262 research outputs found
The DICE calibration project: design, characterization, and first results
We describe the design, operation, and first results of a photometric
calibration project, called DICE (Direct Illumination Calibration Experiment),
aiming at achieving precise instrumental calibration of optical telescopes. The
heart of DICE is an illumination device composed of 24 narrow-spectrum,
high-intensity, light-emitting diodes (LED) chosen to cover the
ultraviolet-to-near-infrared spectral range. It implements a point-like source
placed at a finite distance from the telescope entrance pupil, yielding a flat
field illumination that covers the entire field of view of the imager. The
purpose of this system is to perform a lightweight routine monitoring of the
imager passbands with a precision better than 5 per-mil on the relative
passband normalisations and about 3{\AA} on the filter cutoff positions. The
light source is calibrated on a spectrophotometric bench. As our fundamental
metrology standard, we use a photodiode calibrated at NIST. The radiant
intensity of each beam is mapped, and spectra are measured for each LED. All
measurements are conducted at temperatures ranging from 0{\deg}C to 25{\deg}C
in order to study the temperature dependence of the system. The photometric and
spectroscopic measurements are combined into a model that predicts the spectral
intensity of the source as a function of temperature. We find that the
calibration beams are stable at the level -- after taking the slight
temperature dependence of the LED emission properties into account. We show
that the spectral intensity of the source can be characterised with a precision
of 3{\AA} in wavelength. In flux, we reach an accuracy of about 0.2-0.5%
depending on how we understand the off-diagonal terms of the error budget
affecting the calibration of the NIST photodiode. With a routine 60-mn
calibration program, the apparatus is able to constrain the passbands at the
targeted precision levels.Comment: 25 pages, 27 figures, accepted for publication in A&
Minimal residual disease after transplantation or lenalidomide-based consolidation in myeloma patients: a prospective analysis
We analyzed 50 patients who achieved at least a very good partial response in the RV-MM-EMN-441 study. Patients received consolidation with autologous stem-cell transplantation (ASCT) or cyclophosphamide-lenalidomide-dexamethasone (CRD), followed by Lenalidomide-based maintenance. We assessed minimal residual disease (MRD) by multi-parameter flow cytometry (MFC) and allelic-specific oligonucleotide real-time quantitative polymerase chain reaction (ASO-RQ-PCR) after consolidation, after 3 and 6 courses of maintenance, and thereafter every 6 months until progression. By MFC analysis, 19/50 patients achieved complete response (CR) after consolidation, and 7 additional patients during maintenance. A molecular marker was identified in 25/50 patients, 4/25 achieved molecular-CR after consolidation, and 3 additional patients during maintenance. A lower MRD value by MFC was found in ASCT patients compared with CRD patients (p = 0.0134). Tumor burden reduction was different in patients with high-risk vs standard-risk cytogenetics (3.4 vs 5.2, ln-MFC; 3 vs 6 ln-PCR, respectively) and in patients who relapsed vs those who did not (4 vs 5, ln-MFC; 4.4 vs 7.8 ln-PCR). MRD progression anticipated clinical relapse by a median of 9 months while biochemical relapse by a median of 4 months. MRD allows the identification of a low-risk group, independently of response, and a better characterization of the activity of treatments
The Butterfly Fauna Of The Italian Maritime Alps:Results Of The «Edit» Project
Bonelli, Simona, Barbero, Francesca, Casacci, Luca Pietro, Cerrato, Cristiana, Balletto, Emilio (2015): The butterfly fauna of the Italian Maritime Alps: results of the EDIT project. Zoosystema 37 (1): 139-167, DOI: 10.5252/z2015n1a6, URL: http://dx.doi.org/10.5252/z2015n1a
Euclid preparation. III. Galaxy cluster detection in the wide photometric survey, performance and algorithm selection
Galaxy cluster counts in bins of mass and redshift have been shown to be a competitive probe to test cosmological models. This method requires an efficient blind detection of clusters from surveys with a well-known selection function and robust mass estimates, which is particularly challenging at high redshift. The Euclid wide survey will cover 15 000 deg2 of the sky, avoiding contamination by light from our Galaxy and our solar system in the optical and near-infrared bands, down to magnitude 24 in the H-band. The resulting data will make it possible to detect a large number of galaxy clusters spanning a wide-range of masses up to redshift ∼2 and possibly higher. This paper presents the final results of the Euclid Cluster Finder Challenge (CFC), fourth in a series of similar challenges. The objective of these challenges was to select the cluster detection algorithms that best meet the requirements of the Euclid mission. The final CFC included six independent detection algorithms, based on different techniques, such as photometric redshift tomography, optimal filtering, hierarchical approach, wavelet and friend-of-friends algorithms. These algorithms were blindly applied to a mock galaxy catalog with representative Euclid-like properties. The relative performance of the algorithms was assessed by matching the resulting detections to known clusters in the simulations down to masses of M₂₀₀ ∼ 10^(13.25) M⊙. Several matching procedures were tested, thus making it possible to estimate the associated systematic effects on completeness to 80% completeness for a mean purity of 80% down to masses of 10¹⁴ M⊙ and up to redshift z = 2. Based on these results, two algorithms were selected to be implemented in the Euclid pipeline, the Adaptive Matched Identifier of Clustered Objects (AMICO) code, based on matched filtering, and the PZWav code, based on an adaptive wavelet approach
Telomere length correlates with histopathogenesis according to the germinal center in mature B-cell lymphoproliferative disorders
In this study we investigated telomere restriction fragment (TRF) length in a panel of mature B-cell lymphoproliferative disorders (MBCLDs) and correlated this parameter with histology and histopathogenesis in relation to the germinal center (GC). We assessed 123 MBCLD samples containing 80% or more tumor cells. TRF length was evaluated by Southern blot analysis using a chemiluminescence-based assay. GC status was assessed through screening for stable and ongoing somatic mutations within the immunoglobulin heavy-chain genes. Median TRF length was 6170 bp (range, 1896-11 200 bp) and did not correlate with patient age or sex. TRF length was greater in diffuse large cell lymphoma, Burkitt lymphoma, and follicular lymphoma (medians: 7789 bp, 9471 bp, and 7383 bp, respectively) than in mantle cell lymphoma and chronic lymphocytic leukemia (medians: 3582 bp and 4346 bp, respectively). GC-derived MBCLDs had the longest telomeres, whereas those arising from GC-inexperienced cells had the shortest (P < 10(-9)). We conclude that (1) TRF length in MBCLD is highly heterogeneous; (2) GC-derived tumors have long telomeres, suggesting that minimal telomere erosion occurs during GC-derived lymphomagenesis; and (3) the short TRF lengths of GC-inexperienced MBCLDs indicates that these neoplasms are good candidates for treatment with telomerase inhibitors, a class of molecules currently the subject of extensive preclinical evaluation
ExoClock Project III: 450 new exoplanet ephemerides from ground and space observations
The ExoClock project has been created with the aim of increasing the
efficiency of the Ariel mission. It will achieve this by continuously
monitoring and updating the ephemerides of Ariel candidates over an extended
period, in order to produce a consistent catalogue of reliable and precise
ephemerides. This work presents a homogenous catalogue of updated ephemerides
for 450 planets, generated by the integration of 18000 data points from
multiple sources. These sources include observations from ground-based
telescopes (ExoClock network and ETD), mid-time values from the literature and
light-curves from space telescopes (Kepler/K2 and TESS). With all the above, we
manage to collect observations for half of the post-discovery years (median),
with data that have a median uncertainty less than one minute. In comparison
with literature, the ephemerides generated by the project are more precise and
less biased. More than 40\% of the initial literature ephemerides had to be
updated to reach the goals of the project, as they were either of low precision
or drifting. Moreover, the integrated approach of the project enables both the
monitoring of the majority of the Ariel candidates (95\%), and also the
identification of missing data. The dedicated ExoClock network effectively
supports this task by contributing additional observations when a gap in the
data is identified. These results highlight the need for continuous monitoring
to increase the observing coverage of the candidate planets. Finally, the
extended observing coverage of planets allows us to detect trends (TTVs -
Transit Timing Variations) for a sample of 19 planets. All products, data, and
codes used in this work are open and accessible to the wider scientific
community.Comment: Recommended for publication to ApJS (reviewer's comments
implemented). Main body: 13 pages, total: 77 pages, 7 figures, 7 tables. Data
available at http://doi.org/10.17605/OSF.IO/P298
Rate and duration of hospitalisation for acute pulmonary embolism in the real-world clinical practice of different countries : Analysis from the RIETE registry
publishersversionPeer reviewe
Euclid Preparation. XXXVII. Galaxy colour selections with Euclid and ground photometry for cluster weak-lensing analyses
We derived galaxy colour selections from Euclid and ground-based photometry,
aiming to accurately define background galaxy samples in cluster weak-lensing
analyses. Given any set of photometric bands, we developed a method for the
calibration of optimal galaxy colour selections that maximises the selection
completeness, given a threshold on purity. We calibrated galaxy selections
using simulated ground-based and Euclid
photometry. Both selections produce a purity higher than 97%. The
selection completeness ranges from 30% to 84% in the lens redshift range
. With the full
selection, the completeness improves by up to percentage points, and the
range extends up to . The calibrated colour
selections are stable to changes in the sample limiting magnitudes and
redshift, and the selection based on bands provides excellent results on
real external datasets. The selection is also purer at high redshift and
more complete at low redshift compared to colour selections found in the
literature. We find excellent agreement in terms of purity and completeness
between the analysis of an independent, simulated Euclid galaxy catalogue and
our calibration sample, except for galaxies at high redshifts, for which we
obtain up to 50 percent points higher completeness. The combination of colour
and photo- selections applied to simulated Euclid data yields up to 95%
completeness, while the purity decreases down to 92% at high . We
show that the calibrated colour selections provide robust results even when
observations from a single band are missing from the ground-based data.
Finally, we show that colour selections do not disrupt the shear calibration
for stage III surveys.Comment: 20 pages, 13 figures. Published by A&
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