109 research outputs found
An investigation of the reading interests of middle-grade children
Thesis (Ed.M.)--Boston University, 1949. This item was digitized by the Internet Archive
Ī³-Guanidinobutyric Acid: An Inhibitor of Clot Formation and of Clot Lysis
During a study of the effects of a series of guanidine compounds on the esterolytic activities of thrombin, plasmin, and streptokinase plus plasmin or plasminogen, it was found that one of these compunds, Ī³-guanidinobutyric acid (GGBA), acted in several ways like Īµ-aminocaproic acid (EACA). Neither compound had any inhibiting effects on the rate of hydrolysis of TAMe (p-toluenesulfonyl-L-arginine methyl ester), but both inhibited the activation of plasminogen by streptokinase. EACA was the more potent inhibitor. Since EACA has been shown to inhibit the lysis of fibrin, primarily because it inhibits the activation of plasminogen (Ablondi et al., 1959, Alkjaersig, Fletcher, and Sherry, 1959), GGBA was tested to see if it, too, would inhibit the lysis of blood clots. It was found to do so. In addition, it was found that GGBA also inhibits the formation of blood clots, which EACA does not do. These preliminary results are reported here
Perceived Barriers to Higher Education in STEM Among Disadvantaged Rural Students: A Case Study
This case study examined the perceptions of scholarship recipients participating in Southwest Virginia Community Collegeās (SWCCās) S-STEM scholarship program which examined whether the program helped remove barriers to studentsā educational goals and STEM career aspirations. The study used a focus group and a survey to elicit responses from student participants in the SWCC S-STEM program. Participants were low-income residents of rural Appalachia, and many were first generation college students. Results indicated that students in the SWCC S-STEM program experienced a wide variety of barriers to STEM educational and career success, including economic, geographic, social, and educational barriers, and that the S-STEM program assisted students in overcoming these barriers. This study may inform efforts to further increase the number of underrepresented students who enroll in and complete STEM education programs
The Effect of Ī³-Guanidinobutyric Acid on the Clotting Time of Normal Plasma and on the Euglobulin Lysis Time of Fibrinolytically Active Plasma
It has been established that Īµ-aminocaproic acid (EACA) inhibits the activation of human plasminogen (Ablondi et al., 1959; Alkjaersig, Fletcher, and Sherry, 1959). Because of this observation, this compound has been used extensively to inhibit the pathologically occurring fibrinolytic system in patients. Recently Roberts (1965) reported that another compound, Ī³-guanidinobutyric acid (GGBA), like EACA, inhibits the lysis of human blood clots. Furthermore, GGBA, unlike EACA, retards the formation of these clots. The present investigation was undertaken to determine whether GGBA inhibits clot formation in the one-stage prothrombin and in the partial thromboplastin time tests. In addition, the ability of GGBA to inhibit clot lysis was tested using blood from a patient showing active fibrinolysis
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Even free radicals should follow some rules: a guide to free radical research terminology and methodology.
Free radicals and oxidants are now implicated in physiological responses and in several diseases. Given the wide range of expertise of free radical researchers, application of the greater understanding of chemistry has not been uniformly applied to biological studies. We suggest that some widely used methodologies and terminologies hamper progress and need to be addressed. We make the case for abandonment and judicious use of several methods and terms and suggest practical and viable alternatives. These changes are suggested in four areas: use of fluorescent dyes to identify and quantify reactive species, methods for measurement of lipid peroxidation in complex biological systems, claims of antioxidants as radical scavengers, and use of the terms for reactive species
The Lantern Vol. 27, No. 3, Fall 1960
ā¢ Thoughts in DaVinici\u27s Coffeehouse ā¢ Kinesiology Class ā¢ No One is Named Alistair ā¢ The Beat Generation ā¢ The Super Highway Blues ā¢ Panic and the Mountain Peak ā¢ The Lake ā¢ Later ā¢ Ares ā¢ The Light ā¢ The Room ā¢ Thoughts After Three-Thirty ā¢ Critique ā¢ There ā¢ Organized Religion - Pro ā¢ Organized Religion - Con ā¢ Longing ā¢ Apologies to Francois Villon ā¢ The Fortune Teller ā¢ At Twilight ā¢ The Ledge ā¢ Waiting at Evening for the Sky to Fall ā¢ In Memory of a Friend ā¢ The Gentleman ā¢ Consumption ā¢ Post-Panegyric ā¢ The Everglades ā¢ Awareness ā¢ The Art of Two-Timing ā¢ Meditations of an Egyptologist ā¢ Sonnet to Mao Tse-Tung ā¢ A Strange Affair ā¢ With Us Tonight ā¢ The Form in Fronthttps://digitalcommons.ursinus.edu/lantern/1078/thumbnail.jp
A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase Ī²
DNA repair is required to maintain genome stability in stem cells and early embryos. At critical junctures, oxidative damage to DNA requires the base excision repair (BER) pathway. Since early zebrafish embryos lack the major polymerase in BER, DNA polymerase Ć, repair proceeds via replicative polymerases, even though there is ample polb mRNA. Here, we report that Polb protein fails to appear at the appropriate time in development when AP endonuclease 1 (Apex), the upstream protein in BER, is knocked down. Because polb contains a Creb1 binding site, we examined whether knockdown of Apex affects creb1. Apex knockdown results in loss of Creb1 and Creb complex members but not Creb1 phosphorylation. This effect is independent of p53. Although both apex and creb1 mRNA rescue Creb1 and Polb after Apex knockdown, Apex is not a co-activator of creb1 transcription. This observation has broad significance, as similar results occur when Apex is inhibited in B cells from apex+/ā mice. These results describe a novel regulatory circuit involving Apex, Creb1 and Polb and provide a mechanism for lethality of Apex loss in higher eukaryotes
HelioSwarm: A Multipoint, Multiscale Mission to Characterize Turbulence
HelioSwarm (HS) is a NASA Medium-Class Explorer mission of the Heliophysics Division designed to explore the dynamic three-dimensional mechanisms controlling the physics of plasma turbulence, a ubiquitous process occurring in the heliosphere and in plasmas throughout the universe. This will be accomplished by making simultaneous measurements at nine spacecraft with separations spanning magnetohydrodynamic and sub-ion spatial scales in a variety of near-Earth plasmas. In this paper, we describe the scientific background for the HS investigation, the mission goals and objectives, the observatory reference trajectory and instrumentation implementation before the start of Phase B. Through multipoint, multiscale measurements, HS promises to reveal how energy is transferred across scales and boundaries in plasmas throughout the universe
The essential role of multi-point measurements in investigations of turbulence, three-dimensional structure, and dynamics: the solar wind beyond single scale and the Taylor Hypothesis
Space plasmas are three-dimensional dynamic entities. Except under very
special circumstances, their structure in space and their behavior in time are
not related in any simple way. Therefore, single spacecraft in situ
measurements cannot unambiguously unravel the full space-time structure of the
heliospheric plasmas of interest in the inner heliosphere, in the Geospace
environment, or the outer heliosphere. This shortcoming leaves numerous central
questions incompletely answered. Deficiencies remain in at least two important
subjects, Space Weather and fundamental plasma turbulence theory, due to a lack
of a more complete understanding of the space-time structure of dynamic
plasmas. Only with multispacecraft measurements over suitable spans of spatial
separation and temporal duration can these ambiguities be resolved. We note
that these characterizations apply to turbulence across a wide range of scales,
and also equally well to shocks, flux ropes, magnetic clouds, current sheets,
stream interactions, etc. In the following, we will describe the basic
requirements for resolving space-time structure in general, using turbulence'
as both an example and a principal target or study. Several types of missions
are suggested to resolve space-time structure throughout the Heliosphere.Comment: White Paper submitted to: Decadal Survey for Solar and Space Physics
(Heliophysics) 2024-2033. arXiv admin note: substantial text overlap with
arXiv:1903.0689
A New Technique for the Calculation and 3D Visualisation of Magnetic Complexities on Solar Satellite Images
YesIn this paper, we introduce two novel models for processing real-life satellite images to quantify and then
visualise their magnetic structures in 3D. We believe this multidisciplinary work is a real convergence between
image processing, 3D visualization and solar physics. The first model aims to calculate the value of the magnetic
complexity in active regions and the solar disk. A series of experiments are carried out using this model and a
relationship has been indentified between the calculated magnetic complexity values and solar flare events. The
second model aims to visualise the calculated magnetic complexities in 3D colour maps in order to identify the
locations of eruptive regions on the Sun. Both models demonstrate promising results and they can be potentially
used in the fields of solar imaging, space weather and solar flare prediction and forecasting
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