Genetic Race? DNA Ancestry Tests, Racial Identity, and the Law

Can genetic tests determine race? Americans are fascinated with DNA ancestry testing services like 23andMe and AncestryDNA. Indeed, in recent years, some people have changed their racial identity based upon DNA ancestry tests and have sought to use test results in lawsuits and for other strategic purposes. Courts may be similarly tempted to use genetic ancestry in determining race. In this Essay, we examine the ways in which DNA ancestry tests may affect contemporary understandings of racial identity. We argue that these tests are poor proxies for race because they fail to reflect the social, cultural, relational, and experiential norms that shape identity. We consider three separate legal contexts in which these issues arise: (1) employment discrimination, (2) race-conscious initiatives, and (3) immigration. Based on this analysis, we strongly caution against defining race in predominantly genetic term

A study of a culturally focused psychiatric consultation service for Asian American and Latino American primary care patients with depression

<p>Abstract</p> <p>Background</p> <p>Ethnic minorities with depression are more likely to seek mental health care through primary care providers (PCPs) than mental health specialists. However, both provider and patient-specific challenges exist. PCP-specific challenges include unfamiliarity with depressive symptom profiles in diverse patient populations, limited time to address mental health, and limited referral options for mental health care. Patient-specific challenges include stigma around mental health issues and reluctance to seek mental health treatment. To address these issues, we implemented a multi-component intervention for Asian American and Latino American primary care patients with depression at Massachusetts General Hospital (MGH).</p> <p>Methods/Design</p> <p>We propose a randomized controlled trial to evaluate a culturally appropriate intervention to improve the diagnosis and treatment of depression in our target population. Our goals are to facilitate a) primary care providers' ability to provide appropriate, culturally informed care of depression, and b) patients' knowledge of and resources for receiving treatment for depression. Our two-year long intervention targets Asian American and Latino American adult (18 years of age or older) primary care patients at MGH screening positive for symptoms of depression. All eligible patients in the intervention arm of the study who screen positive will be offered a culturally focused psychiatric (CFP) consultation. Patients will meet with a study clinician and receive toolkits that include psychoeducational booklets, worksheets and community resources. Within two weeks of the initial consultation, patients will attend a follow-up visit with the CFP clinicians. Primary outcomes will determine the feasibility and cost associated with implementation of the service, and evaluate patient and provider satisfaction with the CFP service. Exploratory aims will describe the study population at screening, recruitment, and enrollment and identify which variables influenced patient participation in the program.</p> <p>Discussion</p> <p>The study involves an innovative yet practical intervention that builds on existing resources and strives to improve quality of care for depression for minorities. Additionally, it complements the current movement in psychiatry to enhance the treatment of depression in primary care settings. If found beneficial, the intervention will serve as a model for care of Asian American and Latino American patients.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov: <a href="http://www.clinicaltrials.gov/ct2/show/NCT01239407">NCT01239407</a></p

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Genetic Race? DNA Ancestry Tests, Racial Identity, and the Law

Can genetic tests determine race? Americans are fascinated with DNA ancestry testing services like 23andMe and AncestryDNA. Indeed, in recent years, some people have changed their racial identity based upon DNA ancestry tests and have sought to use test results in lawsuits and for other strategic purposes. Courts may be similarly tempted to use genetic ancestry in determining race. In this Essay, we examine the ways in which DNA ancestry tests may affect contemporary understandings of racial identity. We argue that these tests are poor proxies for race because they fail to reflect the social, cultural, relational, and experiential norms that shape identity. We consider three separate legal contexts in which these issues arise: (1) employment discrimination, (2) race-conscious initiatives, and (3) immigration. Based on this analysis, we strongly caution against defining race in predominantly genetic term

Heterogeneity in Genetic Diversity among Non-Coding Loci Fails to Fit Neutral Coalescent Models of Population History

Inferring aspects of the population histories of species using coalescent analyses of non-coding nuclear DNA has grown in popularity. These inferences, such as divergence, gene flow, and changes in population size, assume that genetic data reflect simple population histories and neutral evolutionary processes. However, violating model assumptions can result in a poor fit between empirical data and the models. We sampled 22 nuclear intron sequences from at least 19 different chromosomes (a genomic transect) to test for deviations from selective neutrality in the gadwall (Anas strepera), a Holarctic duck. Nucleotide diversity among these loci varied by nearly two orders of magnitude (from 0.0004 to 0.029), and this heterogeneity could not be explained by differences in substitution rates alone. Using two different coalescent methods to infer models of population history and then simulating neutral genetic diversity under these models, we found that the observed among-locus heterogeneity in nucleotide diversity was significantly higher than expected for these simple models. Defining more complex models of population history demonstrated that a pre-divergence bottleneck was also unlikely to explain this heterogeneity. However, both selection and interspecific hybridization could account for the heterogeneity observed among loci. Regardless of the cause of the deviation, our results illustrate that violating key assumptions of coalescent models can mislead inferences of population history

Data from: A novel multi-scale assessment of community assembly across time, space, and functional niche

A basic ecological tenet is that organisms in a community occupy different niches and have different traits, but how consistently competition, selection, and phylogenetic effects structure communities remains uncertain. Are all communities created equal? We examine how mammalian carnivoran communities are assembled with regard to mass, diet, and locomotion. Here, we use a multivariate nearest-neighbor framework to examine multiple North American localities spanning 3 million years to determine whether community assembly is consistent through time and four modern localities around the world to assess the effects of habitat. Additionally, we examined how trait patterns differ among families and how family-level evolutionary effects affect them. We found some broadly consistent patterns, although differences are more pronounced than similarities. Diet is more affected by evolutionary constraints than by time or place. Locomotion is most affected by habitat, and the ability to partition niches is related to habitat heterogeneity. Mass is influenced by family, but also by habitat and the mass-selective extinction events at the end-Pleistocene. These findings indicate that assembly patterns are not largely determined by within-community interactions but instead show that each community is a product of its independent variables

Revitalization of the University of Iowa's Bird Egg Collection after 100 Years of Dormancy

The University of Iowa Museum of Natural History's egg collection spans many avian orders, 6 continents, and over 160 years. However, this collection of approximately 17,000 egg specimens has remained disorganized and underutilized for most of its history. Only in 2017 did the museum begin taking significant steps toward organizing the eggs, cataloging them, and making them and their data available for researchers. Like many museum egg collections, ours is composed mostly of donated private collections originally collected, purchased, or traded between 1870 and 1910, and with variable amounts of data associated with individual specimens. Since the time the eggs were collected, most of them have been separated from the cards on which collectors stored their data. Much of the current project revolves around reuniting eggs and data cards. We have scanned over 2,000 egg cards, crowdsourced transcriptions of the handwriting, verified the accuracy of each transcription, and added the scans and transcriptions to our database for easy access by museum staff and volunteers. We are using the egg cards, any data written on the eggs, and many books and websites to match eggs with egg cards and integrate the data into our database. The eggs are then placed in new cabinets and relabelled with newly generated database information. Each egg set will be photographed and georeferenced if possible, using the GEOLocate web application. At the end of this project, these specimen records will be integrated into biodiversity repositories such as GBIF (Global Biodiversity Information Facility), Integrated Digitized Biocollections (iDigBio), and VertNet, so they can be downloaded and used by researchers globally, as our bird, mammal and insect collections already are. Most of the work is carried out by a team of volunteers and interns, usually undergraduate students, without whom this project would not be possible at its current pace