2,147 research outputs found
Bose--Einstein Condensation in the Large Deviations Regime with Applications to Information System Models
We study the large deviations behavior of systems that admit a certain form
of a product distribution, which is frequently encountered both in Physics and
in various information system models. First, to fix ideas, we demonstrate a
simple calculation of the large deviations rate function for a single
constraint (event). Under certain conditions, the behavior of this function is
shown to exhibit an analogue of Bose--Einstein condensation (BEC). More
interestingly, we also study the large deviations rate function associated with
two constraints (and the extension to any number of constraints is conceptually
straightforward). The phase diagram of this rate function is shown to exhibit
as many as seven phases, and it suggests a two--dimensional generalization of
the notion of BEC (or more generally, a multi--dimensional BEC). While the
results are illustrated for a simple model, the underlying principles are
actually rather general. We also discuss several applications and implications
pertaining to information system models
Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial.
BACKGROUND: Buruli ulcer is a neglected tropical disease caused by Mycobacterium ulcerans infection that damages the skin and subcutis. It is most prevalent in western and central Africa and Australia. Standard antimicrobial treatment with oral rifampicin 10 mg/kg plus intramuscular streptomycin 15 mg/kg once daily for 8 weeks (RS8) is highly effective, but streptomycin injections are painful and potentially harmful. We aimed to compare the efficacy and tolerability of fully oral rifampicin 10 mg/kg plus clarithromycin 15 mg/kg extended release once daily for 8 weeks (RC8) with that of RS8 for treatment of early Buruli ulcer lesions. METHODS: We did an open-label, non-inferiority, randomised (1:1 with blocks of six), multicentre, phase 3 clinical trial comparing fully oral RC8 with RS8 in patients with early, limited Buruli ulcer lesions. There were four trial sites in hospitals in Ghana (Agogo, Tepa, Nkawie, Dunkwa) and one in Benin (PobÚ). Participants were included if they were aged 5 years or older and had typical Buruli ulcer with no more than one lesion (caterories I and II) no larger than 10 cm in diameter. The trial was open label, and neither the investigators who took measurements of the lesions nor the attending doctors were masked to treatment assignment. The primary clinical endpoint was lesion healing (ie, full epithelialisation or stable scar) without recurrence at 52 weeks after start of antimicrobial therapy. The primary endpoint and safety were assessed in the intention-to-treat population. A sample size of 332 participants was calculated to detect inferiority of RC8 by a margin of 12%. This study was registered with ClinicalTrials.gov, NCT01659437. FINDINGS: Between Jan 1, 2013, and Dec 31, 2017, participants were recruited to the trial. We stopped recruitment after 310 participants. Median age of participants was 14 years (IQR 10-29) and 153 (52%) were female. 297 patients had PCR-confirmed Buruli ulcer; 151 (51%) were assigned to RS8 treatment, and 146 (49%) received oral RC8 treatment. In the RS8 group, lesions healed in 144 (95%, 95% CI 91 to 98) of 151 patients, whereas lesions healed in 140 (96%, 91 to 99) of 146 patients in the RC8 group. The difference in proportion, -0·5% (-5·2 to 4·2), was not significantly greater than zero (p=0·59), showing that RC8 treatment is non-inferior to RS8 treatment for lesion healing at 52 weeks. Treatment-related adverse events were recorded in 20 (13%) patients receiving RS8 and in nine (7%) patients receiving RC8. Most adverse events were grade 1-2, but one (1%) patient receiving RS8 developed serious ototoxicity and ended treatment after 6 weeks. No patients needed surgical resection. Four patients (two in each study group) had skin grafts. INTERPRETATION: Fully oral RC8 regimen was non-inferior to RS8 for treatment of early, limited Buruli ulcer and was associated with fewer adverse events. Therefore, we propose that fully oral RC8 should be the preferred therapy for early, limited lesions of Buruli ulcer. FUNDING: WHO with additional support from MAP International, American Leprosy Missions, Fondation Raoul Follereau France, Buruli ulcer Groningen Foundation, Sanofi-Pasteur, and BuruliVac
UBVRIz light curves of 51 type II supernovae
We present a compilation of UBVRIz light curves of 51 type II supernovae discovered during the course of four
different surveys during 1986â2003: the Cerro Tololo Supernova Survey, the CalĂĄn/Tololo Supernova Program
(C&T), the Supernova Optical and Infrared Survey (SOIRS), and the Carnegie Type II Supernova Survey (CATS). The photometry is based on template-subtracted images to eliminate any potential host galaxy light contamination, and calibrated from foreground stars. This work presents these photometric data, studies the color evolution using different bands, and explores the relation between the magnitude at maximum brightness and the brightness decline parameter (s) from maximum light through the end of the recombination phase. This parameter is found to be shallower for redder bands and appears to have the best correlation in the B band. In addition, it also correlates with the plateau duration, being shorter (longer) for larger (smaller) s values
Implications of Electronics Constraints for Solid-State Quantum Error Correction and Quantum Circuit Failure Probability
In this paper we present the impact of classical electronics constraints on a
solid-state quantum dot logical qubit architecture. Constraints due to routing
density, bandwidth allocation, signal timing, and thermally aware placement of
classical supporting electronics significantly affect the quantum error
correction circuit's error rate. We analyze one level of a quantum error
correction circuit using nine data qubits in a Bacon-Shor code configured as a
quantum memory. A hypothetical silicon double quantum dot quantum bit (qubit)
is used as the fundamental element. A pessimistic estimate of the error
probability of the quantum circuit is calculated using the total number of
gates and idle time using a provably optimal schedule for the circuit
operations obtained with an integer program methodology. The micro-architecture
analysis provides insight about the different ways the electronics impact the
circuit performance (e.g., extra idle time in the schedule), which can
significantly limit the ultimate performance of any quantum circuit and
therefore is a critical foundation for any future larger scale architecture
analysis.Comment: 10 pages, 7 figures, 3 table
Acceleration of Solar Wind Ions by Nearby Interplanetary Shocks: Comparison of Monte Carlo Simulations with Ulysses Observations
The most stringent test of theoretical models of the first-order Fermi
mechanism at collisionless astrophysical shocks is a comparison of the
theoretical predictions with observational data on particle populations. Such
comparisons have yielded good agreement between observations at the
quasi-parallel portion of the Earth's bow shock and three theoretical
approaches, including Monte Carlo kinetic simulations. This paper extends such
model testing to the realm of oblique interplanetary shocks: here observations
of proton and alpha particle distributions made by the SWICS ion mass
spectrometer on Ulysses at nearby interplanetary shocks are compared with test
particle Monte Carlo simulation predictions of accelerated populations. The
plasma parameters used in the simulation are obtained from measurements of
solar wind particles and the magnetic field upstream of individual shocks. Good
agreement between downstream spectral measurements and the simulation
predictions are obtained for two shocks by allowing the the ratio of the
mean-free scattering length to the ionic gyroradius, to vary in an optimization
of the fit to the data. Generally small values of this ratio are obtained,
corresponding to the case of strong scattering. The acceleration process
appears to be roughly independent of the mass or charge of the species.Comment: 26 pages, 6 figures, AASTeX format, to appear in the Astrophysical
Journal, February 20, 199
Cosmological Results from High-z Supernovae
The High-z Supernova Search Team has discovered and observed 8 new supernovae
in the redshift interval z=0.3-1.2. These independent observations, confirm the
result of Riess et al. (1998a) and Perlmutter et al. (1999) that supernova
luminosity distances imply an accelerating universe. More importantly, they
extend the redshift range of consistently observed SN Ia to z~1, where the
signature of cosmological effects has the opposite sign of some plausible
systematic effects. Consequently, these measurements not only provide another
quantitative confirmation of the importance of dark energy, but also constitute
a powerful qualitative test for the cosmological origin of cosmic acceleration.
We find a rate for SN Ia of 1.4+/-0.5E-04 h^3/Mpc^3/yr at a mean redshift of
0.5. We present distances and host extinctions for 230 SN Ia. These place the
following constraints on cosmological quantities: if the equation of state
parameter of the dark energy is w=-1, then H0 t0 = 0.96+/-0.04, and O_l - 1.4
O_m = 0.35+/-0.14. Including the constraint of a flat Universe, we find O_m =
0.28+/-0.05, independent of any large-scale structure measurements. Adopting a
prior based on the 2dF redshift survey constraint on O_m and assuming a flat
universe, we find that the equation of state parameter of the dark energy lies
in the range -1.48-1,
we obtain w<-0.73 at 95% confidence. These constraints are similar in precision
and in value to recent results reported using the WMAP satellite, also in
combination with the 2dF redshift survey.Comment: 50 pages, AAS LateX, 15 figures, 15 tables. Accepted for publication
by Astrophysical Journa
CXCR4 expression on circulating pan-cytokeratin positive cells is associated with survival in patients with advanced non-small cell lung cancer
<p>Abstract</p> <p>Background</p> <p>The CXC chemokine, CXCL12, and its receptor, CXCR4 promote metastases of a variety of solid tumors, including non-small cell lung cancer (NSCLC). The expression of CXCR4 on tumor cells may represent a critical biomarker for their propensity to metastasize. This study was performed to evaluate the hypothesis that co-expression of pan-cytokeratin and CXCR4 may be a prognostic marker for patients with advanced NSCLC.</p> <p>Methods</p> <p>We evaluated CXCR4 levels on circulating pan-cytokeratin positive cells from patients with NSCLC. NSCLC tumor and metastases were also assessed for the presence of CXCR4.</p> <p>Results</p> <p>Pan-cytokeratin positive cells were increased in the circulation of patients with NSCLC, as compared to normal control subjects. Patients with pan-cytokeratin +/CXCR4+ = 2,500 cells/ml had a significant improvement in median survival when compared with patients with pan-cytokeratin +/CXCR4+ >2,500 cells/ml (not achieved versus 14 weeks). CXCR4 expression was found on NSCLC tumors and at sites of tumor metastasis.</p> <p>Conclusion</p> <p>This study suggests that CXCR4 may be a prognostic marker in NSCLC, and provides hypothesis-generating results, which may be important in determining metastatic potential. In future studies, we will prospectively evaluate the prognostic significance of pan-cytokeratin/CXCR4+ cells, and determine the mechanisms involved in the regulation of CXCR4 expression on tumor cells in a larger patient population.</p
Imaging and Demography of the Host Galaxies of High-Redshift Type Ia Supernovae
We present the results of a study of the host galaxies of high redshift Type
Ia supernovae (SNe Ia). We provide a catalog of 18 hosts of SNe Ia observed
with the Hubble Space Telescope (HST) by the High-z Supernova Search Team
(HZT), including images, scale-lengths, measurements of integrated (Hubble
equivalent) BVRIZ photometry in bands where the galaxies are brighter than m ~
25 mag, and galactocentric distances of the supernovae. We compare the
residuals of SN Ia distance measurements from cosmological fits to measurable
properties of the supernova host galaxies that might be expected to correlate
with variable properties of the progenitor population, such as host galaxy
color and position of the supernova. We find mostly null results; the current
data are generally consistent with no correlations of the distance residuals
with host galaxy properties in the redshift range 0.42 < z < 1.06. Although a
subsample of SN hosts shows a formally significant (3-sigma) correlation
between apparent V-R host color and distance residuals, the correlation is not
consistent with the null results from other host colors probed by our largest
samples. There is also evidence for the same correlations between SN Ia
properties and host type at low redshift and high redshift. These similarities
support the current practice of extrapolating properties of the nearby
population to high redshifts pending more robust detections of any correlations
between distance residuals from cosmological fits and host properties.Comment: 35 pages, 12 figures, 4 tables, accepted for publication in A
ROSAT observations of X-ray emission from planetary nebulae
We have searched the entire ROSAT archive for useful observations to study
X-ray emission from Galactic planetary nebulae (PNs). The search yields a
sample of 63 PNs, which we call the ROSAT PN sample. About 20-25% of this
sample show X-ray emission; these include 13 definite detections and three
possible detections (at a 2-sigma level). All X-ray sources in these PNs are
concentrated near the central stars. Only A 30, BD+30 3639, and NGC 6543 are
marginally resolved by the ROSAT instruments. Three types of X-ray spectra are
seen in PNs. Type 1 consists of only soft X-ray emission (<0.5 keV), peaks at
0.1-0.2 keV, and can be fitted by blackbody models at temperatures 1-2 10^5 K.
Type 2 consists of harder X-ray emission, peaks at >0.5 keV, and can be fitted
by thin plasma emission models at temperatures of a few 10^6 K. Type 3 is a
composite of a bright Type 1 component and a fainter Type 2 component.
Unresolved soft sources with Type 1 spectra or the soft component of Type 3
spectra are most likely photospheric emission from the hot central stars.
Absorption cross sections are large for these soft-energy photons; therefore,
only large, tenuous, evolved PNs with hot central stars and small absorption
column densities have been detected. The origin of hard X-ray emission from PNs
is uncertain. PNs with Type 2 spectra are small, dense, young nebulae with
relatively cool (<<10^5 K) central stars, while PNs with Type 3 X-ray spectra
are large, tenuous, evolved nebulae with hot central stars. The hard X-ray
luminosities are also different between these two types of PNs, indicating
perhaps different origins of their hard X-ray emission. Future Chandra and XMM
observations with high spatial and spectral resolution will help to understand
the origin of hard X-ray emission from PNs.Comment: To be published in The Astrophysical Journal Supplement Series. 21
pages, 7 figures, 5 table
The Absolute Magnitudes of Type Ia Supernovae in the Ultraviolet
We examine the absolute magnitudes and light-curve shapes of 14
nearby(redshift z = 0.004--0.027) Type Ia supernovae (SNe~Ia) observed in the
ultraviolet (UV) with the Swift Ultraviolet/Optical Telescope. Colors and
absolute magnitudes are calculated using both a standard Milky Way (MW)
extinction law and one for the Large Magellanic Cloud that has been modified by
circumstellar scattering. We find very different behavior in the near-UV
filters (uvw1_rc covering ~2600-3300 A after removing optical light, and u
~3000--4000 A) compared to a mid-UV filter (uvm2 ~2000-2400 A). The uvw1_rc-b
colors show a scatter of ~0.3 mag while uvm2-b scatters by nearly 0.9 mag.
Similarly, while the scatter in colors between neighboring filters is small in
the optical and somewhat larger in the near-UV, the large scatter in the
uvm2-uvw1 colors implies significantly larger spectral variability below 2600
A. We find that in the near-UV the absolute magnitudes at peak brightness of
normal SNe Ia in our sample are correlated with the optical decay rate with a
scatter of 0.4 mag, comparable to that found for the optical in our sample.
However, in the mid-UV the scatter is larger, ~1 mag, possibly indicating
differences in metallicity. We find no strong correlation between either the UV
light-curve shapes or the UV colors and the UV absolute magnitudes. With larger
samples, the UV luminosity might be useful as an additional constraint to help
determine distance, extinction, and metallicity in order to improve the utility
of SNe Ia as standardized candles.Comment: 59 pages, accepted for publication in Ap
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