Newborn survival: a multi-country analysis of a decade of change

Neonatal deaths account for 40% of global under-five mortality and are ever more important if we are to achieve the Millennium Development Goal 4 (MDG 4) on child survival. We applied a results framework to evaluate global and national changes for neonatal mortality rates (NMR), healthy behaviours, intervention coverage, health system change, and inputs including funding, while considering contextual changes. The average annual rate of reduction of NMR globally accelerated between 2000 and 2010 (2.1% per year) compared with the 1990s, but was slower than the reduction in mortality of children aged 1-59 months (2.9% per year) and maternal mortality (4.2% per year). Regional variation of NMR change ranged from 3.0% per year in developed countries to 1.5% per year in sub-Saharan Africa. Some countries have made remarkable progress despite major challenges. Our statistical analysis identifies inter-country predictors of NMR reduction including high baseline NMR, and changes in income or fertility. Changes in intervention or package coverage did not appear to be important predictors in any region, but coverage data are lacking for several neonatal-specific interventions. Mortality due to neonatal infection deaths, notably tetanus, decreased, and deaths from complications of preterm birth are increasingly important. Official development assistance for maternal, newborn and child health doubled from 2003 to 2008, yet by 2008 only 6% of this aid mentioned newborns, and a mere 0.1% (US$4.56m) exclusively targeted newborn care. The amount of newborn survival data and the evidence based increased, as did recognition in donor funding. Over this decade, NMR reduction seems more related to change in context, such as socio-economic factors, than to increasing intervention coverage. High impact cost-effective interventions hold great potential to save newborn lives especially in the highest burden countries. Accelerating progress requires data-driven investments and addressing context-specific implementation realitie

A GALEX Ultraviolet Imaging Survey of Galaxies in the Local Volume

We present results from a GALEX ultraviolet (UV) survey of a complete sample of 390 galaxies within ~11 Mpc of the Milky Way. The UV data are a key component of the composite Local Volume Legacy (LVL), an ultraviolet-to-infrared imaging program designed to provide an inventory of dust and star formation in nearby spiral and irregular galaxies. The ensemble dataset is an especially valuable resource for studying star formation in dwarf galaxies, which comprise over 80% of the sample. We describe the GALEX survey programs which obtained the data and provide a catalog of far-UV (~1500 Angstroms) and near-UV (~2200 Angstroms) integrated photometry. General UV properties of the sample are briefly discussed. We compute two measures of the global star formation efficiency, the SFR per unit HI gas mass and the SFR per unit stellar mass, to illustrate the significant differences that can arise in our understanding of dwarf galaxies when the FUV is used to measure the SFR instead of H-alpha. We find that dwarf galaxies may not be as drastically inefficient in coverting gas into stars as suggested by prior H-alpha studies. In this context, we also examine the UV properties of late-type dwarf galaxies that appear to be devoid of star formation because they were not detected in previous H-alpha narrowband observations. Nearly all such galaxies in our sample are detected in the FUV, and have FUV SFRs that fall below the limit where the H-alpha flux is robust to Poisson fluctuations in the formation of massive stars. The UV colors and star formation efficiencies of H-alpha-undetected, UV-bright dwarf irregulars appear to be relatively unremarkable with respect to those exhibited by the general population of star-forming galaxies.Comment: submitted to ApJS, revised per referee's comments; accepted Oct. 30 w/o further revision; 37 pages; figure 6 omitted due to size; figure available from http://users.obs.carnegiescience.edu/jlee/paper

Characterizing Ultraviolet and Infrared Observational Properties for Galaxies. I. Influences of Dust Attenuation and Stellar Population Age

The correlation between infrared-to-ultraviolet luminosity ratio and ultraviolet color, i.e. the IRX-UV relation, was regarded as a prevalent recipe for correcting extragalactic dust attenuation. Considerable dispersion in this relation discovered for normal galaxies, however, complicates its usability. In order to investigate the cause of the dispersion, in this paper, we select five nearby spiral galaxies, and perform spatially resolved studies on each of the galaxies, with a combination of ultraviolet and infrared imaging data. We measure all positions within each galaxy and divide the extracted regions into young and evolved stellar populations. By means of this approach, we attempt to discover separate effects of dust attenuation and stellar population age on the IRX-UV relation for individual galaxies. In this work, in addition to dust attenuation, stellar population age is interpreted to be another parameter in the IRX-UV function, and the diversity of star formation histories is suggested to disperse the age effects. At the same time, strong evidence shows the necessity of more parameters in the interpretation of observational data, such as variations in attenuation/extinction law. Fractional contributions of different components to the integrated luminosities of the galaxies suggest that the integrated measurements of galaxies which comprise different populations would weaken the effect of the age parameter on IRX-UV diagrams. The dependance of the IRX-UV relation on luminosity and radial distance in galaxies presents weak trends, which offers an implication of selective effects. The two-dimensional maps of the UV color and the infrared-to-ultraviolet ratio are displayed and show a disparity in the spatial distributions between the two parameters in galaxies, which offers a spatial interpretation of the scatter in the IRX-UV relation.Comment: 23 pages, 27 figures, 4 tables; accepted for publication in The Astrophysical Journal; re-typesetted in the emulateapj style; minor corrections in the figure symbols and in the tex

Star Formation in Luminous HII regions in M33

We present a multiwavelength (ultraviolet, infrared, optical and CO) study of a set of luminous HII regions in M33: NGC 604, NGC 595, NGC 592, NGC 588 and IC131. We study the emission distribution in the interiors of the HII regions to investigate the relation between the dust emission at 8 micron and 24 micron and the location of the massive stars and gas. We find that the 24 micron emission is closely related to the location of the ionized gas, while the 8 micron emission is more related to the boundaries of the molecular clouds consistently with its expected association with photodissociation regions (PDRs). Ultraviolet emission is generally surrounded by the H-alpha emission. For NGC 604 and NGC 595, where CO data are available, we see a radial gradient of the emission distribution at the wavelengths studied here: from the center to the boundary of the HII regions we observe ultraviolet, H-alpha, 24 micron, 8 micron and CO emission distributions. We quantify the star formation for our HII regions using the integrated fluxes at the set of available wavelengths, assuming an instantaneous burst of star formation. We show that a linear combination of 24 micron and H-alpha emission better describes the star formation for these objects than the dust luminosities by themselves. For NGC 604, we obtain and compare extinction maps derived from the Balmer decrement and from the 24 micron and H-alpha emission line ratio. Although the maps show locally different values in extinction, we find similar integrated extinctions derived from the two methods. We also investigate here the possible existence of embedded star formation within NGC 604.Comment: 46 pages, 12 figures, accepted for publication in The Astrophysical Journal; pdf format available at http://www.ast.cam.ac.uk/~mrelano

Comparison of H-alpha and UV Star Formation Rates in the Local Volume: Systematic Discrepancies for Dwarf Galaxies

(abridged) Using a complete sample of ~300 star-forming galaxies within 11 Mpc, we evaluate the consistency between star formation rates (SFRs) inferred from the far ultraviolet (FUV) non-ionizing continuum and H-alpha nebular emission, assuming standard conversion recipes in which the SFR scales linearly with luminosity at a given wavelength. Our analysis probes SFRs over 5 orders of magnitude, down to ultra-low activities on the order of ~0.0001 M_sun/yr. The data are drawn from the 11 Mpc H-alpha and Ultraviolet Galaxy Survey (11HUGS), which has obtained H-alpha fluxes from ground-based narrowband imaging, and UV fluxes from imaging with GALEX. For normal spiral galaxies (SFR~1 M_sun/yr), our results are consistent with previous work which has shown that FUV SFRs tend to be lower than H-alpha SFRs before accounting for internal dust attenuation, but that there is relative consistency between the two tracers after proper corrections are applied. However, a puzzle is encountered at the faint end of the luminosity function. As lower luminosity dwarf galaxies, roughly less active than the Small Magellanic Cloud, are examined, H-alpha tends to increasingly under-predict the SFR relative to the FUV. Although past studies have suggested similar trends, this is the first time this effect is probed with a statistical sample for galaxies with SFR~<0.1 M_sun/yr. A range of standard explanations does not appear to be able to account for the magnitude of the systematic. Some recent work has argued for an IMF which is deficient in high mass stars in dwarf and low surface brightness galaxies, and we also consider this scenario.Comment: 29 pages, 10 figures, 2 tables, accepted for publication in Ap

Ultraviolet and Infrared Diagnostics of Star Formation and Dust in NGC 7331

We present images of NGC 7331 obtained with GALEX and Spitzer, tracing UV and IR signatures of star formation. NGC 7331's morphology at 8-850 μm is dominated by a central dust ring. This structure is a vigorous site of star formation (hosting one-third of the present activity) but remains inconspicuous in our GALEX UV imagery. Radial profile analysis and photometry for discrete UV- and UV+IR-selected substructures indicate a decline in UV extinction with increasing galactocentric distance, although highly attenuated star-forming regions can be found throughout the disk. UV-optical surface brightness profiles suggest a recent birthrate parameter (b_8) that is highest in the outer part of the disk, even though the local star formation intensity peaks in the ring. Bolometric luminosity and UV attenuation are correlated in substructures on 0.4 kpc scales, with a relationship similar to that established for starburst galaxies. The distribution of substructures in L(IR)/L(FUV), L_λ(FUV)/L_λ(NUV) space suggests that the majority of the disk is best characterized by Milky Way-type dust, with the exception of sources in the star-forming ring. As found by Calzetti et al. in M51, the observed 8 and 24 μm luminosity for substructures in NGC 7331 are correlated, showing a decline in L_ν(8 μm)/L_ν(24 μm) with increasing luminosity. We demonstrate the dependence of L_ν(8 μm)/L_ν(24 μm) on the local extinction-corrected Hα surface brightness (hence current Σ_(SFR)). A power law of slope 1.64 (1.87) accurately describes the Schmidt-law relation versus Σ_(H_2) (Σ_(gas)) for molecular-dominated environments. The same locations show no correlation between Σ_(SFR) and Σ_(HI). For atomic-dominated regions above an apparent local star formation threshold, we found a trend for increasing Σ_(SFR) at higher Σ_(HI) , although the Schmidt-law correlation with molecular-only surface density persists in areas dominated by atomic gas

Heat Safety in the Workplace:Modified Delphi Consensus to Establish Strategies and Resources to Protect U.S Workers

The purpose of this consensus document was to develop feasible, evidence‐based occupational heat safety recommendations to protect the US workers that experience heat stress. Heat safety recommendations were created to protect worker health and to avoid productivity losses associated with occupational heat stress. Recommendations were tailored to be utilized by safety managers, industrial hygienists, and the employers who bear responsibility for implementing heat safety plans. An interdisciplinary roundtable comprised of 51 experts was assembled to create a narrative review summarizing current data and gaps in knowledge within eight heat safety topics: (a) heat hygiene, (b) hydration, (c) heat acclimatization, (d) environmental monitoring, (e) physiological monitoring, (f) body cooling, (g) textiles and personal protective gear, and (h) emergency action plan implementation. The consensus‐based recommendations for each topic were created using the Delphi method and evaluated based on scientific evidence, feasibility, and clarity. The current document presents 40 occupational heat safety recommendations across all eight topics. Establishing these recommendations will help organizations and employers create effective heat safety plans for their workplaces, address factors that limit the implementation of heat safety best‐practices and protect worker health and productivity

DNA Polymerase Epsilon Deficiency Causes IMAGe Syndrome with Variable Immunodeficiency.

During genome replication, polymerase epsilon (Pol ε) acts as the major leading-strand DNA polymerase. Here we report the identification of biallelic mutations in POLE, encoding the Pol ε catalytic subunit POLE1, in 15 individuals from 12 families. Phenotypically, these individuals had clinical features closely resembling IMAGe syndrome (intrauterine growth restriction [IUGR], metaphyseal dysplasia, adrenal hypoplasia congenita, and genitourinary anomalies in males), a disorder previously associated with gain-of-function mutations in CDKN1C. POLE1-deficient individuals also exhibited distinctive facial features and variable immune dysfunction with evidence of lymphocyte deficiency. All subjects shared the same intronic variant (c.1686+32C>G) as part of a common haplotype, in combination with different loss-of-function variants in trans. The intronic variant alters splicing, and together the biallelic mutations lead to cellular deficiency of Pol ε and delayed S-phase progression. In summary, we establish POLE as a second gene in which mutations cause IMAGe syndrome. These findings add to a growing list of disorders due to mutations in DNA replication genes that manifest growth restriction alongside adrenal dysfunction and/or immunodeficiency, consolidating these as replisome phenotypes and highlighting a need for future studies to understand the tissue-specific development roles of the encoded proteins

The Cell Adhesion Molecule “CAR” and Sialic Acid on Human Erythrocytes Influence Adenovirus In Vivo Biodistribution

Although it has been known for 50 years that adenoviruses (Ads) interact with erythrocytes ex vivo, the molecular and structural basis for this interaction, which has been serendipitously exploited for diagnostic tests, is unknown. In this study, we characterized the interaction between erythrocytes and unrelated Ad serotypes, human 5 (HAd5) and 37 (HAd37), and canine 2 (CAV-2). While these serotypes agglutinate human erythrocytes, they use different receptors, have different tropisms and/or infect different species. Using molecular, biochemical, structural and transgenic animal-based analyses, we found that the primary erythrocyte interaction domain for HAd37 is its sialic acid binding site, while CAV-2 binding depends on at least three factors: electrostatic interactions, sialic acid binding and, unexpectedly, binding to the coxsackievirus and adenovirus receptor (CAR) on human erythrocytes. We show that the presence of CAR on erythrocytes leads to prolonged in vivo blood half-life and significantly reduced liver infection when a CAR-tropic Ad is injected intravenously. This study provides i) a molecular and structural rationale for Ad–erythrocyte interactions, ii) a basis to improve vector-mediated gene transfer and iii) a mechanism that may explain the biodistribution and pathogenic inconsistencies found between human and animal models