Comparative life cycle assessment of a novel sustainable road pavement system adopting recycled plastic from PET bottles and carbonated aggregate

Road surfacing is crucial in improving community accessibility and mobility. Adopting sustainable measures is extremely important to prevent the significantly high environmental burdens associated with road pavement systems production. This study presents a comparative life cycle assessment of traditional pavement systems and their sustainable alternatives made and tested at the London South Bank University laboratories. The low-impact pavement mixes proposed herein provide a novel, innovative method for producing sustainable road systems. Unlike traditional approaches, these asphalt mixes utilise materials derived from recycled polyethylene terephthalate (plastics) and carbonated aggregates and are produced at temperatures significantly lower (warm mix). The Simapro software (Consultants, 2023) [1] was used to model the analysed asphalt mixes, and all life cycle inputs and outputs were characterised during the life cycle impact assessment phase into potential impacts using the IMPACT World + Midpoint method. Additionally, an uncertainty analysis employing Monte Carlo simulation was conducted to validate the life cycle assessment findings, reinforcing the robustness and credibility of this study's results. Notably, the assessment shows substantial reductions in the environmental impact of road pavement mixes adopting recycled plastic and carbonated aggregates, with various outcomes. Compared to traditional mixes, Climate Change emissions are reduced by approximately 40 %–60 %, Marine Eutrophication exhibits reductions of up to 30 %, and Freshwater Eutrophication decreases by up to 20 %. These findings suggest that integrating this sustainable road pavement approach can significantly reduce the environmental burdens of asphalt production and give asphalt a pivotal role in tackling waste reduction, carbon sequestration, and achieving Net Zero. Also, the proposed system can positively contribute to the current United Kingdom's (UK) circular policy model by reconsidering current waste management frameworks and integrating more efficient settings

Mechanical and GWP Assessment of Concrete Using Blast Furnace Slag, Silica Fume and Recycled Aggregate

Demolition waste and cement production is responsible for 36% of total waste produced on earth and 8% of the worlds CO2 emissions, respectively. Due to limited research on concrete mixes containing ternary cementitious mixes (Ground Granulated Blast-furnace Slag (GGBS) and Silica Fume (SF)) and demolition waste, the paper reviewed the mechanical properties of concrete, and structural performance of reinforced beams. Thereafter, life cycle analysis (LCA) was investigated to understand the true environmental impact, focusing on Global Warming Potential (GWP). Results show that recycled concrete aggregates (RCA) had no significant negative impact on the compressive strength, tensile strength, and modulus of rupture of concrete. The inclusion of GGBS and SF in mixes containing RCA eliminated any negative impact and for all mixes produced greater strengths in comparison to the control mix, due to the secondary reaction of Ca (OH)2 and pore refinement. The flexural behavior of the concrete beams with 0%, 25%, 50% and 100% RCA, 25% GGBS and 5% SF is similar. LCA results showed that replacing NA with 25%, 50% or 100% RCA has no significant impact on the GWP emissions. This is because of the similar emissions associated with manufacturing and processing of recycled and natural aggregates. However, replacing cement with 5% SF and 25% GGBS improves the GWP environmental response of concrete significantly. Additionally, natural aggregates have a higher GWP contribution than that of recycled concrete aggregates by almost 80% since the process of NA required quarry operation and transportation while the RCA are produced on site from an existing building waste

Mechanical and GWP assessment of concrete using Blast Furnace Slag, Silica Fume and recycled aggregate

Data Availability: Data will be made available on request.Demolition waste and cement production is responsible for 36 % of total waste produced on earth and 8 % of the worlds CO2 emissions, respectively. Due to limited research on concrete mixes containing ternary cementitious mixes (Ground Granulated Blast-furnace Slag (GGBS) and Silica Fume (SF)) and demolition waste, the paper reviewed the mechanical properties of concrete, and structural performance of reinforced beams. Thereafter, life cycle analysis (LCA) was investigated to understand the true environmental impact, focusing on Global Warming Potential (GWP). Results show that recycled concrete aggregates (RCA) had no significant negative impact on the compressive strength, tensile strength, and modulus of rupture of concrete. The inclusion of GGBS and SF in mixes containing RCA eliminated any negative impact and for all mixes produced greater strengths in comparison to the control mix, due to the secondary reaction of Ca (OH)2 and pore refinement. The flexural behaviour of the concrete beams with 0 %, 25 %, 50 % and 100 % RCA, 25 % GGBS and 5 % SF is similar. LCA results showed that replacing NA with 25 %, 50 % or 100 % RCA has no significant impact on the GWP emissions. This is because of the similar emissions associated with manufacturing and processing of recycled and natural aggregates. However, replacing cement with 5 % SF and 25 % GGBS improves the GWP environmental response of concrete significantly. Additionally, natural aggregates have a higher GWP contribution than that of recycled concrete aggregates by almost 80 % since the process of NA required quarry operation and transportation while the RCA are produced on site from an existing building waste

Urbilaterian origin of paralogous GnRH and corazonin neuropeptide signalling pathways

This work was supported by funding from the China Scholarship Council (awarded to ST), Leverhulme Trust (grant RGP-2013-351, awarded to MRE), BBSRC (grant BB/M001644/1 awarded to MRE; grant BB/M001032/1 awarded to JHS) and a Company of Biologists (Journal of Experimental Biology) Travelling Fellowship awarded to MZ. IB is supported by a postdoctoral fellowship from the Research Foundation–Flanders (FWO)

Development of a concept and basis for the DEMO diagnostic and control system

An initial concept for the plasma diagnostic and control (D&C) system has been developed as part of European studies towards the development of a demonstration tokamak fusion reactor (DEMO). The main objective is to develop a feasible, integrated concept design of the DEMO D&C system that can provide reliable plasma control and high performance (electricity output) over extended periods of operation. While the fusion power is maximized when operating near to the operational limits of the tokamak, the reliability of operation typically improves when choosing parameters significantly distant from these limits. In addition to these conflicting requirements, the D&C development has to cope with strong adverse effects acting on all in vessel components on DEMO (harsh neutron environment, particle fluxes, temperatures, electromagnetic forces, etc.). Moreover, space allocation and plasma access are constrained by the needs for first wall integrity and optimization of tritium breeding. Taking into account these boundary conditions, the main DEMO plasma control issues have been formulated, and a list of diagnostic systems and channels needed for plasma control has been developed, which were selected for their robustness and the required coverage of control issues. For a validation and refinement of this concept, simulation tools are being refined and applied for equilibrium, kinetic and mode control studies

A public early intervention approach to first-episode psychosis: Treated incidence over 7 years in the Emilia-Romagna region

AimTo estimate the treated incidence of individuals with first-episode psychosis (FEP) who contacted the Emilia-Romagna public mental healthcare system (Italy); to examine the variability of incidence and user characteristics across centres and years. MethodsWe computed the raw treated incidence in 2013-2019, based on FEP users aged 18-35, seen within or outside the regional program for FEP. We modelled FEP incidence across 10 catchment areas and 7 years using Bayesian Poisson and Negative Binomial Generalized Linear Models of varying complexity. We explored associations between user characteristics, study centre and year comparing variables and socioclinical clusters of subjects. ResultsThousand three hundred and eighteen individuals were treated for FEP (raw incidence: 25.3 / 100.000 inhabitant year, IQR: 15.3). A Negative Binomial location-scale model with area, population density and year as predictors found that incidence and its variability changed across centres (Bologna: 36.55; 95% CrI: 30.39-43.86; Imola: 3.07; 95% CrI: 1.61-4.99) but did not follow linear temporal trends or density. Centers were associated with different user age, gender, migrant status, occupation, living conditions and cluster distribution. Year was associated negatively with HoNOS score (R = -0.09, p < .001), duration of untreated psychosis (R = -0.12, p < .001) and referral type. ConclusionsThe Emilia-Romagna region presents a relatively high but variable incidence of FEP across areas, but not in time. More granular information on social, ethnic and cultural factors may increase the level of explanation and prediction of FEP incidence and characteristics, shedding light on social and healthcare factors influencing FEP

Overview of the TCV tokamak experimental programme

The tokamak a configuration variable (TCV) continues to leverage its unique shaping capabilities, flexible heating systems and modern control system to address critical issues in preparation for ITER and a fusion power plant. For the 2019-20 campaign its configurational flexibility has been enhanced with the installation of removable divertor gas baffles, its diagnostic capabilities with an extensive set of upgrades and its heating systems with new dual frequency gyrotrons. The gas baffles reduce coupling between the divertor and the main chamber and allow for detailed investigations on the role of fuelling in general and, together with upgraded boundary diagnostics, test divertor and edge models in particular. The increased heating capabilities broaden the operational regime to include T (e)/T (i) similar to 1 and have stimulated refocussing studies from L-mode to H-mode across a range of research topics. ITER baseline parameters were reached in type-I ELMy H-modes and alternative regimes with \u27small\u27 (or no) ELMs explored. Most prominently, negative triangularity was investigated in detail and confirmed as an attractive scenario with H-mode level core confinement but an L-mode edge. Emphasis was also placed on control, where an increased number of observers, actuators and control solutions became available and are now integrated into a generic control framework as will be needed in future devices. The quantity and quality of results of the 2019-20 TCV campaign are a testament to its successful integration within the European research effort alongside a vibrant domestic programme and international collaborations

Overview of the FTU results

Since the 2018 IAEA FEC Conference, FTU operations have been devoted to several experiments covering a large range of topics, from the investigation of the behaviour of a liquid tin limiter to the runaway electrons mitigation and control and to the stabilization of tearing modes by electron cyclotron heating and by pellet injection. Other experiments have involved the spectroscopy of heavy metal ions, the electron density peaking in helium doped plasmas, the electron cyclotron assisted start-up and the electron temperature measurements in high temperature plasmas. The effectiveness of the laser induced breakdown spectroscopy system has been demonstrated and the new capabilities of the runaway electron imaging spectrometry system for in-flight runaways studies have been explored. Finally, a high resolution saddle coil array for MHD analysis and UV and SXR diamond detectors have been successfully tested on different plasma scenarios

Breast cancer "tailored follow-up" in Italian oncology units: a web-based survey

urpose: Breast cancer follow-up procedures after primary treatment are still a controversial issue. Aim of this study was to investigate, through a web-based survey, surveillance methodologies selected by Italian oncologists in everyday clinical practice. Methods: Referents of Italian medical oncology units were invited to participate to the study via e-mail through the SurveyMonkey website. Participants were asked how, in their institution, exams of disease staging and follow-up are planned in asymptomatic women and if surveillance continues beyond the 5th year. Results: Between February and May 2013, 125 out of 233 (53.6%) invited referents of Italian medical oncology units agreed to participate in the survey. Ninety-seven (77.6%) referents state that modalities of breast cancer follow-up are planned according to the risk of disease progression at diagnosis and only 12 (9.6%) oncology units apply the minimal follow-up procedures according to international guidelines. Minimal follow-up is never applied in high risk asymptomatic women. Ninety-eight (78.4%) oncology units continue follow-up in all patients beyond 5 years. Conclusions: Our survey shows that 90.4% of participating Italian oncology units declare they do not apply the minimal breast cancer follow-up procedures after primary treatment in asymptomatic women, as suggested by national and international guidelines. Interestingly, about 80.0% of interviewed referents performs the so called "tailored follow-up", high intensity for high risk, low intensity for low risk patients. There is an urgent need of randomized clinical trials able to determine the effectiveness of risk-based follow-up modalities, their ideal frequency and persistence in time