Spectral synthesis in the multiplier algebra of a C_0(X)-algebra

We are grateful to the referee for a number of helpful comments and for pointing out an error in the original proof of Theorem 3.6.Peer reviewedPostprin

The Inner Corona Algebra of a C0(X)-Algebra

We are grateful to the referee for a number of helpful comments.Peer reviewedPostprin

Separation properties in the primitive ideal space of a multiplier algebra

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Norms of inner derivations for multiplier algebras of C ∗ -algebras and group C ∗ -algebras, II

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The centre-quotient property and weak centrality for C∗-algebras

Funding The second-named author was fully supported by the Croatian Science Foundation under the project IP-2016-06-1046.Peer reviewedPostprin

Local variants of the Dixmier property and weak centrality for C*-algebras

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Minimal primal ideals in the inner corona algebra of a C_{0}(X)-algebra

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Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

On the real rank of C∗C^\ast-algebras of nilpotent locally compact groups

If $G$ is an almost connected, nilpotent, locally compact group then the real rank of the $C^\ast$-algebra $C^\ast (G)$ is given by $\operatorname {RR} (C^\ast (G)) = \operatorname {rank} (G/[G,G]) = \operatorname {rank} (G_0/[G_0,G_0])$, where $G_0$ is the connected component of the identity element. In particular, for the continuous Heisenberg group $G_3$, $\operatorname {RR} C^\ast (G_3))=2$