Decoupling the rotation of stars and gas - I::the relationship with morphology and halo spin

Funding: UK Science and Technology Funding Council (STFC) via an PhD studentship (grant number ST/N504427/1).We use a combination of data from the MaNGA survey and MaNGA-like observations in IllustrisTNG100 to determine the prevalence of misalignment between the rotational axes of stars and gas. This census paper outlines the typical characteristics of misaligned galaxies in both observations and simulations to determine their fundamental relationship with morphology and angular momentum. We present a sample of ˜4500 galaxies from MaNGA with kinematic classifications which we use to demonstrate that the prevalence of misalignment is strongly dependent on morphology. The misaligned fraction sharply increases going to earlier morphologies (28 ± 3 per cent of 301 early-type galaxies, 10 ± 1 per cent of 677 lenticulars, and 5.4 ±0.6 per cent of 1634 pure late-type galaxies). For early-types, aligned galaxies are less massive than the misaligned sample whereas this trend reverses for lenticulars and pure late-types. We also find that decoupling depends on group membership for early-types with centrals more likely to be decoupled than satellites. We demonstrate that misaligned galaxies have similar stellar angular momentum to galaxies without gas rotation, much lower than aligned galaxies. Misaligned galaxies also have a lower gas mass than the aligned, indicative that gas loss is a crucial step in decoupling star-gas rotation. Through comparison to a mock MaNGA sample, we find that the strong trends with morphology and angular momentum hold true in IllustrisTNG100. We demonstrate that the lowered angular momentum is, however, not a transient property and that the likelihood of star-gas misalignment at z= 0 is correlated with the spin of the dark matter halo going back to z= 1.Publisher PDFPeer reviewe

Withania somnifera against glutamate excitotoxicity and neuronal cell loss in a scopolamine-induced rat model of Alzheimer’s disease

Alzheimer’s disease, a chronic and progressive neurodegenerative disorder with no prevention and cure, affecting nearly 50 million people worldwide. Glutamate is the principal excitatory neurotransmitter in the central nervous system involved in 50% of basic brain functions, especially cortical and hippocampal regions, like memory, cognition, and learning. The glutamate-mediated toxicity is termed as excitotoxicity. The present study was aimed to determine whether the methanolic and water extracts of root from the medicinal plant, Withania somnifera, could decrease the glutamate excitotoxicity and its related neuronal cell loss in a scopolamine-induced animal model of Alzheimer's disease. The rats were randomly divided into different groups of 5 in each: normal control - treated orally with saline; AD model - injected intra peritoneally with scopolamine (2 mg/Kg body wt) alone to induce Alzheimer's disease; AD model rats treated orally with the methanolic extract (AD+ME-WS) (300 mg/Kg body wt), water extract (AD+WE-WS) (300 mg/Kg body wt), and donepezil hydrochloride, a standard control (AD+DZ) (5 mg/Kg body wt) for 30 consecutive days. Increased glutamate (Glu) levels and decreased glutamate dehydrogenase (GDH) activity were reversed with Withania somnifera root extracts in both the cerebral cortex and hippocampus regions in scopolamine-induced Alzheimer's disease model rat brain. The histopathological studies of the same treatment also showed protection against neuronal cell loss in both regions. These results support the idea that these extracts could be effective for the reduction of brain damage by preventing glutamate excitotoxicity generated neuronal cell loss in the scopolamine-induced Alzheimer's disease model. DOI: http://dx.doi.org/10.5281/zenodo.442677

Apolipoproteins for Cardiovascular Risk Assessment

Clinical Question: Is measurement of apolipoproteins better than traditional lipid measurements for predicting cardiovascular risk? Evidence-Based Answer: Measurement of apolipoprotein B and apolipoprotein A-I is no better than traditional lipid measurements and should not be used to predict cardiovascular risk. (Strength of Recommendation: B, based on meta-analyses with conflicting results.) Apolipoprotein B and non-high-density lipoprotein cholesterol (HDL-C) predict cardiovascular risk slightly better than low-density lipoprotein cholesterol. Elevated levels of apolipoprotein A-I predict a lower risk of cardiovascular events except stroke, but not as well as elevated HDL-C levels

Initialization and Ensemble Generation for Decadal Climate Predictions: A Comparison of Different Methods

Five initialization and ensemble generation methods are investigated with respect to their impact on the prediction skill of the German decadal prediction system “Mittelfristige Klimaprognose” (MiKlip). Among the tested methods, three tackle aspects of model‐consistent initialization using the ensemble Kalman filter, the filtered anomaly initialization, and the initialization method by partially coupled spin‐up (MODINI). The remaining two methods alter the ensemble generation: the ensemble dispersion filter corrects each ensemble member with the ensemble mean during model integration. And the bred vectors perturb the climate state using the fastest growing modes. The new methods are compared against the latest MiKlip system in the low‐resolution configuration (Preop‐LR), which uses lagging the climate state by a few days for ensemble generation and nudging toward ocean and atmosphere reanalyses for initialization. Results show that the tested methods provide an added value for the prediction skill as compared to Preop‐LR in that they improve prediction skill over the eastern and central Pacific and different regions in the North Atlantic Ocean. In this respect, the ensemble Kalman filter and filtered anomaly initialization show the most distinct improvements over Preop‐LR for surface temperatures and upper ocean heat content, followed by the bred vectors, the ensemble dispersion filter, and MODINI. However, no single method exists that is superior to the others with respect to all metrics considered. In particular, all methods affect the Atlantic Meridional Overturning Circulation in different ways, both with respect to the basin‐wide long‐term mean and variability and with respect to the temporal evolution at the 26° N latitude

The AIDS epidemic in the Amazon region: a spatial case-control study in Rondonia, Brazil

OBJETIVO Analisar mudanças espaciais no risco de Aids e a relação entre incidência da doença e variáveis socioeconômicas. MÉTODOS Estudo caso-controle espacial, de base populacional, realizado em Rondônia, Brasil, com 1.780 casos notificados pelo Sistema de Vigilância Epidemiológica e os controles a partir de dados demográficos de 1987 a 2006. Os casos foram agrupados em cinco períodos de cinco anos consecutivos. Um modelo aditivo generalizado foi ajustado aos dados. O status dos indivíduos (caso ou controle) foi considerado como a variável dependente e independente: um alisamento ( spline ) bidimensional das coordenadas geográficas e variáveis socioeconômicas municipais. Os valores observados para o teste Moran I foram comparados com a distribuição de referência dos valores obtidos em condições de aleatoriedade espacial. RESULTADOS O risco de Aids apresentou padrão espacial e temporal marcado. A incidência associou-se a indicadores socioeconômicos municipais, como urbanização e capital humano. As maiores taxas de incidência de Aids ocorreram em municípios ao longo da rodovia BR-364; os resultados do teste Moran I mostram correlação espacial positiva associada à contiguidade dos municípios com a rodovia, no terceiro e quarto períodos (p = 0,05). CONCLUSÕES A incidência da doença foi maior em municípios de maior riqueza econômica e urbanização e naqueles cortados pelas estradas principais de Rondônia. O rápido desenvolvimento associado à ocupação de regiões remotas pode ser acompanhado por aumento de riscos à saúde.OBJETIVO Analizar cambios espaciales en el riesgo de Sida y la relación entre incidencia de la enfermedad y variables socioeconómicas. MÉTODOS Estudio caso-control espacial, de base poblacional, realizado en Rondonia, Brasil con 1.780 casos notificados por el Sistema de Vigilancia Epidemiológica y los controles a partir de datos demográficos de 1987 a 2006. Los casos fueron agrupados en cinco períodos de cinco años consecutivos. Un modelo aditivo generalizado fue ajustado a los datos. El estatus de los individuos (caso o control) fue considerado como la variable dependiente e independiente: un alisamiento (spline) bidimensional de las coordenadas geográficas y variables socioeconómicas municipales. Los valores observados para la prueba Moran I fueron comparados con la distribución de referencia de los valores obtenidos en condiciones de aleatoriedad espacial. RESULTADOS El riesgo de Sida presentó patrón espacial y temporal marcado. La incidencia se asoció a indicadores socioeconómicos municipales, como urbanización y capital humano. Las mayores tasas de incidencia de Sida ocurrieron en municipios a lo largo de la carretera BR-364; los resultados de la prueba Moran I muestran correlación espacial positiva asociada a la cercanía de los municipios a la carretera, en el tercero y cuarto periodos (p=0,05). CONCLUSIONES La incidencia de la enfermedad fue mayor en municipios de mayor riqueza económica y urbanización y en aquellos atravesados por las carreteras principales de Rondonia. El rápido desarrollo asociado a la ocupación de regiones remotas puede ser acompañado por aumento de riesgos para la salud.OBJECTIVE To analyze spatial changes in the risk of AIDS and the relationship between AIDS incidence and socioeconomic variables in the state of Rondonia, Amazon region. METHODS A spatial, population case-control study in Rondonia, Brazil, based on 1,780 cases reported to the Epidemiological Surveillance System and controls based on demographic data from 1987 to 2006. The cases were grouped into five consecutive four-year periods. A generalized additive model was adjusted to the data; the dependent variable was the status of the individuals (case or control), and the independent variables were a bi-dimensional spline of the geographic coordinates and some municipality-level socioeconomic variables. The observed values of the Moran’s I test were compared to a reference distribution of values generated under conditions of spatial randomness. RESULTS AIDS risk shows a marked spatial and temporal pattern. The disease incidence is related to socioeconomic variables at the municipal level in Rondônia, such as urbanization and human capital. The highest incidence rates of AIDS are in municipalities along the BR-364 highway and calculations of the Moran’s I test show positive spatial correlation associated with proximity of the municipality to the highway in the third and fourth periods (p = 0.05). CONCLUSIONS Incidence of the disease is higher in municipalities of greater economic wealth and urbanization, and in those municipalities bisected by Rondônia’s main roads. The rapid development associated with the opening up of once remote regions may be accompanied by an increase in these risks to health