Marguerite Blais, La culture sourde. Quêtes identitaires au cœur de la communication

Marguerite Blais est une figure bien connue du public québécois car c’est une animatrice et une journaliste à la radio et à la télévision du Québec. Elle est aussi chercheuse– engagée et en action –, dont l’aboutissement des travaux de doctorat et de maîtrise en communication ne devait pas rester silencieux, à l’instar du monde culturel qui l’intéresse, en l’occurrence celui des Sourds, trop ignoré voire même passé sous silence. La poursuite de recherches postdoctorales à l’université du Québ..

Christophe Prochasson, L’empire des émotions. Les historiens dans la mêlée

Si L’empire des émotions. Les historiens dans la mêlé titre de manière quelque peu provocante cet ouvrage de Christophe Prochasson, c’est que, selon l’auteur, le genre compassionnel est aujourd’hui une forme d’entendement collectivement partagée, immiscée jusque dans l’enseignement et la pratique de l’histoire. Pour attester de cet envahissement, l’auteur rappelle l’exemple marquant de l’investiture du dernier chef de l’État français. La forte densité émotionnelle de son discours politique s’..

Sphingosine Kinase-1 Is Central to Androgen-Regulated Prostate Cancer Growth and Survival

BACKGROUND: Sphingosine kinase-1 (SphK1) is an oncogenic lipid kinase notably involved in response to anticancer therapies in prostate cancer. Androgens regulate prostate cancer cell proliferation, and androgen deprivation therapy is the standard of care in the management of patients with advanced disease. Here, we explored the role of SphK1 in the regulation of androgen-dependent prostate cancer cell growth and survival. METHODOLOGY/PRINCIPAL FINDINGS: Short-term androgen removal induced a rapid and transient SphK1 inhibition associated with a reduced cell growth in vitro and in vivo, an event that was not observed in the hormono-insensitive PC-3 cells. Supporting the critical role of SphK1 inhibition in the rapid effect of androgen depletion, its overexpression could impair the cell growth decrease. Similarly, the addition of dihydrotestosterone (DHT) to androgen-deprived LNCaP cells re-established cell proliferation, through an androgen receptor/PI3K/Akt dependent stimulation of SphK1, and inhibition of SphK1 could markedly impede the effects of DHT. Conversely, long-term removal of androgen support in LNCaP and C4-2B cells resulted in a progressive increase in SphK1 expression and activity throughout the progression to androgen-independence state, which was characterized by the acquisition of a neuroendocrine (NE)-like cell phenotype. Importantly, inhibition of the PI3K/Akt pathway--by negatively impacting SphK1 activity--could prevent NE differentiation in both cell models, an event that could be mimicked by SphK1 inhibitors. Fascinatingly, the reversability of the NE phenotype by exposure to normal medium was linked with a pronounced inhibition of SphK1 activity. CONCLUSIONS/SIGNIFICANCE: We report the first evidence that androgen deprivation induces a differential effect on SphK1 activity in hormone-sensitive prostate cancer cell models. These results also suggest that SphK1 activation upon chronic androgen deprivation may serve as a compensatory mechanism allowing prostate cancer cells to survive in androgen-depleted environment, giving support to its inhibition as a potential therapeutic strategy to delay/prevent the transition to androgen-independent prostate cancer

Fluctuations et cycles économiques dans les écrits de Keynes : essai sur le rôle des facteurs déterminants de l'investissement

The dissertation argues that there is a recurrence in Keynes’s thought as regards economic fluctuations: investment is considered as the primary factor driving these fluctuations. The first part explains how, in the author’s early writings, some topics and problems that would be discussed in the Treatise on Money (1930) would emerge out of an interest for monetary instability. The second part focuses on the Treatise as such, but also on the transition between this book and the General Theory of Employment, Interest and Money (1936) following the economic crisis of the Great Depression. Finally the third part discusses the answer given by the General Theory to this problem, by showing that investment as understood and explained in this book is at the center of an analysis of economic fluctuations and business cycles.Nous démontrons qu’il existe une récurrence dans la pensée de Keynes en matière de fluctuations, à savoir que l’investissement est le facteur majeur guidant les fluctuations économiques. La première partie explore les écrits datant d’avant 1925 environ, en analysant les thématiques et problèmes qui en émergent et qui anticipent ceux du Treatise on Money (1930). La seconde partie se focalise sur le Treatise à proprement parler, ainsi que la transition de cet ouvrage à la Théorie Générale de l’Emploi, de l’Intérêt et de la Monnaie (1936) suite à la crise économique du début des années 1930. La troisième et dernière partie aborde ainsi la réponse apportée par la Théorie Générale à ce problème, en démontrant que la théorie de l’investissement qui y est développée est au coeur de son analyse des fluctuations et cycles économiques

Die Relevanz von Fortbildungsmaßnahmen zur Führungskräftegewinnung als Faktor der Gelingensbedingungen weiblicher Führungskräftebiografien

Im Zentrum der Masterarbeit stehen hessische Schulleiterinnen und die Frage, welchen Einfluss Fortbildungsmaßnahmen zum positiven Verlauf ihrer Berufskarrieren beigetragen haben. Zur empirischen Untersuchung der Fragestellung wurde zuerst eine quantitative Online-Befragung angelegt und durchgeführt, der dann eine qualitative Untersuchung mittels Telefoninterviews folgte

Economic fluctuations and business cycles in Keynes's writings : essays on the role of the determining factors of investment

Nous démontrons qu’il existe une récurrence dans la pensée de Keynes en matière de fluctuations, à savoir que l’investissement est le facteur majeur guidant les fluctuations économiques. La première partie explore les écrits datant d’avant 1925 environ, en analysant les thématiques et problèmes qui en émergent et qui anticipent ceux du Treatise on Money (1930). La seconde partie se focalise sur le Treatise à proprement parler, ainsi que la transition de cet ouvrage à la Théorie Générale de l’Emploi, de l’Intérêt et de la Monnaie (1936) suite à la crise économique du début des années 1930. La troisième et dernière partie aborde ainsi la réponse apportée par la Théorie Générale à ce problème, en démontrant que la théorie de l’investissement qui y est développée est au coeur de son analyse des fluctuations et cycles économiques.The dissertation argues that there is a recurrence in Keynes’s thought as regards economic fluctuations: investment is considered as the primary factor driving these fluctuations. The first part explains how, in the author’s early writings, some topics and problems that would be discussed in the Treatise on Money (1930) would emerge out of an interest for monetary instability. The second part focuses on the Treatise as such, but also on the transition between this book and the General Theory of Employment, Interest and Money (1936) following the economic crisis of the Great Depression. Finally the third part discusses the answer given by the General Theory to this problem, by showing that investment as understood and explained in this book is at the center of an analysis of economic fluctuations and business cycles

The audience’s favourite: Romantic Comedy : the modern fairy tale. A comparative analysis of success of KEINOHRHASEN and WHAT A MAN

Ziel dieser Arbeit ist anhand der Filme KEINOHRHASEN und WHAT A MAN exemplarisch zu erörtern, welche Faktoren Beziehungskomödien zum Publikumsliebling machen. Zu diesem Zweck werden im Besonderen die Bereiche Genre und Inhalt, Aufbau, Produktionsbudget, Marketing und Verleih sowie Besetzung betrachtet

Target group segmentation and cluster analysis of German equestrians

Horse riding is deeply rooted into the European equestrian heritage, triggering a specific consumer behaviour based mostly on key values such as fitness, success and social recognition. Riding schools are the main access point to equestrian sports and thus of great importance to the entire industry. This research intends to elaborate on how the horse riding service providers (mainly riding schools) could become more competitive and more sustainable through understanding consumer buying behaviour. The first stage of the research was to identify the consumer segments of the German horse riding market, more precisely potential and existing equestrians. A sample of 679 people was investigated via an on-line survey. The main findings of the cluster analysis are that Cluster 1 – formed by the youngest respondents - is driven mainly by the desire to compete, be healthy and fit, be successful and active. Moreover this segment seems to be willing to pay the most for the ‘perfect single riding lesson’. Cluster 2 – having the highest income and education - is not driven by new trends but rather by an everlasting and traditional love for equines and partnership with the horse and also by pastime – relaxing opportunities. In this group we can find people interested in other equine activities such as: hacking, groundwork, horsemanship, endurance riding or working equitation. The last group - Cluster 3 also gives low importance to competition, success and thrill, but values exercising/being active and health and fitness more than the previous cluster. Overcoming fears, sociability and work/life balance are also important motivations, but not as much as for Cluster 1, whilst social recognition and the fact that riding is trendy only play a minor role in their decision. According to the self-evaluation of Cluster 3 equestrians they have the lowest riding skills being also the oldest group. With an average of 40 euros this group would be willing to pay the least for the ‘perfect single riding lesson’. Yet, they are the ones who are currently paying the most for their equestrian training