7 research outputs found
iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks
Mapping gene regulatory networks is a significant challenge in systems biology, yet only a few methods are currently capable of systems-level identification of transcription factors (TFs) that bind a specific regulatory element. We developed a microfluidic method for integrated systems-level interaction mapping of TF-DNA interactions, generating and interrogating an array of 423 full-length Drosophila TFs. With integrated systems-level interaction mapping, it is now possible to rapidly and quantitatively map gene regulatory networks of higher eukaryote
MITOMI: A Microfluidic Platform for In Vitro Characterization of Transcription FactorâDNA Interaction
iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks
Mapping gene regulatory networks is a significant challenge in systems biology, yet only a few methods are currently capable of systems-level identification of transcription factors (TFs) thatbind a specific regulatory element. We developed a microfluidic method for integrated systems-level interaction mapping of TFâDNA interactions, generating and interrogating an array of 423 full-length Drosophila TFs. With integrated systems-level interaction mapping, it is now possible to rapidly and quantitatively map gene regulatory networks of higher eukaryotes