An anatomy of the cooling of the North Atlantic Ocean in the 1960s and 1970s

In the 1960s and early 1970s sea surface temperatures in the North Atlantic Ocean cooled rapidly. There is still considerable uncertainty about the causes of this event, although various mechanisms have been proposed. In this observational study it is demonstrated that the cooling proceeded in several distinct stages. Cool anomalies initially appeared in the mid-1960s in the Nordic Seas and Gulf Stream Extension, before spreading to cover most of the Subpolar Gyre. Subsequently, cool anomalies spread into the tropical North Atlantic before retreating, in the late 1970s, back to the Subpolar Gyre. There is strong evidence that changes in atmospheric circulation, linked to a southward shift of the Atlantic ITCZ, played an important role in the event, particularly in the period 1972-76. Theories for the cooling event must account for its distinctive space-time evolution. Our analysis suggests that the most likely drivers were: 1) The “Great Salinity Anomaly” of the late 1960s; 2) An earlier warming of the subpolar North Atlantic, which may have led to a slow-down in the Atlantic Meridional Overturning Circulation; 3) An increase in anthropogenic sulphur dioxide emissions. Determining the relative importance of these factors is a key area for future work

Controle da podridão cinzenta da maçã por produtos naturais biologicamente ativos

Indexación: Web of Science; ScieloBiorend SC (chitosan), BC-1000 EC (grapefruit extract plus bioflavonoids) and ECO-100 SC (bioflavonoids plus organic acids, citric phytoalexins, fatty acids, glycerides and sugars), respectively, suppressed grey rot of apple caused by B. cinerea by 80.1%, 79.0% and 76.5% when used as post-harvest treatments under controlled conditions. When applied as combined pre- and post-harvest treatments Biorend SC inhibited fruit rot by 49.9 %, while BC-1000 EC and ECO-100 SC were ineffective. None of the products inhibited fruit rot when applied as pre-harvest treatments under controlled conditions or as post-harvest treatments under commercial conditions. The algal polysaccharide ulvan used in post-harvest treatments suppressed grey rot by 56.0% under controlled conditions, but had no inhibitory effect on combined pre- and post-harvest treatments. The inability of products to activate defense mechanisms (chitinase and peroxidase) of fruits was consistent with the unsuccessful control of rot by pre-harvest treatment. The results suggest that the natural products used have potential for use in integrated management of Botrytis rot when applied after harvest.Biorend SC (quitosana), BC-1000 EC (extrato de toranja mais flavonóides), e ECO-100 SC (bioflavonóides mais ácidos orgânicos, fitoalexinas cítricas, ácidos graxos glicerídeos e açúcares) inibiram em 80,1%, 79,0% e 76,5%, respectivamente, a podridão causada por Botrytis cinerea quando utilizados no tratamento pós-colheita de frutos de maçã sob condições controladas.Tratamento combinado de Biorend SC, com aplicação tanto em pré como no pós-colheita, proporcionou 49,9% de inibição da podridão, enquanto BC-1000 e ECO-100 EC não foram efetivos. Nenhum desses produtos inibiu a podridão cinzenta, quando utilizados em tratamento de pré-colheita em condições controladas ou em tratamento de pós-colheita em condições comerciais. O polissacarídeo algal ulvana, utilizado nos tratamentos de pós-colheita, reduziu em 56% a podridão cinzenta das maçãs em condições controladas, mas não teve efeito inibitório nos tratamentos combinados de pré e pós-colheita. A incapacidade dos produtos em ativar mecanismos de defesa (quitinases e peroxidases) nos frutos, após o tratamento em pré-colheita, foi consistente com a falta de controle da podridão nesse tipo de ensaio. Pelos resultados, sugere-se que os produtos naturais utilizados apresentam potencial para a utilização no manejo integrado da podridão de Botrytis quando aplicados em pós-colheita.http://ref.scielo.org/kcxb9

Quantum Monte Carlo calculations of six-quark states

The variational Monte Carlo method is used to find the ground state of six quarks confined to a cavity of diameter R_c, interacting via an assumed non-relativistic constituent quark model (CQM) Hamiltonian. We use a flux-tube model augmented with one-gluon and one-pion exchange interactions, which has been successful in describing single hadron spectra. The variational wave function is written as a product of three-quark nucleon states with correlations between quarks in different nucleons. We study the role of quark exchange effects by allowing flux-tube configuration mixing. An accurate six-body variational wave function is obtained. It has only ~13% rms fluctuation in the total energy and yields a standard deviation of ~<.1%; small enough to be useful in discerning nuclear interaction effects from the large rest mass of the two nucleons. Results are presented for three values of the cavity diameter, R_c=2, 4, and 6 fm. They indicate that the flux-tube model Hamiltonian with gluon and pion exchange requires revisions in order to obtain agreement with the energies estimated from realistic two-nucleon interactions. We calculate the two-quark probability distribution functions and show how they may be used to study and adjust the model Hamiltonian.Comment: 49 pages, 13 figures, submitted to Phys. Rev.

Developing a quality assurance metric: a panoptic view

This article is a post-print of the published article that may be accessed at the link below. Copyright @ 2006 Sage Publications.There are a variety of techniques that lecturers can use to get feedback on their teaching - for example, module feedback and coursework results. However, a question arises about how reliable and valid are the content that goes into these quality assurance metrics. The aim of this article is to present a new approach for collecting and analysing qualitative feedback from students that could be used as the first stage in developing more reliable quality assurance metrics. The approach, known as the multi-dimensional crystal view, is based on the belief that individuals have different views on the benefits that the embedded process in a system can have on the behaviour of the system. The results of this study indicate that in the context of evaluation and feedback methods, the multi-dimensional approach appears to provide the opportunity for developing more effective student feedback mechanisms

Complex Scaled Spectrum Completeness for Coupled Channels

The Complex Scaling Method (CSM) provides scattering wave functions which regularize resonances and suggest a resolution of the identity in terms of such resonances, completed by the bound states and a smoothed continuum. But, in the case of inelastic scattering with many channels, the existence of such a resolution under complex scaling is still debated. Taking advantage of results obtained earlier for the two channel case, this paper proposes a representation in which the convergence of a resolution of the identity can be more easily tested. The representation is valid for any finite number of coupled channels for inelastic scattering without rearrangement.Comment: Latex file, 13 pages, 4 eps-figure

Involvement of Sigma-1 Receptors in the Antidepressant-like Effects of Dextromethorphan

Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to display rapid-acting antidepressant activity based on pharmacodynamic similarities to the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine. In addition to binding to NMDA receptors, dextromethorphan binds to sigma-1 (σ1) receptors, which are believed to be protein targets for a potential new class of antidepressant medications. The purpose of this study was to determine whether dextromethorphan elicits antidepressant-like effects and the involvement of σ1 receptors in mediating its antidepressant-like actions. The antidepressant-like effects of dextromethorphan were assessed in male, Swiss Webster mice using the forced swim test. Next, σ1 receptor antagonists (BD1063 and BD1047) were evaluated in conjunction with dextromethorphan to determine the involvement of σ receptors in its antidepressant-like effects. Quinidine, a cytochrome P450 (CYP) 2D6 inhibitor, was also evaluated in conjunction with dextromethorphan to increase the bioavailability of dextromethorphan and reduce exposure to additional metabolites. Finally, saturation binding assays were performed to assess the manner in which dextromethorphan interacts at the σ1 receptor. Our results revealed dextromethorphan displays antidepressant-like effects in the forced swim test that can be attenuated by pretreatment with σ1 receptor antagonists, with BD1063 causing a shift to the right in the dextromethorphan dose response curve. Concomitant administration of quinidine potentiated the antidepressant-like effects of dextromethorphan. Saturation binding assays revealed that a Ki concentration of dextromethorphan reduces both the Kd and the Bmax of [3H](+)-pentazocine binding to σ1 receptors. Taken together, these data suggest that dextromethorphan exerts some of its antidepressant actions through σ1 receptors

The association between benzodiazepine use and sleep quality in residential aged care facilities: a cross-sectional study

BACKGROUND: Benzodiazepines are commonly prescribed in residential aged care facilities (RACFs) for their sedative and anxiolytic effects. The objective of this study was to investigate the association between benzodiazepine use and sleep quality in residents of RACFs. METHODS: A cross-sectional study involving 383 participants was conducted in six Australian RACFs. Night-time sleep quality, day-time drowsiness and day-time napping behavior were assessed using a validated questionnaire. Logistic regression was used to compute adjusted odds ratios (AORs) and 95% confidence intervals (CIs) for the association between benzodiazepine use and sleep quality. Covariates included pain, dementia severity, depression, insomnia and other sedative use. RESULTS: Of the 383 residents (mean age 87.5 years, 77.5% female), 96(25.1%) used a benzodiazepine on a regular basis. Residents who used long-acting benzodiazepines on a regular basis had higher night-time sleep quality than non-users (AOR = 4.00, 95%CI 1.06 - 15.15). Residents who used short-acting benzodiazepines on a PRN only basis had longer daytime napping times than non-users (AOR = 1.77, 95%CI 1.01 - 3.08). No benzodiazepine category was associated with day-time drowsiness. CONCLUSIONS: The association between benzodiazepine use and sleep quality is dependent on the half-life and prescribing pattern of the benzodiazepine. Short-acting PRN benzodiazepines were associated with lower night time sleep quality and longer day-time napping compared to long-acting regular benzodiazepines. Longitudinal studies are needed to determine whether these findings reflect channeling of short-acting agents to residents at higher risk of sleep disorders.Lynna Chen, J. Simon Bell, Renuka Visvanathan, Sarah N. Hilmer, Tina Emery, Leonie Robson, Jessica M. Hughes and Edwin C. K. Ta

Visualização de Dados do Exame Nacional Brasileiro do Ensino Médio: VisDadosEnem

Artigo apresentado no I Workshop de Informação, Dados e Tecnologia, realizado entre nos dias 04 e 06 de setembro de 2017, na cidade de Florianópolis (SC), no Auditório do Espaço Físico Integrado (EFI) da Universidade Federal de Santa Catarina (UFSC).Hoje em dia, baseado na quantidade de dados disponíveis surgem situações em que a visualização da informação torna-se fundamental para o entendimento e interpretação dos dados. Dentro deste contexto, este estudo tem como objetivo relacionar e explorar, através de técnicas de visualização, dados abertos educacionais em um contexto multidisciplinar. Para tal, foi desenvolvido uma aplicação Web para visualização de dados do exame nacional Brasileiro do ensino médio (ENEM). Neste estudo utilizou-se os microdados do ENEM, a partir do portal Brasileiro de dados abertos. Como resultado das análises comparativas realizadas sobre os dados, por estados, regiões e tipos de escolas, observou-se quais estados obtiveram as maiores e menores médias do ENEM em relação as médias nacionais. Por exemplo, no estado de Santa Catarina os alunos oriundos de escolas particulares obtiveram 12.70% acima da média nacional para este tipo de escola e a menor média de idade dos alunos inscritos correspondendo a 21,6 anos de idade. A aplicação Web de visualização possibilitou uma análise comparativa sobre o grande conjunto de dados e a exploração de possibilidades de visualização que seriam dificilmente possíveis de realizar por meio de representações tradicionais.Nowadays, based on the amount of available data, there are situations in which the information visualization becomes fundamental for the understanding and interpretation of the data. In this context, the study aims to relate and explore, through visualization techniques, open educational data in a multidisciplinary context. For that, a Web application was developed for data visualization of the Brazilian national high school exam (ENEM). In this study, the ENEM microdata was used, from the Brazilian open data portal. As a result of the comparative analyzes performed on the data, by states, regions and types of schools, it was observed which states obtained the highest and lowest averages of ENEM in relation to national averages. For example, in the state of Santa Catarina, students from private schools obtained 12.70% above the national average for that type of school and the lowest average age of enrolled students corresponding to 21.6 years old. The visualization Web application made possible a comparative analysis on the large dataset and the exploration of visualization possibilities that would be difficult to perform through traditional representations