Reliability and the validity of the Psychosocial Distress Questionnaire-Breast Cancer(PDQ-BC)

Background and Purpose:  To evaluate the psychometric properties of the Psychosocial Distress Questionnaire-Breast Cancer (PDQ-BC) and to compare its referrals with the Distress Thermometer (DT).  Methods:  Group 1 (N = 54) and Group 2 (N = 80) completed the PDQ-BC. Group 2 also completed the DT, the Hospital Anxiety and Depression Scale (HADS), and World Health Organization Quality of Life instrument-100 (WHOQOL-100; n = 55). Results: Moderate to high correlations (r ≥ .44, p < .001) were found between related facets of the PDQ-BC, WHOQOL-100, and DT. The subscales state anxiety and depressive symptoms (PDQ-BC) have a sensitivity of 87.5% and 78.6%, respectively, and a specificity of 81.1% and 73.0%, respectively, compared to the HADS.  Conclusions:  The PDQ-BC shows good construct validity, test–retest reliability, and sensitivity to change. The PDQ-BC has a satisfactory sensitivity and specificity of the subscales state anxiety and depressive symptoms

The Psychosocial Distress Questionnaire-Breast Cancer (PDQ-BC) is a useful instrument to screen psychosocial problems

Purpose Recently, the Psychosocial Distress Questionnaire-Breast Cancer (PDQ-BC), a screening instrument specific for patients with early-stage breast cancer, was developed. The aim of this study was to further examine the psychometric properties of the PDQ-BC, in particular the subscales social support, sexual problems and financial problems. Methods Before patients received treatment (N = 123), they completed the PDQ-BC, the World Health Organization Quality of Life (WHOQOL-100) and the Center for Epidemiologic Studies Depression Scale (CES-D). Results Floor effects were present in 44% of the subscales, whereas ceiling effects were only found in the social support subscale (11%). The PDQ-BC subscales social support, sexual problems and financial problems were highly correlated with the corresponding WHOQOL-100 facets social support, sexual activity and financial resources. Furthermore, the subscale depressive symptoms (PDQ-BC) was highly significantly correlated with the CES-D. Low correlations were found between the PDQ-BC subscales and questionnaires that were expected to be unrelated. Exceptions are the subscales trait anxiety and state anxiety, which had a high correlation with the CES-D. The Cronbach’s alpha coefficients of the subscales trait anxiety, state anxiety, depressive symptoms, body image and physical problems ranged from 0.70 to 0.87. Social problems had a low consistency (0.39). Corrected item–total correlations confirmed the PDQ-BC structure. Conclusions The PDQ-BC has expected floor effects, few ceiling effects and sufficient internal consistency. Furthermore, the construct validity on the PDQ-BC subscales social support, sexual problems and financial problems was good. Thus, the PDQ-BC can be used to screen psychosocial problems in patients with early-stage breast cancer as part of routine care. Keywords: Oncology, Cancer, Psychosocial problems, Breast cancer, Screening, Psychometric

Hepatic arterial 5-fluorouracil in patients with liver metastases of colorectal cancer: single-centre experience in 145 patients.

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Plasma biomarker analysis in patients with HER2-negative locally recurrent or metastatic breast cancer (LR/MBC) treated with first-line bevacizumab (A) and paclitaxel (T) without or with capecitabine (X)

Experimentele farmacotherapi

Genetic polymorphisms (SNPs) as predictive markers for paclitaxel-induced peripheral neuropathy (PNP) and capecitabine-induced hand-foot syndrome (HFS) in HER-2 negative metastatic breast cancer patients

Experimentele farmacotherapi