Proyecto técnico de reforma integral y refuerzo de estructura de vivienda unifamiliar adosada, Jávea (Alicante)

[ES] El propósito de este trabajo final de grado es el aprovechamiento del potencial socioeconómico que presenta la parcela a atender. Se trata de una reforma completa de vivienda unifamiliar distribuida en planta baja y planta primera, en la que se pretende la eliminación de barreras arquitectónicas mediante un refuerzo estructural, el cual aporta garantía de durabilidad a la vez que versatilidad en la distribución de espacios. Asimismo, se ha querido centrar los esfuerzos en la utilización de materiales sostenibles, naturales y autóctonos de la Comunidad Valenciana, en todas sus aplicaciones: aislamiento, revestimiento, refuerzo estructural. Hablamos de un edificio en segunda línea de mar, a escasos cincuenta metros, respondiendo a la construcción de una casa de pescadores de la época; catalogado como zona de casco antiguo con grandes limitaciones arquitectónicas respecto a su estética exterior, alineación de fachada y tipología de cubiertas. Es así como se pretende integrar la estética tradicional, con métodos constructivos actuales y una materialidad vanguardista.[EN] The purpose of this final degree project is to take advantage of the socio-economic potential of the plot to be addressed. It is a complete reform of a single-family house distributed in first floor and second floor, which aims to eliminate architectural barriers through a structural reinforcement, which provides durability guarantee while versatility in the distribution of spaces. Likewise, efforts have been focused on the use of sustainable, natural and native materials from the Valencian Community, in all its applications: insulation, cladding, structural reinforcement. We are talking about a building on the second line of the sea, just fifty meters away, responding to the construction of a fishermen's house of the time; cataloged as an old town area with great architectural limitations regarding its exterior aesthetics, facade alignment and typology of roofs. This is how we intend to integrate traditional aesthetics with current construction methods and avant-garde materiality.Rocamora Rodrigo, EL. (2021). Proyecto técnico de reforma integral y refuerzo de estructura de vivienda unifamiliar adosada, Jávea (Alicante). Universitat Politècnica de València. http://hdl.handle.net/10251/175135TFG

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old