296 research outputs found
Network reachability of real-world contact sequences
We use real-world contact sequences, time-ordered lists of contacts from one
person to another, to study how fast information or disease can spread across
network of contacts. Specifically we measure the reachability time -- the
average shortest time for a series of contacts to spread information between a
reachable pair of vertices (a pair where a chain of contacts exists leading
from one person to the other) -- and the reachability ratio -- the fraction of
reachable vertex pairs. These measures are studied using conditional uniform
graph tests. We conclude, among other things, that the network reachability
depends much on a core where the path lengths are short and communication
frequent, that clustering of the contacts of an edge in time tend to decrease
the reachability, and that the order of the contacts really do make sense for
dynamical spreading processes.Comment: (v2: fig. 1 fixed
Information dynamics shape the networks of Internet-mediated prostitution
Like many other social phenomena, prostitution is increasingly coordinated
over the Internet. The online behavior affects the offline activity; the
reverse is also true. We investigated the reported sexual contacts between
6,624 anonymous escorts and 10,106 sex-buyers extracted from an online
community from its beginning and six years on. These sexual encounters were
also graded and categorized (in terms of the type of sexual activities
performed) by the buyers. From the temporal, bipartite network of posts, we
found a full feedback loop in which high grades on previous posts affect the
future commercial success of the sex-worker, and vice versa. We also found a
peculiar growth pattern in which the turnover of community members and sex
workers causes a sublinear preferential attachment. There is, moreover, a
strong geographic influence on network structure-the network is geographically
clustered but still close to connected, the contacts consistent with the
inverse-square law observed in trading patterns. We also found that the number
of sellers scales sublinearly with city size, so this type of prostitution does
not, comparatively speaking, benefit much from an increasing concentration of
people
Labelling and clinical performance of human leukocytes labelled with 99m Tc-HMPAO using leukokitÂź with gelofusine versus leukokitÂź with HES as sedimentation agent
The scintigraphy with radiolabelled autologous leukocytes (WBCs) is considered the gold-standard technique for imaging infections. Leukokit (R) is a commercially available, disposable, sterile kit for labelling WBCs ex vivo. In this kit, WBCs isolation from red blood cells (RBCs) was performed using poly(O-2-hydroxyethyl)starch (HES) as the RBCs sedimentation agent. Due to its poor availability, HES has been recently replaced by Gelofusine as the RBC sedimentation agent. The aim of this study was to compare the labelling efficiency and the diagnostic accuracy of WBCs labelled with Leukokit (R) with HES vs Leukokit (R) with Gelofusine. WBCs were isolated using HES or Gelofusine for 45minutes and then purified from platelets (PLTs) and labelled with 1.1 +/- 0.3 GBq of freshly prepared Tc-99m- HMPAO. The following parameters were evaluated: the number and type of recovered WBCs, RBCs contamination, PLTs contamination, vitality of neutrophils, and chemotactic properties of neutrophils. Clinical comparison was performed between 80 patients (33 males; age 67.5 +/- 14.2) injected with Tc-99m-HMPAO-WBCs, using HES as the sedimentation agent, and 92 patients (38 males; age 68.2 +/- 12.8) injected with Tc-99m-HMPAO-WBCs using Gelofusine as the sedimentation agent. Patients were affected by prosthetic joint infections, peripheral bone osteomyelitis, or vascular graft infection. We compared radiolabelling efficiency (LE), final recovery yield (RY), and diagnostic outcome based on microbiology or 2-year follow-up. Results showed that HES provides the lowest RBCs and PLTs contamination, but Gelofusine provides the highest WBC recovery. Both agents did not influence the chemotactic properties of WBCs, and no differences were found in terms of LE and RY. Sensitivity, specificity, and accuracy were also not significantly different for WBCs labelled with both agents (diagnostic accuracy 90.9%, CI = 74.9-96.1 vs 98.3%, CI = 90.8-100, for HES and Gelofusine, respectively). In conclusion, Gelofusine can be considered a suitable alternative of HES for WBCs separation and labelling
Common Variable Immunodeficiency and Autoimmune Diseases: A Retrospective Study of 95 Adult Patients in a Single Tertiary Care Center
Common variable immunodeficiency (CVID) is the most common clinically significant primary immunodeficiency in adulthood, which presents a broad spectrum of clinical manifestations, often including non-infectious complications in addition to heightened susceptibility to infections. These protean manifestations may significantly complicate the differential diagnosis resulting in diagnostic delay and under-treatment with increased mortality and morbidity. Autoimmunity occurs in up to 30% of CVID patients, and it is an emerging cause of morbidity and mortality in this type of patients. 95 patients (42 males and 53 females) diagnosed with CVID, basing on ESID diagnostic criteria, were enrolled in this retrospective cohort study. Clinical phenotypes were established according to Chapel 2012: i) no other disease-related complications, ii) cytopenias (thrombocytopenia/autoimmune hemolytic anemia/neutropenia), iii) polyclonal lymphoproliferation (granuloma/lymphoid interstitial pneumonitis/persistent unexplained lymphadenopathy), and iv) unexplained persistent enteropathy. Clinical items in the analysis were age, gender, and clinical features. Laboratory data included immunoglobulin (Ig)G, IgM and IgA levels at diagnosis, flow-cytometric analysis of peripheral lymphocytes (CD3+, CD3+CD4+, CD3+CD8+, CD19+, CD4+CD25highCD127low, CD19hiCD21loCD38lo, and follicular T helper cell counts). Comparisons of continuous variables between groups were performed with unpaired t-test, when applicable. 39 patients (41%) showed autoimmune complications. Among them, there were 21 females (53.8%) and 18 males (46.2%). The most prevalent autoimmune manifestations were cytopenias (17.8%), followed by arthritis (11.5%), psoriasis (9.4%), and vitiligo (6.3%). The most common cytopenia was immune thrombocytopenia, reported in 10 out of 95 patients (10.5%), followed by autoimmune hemolytic anemia (n=3, 3.1%) and autoimmune neutropenia (n=3, 3.1%). Other autoimmune complications included thyroiditis, coeliac disease, erythema nodosum, Raynaudâs phenomenon, alopecia, recurring oral ulcers, autoimmune gastritis, and primary biliary cholangitis. There were no statistically significant differences comparing immunoglobulin levels between CVID patients with or without autoimmune manifestations. There was no statistical difference in CD3+, CD8+, CD4+CD25highCD127low T, CD19, CD19hiCD21loCD38lo, and follicular T helper cell counts in CVID patients with or without autoimmune disorders. In conclusion, autoimmune manifestations often affect patients with CVID. Early recognition and tailored treatment of these conditions are pivotal to ensure a better quality of life and the reduction of CVID associated complications
Evolutionary instability of Zero Determinant strategies demonstrates that winning isn't everything
Zero Determinant (ZD) strategies are a new class of probabilistic and
conditional strategies that are able to unilaterally set the expected payoff of
an opponent in iterated plays of the Prisoner's Dilemma irrespective of the
opponent's strategy, or else to set the ratio between a ZD player's and their
opponent's expected payoff. Here we show that while ZD strategies are weakly
dominant, they are not evolutionarily stable and will instead evolve into less
coercive strategies. We show that ZD strategies with an informational advantage
over other players that allows them to recognize other ZD strategies can be
evolutionarily stable (and able to exploit other players). However, such an
advantage is bound to be short-lived as opposing strategies evolve to
counteract the recognition.Comment: 14 pages, 4 figures. Change in title (again!) to comply with Nature
Communications requirements. To appear in Nature Communication
Statistical Mechanics of Dilute Batch Minority Games with Random External Information
We study the dynamics and statics of a dilute batch minority game with random
external information. We focus on the case in which the number of connections
per agent is infinite in the thermodynamic limit. The dynamical scenario of
ergodicity breaking in this model is different from the phase transition in the
standard minority game and is characterised by the onset of long-term memory at
finite integrated response. We demonstrate that finite memory appears at the
AT-line obtained from the corresponding replica calculation, and compare the
behaviour of the dilute model with the minority game with market impact
correction, which is known to exhibit similar features.Comment: 22 pages, 6 figures, text modified, references updated and added,
figure added, typos correcte
Dynamic instabilities induced by asymmetric influence: Prisoners' dilemma game on small-world networks
A two-dimensional small-world type network, subject to spatial prisoners'
dilemma dynamics and containing an influential node defined as a special node
with a finite density of directed random links to the other nodes in the
network, is numerically investigated. It is shown that the degree of
cooperation does not remain at a steady state level but displays a punctuated
equilibrium type behavior manifested by the existence of sudden breakdowns of
cooperation. The breakdown of cooperation is linked to an imitation of a
successful selfish strategy of the influential node. It is also found that
while the breakdown of cooperation occurs suddenly, the recovery of it requires
longer time. This recovery time may, depending on the degree of steady state
cooperation, either increase or decrease with an increasing number of long
range connections.Comment: 5 pages, 6 figure
Lightweight Interactions for Reciprocal Cooperation in a Social Network Game
The construction of reciprocal relationships requires cooperative
interactions during the initial meetings. However, cooperative behavior with
strangers is risky because the strangers may be exploiters. In this study, we
show that people increase the likelihood of cooperativeness of strangers by
using lightweight non-risky interactions in risky situations based on the
analysis of a social network game (SNG). They can construct reciprocal
relationships in this manner. The interactions involve low-cost signaling
because they are not generated at any cost to the senders and recipients.
Theoretical studies show that low-cost signals are not guaranteed to be
reliable because the low-cost signals from senders can lie at any time.
However, people used low-cost signals to construct reciprocal relationships in
an SNG, which suggests the existence of mechanisms for generating reliable,
low-cost signals in human evolution.Comment: 13 pages, 2 figure
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