Efectividad de los ejercicios nórdicos sobre la incidencia de lesiones de isquiotibiales en futbolistas profesionales y amateur masculinos entre los 15 y 41 años. Revisión sistemática

Introduction: muscular injuries are the most common among soccer players, being hamstring injury the most frequent. Objective: The aim of this study was to analyze the existing evidence on the effects of Nordic exercises on the incidence of hamstring injuries in professional and amateur male soccer players between 15 and 41 years of age. Methods: A systematic review was carried out following the PRISMA guidelines recommendations, a search was carried out for articles in PubMed, BVS, Cochrane, Web OF Science and SCOPUS, in addition Google Scholar was consulted. The search was performed based on the PICO strategy with the following terms: hamstring muscles, exercise, rehabilitation, therapy, athletic injuries, soccer. Results: a total of 257 articles resulted from the search, 5 of which were included in this study. All studies showed positive effects of Nordic exercises for athletes. Conclusions: Nordic exercises reduced the incidence of hamstring injury in 4 of the studies analyzed, the percentage of compliance with the intervention sessions conditioned the quality of the effects while the moment of application of the intervention (pre- or post-training) had no influence.Introducción: Las lesiones musculares son comunes en futbolistas, siendo la lesión de isquiotibiales la más frecuente. Objetivo: Analizar la evidencia existente sobre los efectos de los ejercicios nórdicos en la incidencia de lesiones de isquiotibiales en jugadores de fútbol profesional y amateur masculinos entre los 15 y 41 años. Materiales y métodos: Se llevó a cabo una revisión sistemática siguiendo las recomendaciones de la declaración PRISMA, realizando la búsqueda de artículos en PubMed, BVS, Cochrane, Web OF Science y SCOPUS, además de consultar Google Scholar. La búsqueda se realizó basada en la estrategia PICO con los siguientes términos: hamstring muscles, exercise, rehabilitation, therapy, athletic injuries, soccer. Resultados: un total de 257 artículos resultaron de la búsqueda, siendo 5 los artículos incluidos en este estudio. Todos los estudios evidenciaron efectos positivos de los ejercicios nórdicos para los deportistas. Conclusiones: los ejercicios nórdicos redujeron la incidencia de lesión de isquiotibiales en 4 de los estudios analizados, el porcentaje de cumplimiento de las sesiones de intervención condicionaron la calidad de los efectos mientras que el momento de aplicación de la intervención (pre- o post-entreno) no influy

Antigenic Proteins Involved in Occupational Rhinitis 1 and Asthma Caused by Obeche Wood (Triplochiton Scleroxylon)

Background Obeche wood dust is a known cause of occupational asthma where an IgE-mediated mechanism has been demonstrated. Objective To characterize the allergenic profile of obeche wood dust and evaluate the reactivity of the proteins by in vitro, ex vivo and in vivo assays in carpenters with confirmed rhinitis and/or asthma Materials and methods An in-house obeche extract was obtained, and two IgE binding bands were purified (24 and 12 kDa) and sequenced by N-terminal identity. Specific IgE and IgG, basophil activation tests and skin prick tests (SPTs) were performed with whole extract and purified proteins. CCD binding was analyzed by ELISA inhibition studies. Results Sixty-two subjects participated: 12 with confirmed occupational asthma/rhinitis (ORA+), 40 asymptomatic exposed (ORA−), and 10 controls. Of the confirmed subjects, 83% had a positive SPT to obeche. There was a 100% recognition by ELISA in symptomatic subjects vs. 30% and 10% in asymptomatic exposed subjects and controls respectively (p<0.05). Two new proteins were purified, a 24 kDa protein identified as a putative thaumatin-like protein and a 12 kDa gamma-expansin. Both showed allergenic activity in vitro, with the putative thaumatin being the most active, with 92% recognition by ELISA and 100% by basophil activation test in ORA+ subjects. Cross-reactivity due to CCD was ruled out in 82% of cases. Conclusions Two proteins of obeche wood were identified and were recognized by a high percentage of symptomatic subjects and by a small proportion of asymptomatic exposed subjects. Further studies are required to evaluate cross reactivity with other plant allergens

Deciphering the universe of RNA structures and trans RNA-RNA interactions of transcriptomes in vivo: from experimental protocols to computational analyses

The last few years have seen an explosion of experimental and computational methods for investigating RNA structures of entire transcriptomes in vivo. Very recent experimental protocols now also allow trans RNA–RNA interactions to be probed in a transcriptome-wide manner. All of the experimental strategies require comprehensive computational pipelines for analysing the raw data and converting it back into actual RNA structure features or trans RNA–RNA interactions. The overall performance of these methods thus strongly depends on the experimental and the computational protocols employed. In order to get the best out of both worlds, both aspects need to be optimised simultaneously. This review introduced the methods and proposes ideas how they could be further improved

COVID-19 Severity and Survival over Time in Patients with Hematologic Malignancies: A Population-Based Registry Study

Mortality rates for COVID-19 have declined over time in the general population, but data in patients with hematologic malignancies are contradictory. We identified independent prognostic factors for COVID-19 severity and survival in unvaccinated patients with hematologic malignancies, compared mortality rates over time and versus non-cancer inpatients, and investigated post COVID-19 condition. Data were analyzed from 1166 consecutive, eligible patients with hematologic malignancies from the population-based HEMATO-MADRID registry, Spain, with COVID-19 prior to vaccination roll-out, stratified into early (February–June 2020; n = 769 (66%)) and later (July 2020–February 2021; n = 397 (34%)) cohorts. Propensity-score matched non-cancer patients were identified from the SEMI-COVID registry. A lower proportion of patients were hospitalized in the later waves (54.2%) compared to the earlier (88.6%), OR 0.15, 95%CI 0.11–0.20. The proportion of hospitalized patients admitted to the ICU was higher in the later cohort (103/215, 47.9%) compared with the early cohort (170/681, 25.0%, 2.77; 2.01–3.82). The reduced 30-day mortality between early and later cohorts of non-cancer inpatients (29.6% vs. 12.6%, OR 0.34; 0.22–0.53) was not paralleled in inpatients with hematologic malignancies (32.3% vs. 34.8%, OR 1.12; 0.81–1.5). Among evaluable patients, 27.3% had post COVID-19 condition. These findings will help inform evidence-based preventive and therapeutic strategies for patients with hematologic malignancies and COVID-19 diagnosis.Depto. de MedicinaFac. de MedicinaTRUEFundación Madrileña de Hematología y HemoterapiaFundación Leucemia y LinfomaAsociación Madrileña de Hematología y Hemoterapiapu

Compendio histórico de la fundación, progresos, y estado actual de la ciudad de Cartago en la provincia de Popayán en el Nuevo Reyno de Granada de la América Meridional, y de la portentosa aparición y renovación de la santa imagen de María Santísima, que con el título de Nuestra Señora de la Pobreza se venera en el convento de religiosos de S. Francisco de la misma ciudad, con alguna noticia de sus maravillas dividido en tres partes

Con licencia3 t. en 1 v. con 3 lám. de grab

Padrones de Cartago

10 ImágenesPadrones de la ciudad de Cartago en los años 1780, 1781, 1783 y 1784, firmados por Francisco Díaz de la Cantera, Juan Bautista Sanz y Vicuña y Miguel de Rivas. Incluye: oficio dirigido por Alfonso Junco y Cortés al gobernador de Popayán. Fechados en Cartago

Gypsophile vegetation patterns under a range of soil properties induced by topographical position

11 páginas, 1 figura, 5 tablas.Iberian gypsophile plant communities are considered a priority for conservation by the European Community because of their highly specialized flora in gypsum outcrops in arid and semiarid regions. Despite the ecological importance of these ecosystems, the edaphic factors that constrain plant communities on gypsiferous soils remain unclear. It has been proposed that both the chemical and physical restrictive conditions of gypsum soils determine gypsophily in plants. Here we hypothesize that the rigors of the gypsum soil environment depends on topography, decreasing from flat areas on hilltops to south-oriented slopes and finally to slopes oriented to the north. We also hypothesized that the relaxation of the rigors of the gypsum soil environment with topography affects both to individual plant and community characteristics of gypsophile vegetation: we expect a reduction of gypsophyte abundance, an increase of diversity and the amelioration of facilitative interactions of plant species. We analysed the physical and chemical properties of gypsum soils that have been proposed that determine the rigors of the gypsum soil environment (i.e.: unbalanced ion concentrations and superficial soil crust). The predicted rigor gradient along topographical locations was confirmed and was mainly caused by superficial soil crust. The decreasing rigor gradient was accompanied by a fall in the abundance of gypsophytes. However, when gypsophytes were considered separately, several patterns were observed, indicating distinct tolerance to relaxation of rigor of the gypsum soil conditions and different competition abilities between gypsophytes. Plant species were more clumped, and gypsophile communities presented higher diversity, evenness and richness values where rigor of gypsum soil conditions were maximum (flat hilltop positions). Relaxation of rigor (north-oriented slopes) was characterized by loss of facilitative interaction between species and the dominance of the gypsovag Rosmarinus officinalis L., although richness was still very high, which can be attributed to the coexistence of gypsophytes and gypsovags. We conclude that the rigor of gypsum soil environment gradient with topography is mainly determined by superficial soil crust, and it is a crucial determinant of gypsophile plant communities.This study was supported by the Spanish CICYT projects REN2002-04668 and CGL2005- 01625/BOS. The Government of Aragón and C.S.I.C. also supported the research through a contract to Y. P.Peer reviewe