Ocular lesions in a domestic feline: : a closer look at the fungal pathogen Sporothrix brasiliensis

A esporotricose é uma dermatozoonose causada por fungos patogênicos dimórficos do gênero Sporothrix. Embora o Sporothrix brasiliensis seja a espécie mais patogênica e prevalente na hiperendemia brasileira de esporotricose, segundo nosso conhecimento este é o primeiro relato de um gato com lesões oculares causadas por esta espécie, via diagnóstico molecular. Um felino doméstico com três meses de idade apresentou manifestação ocular com granuloma em conjuntiva palpebral inferior esquerda, além de lesões mucocutâneas em diferentes áreas do corpo. Amostras foram coletadas para posterior citopatologia, cultura de fungos, sorologia e genotipagem molecular. O itraconazol foi prescrito para o tratamento da esporotricose e o animal foi considerado clinicamente curado ao final de cinco meses de tratamento, recebendo alta. As interações do S. brasiliensis com o gato podem se manifestar com uma infinidade de formas clínicas que se assemelham a doenças infecciosas ou não. A necessidade de avaliação física meticulosa desses animais por um médico veterinário, seguida do diagnóstico laboratorial preciso, são medidas essenciais em saúde pública na área hiperendêmica para a esporotricose no Brasil.Sporotrichosis is a dermatozoonosis, caused by dimorphic pathogenic fungi of the genus Sporothrix. Although Sporothrix brasiliensis is the most frequent and pathogenic species identified from the Brazilian sporotrichosis hyperendemic, to the best of our knowledge this is the first report of its molecular diagnosis from a cat with ocular lesions. A 3-month old female, domestic feline presented an ocular manifestation with granuloma in the lower-left palpebral conjunctiva, in addition to mucocutaneous lesions in varied locations throughout the body. Samples were collected for subsequent cytopathology, fungal culture, serology, and molecular genotyping. Itraconazole was prescribed for the treatment of sporotrichosis and the animal was considered clinically cured at the end of 5 months of treatment and discharged. S. brasiliensis cat interactions can manifest with a multitude of clinical forms that resemble either infectious or noninfectious diseases. Both the need for meticulous cat physical evaluation by a veterinarian followed by accurate laboratory diagnosis are key Public Health measures in the Brazilian sporotrichosis hyperendemic area

Transfusional iron overload in patients with sickle cell anemia: comparison between magnetic resonance imaging and serum ferritin

OBJECTIVE: To identify predictive variables of iron overload in patients with sickle cell anemia, correlating biochemical and imaging markers. MATERIALS AND METHODS: The authors developed a cross-sectional study involving 32 patients with sickle cell anemia who were evaluated for ferritin and iron serum levels and submitted to liver magnetic resonance imaging with one spin-echo and five gradient-echo sequences. The signal intensity was obtained at each sequence, corresponding to the arithmetical mean of the measurements on regions of interest in the liver and paraspinal muscles to obtain the liver/muscle signal intensity ratio (SIR). Based on such SIR, the liver iron concentration (LIC) was estimated by means of the following formula: e[5.808 - (0.877 × T2*) - (1.518 × IW)], where T2* is the SIR on the sequence with echo time = 13 ms and IW is the SIR on the intermediate-weighted sequence. Patients were grouped according to their blood transfusion regimen (regular monthly versus sporadic transfusions). RESULTS: The comparison between the transfusion groups was based on clinical-laboratory variables, with significant differences in SIR, LIC and serum ferritin levels: the group with regular transfusions demonstrated greater hepatic iron overload. CONCLUSION: Magnetic resonance imaging is an efficient tool for evaluating liver iron overload in patients with sickle cell anemia

Epidemiologic analysis of salivary gland tumors over a 10-years period diagnosed in a northeast Brazilian population

Salivary gland tumors (SGT) correspond to a heterogeneous group of lesions with variable biological behavior. The present study aimed to determine the distribution and demographic findings of salivary gland neoplasms in a northeast Brazilian population. A retrospective descriptive cross-sectional study was performed. A total of 588 cases of SGT were diagnosed between 2006 and 2016 of 4 pathology services in the state of Sergipe, Brazil. All cases were reviewed, and data such as sex, age, anatomical location, and histopathological diagnosis were collected. A total of 470 (79.9%) tumors were benign and 118 (20.1%) were malignant. The majority of the patients were females (n=328, 55.8%) with an overall female:male ratio of 1.2:1. The major salivary glands were affected more than the minor glands (69.5% vs. 30.5%). Pleomorphic adenoma (n=419, 71.3%) and mucoepidermoid carcinoma (n=29, 4.9%) were the most frequent benign and malignant tumors, respectively. In addition, both benign and malignant tumors occurred more frequently in the parotid gland (n=300, 51%, p<0.05). The epidemiologic profile and clinical characteristics of SGT were similar to those described in other countries and other regions of Brazil. Epidemiological studies of SGT help to understand their clinical and pathological features and are essential to establish the proper management and prognosis

EFEITO DE VERMIFUGAÇÃO ESTRATÉGICA, COM PRINCÍPIO ATIVO À BASE DE IVERMECTINA NA INCIDÊNCIA DE PARASITOS GASTRINTESTINAIS NO REBANHO CAPRINO DA UFPI

Objetivou-se avaliar a eficácia de vermifugação realizada durante um ano no rebanho caprino da raça anglonubiana da Universidade Federal do Piauí, sendo a estratégia adotada caracterizada por vermifugações no período seco e no período chuvoso, com princípio ativo à base de ivermectina em aplicação oral. Avaliou-se a prevalência estacional de nematódeos gastrintestinais em cabritos, machos e fêmeas de seis a dez meses, cabra e reprodutor. Estimou-se o número médio de ovos e larvas de acordo com a época do ano, considerando-se os exames mensais como repetições dentro da época. Os resultados foram interpretados com base em estatísticas descritiva,médias e desvios padrões. Constatou-se baixa prevalência de ovos de nematódeos, oocistos de protozoários e larvas infectantes. Entretanto a variabilidade dentro da estação foi alta e, portanto, não se pode estabelecer com segurança associação entre a freqüência dos parasitas com a categoria animal, nem mesmo com a época do ano, mas há indícios de que a estratégia de vermifugação adotada interferiu no ciclo parasitário, alterando a maior incidência de parasitos gastrintestinais durante o período chuvoso. PALAVRAS-CHAVE: Caprino, helmintos gastrintestinais, protozoários

Prevalence Of Maxillary Sinus Jaw Mucuous Cysts In University Dental Radiology Service

Background: Mucosal cyst of the maxillary sinus or antral pseudocyst is one of great importance injury, being the pathology that affects more the maxillary sinus. Their discovery, in most cases, it is for the interpretation of the images in routine panoramic radiography. Aims: The research aimed to evaluate the prevalence of mucous cyst in maxillary sinus in radiology clinic at Ceara Federal University. Material and Methods: To this study conduction, were analyzed 1996 panoramic radiographs from a digital file obtained between April 2011 to April 2013 Results:. Aspects as gender, affected side and teeth absence next to the cyst in the respective quadrant were evaluated.It was observed in the sample the occurrence of 45 patients with suggested images of mucous cysts in maxillary sinus,making a prevalence of 2,25%. From them, 26 (57,8%)were female and 19 (42,2%) were male. 48 maxillary sinuswere affected with the wound, from which28 (58,3%) it was in the left side and 20 (41,7%) in the right site. Three patients presented the wound in both sides, what represents 6,7% of the affected patients. From those 48 Mucous retention cyst, 40 (83,3%) were not related to an edentulous area in ipsilateral quadrant and 8 (16,7%) were shown next to an edentulous area. Conclusion: The conclusion was that the cyst of retention mucous in the maxillary sinus had prevalence in males and in the left side of the maxillary sinus. It was not found a relation between the cyst and the edentulous area