagocyte cell death, which was not observed when Mtb aggregates were heat killed prior to phagocytosis. Mtb aggregates, observed in a granuloma from a patient, were found surrounding a lesion cavity. These observations suggest that TB aggregation may be a mechanism for pathogenesis. They raise the possibility that aggregated Mtb, if spread from individual to individual, could facilitate increased inflammation, Mtb growth, and macrophage cell death, potentially leading to active disease, cell necrosis, and additional cycles of transmission

Timing to achieve the highest rate of pCR after preoperative radiochemotherapy in rectal cancer: a pooled analysis of 3085 patients from 7 randomized trials

Purpose: Optimal timing of surgery after neoadjuvant chemoradiotherapy (Nad-CRT) is still controversial in locally advanced rectal cancer (LARC). The primary goal of this study was to determine the best surgical interval (SI) to achieve the highest rate of pathological complete response (pCR) and secondly to evaluate the effect on survival outcomes according to the SI.Patients and methods: Patients data were extracted from the international randomized trials: Accord12/0405, EORTC22921, FFCD9203, CAO/ARO/AIO-94, CAO-ARO-AIO-04, INTERACT and TROG01.04. Inclusion criteria were: age &gt;= 18, cT3-T4 and cN0-2, no clinical evidence of distant metastasis at diagnosis, Nad-CRT followed by surgery.Pearson's Chi-squared test with Yates' continuity correction for categorical variables, the MannWhitney test for continuous variables, Mann-Kendall test, Kaplan-Meier curves with log-rank test, univariate and multivariate logistic regression model was used for data analysis. Results: 3085 patients met the inclusion criteria. Overall, the pCR rate was 14% at a median SI of 6 weeks (range 1-31). The cumulative pCR rate increased significantly when SI lengthened, with 95% of pCR events within 10 weeks from Nad-CRT.At univariate and multivariate logistic regression analysis, lengthening of SI (p&lt; 0.01), radiotherapy dose (p&lt; 0.01), and the addition of oxaliplatin to Nad-CRT (p&lt; 0.01) had a favorable impact on pCR. Furthermore, lengthening of SI was not impact on local recurrences, distance metastases, and overall survival.Conclusion: This pooled analysis suggests that the best time to achieve pCR in LARC is at 10 weeks, considering that the lengthening of SI is not detrimental concerning survival outcomes. (C) 2020 Elsevier B.V. All rights reserved.</p

An amphitropic cAMP-binding protein in yeast mitochondria

ABSTRACT: We describe the first example of a mitochondrial protein with a covalently attached phos-phatidylinositol moiety acting as a membrane anchor. The protein can be metabolically labeled with both stearic acid and inositol. The stearic acid label is removed by phospholipase D whereupon the protein with the retained inositol label is released from the membrane. This protein is a cAMP receptor of the yeast Saccharomyces cereuisiae and tightly associated with the inner mitochondrial membrane. However, it is converted into a soluble form during incubation of isolated mitochondria with Ca2+ and phospholipid (or lipid derivatives). This transition requires the action of a proteinaceous, N-ethylmaleimide-sensitive component of the intermembrane space and is accompanied by a decrease in the lipophilicity of the cAMP receptor. We propose that the component of the intermembrane space triggers the amphitropic behavior of the mitochondrial lipid-modified CAMP-binding protein through a phospholipase activity. Only in recent years specific fatty acids have been recog-nized to play important roles in the association of proteins with membranes. Both noncovalent and covalent interactions be-tween fatty acids and proteins have been reported. Among the latter are GTP-binding proteins (Molenaar et al., 1988)