An Infant Formula with Partially Hydrolyzed Whey Protein Supports Adequate Growth and Is Safe and Well-Tolerated in Healthy, Term Infants: A Randomized, Double-Blind, Equivalence Trial

The current study evaluates the safety and tolerance of a partially hydrolyzed whey protein-based infant formula (PHF) versus an in intact cow's milk protein formula (IPF). Breastfed infants were included as a reference group. In a multi-country, multicenter, randomized, double-blinded, controlled clinical trial, infants whose mothers intended to fully formula feed were randomized to PHF (n= 134) or IPF (n= 134) from <= 14 days to 17 weeks of age. The equivalence analysis of weight gain per day within margins of +/-3 g/d (primary outcome), the recorded adverse events, growth and gastro-intestinal tolerance parameters were considered for the safety evaluation. Equivalence of weight gain per day from enrolment until 17 weeks of age was demonstrated in the PHF group compared to the IPF group (difference in means -1.2 g/d; 90% CI (-2.42; 0.02)), with estimated means (SE) of 30.2 (0.5) g/d and 31.4 (0.5) g/d, respectively. No significant differences in growth outcomes, the number, severity or type of (serious) adverse events and tolerance outcomes, were observed between the two formula groups. A partially hydrolyzed whey protein-based infant formula supports adequate infant growth, with a daily weight gain equivalent to a standard intact protein-based formula; it is also safe for use and well-tolerated in healthy term infants

Multimodality imaging: Bird’s eye view from The European Society of Cardiology Congress 2015 London, August 29-September 2, 2015

Cardiolog

Highlights lecture EANM 2015: the search for nuclear medicine’s superheroes

The EANM 2015 Annual Congress, held from October 10th to 14th in Hamburg, Germany, was outstanding in many respects. With 5550 participants, this was by far the largest European congress concerning nuclear medicine. More than 1750 scientific presentations were submitted, with more than 250 abstracts from young scientists, indicating that the future success of our discipline is fuelled by a high number of young individuals becoming involved in a multitude of scientific activities. Significant improvements have been made in molecular imaging of cancer, particularly in prostate cancer. PSMA-directed PET/CT appears to become a new gold standard for staging and restaging purposes. Novel tumour specific compounds have shown their potential for target identification also in other solid neoplasms and further our understanding of tumour biology and heterogeneity. In addition, a variety of nuclear imaging techniques guiding surgical interventions have been introduced. A particular focus of the congress was put on targeted, radionuclide based therapies. Novel theranostic concepts addressing also tumour entities with high incidence rates such as prostate cancer, melanoma, and lymphoma, have shown effective anti-tumour activity. Strategies have been presented to improve further already established therapeutic regimens such as somatostatin receptor based radio receptor therapy for treating advanced neuroendocrine tumours. Significant contributions were presented also in the neurosciences track. An increasing number of target structures of high interest in neurology and psychiatry are now available for PET and SPECT imaging, facilitating specific imaging of different subtypes of dementia and movement disorders as well as neuroinflammation. Major contributions in the cardiovascular track focused on further optimization of cardiac perfusion imaging by reducing radiation exposure, reducing scanning time, and improving motion correction. Besides coronary artery disease, many contributions focused on cardiac inflammation, cardiac sarcoidosis, and specific imaging of large vessel vasculitis. The physics and instrumentation track included many highlights such as novel, high resolution scanners. The most noteworthy news and developments of this meeting were summarized in the highlights lecture. Only 55 scientific contributions were mentioned, and hence they represent only a brief summary, which is outlined in this article. For a more detailed view, all presentations can be accessed by the online version of the European Journal of Nuclear Medicine and Molecular Imaging (Volume 42, Supplement 1)

The emerging pharmacology and function of GPR35 in the nervous system

G protein-coupled receptor 35 (GPR35) is an orphan G protein-coupled receptor (GPCR) that can be activated by kynurenic acid at high micromolar concentrations. A previously unappreciated mechanism of action of GPR35 has emerged as a Gαi/o-coupled inhibitor of synaptic transmission, a finding that has significant implications for the accepted role of kynurenic acid as a broad-spectrum antagonist of the NMDA, AMPA/kainite and α7 nicotinic receptors. In conjunction with previous findings that link agonism of GPR35 with significant reduction in nociceptive pain, GPR35 has emerged as a potential effector of regulation of mechanical sensitivity and analgesia of the Ret tyrosine kinase, and as a receptor involved in the transmission of anti-inflammatory effects of aspirin- potentially through affecting leucocyte rolling, adhesion and extravasation. Single nucleotide polymorphisms of GPR35 have linked this receptor to coronary artery calcification, inflammatory bowel disease and primary sclerosing cholangitis, while chromosomal aberrations of the 2q37.3 locus and altered copy number of GPR35 have been linked with autism, Albight's hereditary osteodystrophy-like syndrome, and congenital malformations, respectively. Herein, we present an update on both the pharmacology and potential function of GPR35, particularly pertaining to the nervous system. This review forms part of a special edition focussing on the role of lipid-sensing GPCRs in the nervous system

The politics of survival : towards a global, long-term and reflexive interpretation of the African contemporary experience

This paper proposes a conceptual framework for the systematic linking of theory and empiricism in a transnational perspective accommodating the local, the national and the international simultaneously. The argument expands the narrow State-centred approach of Patrick Chabal and Jean-Pascal Daloz in 'Africa works: disorder as political instrument' (1999), replacing a linear understanding of the global historical trajectory with a nonlinear understanding, and distinguishing between the nature of industrial and reflexive modernity (or First and Second Modernity), and between active and passive trust. The African continent entered the Second Modernity with the beginning of the slave trade; the West did so in the 1960s. Conceptualizations of the individual, the relation of the individual to society, and the nature of power relations are remarkably similar in the Second Modernity and Pre-Modern societies. The concept 'triple chevauchement' permits analysis of the overlapping logics and realities of the "three (coexisting) modernities". Contrary to Chabal and Daloz, whose suggestion that the African postcolonial cultural order constitutes a distinct universe legitimates noncommunication between Africa and the West, the present author's global, long-term historical and reflexive interpretation highlights the similarities between Africa and the West and underlines the need for dialogue. Effective communication will enable a coming to terms with the long common history of domination and opportunistic defence, and may be the ultimate condition for Africa's inclusion in the emerging global economy of knowledge

Démocratisation en Afrique au sud du Sahara (1989-1992): un aperçu de la littérature

Ce rapport présente un aperçu de la littérature sur la démocratisation en Afrique au sud du Sahara (1989-1992). D'abord, les auteurs évoquent un certain nombre de traits dominants de la vie politique en Afrique qui forment l'arrière-plan nécessaire à comprendre les changements actuels concernant la démocratisation. Ensuite ils résument le débat scientifique sur la démocratie en Afrique dans la période 1960-1989, qui a ses racines dans les mouvements d'indépendance et se concentre sur l'échec des modèles Westminster/Élysée. Ils décrivent les arguments tels qu'ils ont été employés pour légitimer l'État à parti unique et, finalement, l'État sans parti. Au cours des années 70 on s'inquiéta de la répression grandissante et de l'évolution stagnante dans les pays africains. Ce n'est qu'au cours des années 80 que l'attention se tourna vers la société civile. Dans le contexte économique et politique radicalement changé à la fin des années 80, on attache une plus grande valeur à la démocratie. La question fondamentale de savoir si la démocratie est un concept universel ou purement occidental, et les différentes définitions de la démocratie, ont conduit à des discussions sur l'État et la société civile, la fonction du multipartisme dans la démocratisation, "good governance", la démocratie et le droit et la démocratie et le développement. Finalement, les auteurs font le bilan du processus de démocratisation actuel en Afrique. ASC – Publicaties niet-programma gebonde