Emerging in the Image of God: From Evolution to Ethics in a Second Naïveté Understanding of Christian Anthropology

Through a careful integration of theological, philosophical, and the natural scientific sources, the biblical concepts of the image of God and the knowledge of good and evil have the potential to remain important and appropriate descriptors of the human condition, including the possibility and necessity of human morality. This study employs French philosopher Paul Ricoeur\u27s notion of second naïveté understanding to demonstrate the hermeneutical significance of contemporary biocultural evolutionary theory for reinterpreting and reappropriating these ancient symbols of Christian anthropology as terms equipped to encapsulate a morally fruitful and intellectually honest conceptual framework for constructing, conducting, and evaluating theological anthropology and ethics today. Forging and polishing this hermeneutical lens for the purpose of recasting a biblically-based picture of humanity involves alloying these ancient concepts with others from the interrelated fields of cognitive linguistics, evolutionary psychology, and emergence. Viewed through this lens, the dissertationing chapters of Genesis describe human beings as creatures wrought of the creation and embedded within it to the same extent as all other creatures. Though ordinary in every other aspect, human creatures are unique in that they have emerged with an ambivalent condition of freedom through which they bear the vocation to re-present the creative beneficence of the God who shares power and does not create through violence. I defend this thesis in seven chapters. In the first chapter, I introduce the research topic, goals, and hermeneutical procedure for this study. Chapters 2 and 3 describe biocultural evolution and evolutionary psychology within a non-reductive emergentist perspective as sources and resources for contemporary theological anthropology. In chapter 4, I propose an articulation of the doctrine of the imago Dei within this evolutionary worldview. Chapter 5 situates the knowledge of good and evil vis-à-vis biocultural evolution and recent biblical studies. I then construct a proposal in chapter 6 for how this second naïveté understanding of the image of God and the knowledge of good and evil dissertations up new frameworks and frontiers for fundamental theological ethics. Finally, chapter 7 offers a summative and prospective conclusion to this study and its likely impact on my future research

AMPR and Radar Observations from Iphex: Data Quality Control and Product Generation

No abstract availabl

Effect of obesity on the population pharmacokinetics of meropenem in critically ill patients

Severe pathophysiological changes in critical illness can lead to dramatically altered antimicrobial pharmacokinetics (PK). The additional effect of obesity on PK potentially increases the challenge for effective dosing. The aim of this prospective study was to describe the population PK of meropenem for a cohort of critically ill patients, including obese and morbidly obese patients. Critically ill patients prescribed meropenem were recruited into the following three body mass index (BMI) groups: nonobese (18.5 to 29.9 kg/m(2)), obese (30.0 to 39.9 kg/m(2)), and morbidly obese (>= 40 kg/m(2)). Serial plasma samples were taken, and meropenem concentrations were determined using a validated chromatographic method. Population PK analysis and Monte Carlo dosing simulations were undertaken with Pmetrics. Nineteen critically ill patients with different BMI categories were enrolled. The patients' mean +/- standard deviation (SD) age, weight, and BMI were 49 +/- 15.9 years, 95 +/- 22.0 kg, and 33 +/- 7.0 kg/m(2), respectively. A two-compartment model described the data adequately. The mean +/- SD parameter estimates for the final covariate model were as follows: clearance (CL), 15.5 +/- 6.0 liters/h; volume of distribution in the central compartment (V-1), 11.7 +/- 5.8 liters; intercompartmental clearance from the central compartment to the peripheral compartment, 25.6 +/- 35.1 liters h(-1); and intercompartmental clearance from the peripheral compartment to the central compartment, 8.32 +/- 12.24 liters h(-1). Higher creatinine clearance (CLCR) was associated with a lower probability of target attainment, with BMI having little effect. Although obesity was found to be associated with an increased V-1, dose adjustment based on CLCR appears to be more important than patient BMI

A meta-analysis of protein binding of flucloxacillin in healthy volunteers and hospitalized patients

Objectives: The aim of this study was to develop a mechanistic protein-binding model to predict the unbound flucloxacillin concentrations in different patient populations. Methods: A mechanistic protein-binding model was fitted to the data using non-linear mixed-effects modelling. Data were obtained from four datasets, containing 710 paired total and unbound flucloxacillin concentrations from healthy volunteers, non-critically ill and critically ill patients. A fifth dataset with data from hospitalized patients was used for evaluation of our model. The predictive performance of the mechanistic model was evaluated and compared with the calculation of the unbound concentration with a fixed unbound fraction of 5%. Finally, we performed a fit-for-use evaluation, verifying whether the model-predicted unbound flucloxacillin concentrations would lead to clinically incorrect dose adjustments. Results: The mechanistic protein-binding model predicted the unbound flucloxacillin concentrations more accurately than assuming an unbound fraction of 5%. The mean prediction error varied between -26.2% to 27.8% for the mechanistic model and between -30.8% to 83% for calculation with a fixed factor of 5%. The normalized root mean squared error varied between 36.8% and 69% respectively between 57.1% and 134%. Predicting the unbound concentration with the use of the mechanistic model resulted in 6.1% incorrect dose adjustments versus 19.4% if calculated with a fixed unbound fraction of 5%. Conclusions: Estimating the unbound concentration with a mechanistic protein-binding model outperforms the calculation with the use of a fixed protein binding factor of 5%, but neither demonstrates acceptable performance. When performing dose individualization of flucloxacillin, this should be done based on measured unbound concentrations rather than on estimated unbound concentrations from the measured total concentrations. In the absence of an assay for unbound concentrations, the mechanistic binding model should be preferred over assuming a fixed unbound fraction of 5%

X-Ray and Optical Properties of Black Widows and Redbacks

Black widows and redbacks are binary systems consisting of a millisecond pulsar in a close binary with a companion having matter driven off of its surface by the pulsar wind. X-rays due to an intra-binary shock have been observed from many of these systems, as well as orbital variations in the optical emission from the companion due to heating and tidal distortion. We have been systematically studying these systems in radio, optical and X-rays. Here we will present an overview of X-ray and optical studies of these systems, including new XMM-Newton and NuStar data obtained from several of them, along with new optical photometry.Comment: 4 pages, 1 figure, Proceedings of IAU Symposium 337 "Pulsar Astrophysics - The Next 50 Years" held in Jodrell Bank Observatory, UK Sept. 4-8 201

Development of virus-like particles with inbuilt immunostimulatory properties as vaccine candidates

The development of virus-like particle (VLP) based vaccines for human papillomavirus, hepatitis B and hepatitis E viruses represented a breakthrough in vaccine development. However, for dengue and COVID-19, technical complications, such as an incomplete understanding of the requirements for protective immunity, but also limitations in processes to manufacture VLP vaccines for enveloped viruses to large scale, have hampered VLP vaccine development. Selecting the right adjuvant is also an important consideration to ensure that a VLP vaccine induces protective antibody and T cell responses. For diseases like COVID-19 and dengue fever caused by RNA viruses that exist as families of viral variants with the potential to escape vaccine-induced immunity, the development of more efficacious vaccines is also necessary. Here, we describe the development and characterisation of novel VLP vaccine candidates using SARS-CoV-2 and dengue virus (DENV), containing the major viral structural proteins, as protypes for a novel approach to produce VLP vaccines. The VLPs were characterised by Western immunoblot, enzyme immunoassay, electron and atomic force microscopy, and in vitro and in vivo immunogenicity studies. Microscopy techniques showed proteins self-assemble to form VLPs authentic to native viruses. The inclusion of the glycolipid adjuvant, α-galactosylceramide (α-GalCer) in the vaccine formulation led to high levels of natural killer T (NKT) cell stimulation in vitro, and strong antibody and memory CD8+ T cell responses in vivo, demonstrated with SARS-CoV-2, hepatitis C virus (HCV) and DEN VLPs. This study shows our unique vaccine formulation presents a promising, and much needed, new vaccine platform in the fight against infections caused by enveloped RNA viruses