Adapting to Retention: A Naturalistic Study Revealing the Coping Resources of Nonpromoted Students and Their Parents

The purpose of this study was to uncover the feelings and reactions of students and their parents in regard to the nonpromotion experience. Families with children who had been retained at least once in grades one through eight were purposefully selected as units of study from one of four area school systems. A total of 52 family members from 22 family units participated in 46 separate, qualitative interviews. The information collected from the interviews was inductively analyzed. Building upon Schlossberg\u27s theory for human adaptation to transitions, seven factors or coping resources emerged from the data that affected the adaptation of a parent or a student to a grade level retention. These factors fell into one of three categories--the characteristics of the individual, the characteristics surrounding the transition (the retention), and the characteristics of the individual\u27s environment. The analysis revealed the following seven coping resources: self-definition of an individual, previous experience with retention, retention philosophy of the individual, feelings of empowerment connected to the retention decision, retention rationale or reason for the retention, sense of belonging to the school community, and support systems available to the individual. From the findings, the investigator reached the following conclusions: (1) regardless of their initial feelings toward a retention decision, most students, as well as other family members, eventually assimilated a nonpromotion experience; (2) the seven identified coping resources influenced the success of an individual\u27s adaptation to a retention experience; (3) school personnel did little to initially prepare a child for a nonpromotion and generally offered little support to aid adaptation to the retention; (4) the relationships an educator developed with family members were essential in establishing a sense of trust and of cooperation between the home and the school; (5) school systems rarely provided parents of children in grades one through eight with the strategies necessary to academically aid a child within the home environment; (6) adherence to rigid, grade level curriculum placed undue stress on many students and their families, inadvertently reinforcing the acceptance of the practice of retention by parents and by students

Immunotherapy of Neuroblastoma: Facts and Hopes

While the adoption of multimodal therapy including surgery, radiation, and aggressive combination-chemotherapy has improved outcomes for many children with high-risk neuroblastoma, we appear to have reached a plateau in what can be achieved with cytotoxic therapies alone. Most children with cancer, including high-risk neuroblastoma, do not benefit from treatment with immune-checkpoint-inhibitors (ICI) that have revolutionized the treatment of many highly immunogenic adult solid tumors. This likely reflects the low tumor mutation burden as well as the downregulated MHC-I that characterizes most high-risk neuroblastomas. For these reasons, neuroblastoma represents an immunotherapeutic challenge that may be a model for the creation of effective immunotherapy for other "cold" tumors in children and adults that do not respond to ICI. The identification of strong expression of the disialoganglioside, GD2, on the surface of nearly all neuroblastoma cells provided a target for immune recognition by anti-GD2 mAbs which recruit Fc-receptor-expressing innate immune cells that mediate cytotoxicity or phagocytosis. Adoption of anti-GD2 antibodies into both upfront and relapse treatment protocols has dramatically increased survival rates and altered the landscape for children with high-risk neuroblastoma. This review describes how these approaches have been expanded to additional combinations and forms of immunotherapy that have already demonstrated clear clinical benefit. We also describe the efforts to identify additional immune targets for neuroblastoma. Finally we summarize newer approaches being pursued that may well help both innate and adaptive immune cells, endogenous or genetically engineered, to more effectively destroy neuroblastoma cells, in order to better induce complete remission and prevent recurrence

Attachment and Autism Spectrum Conditions: Exploring Mary Main’s Coding Notes

Distinguishing autism spectrum behaviours from behaviours relating to disorganised attachment can be challenging. There is, for instance, a notable overlap between both conditions in terms of behaviours deemed stereotypical. In addition, there are also similarities regarding some atypical social overtures. Responding to this overlap has been the subject for much debate in the literature. Disorganised attachment was first introduced and conceptualised by the attachment researcher, Mary Main. Main is considered the leading authority on coding this phenomenon. During the course of archival research, we obtained Main’s notes on coding attachment in a group of fifteen children with autism spectrum conditions (hereafter ASC). Drawing on these texts, this paper explores Main’s reasoning when making distinctions between ASC and attachment at the behavioural level. Our approach is informed by Chang’s (2017) argument for the potential of “history as complementary science. Analysis indicate that, for Main, frequency and timing was an important differential factor when attributing a behaviour to either ASC or the child’s attachment pattern.The authors wish to thank the Wellcome Trust [Grant WT103343MA] and the NIHR School of Primary Care Research [RG94577

Banner News

https://openspace.dmacc.edu/banner_news/1104/thumbnail.jp

Banner News

https://openspace.dmacc.edu/banner_news/1099/thumbnail.jp

Identifying quality improvement intervention publications - A comparison of electronic search strategies

Abstract Background The evidence base for quality improvement (QI) interventions is expanding rapidly. The diversity of the initiatives and the inconsistency in labeling these as QI interventions makes it challenging for researchers, policymakers, and QI practitioners to access the literature systematically and to identify relevant publications. Methods We evaluated search strategies developed for MEDLINE (Ovid) and PubMed based on free text words, Medical subject headings (MeSH), QI intervention components, continuous quality improvement (CQI) methods, and combinations of the strategies. Three sets of pertinent QI intervention publications were used for validation. Two independent expert reviewers screened publications for relevance. We compared the yield, recall rate, and precision of the search strategies for the identification of QI publications and for a subset of empirical studies on effects of QI interventions. Results The search yields ranged from 2,221 to 216,167 publications. Mean recall rates for reference publications ranged from 5% to 53% for strategies with yields of 50,000 publications or fewer. The 'best case' strategy, a simple text word search with high face validity ('quality' AND 'improv*' AND 'intervention*') identified 44%, 24%, and 62% of influential intervention articles selected by Agency for Healthcare Research and Quality (AHRQ) experts, a set of exemplar articles provided by members of the Standards for Quality Improvement Reporting Excellence (SQUIRE) group, and a sample from the Cochrane Effective Practice and Organization of Care Group (EPOC) register of studies, respectively. We applied the search strategy to a PubMed search for articles published in 10 pertinent journals in a three-year period which retrieved 183 publications. Among these, 67% were deemed relevant to QI by at least one of two independent raters. Forty percent were classified as empirical studies reporting on a QI intervention. Conclusions The presented search terms and operating characteristics can be used to guide the identification of QI intervention publications. Even with extensive iterative development, we achieved only moderate recall rates of reference publications. Consensus development on QI reporting and initiatives to develop QI-relevant MeSH terms are urgently needed

(En)gendering the political: Citizenship from marginal spaces

This introduction sets out the central concerns of this special issue, the relationship between marginality and the political. In doing so it makes the argument that the process of marginalisation, the sites and experiences of ‘marginality’ provide a different lens through which to understand citizenship. Viewing the political as the struggle over belonging it considers how recent studies of citizenship have understood political agency. It argues that marginality can help us understand multiple scales, struggles and solidarities both within and beyond citizenship. Whilst there is a radical potential in much of the existing literature in citizenship studies it is also important to consider political subjectivities and acts which are not subsumed by right claims. Exploring marginality in this way means understanding how subjects are disenfranchised by regimes of citizenship and at the same how time this also (en)genders new political possibilities which are not always orientated towards 'inclusion'. The introduction then sets out how each article contributes to this project

A transient presence: black visitors and sojourners in Imperial Germany, 1884-1914

The onset of German colonial rule in Africa brought increasing numbers of Black men and women to Germany. Pre-1914 the vast majority of these Africans can best be described as visitors or sojourners and the Black population as a whole was a transient one. This makes recovering their presence in the archival record exceptionally difficult and it is not surprising that the existing historiography almost exclusively focuses on individual biographies of well documented lives. Through utilising a number of newly digitised archival materials, particularly the Hamburg Passenger Lists, this article draws upon a database with information on 1092 individuals from sub-Saharan Africa who spent time in Germany over the period 1884-1914 in order to add considerable bread and depth to our understanding of the Black presence as a whole. It provides increasing empirical detail about the make-up and character of this fluid population - where visitors came from, why they came to Germany, their age on arrival - as well as more accurate detail on the temporal and, to a lesser extent, spatial distribution of visitors

Peripheral blood mononuclear cells from neovascular age-related macular degeneration patients produce higher levels of chemokines CCL2 (MCP-1) and CXCL8 (IL-8)

Flow cytometry analysis of PBMCs. PBMCs were first divided into CD11b+CD3−, CD11b−CD3+ and CD11b−CD3− cells (A) and the average percentage of all samples (n = 55) was analysed before and after stimulation with PMA/ionomycin (B). Figure S2. Percentage of total IL-4 and IL-10 producing PBMCs and percentage of CD11b−CD3+ IL-17A and IFNγ producing PBMCs (almost all of IL-17A and IFNγ producing PBMCs were CD11b−CD3+) from controls and nAMD patients under non-stimulated culture conditions and after stimulation with PMA/ionomycin. Controls n = 27, nAMD = 28; mean + SEM are shown. (PDF 413 kb