Star formation and gas inflows in the OH Megamaser galaxy IRAS03056+2034

We have obtained observations of the OH Megamaser galaxy IRAS03056+0234 using Gemini Multi-Object Spectrograph (GMOS) Integral Field Unit (IFU), Very Large Array (VLA) and Hubble Space Telescope (HST). The HST data reveals spiral arms containing knots of emission associated to star forming regions. The GMOS-IFU data cover the spectral range of 4500 to 7500 \AA\ at a velocity resolution of 90 km s$^{-1}$ and spatial resolution of 506 pc. The emission-line flux distributions reveal a ring of star forming regions with radius of 786 pc centred at the nucleus of the galaxy, with an ionized gas mass of 1.2$\times$ 10$^{8}$M$_{\odot}$, an ionizing photon luminosity of log Q[H$^{+}$]=53.8 and a star formation rate of 4.9 M$_{\odot}$ yr$^{-1}$. The emission-line ratios and radio emission suggest that the gas at the nuclear region is excited by both starburst activity and an active galactic nucleus. The gas velocity fields are partially reproduced by rotation in the galactic plane, but show, in addition, excess redshifts to the east of the nucleus, consistent with gas inflows towards the nucleus, with velocity of $\sim$45 km s$^{-1}$ and a mass inflow rate of $\sim$7.7$\times$10$^{-3}$ M$_{\odot}$ yr$^{-1}$.Comment: To be published in MNRA

GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity.

Abnormal activation of the epidermal growth factor receptor (EGFR) due to a deletion of exons 2-7 of EGFR (EGFRvIII) is a common alteration in glioblastoma (GBM). While this alteration can drive gliomagenesis, tumors harboring EGFRvIII are heterogeneous. To investigate the role for EGFRvIII activation in tumor phenotype we used a neural progenitor cell-based murine model of GBM driven by EGFR signaling and generated tumor progenitor cells with high and low EGFRvIII activation, pEGFRHi and pEGFRLo. In vivo, ex vivo, and in vitro studies suggested a direct association between EGFRvIII activity and increased tumor cell proliferation, decreased tumor cell adhesion to the extracellular matrix, and altered progenitor cell phenotype. Time-lapse confocal imaging of tumor cells in brain slice cultures demonstrated blood vessel co-option by tumor cells and highlighted differences in invasive pattern. Inhibition of EGFR signaling in pEGFRHi promoted cell differentiation and increased cell-matrix adhesion. Conversely, increased EGFRvIII activation in pEGFRLo reduced cell-matrix adhesion. Our study using a murine model for GBM driven by a single genetic driver, suggests differences in EGFR activation contribute to tumor heterogeneity and aggressiveness

A comparison of the polytomous Rasch analysis output of RUMM2030 and R (ltm/eRm/TAM/lordif)

© 2019 The Author(s). Background: Patient-reported outcome measures developed using Classical Test Theory are commonly comprised of ordinal level items on a Likert response scale are problematic as they do not permit the results to be compared between patients. Rasch analysis provides a solution to overcome this by evaluating the measurement characteristics of the rating scales using probability estimates. This is typically achieved using commercial software dedicated to Rasch analysis however, it is possible to conduct this analysis using non-specific open source software such a R. Methods: Rasch analysis was conducted using the most commonly used commercial software package, RUMM 2030, and R, using four open-source packages, with a common data set (6-month post-injury PRWE Questionnaire responses) to evaluate the statistical results for consistency. The analysis plan followed recommendations used in a similar study supported by the software package\u27s instructions in order to obtain category thresholds, item and person fit statistics, measures of reliability and evaluate the data for construct validity, differential item functioning, local dependency and unidimensionality of the items. Results: There was substantial agreement between RUMM2030 and R with regards for most of the results, however there are some small discrepancies between the output of the two programs. Conclusions: While the differences in output between RUMM2030 and R can easily be explained by comparing the underlying statistical approaches taken by each program, there is disagreement on critical statistical decisions made by each program. This disagreement however should not be an issue as Rasch analysis requires users to apply their own subjective analysis. While researchers might expect that Rasch performed on a large sample would be a stable, two authors who complete Rasch analysis of the PRWE found somewhat dissimilar findings. So, while some variations in results may be due to samples, this paper adds that some variation in findings may be software dependent

Summer 1975

Getting Back to Basics--Turfgrass Fertilization (page 3) Carefree Herbaceous Perennials For Gardens and Borders (9) Back and Beyond (10) Turf News--New Lifting Technique accepted (14) Vandalism on Golf Courses (15) UMass Turfgrass Research Fund (20

Integrating a Simple Traffic Incident Model for Rapid Evacuation Analysis

Road transportation networks are a segment of society\u27s critical infrastructure particularly susceptible to service disruptions. Traffic incidents disrupt road networks by producing blockages and increasing travel times, creating significant impacts during emergency events such as evacuations. For this reason, it is extremely important to incorporate traffic incidents in evacuation planning models. Emergency managers and decision makers need tools that enable rapid assessment of multiple, varied scenarios. Many evacuation simulations require high-fidelity data input making them impractical for rapid deployment by practitioners. Since there is such variation in evacuation types and the method of disruption, evacuation models do not require the high-fidelity data needed by other types of transportation models. This paper\u27s purpose is to show that decision makers can gain useful information from rapid evacuation modeling which includes a simple traffic incident model. To achieve this purpose, the research team integrated a generic incident model into the Real-time Evacuation Planning Model (RtePM), a tool commissioned by the U.S. Department of Homeland Security to help emergency planners determine regional evacuation clearance times in the United States. RtePM is a simple, web-based tool that enables emergency planners to consider multiple evacuation plans at no additional cost to the user. Using this tool, we analyzed a simple scenario of the United States\u27 National Capital Region (NCR) to determine the impact of traffic incidents when different destination routes are blocked. The results indicate significant variations in evacuation duration when blockages are considered

Millisecond Pulsars as Probes of Mass Segregation in the Galactic Center

We propose a simple test for the existence of a cluster of black hole remnants around Sgr A* that is based on a small sample of any type of Galactic Center objects, provided they are substantially less massive than the black holes and constitute part of an old (> 1 Gyr) population. The test relies on the fact that, under the presence of such a cluster of heavy remnants and because of energy equipartition, lower mass objects would be expelled from the central regions and settle into a distribution very different than the cusp expected to be induced by the supermassive black hole alone. We show that with a sample of just 50 objects and using only their angular positions on the sky relative to Sgr A* it is possible to clearly differentiate between a distribution consistent with the presence of the cluster of black holes and a power-law cusp distribution. We argue that millisecond pulsars might currently be the best candidate to perform this test, because of the large uncertainties involved in the age determination of less exotic objects. In addition, by measuring their first and second period derivatives, millisecond pulsars offer the rare opportunity of determining the complete phase space information of the objects. We show that this extra information improves the detection of mass segregation by about 30%.Comment: 16 pages, 1 Postscript figure; version accepted for publication in Ap

Streaming Motions Towards the Supermassive Black Hole in NGC 1097

We have used GMOS-IFU and high resolution HST-ACS observations to map, in unprecedented detail, the gas velocity field and structure within the 0.7 kpc circumnuclear ring of the SBb LINER/Seyfert 1 galaxy NGC 1097. We find clear evidence of radial streaming motions associated with spiral structures leading to the unresolved (<3.5 parsecs) nucleus, which we interpret as part of the fueling chain by which gas is transported to the nuclear starburst and supermassive black hole.Comment: 4 pages, 3 figures using emulateapj. Accepted for publication in Astrophysical Journal Letters. Download high-resolution version from http://www.astro.uu.se/~kambiz/DOC/paper-N1097.pd

Finding the Needles in the Haystacks: High-Fidelity Models of the Modern and Archean Solar System for Simulating Exoplanet Observations

We present two state-of-the-art models of the solar system, one corresponding to the present day and one to the Archean Eon 3.5 billion years ago. Each model contains spatial and spectral information for the star, the planets, and the interplanetary dust, extending to 50 AU from the sun and covering the wavelength range 0.3 to 2.5 micron. In addition, we created a spectral image cube representative of the astronomical backgrounds that will be seen behind deep observations of extrasolar planetary systems, including galaxies and Milky Way stars. These models are intended as inputs to high-fidelity simulations of direct observations of exoplanetary systems using telescopes equipped with high-contrast capability. They will help improve the realism of observation and instrument parameters that are required inputs to statistical observatory yield calculations, as well as guide development of post-processing algorithms for telescopes capable of directly imaging Earth-like planets.Comment: Accepted for publication in PAS

Meningococcal disease in children in Merseyside, England:a 31 year descriptive study

Meningococcal disease (MCD) is the leading infectious cause of death in early childhood in the United Kingdom, making it a public health priority. MCD most commonly presents as meningococcal meningitis (MM), septicaemia (MS), or as a combination of the two syndromes (MM/MS). We describe the changing epidemiology and clinical presentation of MCD, and explore associations with socioeconomic status and other risk factors. A hospital-based study of children admitted to a tertiary children's centre, Alder Hey Children's Foundation Trust, with MCD, was undertaken between 1977 to 2007 (n = 1157). Demographics, clinical presentations, microbiological confirmation and measures of deprivation were described. The majority of cases occurred in the 1-4 year age group and there was a dramatic fall in serogroup C cases observed with the introduction of the meningococcal C conjugate (MCC) vaccine. The proportion of MS cases increased over the study period, from 11% in the first quarter to 35% in the final quarter. Presentation with MS (compared to MM) and serogroup C disease (compared to serogroup B) were demonstrated to be independent risk factors for mortality, with odds ratios of 3.5 (95% CI 1.18 to 10.08) and 2.18 (95% CI 1.26 to 3.80) respectively. Cases admitted to Alder Hey were from a relatively more deprived population (mean Townsend score 1.25, 95% CI 1.09 to 1.41) than the Merseyside reference population. Our findings represent one of the largest single-centre studies of MCD. The presentation of MS is confirmed to be a risk factor of mortality from MCD. Our study supports the association between social deprivation and MCD