Adaptació dels contenidors d'escombraries i millora de la seva accessibilitat a la ciutat de Barcelona per les persones amb disminució

Aquest treball té com a objectiu el redisseny i l’adaptació dels contenidors de càrrega lateral de 3.2 i 2.4 m3, fabricats per l’empresa Ros Roca S.A., per tal que siguin accessibles per a tothom i no perdin la funcionalitat que tenen actualment. Dins del projecte, s’engloba el redisseny dels contenidors de selectiva (paper i envasos), el de RSU senzill i el bicompartimentat (RSU + orgànica). També s’inclou un contenidor (actualment en estat de prototipus) desenvolupat amb l’empresa durant el conveni UPC-empresa, que està destinat a substituir el que hi ha actualment a la ciutat. El projecte inclou també un estudi sobre l’accessibilitat a aquests contenidors per a les persones amb disminució (especialment les usuàries de cadira de rodes). Inicialment es va realitzar un estudi sobre l’estat de la tècnica, consistent en una cerca de patents i l’elaboració d’una base de dades amb les més rellevants. Complementat per un estudi de la competència i un reportatge fotogràfic de contenidors amb la seva ubicació per l’àrea metropolitana de Barcelona. Es van fer visites a l’Ajuntament (departament BCN neta), a Ros Roca i a un dels contractistes de recollida de deixalles, per tal de recopilar tota la informació tècnica necessària. Després d’aquestes visites i després de la primera reunió del conveni, amb el responsable de l’Ajuntament i el cap de R+D de l’empresa, es va realitzar un “Brainstorming” inicial, d’on van aparèixer les primeres idees de solució. Aquestes idees van anar evolucionant a mida que es produïen reunions i es treballava en elles. Es va completar amb la visita a un col·lectiu de discapacitats. Es va aprofitar aquesta visita per resoldre els dubtes que es tenien sobre les seves necessitats i per fer una enquesta per la posterior elaboració d’un QFD. ( casa de qualitat) Com a resultat s’han aconseguit dos contenidors: un per la recollida selectiva amb un sistema de bústia accessible bifuncional (serveix per la fracció de paper i per la d’envasos) amb limitador, situada al frontal del contenidor, al que se li practica una obertura; i un segon de RSU bicompartimentat (solució vàlida pel RSU senzill) on els usuaris que no hi puguin accedir, disposaran d’una “clau” que els permetrà desbloquejar la tapa d’orgànica i mitjançant una palanca podran obrir-la i dipositar la brossa. Com a conclusions destacar que s’ha aconseguit dos contenidors accessibles que mantenen l’estructura exterior i els mecanismes originals, que segueixen complint la normativa europea EN 12574 i que resulten senzills d’utilitzar i econòmics de fabricar

Adaptació dels contenidors d'escombraries i millora de la seva accessibilitat a la ciutat de Barcelona per les persones amb disminució

Aquest treball té com a objectiu el redisseny i l’adaptació dels contenidors de càrrega lateral de 3.2 i 2.4 m3, fabricats per l’empresa Ros Roca S.A., per tal que siguin accessibles per a tothom i no perdin la funcionalitat que tenen actualment. Dins del projecte, s’engloba el redisseny dels contenidors de selectiva (paper i envasos), el de RSU senzill i el bicompartimentat (RSU + orgànica). També s’inclou un contenidor (actualment en estat de prototipus) desenvolupat amb l’empresa durant el conveni UPC-empresa, que està destinat a substituir el que hi ha actualment a la ciutat. El projecte inclou també un estudi sobre l’accessibilitat a aquests contenidors per a les persones amb disminució (especialment les usuàries de cadira de rodes). Inicialment es va realitzar un estudi sobre l’estat de la tècnica, consistent en una cerca de patents i l’elaboració d’una base de dades amb les més rellevants. Complementat per un estudi de la competència i un reportatge fotogràfic de contenidors amb la seva ubicació per l’àrea metropolitana de Barcelona. Es van fer visites a l’Ajuntament (departament BCN neta), a Ros Roca i a un dels contractistes de recollida de deixalles, per tal de recopilar tota la informació tècnica necessària. Després d’aquestes visites i després de la primera reunió del conveni, amb el responsable de l’Ajuntament i el cap de R+D de l’empresa, es va realitzar un “Brainstorming” inicial, d’on van aparèixer les primeres idees de solució. Aquestes idees van anar evolucionant a mida que es produïen reunions i es treballava en elles. Es va completar amb la visita a un col·lectiu de discapacitats. Es va aprofitar aquesta visita per resoldre els dubtes que es tenien sobre les seves necessitats i per fer una enquesta per la posterior elaboració d’un QFD. ( casa de qualitat) Com a resultat s’han aconseguit dos contenidors: un per la recollida selectiva amb un sistema de bústia accessible bifuncional (serveix per la fracció de paper i per la d’envasos) amb limitador, situada al frontal del contenidor, al que se li practica una obertura; i un segon de RSU bicompartimentat (solució vàlida pel RSU senzill) on els usuaris que no hi puguin accedir, disposaran d’una “clau” que els permetrà desbloquejar la tapa d’orgànica i mitjançant una palanca podran obrir-la i dipositar la brossa. Com a conclusions destacar que s’ha aconseguit dos contenidors accessibles que mantenen l’estructura exterior i els mecanismes originals, que segueixen complint la normativa europea EN 12574 i que resulten senzills d’utilitzar i econòmics de fabricar

Lipidomic Alterations in the Cerebral Cortex and White Matter in Sporadic Alzheimer’s Disease

Non-targeted LC-MS/MS-based lipidomic analysis was conducted in post-mortem human grey matter frontal cortex area 8 (GM) and white matter of the frontal lobe centrum semi-ovale (WM) to identify lipidome fingerprints in middle-aged individuals with no neurofibrillary tangles and senile plaques, and cases at progressive stages of sporadic Alzheimer's disease (sAD). Complementary data were obtained using RT-qPCR and immunohistochemistry. The results showed that WM presents an adaptive lipid phenotype resistant to lipid peroxidation, characterized by a lower fatty acid unsaturation, peroxidizability index, and higher ether lipid content than the GM. Changes in the lipidomic profile are more marked in the WM than in GM in AD with disease progression. Four functional categories are associated with the different lipid classes affected in sAD: membrane structural composition, bioenergetics, antioxidant protection, and bioactive lipids, with deleterious consequences affecting both neurons and glial cells favoring disease progression

Lipidomic traits of plasma and cerebrospinal fluid in amyotrophic lateral sclerosis correlate with disease progression

Since amyotrophic lateral sclerosis cases exhibit significant heterogeneity, we aim to investigate the association of lipid composition of plasma and CSF with amyotrophic lateral sclerosis diagnosis, its progression and clinical characteristics. Lipidome analyses would help to stratify patients on a molecular basis. For this reason, we have analysed the lipid composition of paired plasma and CSF samples from amyotrophic lateral sclerosis cases and age-matched non-amyotrophic lateral sclerosis individuals (controls) by comprehensive liquid chromatography coupled to mass spectrometry. The concentrations of neurofilament light chain-an index of neuronal damage-were also quantified in CSF samples and plasma. Amyotrophic lateral sclerosis versus control comparison, in a moderate stringency mode, showed that plasma from cases contains more differential lipids (n = 122 for raw P < 0.05; n = 27 for P < 0.01) than CSF (n = 17 for raw P < 0.05; n = 4 for P < 0.01), with almost no overlapping differential species, mainly characterized by an increased content of triacylglyceride species in plasma and decreased in CSF. Of note, false discovery rate correction indicated that one of the CSF lipids (monoacylglycerol 18:0) had high statistic robustness (false discovery rate-P < 0.01). Plasma lipidomes also varied significantly with the main involvement at onset (bulbar, spinal or respiratory). Notably, faster progression cases showed particular lipidome fingerprints, featured by decreased triacylclycerides and specific phospholipids in plasma, with 11 lipids with false discovery rate-P < 0.1 (n = 56 lipids in plasma for raw P < 0.01). Lipid species associated with progression rate clustered in a relatively low number of metabolic pathways, mainly triacylglyceride metabolism and glycerophospholipid and sphingolipid biosynthesis. A specific triacylglyceride (68:12), correlated with neurofilament content (r = 0.8, P < 0.008). Thus, the present findings suggest that systemic hypermetabolism-potentially sustained by increased triacylglyceride content-and CNS alterations of specific lipid pathways could be associated as modifiers of disease progression. Furthermore, these results confirm biochemical lipid heterogeneity in amyotrophic lateral sclerosis with different presentations and progression, suggesting the use of specific lipid species as potential disease classifiers

Prevalence and Characterization of Psychological Trauma in Patients with Fibromyalgia: A Cross-Sectional Study

Preliminary evidence suggests that psychological trauma, especially childhood trauma, is a risk factor for the onset of fibromyalgia (FM).The main objective of this study consisted of evaluating the prevalence and detailed characteristics of psychological trauma in a sample of patients with FM, the chronology of trauma across the lifespan, and its clinical symptoms. We also calculated whether childhood trauma could predict the relationship with different clinical variables.Eighty-eight females underwent an interview to assess sociodemographic data, psychiatric comorbidities, level of pain, FM impact, clinical symptoms of anxiety, depression, insomnia, quality of life, and psychological trauma.The majority of participants (71.5%) met the diagnostic criteria for current post-traumatic stress disorder (PTSD). Participants reported having suffered traumatic events throughout their lifespan, especially in childhood and early adolescence, in the form of emotional abuse, emotional neglect, sexual abuse, and physical abuse. Traumatic events predict both poor quality of life and a level of pain in adulthood. All patients showed clinically relevant levels of anxiety, depression, insomnia, suicidal thoughts, and pain, as well as somatic comorbidities and poor quality of life. Pain levels predicted anxiety, depression, dissociation, and insomnia symptoms. 84% of the sample suffered one or more traumatic events prior to the onset of pain.Our data highlight the clinical complexity of patients with FM and the role of childhood trauma in the onset and maintenance of FM, as well as the high comorbidity between anxiety, depression, somatic symptoms, and FM. Our data also supports FM patients experiencing further retraumatization as they age, with an extremely high prevalence of current PTSD in our sample. These findings underscore the need for multidisciplinary programs for FM patients to address their physical pain and their psychiatric and somatic conditions, pay special attention to the assessment of psychological trauma, and provide trauma-focused interventions. Trial registration: ClinicalTrials.gov NCT04476316. Registered on July 20th, 2020.Copyright © 2022 Itxaso Gardoki-Souto et al

The Demeter project. Eight millennia of agrobiodiversity changes in the northwest Mediterranean basin

The development of agricultural societies is closely entangled with that of domestic animals and plants. Local and traditional domestic breeds and varieties are the result of millennia of selection by farmers. DEMETER (2020-2025) is an international project which is aiming to characterize the changes in animal and plant agrobiodiversity (pigs, sheep, goats, and barley) in relation with environmental and socioeconomic factors in the northwestern Mediterranean basin since the beginnings of agriculture. The project is based on a combination of approaches including phenomics (through geometric morphometrics), databasing, zooarchaeology, archaeobotany, climate modeling, paleoproteins (ZooMs) and statistical analyses. Several hundreds of archaeological sites from the South of France and Catalonia will be studied, covering the maximum environmental, societal and cultural diversity of context over the course of the last eight millennia

Cueva de La Cocina (Dos Aguas, Valencia) en el marco del Proyecto de Investigación Har2012-33111 “Meso Cocina: Los Últimos Caza-Recolectores y el Paradigma de la Neolitización en el Mediterráneo Peninsular”

Comunicación oral en el VI Congreso del Neolítico en la Península Ibérica: “Los cambios económicos y sus implicaciones sociales durante el Neolítico de la Península Ibérica”, 22-26 junio 2016 GranadaEl objetivo de esta comunicación es dar a conocer los resultados preliminares del proyecto HAR12-33111 “MesoCocina: los últimos caza-recolectores y el paradigma de la neolitización en el Mediterráneo peninsular” que ha tenido como eje de actuación el análisis pormenorizado del excepcional registro prehistórico recuperado en Cueva de la Cocina (Dos Aguas, Valencia). En el transcurso de los tres últimos años se ha procedido al análisis de las colecciones correspondientes a las excavaciones efectuadas por Ll. Pericot en los años 40 del pasado siglo así como aquellos resultados de las campañas dirigidas posteriormente por J. Fortea en los años 70. Al mismo tiempo se han llevado a cabo dos intervenciones de campo en la cavidad con el fin de obtener información precisa sobre las características de una secuencia clave a propósito de las ocupaciones del Mesolítico final en el Mediterráneo occidental, y que además contiene evidencias de frecuentaciones posteriores, desde el Neolítico Antiguo hasta la edad del Bronce. El establecimiento de un marco radiométrico preciso ha sido una de las prioridades junto a la reconstrucción tridimensional de todas las actuaciones realizadas hasta la fecha en el sitio. Bajo esta óptica procederemos a reevaluar la variabilidad de la cultura material, de las actividades de subsistencia, del mundo simbólico y las conexiones sociales en el entorno medioambiental donde se llevaron a cabo desde una amplia perspectiva diacrónica, entre el inicio del IX y el III milenio cal BP. Ciñéndonos al marco de este congreso nos centraremos especialmente en los nuevos datos relativos a la secuencia de los últimos caza-recolectores y el primer Neolítico en la cavidad.Peer Reviewe

High incidence of PTSD diagnosis and trauma-related symptoms in a trauma exposed bipolar I and II sample

Post-traumatic stress disorder (PTSD) is an established comorbidity in Bipolar Disorder (BD), but little is known about the characteristics of psychological trauma beyond a PTSD diagnosis and differences in trauma symptoms between BD-I and BD-II. (1) To present characteristics of a trauma-exposed BD sample; (2) to investigate prevalence and trauma symptom profile across BD-I and BD-II; (3) to assess the impact of a lifetime PTSD diagnosis vs. a history of trauma on BD course; and (4) to research the impacts of sexual and physical abuse. This multi-center study comprised 79 adult participants with BD with a history of psychological trauma and reports baseline data from a trial registered in Clinical Trials (; ref: NCT02634372). Clinical variables were gathered through clinical interview, validated scales and a review of case notes. The majority (80.8%) of our sample had experienced a relevant stressful life event prior to onset of BD, over half of our sample 51.9% had a lifetime diagnosis of PTSD according to the Clinician Administered PTSD scale. The mean Impact of Event Scale-Revised scores indicated high levels of trauma-related distress across the sample, including clinical symptoms in the PTSD group and subsyndromal symptoms in the non-PTSD group. Levels of dissociation were not higher than normative values for BD. A PTSD diagnosis (vs. a history of trauma) was associated with psychotic symptoms [2(1) = 5.404, p = 0.02] but not with other indicators of BD clinical severity. There was no significant difference between BD-I and BD-II in terms of lifetime PTSD diagnosis or trauma symptom profile. Sexual abuse significantly predicted rapid cycling [2(1) = 4.15, p = 0.042], while physical abuse was not significantly associated with any clinical indicator of severity. Trauma load in BD is marked with a lack of difference in trauma profile between BD-I and BD-II. Although PTSD and sexual abuse may have a negative impact on BD course, in many indicators of BD severity there is no significant difference between PTSD and subsyndromal trauma symptoms. Our results support further research to clarify the role of subsyndromic PTSD symptoms, and highlight the importance of screening for trauma in BD patients

High incidence of PTSD diagnosis and trauma-related symptoms in a trauma exposed bipolar I and II sample

Background: Post-traumatic stress disorder (PTSD) is an established comorbidity in Bipolar Disorder (BD), but little is known about the characteristics of psychological trauma beyond a PTSD diagnosis and differences in trauma symptoms between BD-I and BD-II. Objective: (1) To present characteristics of a trauma-exposed BD sample; (2) to investigate prevalence and trauma symptom profile across BD-I and BD-II; (3) to assess the impact of a lifetime PTSD diagnosis vs. a history of trauma on BD course; and (4) to research the impacts of sexual and physical abuse. Methods: This multi-center study comprised 79 adult participants with BD with a history of psychological trauma and reports baseline data from a trial registered in Clinical Trials (https://clinicaltrials.gov; ref: NCT02634372). Clinical variables were gathered through clinical interview, validated scales and a review of case notes. Results: The majority (80.8%) of our sample had experienced a relevant stressful life event prior to onset of BD, over half of our sample 51.9% had a lifetime diagnosis of PTSD according to the Clinician Administered PTSD scale. The mean Impact of Event Scale-Revised scores indicated high levels of trauma-related distress across the sample, including clinical symptoms in the PTSD group and subsyndromal symptoms in the non-PTSD group. Levels of dissociation were not higher than normative values for BD. A PTSD diagnosis (vs. a history of trauma) was associated with psychotic symptoms [2(1) = 5.404, p = 0.02] but not with other indicators of BD clinical severity. There was no significant difference between BD-I and BD-II in terms of lifetime PTSD diagnosis or trauma symptom profile. Sexual abuse significantly predicted rapid cycling [2(1) = 4.15, p = 0.042], while physical abuse was not significantly associated with any clinical indicator of severity. Conclusion: Trauma load in BD is marked with a lack of difference in trauma profile between BD-I and BD-II. Although PTSD and sexual abuse may have a negative impact on BD course, in many indicators of BD severity there is no significant difference between PTSD and subsyndromal trauma symptoms. Our results support further research to clarify the role of subsyndromic PTSD symptoms, and highlight the importance of screening for trauma in BD patients