785 research outputs found
Intestinal microbiota influences non-intestinal related autoimmune diseases
Indexación: Scopus.The human body is colonized by millions of microorganisms named microbiota that interact with our tissues in a cooperative and non-pathogenic manner. These microorganisms are present in the skin, gut, nasal, oral cavities, and genital tract. In fact, it has been described that the microbiota contributes to balancing the immune system to maintain host homeostasis. The gut is a vital organ where microbiota can influence and determine the function of cells of the immune system and contributes to preserve the wellbeing of the individual. Several articles have emphasized the connection between intestinal autoimmune diseases, such as Crohn's disease with dysbiosis or an imbalance in the microbiota composition in the gut. However, little is known about the role of the microbiota in autoimmune pathologies affecting other tissues than the intestine. This article focuses on what is known about the role that gut microbiota can play in the pathogenesis of non-intestinal autoimmune diseases, such as Grave's diseases, multiple sclerosis, type-1 diabetes, systemic lupus erythematosus, psoriasis, schizophrenia, and autism spectrum disorders. Furthermore, we discuss as to how metabolites derived from bacteria could be used as potential therapies for non-intestinal autoimmune diseases. © 2018 Opazo, Ortega-Rocha, Coronado-Arrázola, Bonifaz, Boudin, Neunlist, Bueno, Kalergis and Riedel.https://www.frontiersin.org/articles/10.3389/fmicb.2018.00432/ful
A Model of Habitability Within the Milky Way Galaxy
We present a model of the Galactic Habitable Zone (GHZ), described in terms
of the spatial and temporal dimensions of the Galaxy that may favour the
development of complex life. The Milky Way galaxy is modelled using a
computational approach by populating stars and their planetary systems on an
individual basis using Monte-Carlo methods. We begin with well-established
properties of the disk of the Milky Way, such as the stellar number density
distribution, the initial mass function, the star formation history, and the
metallicity gradient as a function of radial position and time. We vary some of
these properties, creating four models to test the sensitivity of our
assumptions. To assess habitability on the Galactic scale, we model supernova
rates, planet formation, and the time required for complex life to evolve. Our
study improves on other literature on the GHZ by populating stars on an
individual basis and by modelling SNII and SNIa sterilizations by selecting
their progenitors from within this preexisting stellar population. Furthermore,
we consider habitability on tidally locked and non-tidally locked planets
separately, and study habitability as a function of height above and below the
Galactic midplane. In the model that most accurately reproduces the properties
of the Galaxy, the results indicate that an individual SNIa is ~5.6 \times more
lethal than an individual SNII on average. In addition, we predict that ~1.2%
of all stars host a planet that may have been capable of supporting complex
life at some point in the history of the Galaxy. Of those stars with a
habitable planet, ~75% of planets are predicted to be in a tidally locked
configuration with their host star. The majority of these planets that may
support complex life are found towards the inner Galaxy, distributed within,
and significantly above and below, the Galactic midplane.Comment: Accepted for publication in Astrobiology. 40 pages, 12 figures, 3
table
Composição corporal e perfil metabólico na deficiência de vitamina D sérica em adultos
sem informaçãoTo investigate the body composition and metabolic profile in individuals in terms of different concentrations of serum vitamin D, ranging from deficiency to sufficiency. A cross-sectional study of 106 adults of both genders, who were divided into three g304419430sem informaçãosem informaçãosem informaçã
Tuberculosis determined by Mycobacterium bovis in captive waterbucks (Kobus ellipsiprymnus) in São Paulo, Brazil
Two waterbucks from São Paulo Zoo Foundation exhibited respiratory symptoms in July 2004. After euthanasia, granulommas in lungs and mediastinic lymph nodes were observed. Acid-fast bacilli isolated were identified as Mycobacterium bovis spoligotype SB0121 by PRA and spoligotyping. They were born and kept in the same enclosure with the same group, without any contact to other species housed in the zoo. This is the first detailed description of M. bovis infection in Kobus ellipsiprymnus.FAPES
Quantum Conductance in Silver Nanowires: correlation between atomic structure and transport properties
We have analyzed the atomic arrangements and quantum conductance of silver
nanowires generated by mechanical elongation. The surface properties of Ag
induce unexpected structural properties, as for example, predominance of high
aspect ratio rod-like wires. The structural behavior was used to understand the
Ag quantum conductance data and the proposed correlation was confirmed by means
of theoretical calculations. These results emphasize that the conductance of
metal point contacts is determined by the preferred atomic structures and, that
atomistic descriptions are essential to interpret the quantum transport
behavior of metal nanostructures.Comment: 4 pages, 4 figure
Star Models with Dark Energy
We have constructed star models consisting of four parts: (i) a homogeneous
inner core with anisotropic pressure (ii) an infinitesimal thin shell
separating the core and the envelope; (iii) an envelope of inhomogeneous
density and isotropic pressure; (iv) an infinitesimal thin shell matching the
envelope boundary and the exterior Schwarzschild spacetime. We have analyzed
all the energy conditions for the core, envelope and the two thin shells. We
have found that, in order to have static solutions, at least one of the regions
must be constituted by dark energy. The results show that there is no physical
reason to have a superior limit for the mass of these objects but for the ratio
of mass and radius.Comment: 20 pages, 1 figure, references and some comments added, typos
corrected, in press GR
Transport properties of copper phthalocyanine based organic electronic devices
Ambipolar charge carrier transport in Copper phthalocyanine (CuPc) is studied
experimentally in field-effect transistors and metal-insulator-semiconductor
diodes at various temperatures. The electronic structure and the transport
properties of CuPc attached to leads are calculated using density functional
theory and scattering theory at the non-equilibrium Green's function level. We
discuss, in particular, the electronic structure of CuPc molecules attached to
gold chains in different geometries to mimic the different experimental setups.
The combined experimental and theoretical analysis explains the dependence of
the mobilityand the transmission coefficient on the charge carrier type
(electrons or holes) and on the contact geometry. We demonstrate the
correspondence between our experimental results on thick films and our
theoretical studies of single molecule contacts. Preliminary results for
fluorinated CuPc are discussed.Comment: 18 pages, 16 figures; to be published in Eur. Phys. J. Special Topic
Higher dimensional dust collapse with a cosmological constant
The general solution of the Einstein equation for higher dimensional (HD)
spherically symmetric collapse of inhomogeneous dust in presence of a
cosmological term, i.e., exact interior solutions of the Einstein field
equations is presented for the HD Tolman-Bondi metrics imbedded in a de Sitter
background. The solution is then matched to exterior HD Scwarschild-de Sitter.
A brief discussion on the causal structure singularities and horizons is
provided. It turns out that the collapse proceed in the same way as in the
Minkowski background, i.e., the strong curvature naked singularities form and
that the higher dimensions seem to favor black holes rather than naked
singularities.Comment: 7 Pages, no figure
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