Alpine Glaciology: An Historical Collaboration between Volunteers and Scientists and the Challenge Presented by an Integrated Approach

European Alpine glaciology has a long tradition of studies and activities, in which researchers have often relied on the field work of some specialized volunteer operators. Despite the remarkable results of this cooperation, some problems in field data harmonization and in covering the whole range of monitored glaciers are still present. Moreover, dynamics of reduction, fragmentation and decline, which in recent decades characterize Alpine glaciers, make more urgent the need to improve spatial and temporal monitoring, still maintaining adequate quality standards. Scientific field monitoring activities on Alpine glaciers run parallel to a number of initiatives by individuals and amateur associations, keepers of alternative, experiential and para-scientific knowledge of the glacial environment. Problems of harmonization, coordination, recruitment and updating can be addressed with the help of a collaborative approach—citizen science-like—in which the scientific coordination guarantees information quality and web 2.0 tools operate as mediators between expert glaciologists and non-expert contributors. This paper gives an overview of glaciological information currently produced in the European Alpine region, representing it in an organized structure, functional to the discussion. An empowering solution is then proposed, both methodological and technological, for the integration of multisource data. Its characteristics, potentials and problems are discussed

Orthostatic Hypotension in Parkinson's Disease: Do Height and Weight Matter?

Lette

The Ortles ice cores: uncovering an extended climate archive from the Eastern Alps

During the last half century, oxygen and hydrogen stable isotope content of ice cores has been extensively used for air temperature reconstructions. The most suitable glaciers of the Alpine area, most exclusively in the Western Alps, havebeen utilizedfor icecoring formore thanfour decades.The paleoclimatic potential of theEastern Alps isstilllargelyunexploitedandwasscarcelyutilizedinthepastmainlybecauseofthelowerelevation(comparedto Western Alps) and hence the difficulty to find glaciers in cold conditions. The warming temperature trend appears to be particularly pronounced in the Alps, threatening the preservation of the glaciated areas and creating a sense of urgency in retrieving climatic archives before it is too late. In autumn 2011, four deep cores were drilled on Mt Ortles, South Tyrol, Italy, at 3859 m a.s.l. An extensive reconstructed temperature record for the Ortles summit, based on the surrounding meteorological station data, is available for the last 150 years, while an automatic weather station had been operating from 2011 to 2015 in proximity of the drilling site. The new ice core chronology, based on 210Pb, tritium, beta emissions analysis and 14C measurements of the particulate organic carbon, indicates that the bottom ice is 7000 years old, making it the second most extended glaciological archive ever retrieved in the Alps. The three equally long ice cores have been analyzed for oxygen and hydrogen stable isotopes throughout their length, and the goal is to create an Ortles stacked record for d18O and dD and compare the isotopic data to instrumental temperatures and to other Alpine records. Since 2008, several snow pits were dug in proximity of the drilling site during summer, when the temperature can oftenexceedthemeltingpoint.Theisotopicprofilesofthe2015snowpit,dugattheendofanexceptionallywarm summer,showhowtheisotopesignalisnowaffectedbythepost-depositionalprocessesthathaveoccurredduring that summer

Acceleration and interannual variability of creep rates in mountain permafrost landforms (rock glacier velocities) in the European Alps in 1995–2022

Cryospheric long-term timeseries get increasingly important. To document climate-related effects on long-term viscous creep of ice-rich mountain permafrost, we investigated timeseries (1995–2022) of geodetically-derived Rock Glacier Velocity (RGV), i.e. spatially averaged interannual velocity timeseries related to a rock glacier (RG) unit or part of it. We considered 50 RGV from 43 RGs spatially covering the entire European Alps. Eight of these RGs are destabilized. Results show that RGV are distinctly variable ranging from 0.04 to 6.23 m a$^{−1}$. Acceleration and deceleration at many RGs are highly correlated with similar behaviour over 2.5 decades for 15 timeseries. In addition to a general long-term, warming-induced trend of increasing velocities, three main phases of distinct acceleration (2000–2004, 2008–2015, 2018–2020), interrupted by deceleration or steady state conditions, were identified. The evolution is attributed to climate forcing and underlines the significance of RGV as a product of the Essential Climate Variable (ECV) permafrost. We show that RGV data are valuable as climate indicators, but such data should always be assessed critically considering changing local factors (geomorphic, thermal, hydrologic) and monitoring approaches. To extract a climate signal, larger RGV ensembles should be analysed. Criteria for selecting new RGV-sites are proposed

Age of the Mt. Ortles ice cores, the Tyrolean Iceman and glaciation of the highest summit of South Tyrol since the Northern Hemisphere Climatic Optimum

In 2011 four ice cores were extracted from the summit of Alto dell'Ortles (3859 m), the highest glacier of South Tyrol in the Italian Alps. This drilling site is located only 37 km southwest from where the Tyrolean Iceman, similar to 5.3 kyrs old, was discovered emerging from the ablating ice field of Tisenjoch (3210 m, near the Italian-Austrian border) in 1991. The excellent preservation of this mummy suggested that the Tyrolean Iceman was continuously embedded in prehistoric ice and that additional ancient ice was likely preserved elsewhere in South Tyrol. Dating of the ice cores from Alto dell'Ortles based on Pb-210, tritium, beta activity and C-14 determinations, combined with an empirical model (COPRA), provides evidence for a chronologically ordered ice stratigraphy from the modern glacier surface down to the bottom ice layers with an age of similar to 7 kyrs, which confirms the hypothesis. Our results indicate that the drilling site has continuously been glaciated on frozen bedrock since similar to 7 kyrs BP. Absence of older ice on the highest glacier of South Tyrol is consistent with the removal of basal ice from bedrock during the Northern Hemisphere Climatic Optimum (6-9 kyrs BP), the warmest interval in the European Alps during the Holocene. Borehole inclinometric measurements of the current glacier flow combined with surface ground penetration radar (GPR) measurements indicate that, due to the sustained atmospheric warming since the 1980s, an acceleration of the glacier Alto dell'Ortles flow has just recently begun. Given the stratigraphic-chronological continuity of the Mt. Ortles cores over millennia, it can be argued that this behaviour has been unprecedented at this location since the Northern Hemisphere Climatic Optimum

Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System.

INTRODUCTION: Therapeutic strategies targeting protein aggregations are ready for clinical trials in atypical parkinsonian disorders. Therefore, there is an urgent need for neuroimaging biomarkers to help with the early detection of neurodegenerative processes, the early differentiation of the underlying pathology, and the objective assessment of disease progression. However, there currently is not yet a consensus in the field on how to describe utility of biomarkers for clinical trials in atypical parkinsonian disorders. METHODS: To promote standardized use of neuroimaging biomarkers for clinical trials, we aimed to develop a conceptual framework to characterize in more detail the kind of neuroimaging biomarkers needed in atypical parkinsonian disorders, identify the current challenges in ascribing utility of these biomarkers, and propose criteria for a system that may guide future studies. RESULTS: As a consensus outcome, we describe the main challenges in ascribing utility of neuroimaging biomarkers in atypical parkinsonian disorders, and we propose a conceptual framework that includes a graded system for the description of utility of a specific neuroimaging measure. We included separate categories for the ability to accurately identify an intention-to-treat patient population early in the disease (Early), to accurately detect a specific underlying pathology (Specific), and the ability to monitor disease progression (Progression). DISCUSSION: We suggest that the advancement of standardized neuroimaging in the field of atypical parkinsonian disorders will be furthered by a well-defined reference frame for the utility of biomarkers. The proposed utility system allows a detailed and graded description of the respective strengths of neuroimaging biomarkers in the currently most relevant areas of application in clinical trials

Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System

IntroductionTherapeutic strategies targeting protein aggregations are ready for clinical trials in atypical parkinsonian disorders. Therefore, there is an urgent need for neuroimaging biomarkers to help with the early detection of neurodegenerative processes, the early differentiation of the underlying pathology, and the objective assessment of disease progression. However, there currently is not yet a consensus in the field on how to describe utility of biomarkers for clinical trials in atypical parkinsonian disorders.MethodsTo promote standardized use of neuroimaging biomarkers for clinical trials, we aimed to develop a conceptual framework to characterize in more detail the kind of neuroimaging biomarkers needed in atypical parkinsonian disorders, identify the current challenges in ascribing utility of these biomarkers, and propose criteria for a system that may guide future studies.ResultsAs a consensus outcome, we describe the main challenges in ascribing utility of neuroimaging biomarkers in atypical parkinsonian disorders, and we propose a conceptual framework that includes a graded system for the description of utility of a specific neuroimaging measure. We included separate categories for the ability to accurately identify an intention-to-treat patient population early in the disease (Early), to accurately detect a specific underlying pathology (Specific), and the ability to monitor disease progression (Progression).DiscussionWe suggest that the advancement of standardized neuroimaging in the field of atypical parkinsonian disorders will be furthered by a well-defined reference frame for the utility of biomarkers. The proposed utility system allows a detailed and graded description of the respective strengths of neuroimaging biomarkers in the currently most relevant areas of application in clinical trials.</p