716 research outputs found

    Of Monsters and Mothers: Affective Climates and Human-Nonhuman Sociality in Kathy Jetñil-Kijiner’s “Dear Matafele Peinam”

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    This article examines the production of doubt and apathy within climate change debates and argues that the material outcomes of this affective regime perpetuate colonialism in Oceania. By furthering land dispossession, resource depletion, cultural loss, and impoverishment, the affective and material impacts of climate change have been and continue to be a site of activism for Native Pacific peoples. While climate change functions in many ways as an affective regime of colonialism, this affective regime is dismantled through Indigenous Oceania’s affects, epistemes, and ontologies, as exemplified by Marshallese poet and activist Kathy Jetñil-Kijiner’s poem “Dear Matafele Peinam” and its performance at the 2014 UN Summit on Climate Change. Through her use of experiential and embodied knowledges, which inform the affects that circulate in the performance, Jetñil-Kijiner intervenes into the colonial affective regime of climate change. Furthermore, her evocation of Indigenous epistemes and ontologies regarding nonhuman entities points to forms of sociality that I argue can provide alternative frameworks of thinking through not only climate change and its effects but also what an inter-Indigenous Oceanian sociality and politics might look like within contested colonial territories

    Prospects for Stochastic Background Searches Using Virgo and LSC Interferometers

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    We consider the question of cross-correlation measurements using Virgo and the LSC Interferometers (LIGO Livingston, LIGO Hanford, and GEO600) to search for a stochastic gravitational-wave background. We find that inclusion of Virgo into the network will substantially improve the sensitivity to correlations above 200 Hz if all detectors are operating at their design sensitivity. This is illustrated using a simulated isotropic stochastic background signal, generated with an astrophysically-motivated spectrum, injected into 24 hours of simulated noise for the LIGO and Virgo interferometers.Comment: 11 pages, uses IOP style files, submitted to CQG for GWDAW11 proceedings; revised in response to referee comment

    Thalamic medial dorsal nucleus atrophy in medial temporal lobe epilepsy: A VBM meta-analysis

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    Purpose: Medial temporal lobe epilepsy (MTLE) is associated with MTLE network pathology within and beyond the hippocampus. The purpose of this meta-analysis was to identify consistent MTLE structural change to guide subsequent targeted analyses of these areas. Methods: We performed an anatomic likelihood estimation (ALE) meta-analysis of 22 whole-brain voxel-based morphometry experiments from 11 published studies. We grouped these experiments in three ways. We then constructed a meta-analytic connectivity model (MACM) for regions of consistent MTLE structural change as reported by the ALE analysis. Key findings: ALE reported spatially consistent structural change across VBM studies only in the epileptogenic hippocampus and the bilateral thalamus; within the thalamus, the medial dorsal nucleus of the thalamus (MDN thalamus) represented the greatest convergence (Pb0.05 corrected for multiple comparisons). The subsequent MACM for the hippocampus and ipsilateral MDN thalamus demonstrated that the hippocampus and ipsilateral MDN thalamus functionally co-activate and are nodes within the same network, suggesting that MDN thalamic damage could result from MTLE network excitotoxicity. Significance: Notwithstanding our large sample of studies, these findings aremore restrictive thanprevious reports and demonstrate the utility of our inclusion filters and of recently modified meta-analyticmethods in approximating clinical relevance. Thalamic pathology is commonly observed in animal and human studies, suggesting it could be a clinically useful indicator. Thalamus-specific research as a clinical marker awaits further investigation

    Enhanced Whipple Shield

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    A hypervelocity impact (HVI) Whipple Shield and a method for shielding a wall from penetration by high velocity particle impacts where the Whipple Shield is comprised of spaced apart inner and outer metal sheets or walls with an intermediate cloth barrier arrangement comprised of ceramic cloth and high strength cloth which are interrelated by ballistic formulae

    Measurement of low‐density lipoprotein cholesterol levels in primary and secondary prevention patients: Insights from the PALM registry

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    Background The 2013 American College of Cardiology/American Heart Association Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults recommended testing low-density lipoprotein cholesterol ( LDL -C) to identify untreated patients with LDL -C ≥190 mg/dL, assess lipid-lowering therapy adherence, and consider nonstatin therapy. We sought to determine whether clinician lipid testing practices were consistent with these guidelines. Methods and Results The PALM (Patient and Provider Assessment of Lipid Management) registry enrolled primary and secondary prevention patients from 140 US cardiology, endocrinology, and primary care offices in 2015 and captured demographic data, lipid treatment history, and the highest LDL -C level in the past 2 years. Core laboratory lipid levels were drawn at enrollment. Among 7627 patients, 2787 (36.5%) had no LDL -C levels measured in the 2 years before enrollment. Patients without chart-documented LDL -C levels were more often women, nonwhite, uninsured, and non-college graduates (all P\u3c0.01). Patients without prior lipid testing were less likely to receive statin treatment (72.6% versus 76.0%; P=0.0034), a high-intensity statin (21.5% versus 24.3%; P=0.016), nonstatin lipid-lowering therapy (24.8% versus 27.3%; P=0.037), and had higher core laboratory LDL -C levels at enrollment (median 97 versus 92 mg/dL; P\u3c0.0001) than patients with prior LDL -C testing. Of 166 individuals with core laboratory LDL -C levels ≥190 mg/dL, 36.1% had no LDL -C measurement in the prior 2 years, and 57.2% were not on a statin at the time of enrollment. Conclusions In routine clinical practice, LDL -C testing is associated with higher-intensity lipid-lowering treatment and lower achieved LDL -C level

    ALE Meta-Analysis Workflows Via the Brainmap Database: Progress Towards A Probabilistic Functional Brain Atlas

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    With the ever-increasing number of studies in human functional brain mapping, an abundance of data has been generated that is ready to be synthesized and modeled on a large scale. The BrainMap database archives peak coordinates from published neuroimaging studies, along with the corresponding metadata that summarize the experimental design. BrainMap was designed to facilitate quantitative meta-analysis of neuroimaging results reported in the literature and supports the use of the activation likelihood estimation (ALE) method. In this paper, we present a discussion of the potential analyses that are possible using the BrainMap database and coordinate-based ALE meta-analyses, along with some examples of how these tools can be applied to create a probabilistic atlas and ontological system of describing function–structure correspondences

    Potential use of antibodies to provide an earlier indication of lymphatic filariasis resurgence in post–mass drug ad ministration surveillance in American Samoa

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    Background: Under the Global Programme to Eliminate Lymphatic Filariasis (LF), American Samoa conducted 7 rounds of mass drug administration (MDA) between 2000 and 2006. The territory passed transmission assessment surveys (TASs) in 2011 (TAS-1) and 2015 (TAS-2). In 2016, the territory failed TAS-3, indicating resurgence. This study aims to determine if antibodies (Abs) may have provided a timelier indication of LF resurgence in American Samoa. Methods: We examined school-level antigen (Ag) and Ab status (presence/absence of Ag- and Ab-positive children) and prevalence of single and combined Ab responses to Wb123, Bm14, and Bm33 Ags at each TAS. Pearson chi-square test and logistic regression were used to examine associations between school-level Ab prevalence in TAS-1 and TAS-2 and school-level Ag status in TAS-3. Results: Schools with higher prevalence of Wb123 Ab in TAS-2 had higher odds of being Ag-positive in TAS-3 (odds ratio [OR] 24.5, 95% confidence interval [CI] 1.2–512.7). Schools that were Ab-positive for WB123 plus Bm14, Bm33, or both Bm14 and Bm33 in TAS-2 had higher odds of being Ag-positive in TAS-3 (OR 16.0–24.5). Conclusion: Abs could provide earlier signals of resurgence and enable a timelier response. The promising role of Abs in surveillance after MDA and decision making should be further investigated in other settings

    Disease Activity, Proteinuria, and Vitamin D Status in Children with Systemic Lupus Erythematosus and Juvenile Dermatomyositis

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    Objective—To evaluate relationships between vitamin D, proteinuria, and disease activity in pediatric systemic lupus erythematosus (SLE) and juvenile dermatomyositis (JDM). Study design—Multiple linear regression was used to associate subject-reported race, sunscreen use, and vitamin D intake with physician-assessed disease activity and serum 25-hydroxyvitamin D [25(OH)D] in subjects with pediatric SLE (n = 37) or JDM (n = 21). Serum 25(OH)D was correlated with urinary vitamin D binding protein/creatinine ratio (DBP/C) and other indicators of proteinuria. Results—Serum 25(OH)D levels in subjects with SLE were inversely associated with the natural log of urinary DBP/C (r = −0.63, p < 0.001) and urine protein to creatinine ratio (r = −0.60, p<0.001), with an adjusted mean 10.9 (95% CI 5.1, 16.8) ng/mL decrease in 25(OH)D for those with proteinuria. Excluding subjects with proteinuria, serum 25(OH)D levels were inversely associated with disease activity in JDM, but not in SLE. Overall, 66% of all subjects were taking concurrent corticosteroids, but this was not associated with 25(OH)D levels. Conclusions—Low serum 25(OH)D in patients with SLE is associated with proteinuria and urinary DBP. Vitamin D deficiency is associated with disease activity in patients with JDM and SLE; this relationship in SLE may be confounded by proteinuria

    New rodent from Lao PDR

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    31 p. : ill. (some col.), map ; 26 cm.Includes bibliographical references (p. 28-29).Saxatilomys paulinae, a new genus and species of murid rodent in the Dacnomys division is described. It is based on two whole specimens and 14 individuals represented by fragments recovered from owl pellets. The samples come from the Khammouan Limestone National Biodiversity Conservation Area in Khammouan Province in central Lao PDR. This tower karst landscape is part of the Quy Dat limestone massif, which extends eastward into north-central Vietnam (Binh Tri Thien Province). The new genus and species is morphologically (and probably phylogenetically) allied to species of Niviventer and Chiromyscus, which are also members of the Dacnomys division, but its semispinous dark gray upperparts, dark frosted gray underparts, large, extremely bulbous footpads, and a combination of derived and primitive cranial and dental traits exclude it from membership in Niviventer, Chiromyscus, or any other described genus of Indo-Malayan murid. The new species is likely petricolous, and is part of a small but unique community of small nonvolant mammals containing the petricolous gymnure, Hylomys megalotis, and hystricognath, Laonastes aenigmamus. All three species have been collected only in forested, rocky habitats of the Khammouan Limestone, but comparable environments in the adjacent Vietnamese portion of the Quy Dat limestone massif may harbor these same species specialized for living in forested, karstic landscapes
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