New Late Permian paleomagnetic data from Argentina: Refinement of the apparent polar wander path of Gondwana

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95004/1/ggge1994.pd

The Roman fortlet or defended watch-tower/pharos at St John the Baptist, Reedham, Norfolk and the early medieval origins of the church

To locate the source(s) of the Roman building materials re-used in the church of St John the Baptist, Reedham, Norfolk, survey by ground-penetrating radar within the church and churchyard identified areas of potential interest. These were investigated by small-scale excavation. Roman fabric employing Leziate grey quartzite rock, and brick and tile, was found in two locations about 25 m apart. The style of Roman build is consistent with that of a military structure such as the Saxon Shore fort at Brancaster built using the same stone as at Reedham. Tenth-century pottery was found incorporated in patches of mortar flooring located in one trench within the outline of a rectangular structure, c. 11.5 m by 3.75 m, partly confirmed by excavation and aligned parallel with the north wall of the nave. Radiocarbon dates give an approximate terminus post quem for the mortar floor of the mid-seventh to mid-eighth century. The trench was situated opposite a stretch of nave wall built solely of Roman brick and tile and cut by an arch of c. 1200, subsequently blocked c. 1300. Our results suggest an early medieval side chapel or porticus built against the north wall of an early (mid-seventh to mid-eighth-century) medieval church

The propeptide mediates formation of stromal stores of PROMIC-1: Role in determining prostate cancer outcome

The extracellular matrix (ECM) is a reservoir of cellular binding proteins and growth factors that are critical for normal cell behavior, and aberrations in the ECM invariably accompany malignancies such as prostate cancer. Carcinomas commonly overexpress macrophage inhibitory cytokine 1 (MIC-1), a proapoptotic and antitumorigenic transforming growth factor-β superfamily cytokine. Here we show that MIC-1 is often secreted in an unprocessed propeptide containing form. It is variably processed intracellularly, with unprocessed forms being secreted from several tumor lines, including prostate carcinoma lines, PC-3 and LNCaP. Once secreted, only unprocessed proMIC-1 binds ECM, demonstrating for the first time the occurrence of extracellular stores of MIC-1. The propeptide mediates this association via its COOH-terminal 89 amino acids. Xenograft models bearing tumors secreting various engineered forms of MIC-1 show that the propeptide regulates the balance between ECM stores and circulating serum levels of mature MIC-1 in vivo. The absence of propeptide results in ∼ 20-fold increase in serum MIC-1 levels. The significance of stromal MIC-1 stores was evaluated in prostate cancer tissue cores, which show major variation in stromal levels of MIC-1. Stromal MIC-1 levels are linked to prostate cancer outcome following radical prostatectomy, with decreasing stromal levels providing an important independent predictor of disease relapse. In low-grade localized prostate cancer (Gleason sum score ≤6), the level of MIC-1 stromal stores was the best predictor of future relapse when compared with all other clinicopathologic variables. The secretion and ECM association of unprocessed proMIC-1 is likely to play a central role in modulating local bioavailability of MIC-1 which can affect patient outcome in prostate cancer and other epithelial tumors

‘Front of House’

A review of the exhibition ‘Front of House’, featuring Marcos Corrales, Angela Ferreira, Narelle Jubelin and Andrew Renton with the UK premiere of a screening of Maison Tropicale by Manthia Diawara, 16 April–28 May 2008, Parasol Unit, Londo