Gestión de integridad del gasoducto de TGI, cambio de recubrimiento e instalación de refuerzos mecánicos no metálicos sobre la tubería

Spa: El proceso de corrosión que padecen las tuberías de gasoductos, conlleva a ejecutar trabajos de mantenimiento y reparación. La presente monografía de investigación describe e ilustra el proceso directo que se ejecutó en campo, durante la realización de los trabajos de reparación; como cambio de los recubrimientos e instalación de refuerzos mecánicos no metálicos a la principal línea de tubería del gasoducto; entre el municipio de Aipe y la ciudad de Neiva en el departamento del Huila. El principal objetivo a desarrollar en este trabajo de investigación es dar a conocer cómo y cuáles son los trabajos o tareas que se deben realizar para garantizar el restablecimiento de la integridad del gasoducto de la empresa Transportadora de Gas Internacional TGI. En el desarrollo de este documento se describirán de forma detallada mediante registros fotográficos, formatos de campo, ilustraciones, gráficas y tablas, toda la información básica necesaria para la ejecución, registro y control de calidad del proceso de reparación en la intervención del gasoducto. También se dará a conocer los nuevos materiales y accesorios desarrollados y ofrecidos por la industria, como alternativa para la reparación pronta, rápida, segura y a menor costo frente a otros procesos convencionales de reparación de tuberías que transportan hidrocarburos, como es el caso de la cinta en fibra de vidrio clock spring, la cual ofrece ciertas ventajas en el proceso de mantenimiento en líneas de flujo de gas.Bibliografía y webgrafía: página 132.EspecializaciónEspecialista en Gestión de Integridad y Corrosió

Benzotriazole derivatives palladium complex: Synthesis, characterization, antifungal and catalytic activity

Two new palladium benzotriazole complexes (7) and (8) was synthetized from [PdCl2(NCCH3)2] (6) and the benzotriazole derivatives 1,3-phenylenebis-((1H-benzotriazol-1-yl)methanone) (3) and 1,3-bis(1H-benzotriazol-1-yl-methyl)benzene (5). Its antifungal and Mizoroki-Heck catalytic preliminar activity was evaluated, finding that the palladium complexes are more effective than the ligands against Aspergillus niger and the turn over number (TON) for the complexes 7 and 8 was 221 and 219, which are under the average for similar complex reported on literature. 

Benzotriazole derivatives palladium complex: Synthesis, characterization, antifungal and catalytic activity

Two new palladium benzotriazole complexes (7) and (8) was synthetized from [PdCl2(NCCH3)2] (6) and the benzotriazole derivatives 1,3-phenylenebis-((1H-benzotriazol-1-yl)methanone) (3) and 1,3-bis(1H-benzotriazol-1-yl-methyl)benzene (5). Its antifungal and Mizoroki-Heck catalytic preliminar activity was evaluated, finding that the palladium complexes are more effective than the ligands against Aspergillus niger and the turn over number (TON) for the complexes 7 and 8 was 221 and 219, which are under the average for similar complex reported on literature. 

Benzotriazole derivatives palladium complex: Synthesis, characterization, antifungal and catalytic activity

Two new palladium benzotriazole complexes (7) and (8) was synthetized from [PdCl2(NCCH3)2] (6) and the benzotriazole derivatives 1,3-phenylenebis-((1H-benzotriazol-1-yl)methanone) (3) and 1,3-bis(1H-benzotriazol-1-yl-methyl)benzene (5). Its antifungal and Mizoroki-Heck catalytic preliminar activity was evaluated, finding that the palladium complexes are more effective than the ligands against Aspergillus niger and the turn over number (TON) for the complexes 7 and 8 was 221 and 219, which are under the average for similar complex reported on literature. 

Estado actual de las colecciones biológicas del Herbario UPTC mediante la identificación de agentes contaminantes

Grupo de Investigación Herbario UPTC, Escuela de Ciencias Biológicas, Facultad de Ciencias Básicas.El Herbario UPTC está centrado en la colecta de especímenes del Departamento de Boyacá (Colombia). Cuenta actualmente con 17.119 ejemplares entre angiospermas, helechos, briofitos y líquenes. Dado el valor científico, histórico y cultural de cada ejemplar y sus datos es necesario proteger la colección de daños o alteraciones que puedan afectar su uso futuro, teniendo como principio la conservación preventiva. Algunos ejemplares de la colección presentaron signos de aparente contaminación por posibles insectos y hongos, lo cual motivó la realización de este proyecto

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment