Knowledge of Bat Rabies and Human Exposure Among United States Cavers

We surveyed cavers who attended the National Speleological Society convention in June 2000. Fifteen percent of respondents did not consider a bat bite a risk for acquiring rabies; only 20% had received preexposure prophylaxis against the disease. An under-appreciation of the risk for rabies from bat bites may explain the preponderance of human rabies viruses caused by variant strains associated with bats in the United States

Taub--NUT Dyons in Heterotic String Theory

Starting with the Taub--NUT solution to Einstein's equations, together with a constant dilaton, a dyonic Taub--NUT solution of low energy heterotic string theory with non--trivial dilaton, axion and $U(1)$ gauge fields is constructed by employing $O(1,1)$ transformations. The electromagnetic dual of this solution is constructed, using SL(2,\rline) transformations. By an appropriate change to scaled variables, the extremal limit of the dual solution is shown to correspond to the low energy limit of an exact conformal field theory presented previously.Comment: 16 pages (plain TEX), (Revised version has curvature singularities correctly identified), IASSNS-HEP-94/50, McGill/94-2

A comparison of Noether charge and Euclidean methods for Computing the Entropy of Stationary Black Holes

The entropy of stationary black holes has recently been calculated by a number of different approaches. Here we compare the Noether charge approach (defined for any diffeomorphism invariant Lagrangian theory) with various Euclidean methods, specifically, (i) the microcanonical ensemble approach of Brown and York, (ii) the closely related approach of Ba\~nados, Teitelboim, and Zanelli which ultimately expresses black hole entropy in terms of the Hilbert action surface term, (iii) another formula of Ba\~nados, Teitelboim and Zanelli (also used by Susskind and Uglum) which views black hole entropy as conjugate to a conical deficit angle, and (iv) the pair creation approach of Garfinkle, Giddings, and Strominger. All of these approaches have a more restrictive domain of applicability than the Noether charge approach. Specifically, approaches (i) and (ii) appear to be restricted to a class of theories satisfying certain properties listed in section 2; approach (iii) appears to require the Lagrangian density to be linear in the curvature; and approach (iv) requires the existence of suitable instanton solutions. However, we show that within their domains of applicability, all of these approaches yield results in agreement with the Noether charge approach. In the course of our analysis, we generalize the definition of Brown and York's quasilocal energy to a much more general class of diffeomorphism invariant, Lagrangian theories of gravity. In an appendix, we show that in an arbitrary diffeomorphism invariant theory of gravity, the ``volume term" in the ``off-shell" Hamiltonian associated with a time evolution vector field $t^a$ always can be expressed as the spatial integral of $t^a {\cal C}_a$, where ${\cal C}_a = 0$ are the constraints associated with the diffeomorphism invariance.Comment: 29 pages (double-spaced) late

A Higher Dimensional Stationary Rotating Black Hole Must be Axisymmetric

A key result in the proof of black hole uniqueness in 4-dimensions is that a stationary black hole that is ``rotating''--i.e., is such that the stationary Killing field is not everywhere normal to the horizon--must be axisymmetric. The proof of this result in 4-dimensions relies on the fact that the orbits of the stationary Killing field on the horizon have the property that they must return to the same null geodesic generator of the horizon after a certain period, $P$. This latter property follows, in turn, from the fact that the cross-sections of the horizon are two-dimensional spheres. However, in spacetimes of dimension greater than 4, it is no longer true that the orbits of the stationary Killing field on the horizon must return to the same null geodesic generator. In this paper, we prove that, nevertheless, a higher dimensional stationary black hole that is rotating must be axisymmetric. No assumptions are made concerning the topology of the horizon cross-sections other than that they are compact. However, we assume that the horizon is non-degenerate and, as in the 4-dimensional proof, that the spacetime is analytic.Comment: 24 pages, no figures, v2: footnotes and references added, v3: numerous minor revision

Surface Terms as Counterterms in the AdS/CFT Correspondence

We examine the recently proposed technique of adding boundary counterterms to the gravitational action for spacetimes which are locally asymptotic to anti-de Sitter. In particular, we explicitly identify higher order counterterms, which allow us to consider spacetimes of dimensions d<=7. As the counterterms eliminate the need of ``background subtraction'' in calculating the action, we apply this technique to study examples where the appropriate background was ambiguous or unknown: topological black holes, Taub-NUT-AdS and Taub-Bolt-AdS. We also identify certain cases where the covariant counterterms fail to render the action finite, and we comment on the dual field theory interpretation of this result. In some examples, the case of vanishing cosmological constant may be recovered in a limit, which allows us to check results and resolve ambiguities in certain asymptotically flat spacetime computations in the literature.Comment: Revtex, 18 pages. References updated and few typo's fixed. Final versio

Quasilocal Thermodynamics of Dilaton Gravity coupled to Gauge Fields

We consider an Einstein-Hilbert-Dilaton action for gravity coupled to various types of Abelian and non-Abelian gauge fields in a spatially finite system. These include Yang-Mills fields and Abelian gauge fields with three and four-form field strengths. We obtain various quasilocal quantities associated with these fields, including their energy and angular momentum, and develop methods for calculating conserved charges when a solution possesses sufficient symmetry. For stationary black holes, we find an expression for the entropy from the micro-canonical form of the action. We also find a form of the first law of black hole thermodynamics for black holes with the gauge fields of the type considered here.Comment: 41 pages, latex, uses fonts provided by AMSTe

Preliminary evaluation of near infrared spectroscopy as a method to detect plasma leakage in children with dengue hemorrhagic fever

BACKGROUND: Dengue viral infections are prevalent in the tropical and sub-tropical regions of the world, resulting in substantial morbidity and mortality. Clinical manifestations range from a self-limited fever to a potential life-threatening plasma leakage syndrome (dengue hemorrhagic fever). The objective of this study was to assess the utility of near infrared spectroscopy (NIRS) measurements of muscle oxygen saturation (SmO2) as a possible continuous measure to detect plasma leakage in children with dengue. METHODS: Children ages 6 months to 15 years of age admitted with suspected dengue were enrolled from the dengue ward at Queen Sirikit National Institute for Child Health. Children were monitored daily until discharge. NIRS data were collected continuously using a prototype CareGuide Oximeter 1100 with sensors placed on the deltoid or thigh. Daily ultrasound of the chest and a right lateral decubitus chest x-ray the day after defervescence were performed to detect and quantitate plasma leakage in the pleural cavity. RESULTS: NIRS data were obtained from 19 children with laboratory-confirmed dengue. Average minimum SmO2 decreased for all subjects prior to defervescence. Average minimum SmO2 subsequently increased in children with no ultrasound evidence of pleural effusion but remained low in children with pleural effusion following defervescence. Average minimum SmO2 was inversely correlated with pleural space fluid volume. ROC analysis revealed a cut-off value for SmO2 which yielded high specificity and sensitivity. CONCLUSIONS: SmO2 measured using NIRS may be a useful guide for real-time and non-invasive identification of plasma leakage in children with dengue. Further investigation of the utility of NIRS measurements for prediction and management of severe dengue syndromes is warranted

Dengue Viral RNA Levels in Peripheral Blood Mononuclear Cells are Associated with Disease Severity and Preexisting Dengue Immune Status

Background Infection with dengue viruses (DENV) causes a wide range of manifestations from asymptomatic infection to a febrile illness called dengue fever (DF), to dengue hemorrhagic fever (DHF). The in vivo targets of DENV and the relation between the viral burden in these cells and disease severity are not known. Method The levels of positive and negative strand viral RNA in peripheral blood monocytes, T/NK cells, and B cells and in plasma of DF and DHF cases were measured by quantitative RT-PCR. Results Positive strand viral RNA was detected in monocytes, T/NK cells and B cells with the highest amounts found in B cells. Viral RNA levels in CD14+ cells and plasma were significantly higher in DHF compared to DF, and in cases with a secondary infection compared to those undergoing a primary infection. The distribution of viral RNA among cell subpopulations was similar in DF and DHF cases. Small amounts of negative strand RNA were found in a few cases only. The severity of plasma leakage correlated with viral RNA levels in plasma and in CD14+ cells. Conclusions B cells were the principal cells containing DENV RNA in peripheral blood, but overall there was little active DENV RNA replication detectable in peripheral blood mononuclear cells (PBMC). Secondary infection and DHF were associated with higher viral burden in PBMC populations, especially CD14+ monocytes, suggesting that viral infection of these cells may be involved in disease pathogenesis

The "physical process" version of the first law and the generalized second law for charged and rotating black holes

We investigate both the ``physical process'' version of the first law and the second law of black hole thermodynamics for charged and rotating black holes. We begin by deriving general formulas for the first order variation in ADM mass and angular momentum for linear perturbations off a stationary, electrovac background in terms of the perturbed non-electromagnetic stress-energy, $\delta T_{ab}$, and the perturbed charge current density, $\delta j^a$. Using these formulas, we prove the "physical process version" of the first law for charged, stationary black holes. We then investigate the generalized second law of thermodynamics (GSL) for charged, stationary black holes for processes in which a box containing charged matter is lowered toward the black hole and then released (at which point the box and its contents fall into the black hole and/or thermalize with the ``thermal atmosphere'' surrounding the black hole). Assuming that the thermal atmosphere admits a local, thermodynamic description with respect to observers following orbits of the horizon Killing field, and assuming that the combined black hole/thermal atmosphere system is in a state of maximum entropy at fixed mass, angular momentum, and charge, we show that the total generalized entropy cannot decrease during the lowering process or in the ``release process''. Consequently, the GSL always holds in such processes. No entropy bounds on matter are assumed to hold in any of our arguments.Comment: 35 pages; 1 eps figur