Système d’information d’outils d’écoconception - Conception et analyse

A great variety of ecodesign tools exists but the actual implementation level of such tools remains limited or not successfully integrated throughout the different company processes. This article provides a literature review of the existing tools that can be used in various company departments. From this review, 625 tools were found and characterized. A guide (or information system) has been then developed to help companies to choose ecodesign tools for three targets: production, management or communication. In order to facilitate these choices, a free computerized version of this guide, called « Eco-Tool-Seeker », has been developed

Synthetic wastewaters treatment by electrocoagulation to remove silver nanoparticles produced by different routes

International audienceNanoscience is a field that has stood out in recent years. The accurate long-term health and environmental risks associated with these emerging materials are unknown. Therefore, this work investigated how to eliminate silver nanoparticles (AgNPs) from synthetic effluents by electrocoagulation (EC) due to the widespread use of this type of nanoparticle (NP) in industry and its potential inhibition power over microorganisms responsible for biological treatment in effluent treatment plants. Synthesized AgNPs were studied via four different routes by chemical reduction in aqueous solutions to simulate the chemical variations of a hypothetical industrial effluent, and efficiency conditions of the EC treatment were determined. All routes used silver nitrate as the source of silver ions, and two synthesis routes were studied with sodium citrate as a stabilizer. In route I, sodium citrate functioned simultaneously as the reducing agent and stabilizing agent, whereas route II used sodium borohydride as a reducing agent. Route III used d-glucose as the reducing agent and sodium pyrophosphate as the stabilizer; route IV used sodium pyrophosphate as the stabilizing agent and sodium borohydride as the reducing agent. The efficiency of the EC process of the different synthesized solutions was studied. For route I, after 85 min of treatment, a significant decrease in the plasmon resonance peak of the sample was observed, which reflects the efficiency in the mass reduction of AgNPs in the solution by 98.6%. In route II, after 12 min of EC, the absorbance results reached the detection limit of the measurement instrument, which indicates a minimum reduction of 99.9% of AgNPs in the solution. During the 4 min of treatment in route III, the absorbance intensities again reached the detection limit, which indicates a minimum reduction of 99.8%. In route IV, after 10 min of treatment, a minimum AgNP reduction of 99.9% was observed. Based on these results, it was possible to verify that the solutions containing citrate considerably increased the necessary times required to eliminate AgNPs from the synthesized effluent, whereas solutions free of this reagent showed better results on floc formation and, therefore, are best for the treatment. The elimination of AgNPs from effluents by EC proved effective for the studied routes

“Eco-tool-seeker”: A new and unique business guide for choosing ecodesign tools

Environmental sustainability has emerged as a key issue amongst governments, policymakers, researchers, companies and the general public. In Europe, governments are trying to encourage companies to integrate ecodesign into their processes. A great variety of ecodesign tools exists but the actual implementation level of such tools remains limited or not successfully integrated throughout the different company processes. Having identified the main barriers to ecodesign implementation, this article provides a literature review of the existing tools that can be used in various company departments. From this review, 629 tools were found and characterized. Taxonomy was established to classify these tools into 22 categories of ecodesign tools and 5 departments in companies. These tools are classified as normative or non-normative which can be generic or sectorial as well as “environmental” or “improvement”. A guide (or information system) has been then developed to help companies to choose ecodesign tools for three targets: production, management or communication. The proposed guide can also be useful for researchers, teachers, and trainers. In order to facilitate these choices, a free computerized version of this guide, called “Eco-tool-seeker”, has been developed

Quantification Vectorielle Algébrique et Arborescente: Méthode d'Actualisation du Dictionnaire-- Application au Codage

National audienceL'objet de cet article est d'introduire une nouvelle méthode de quantification vectorielle (QV) adaptative pour la compression à bas débits de séquences d'images numériques. Nos travaux précédents décrivent un schéma de QV algébrique et arborescente (QVAA) basée sur une technique d'emboîtements successifs de réseaux tronqués, et aboutissant à une QV multi-étages. A présent nous explorons les aptitudes de ce QVAA au codage adaptif via un schéma mettant à profit sa structure arborescente. Le dictionnaire est alors composé de deux parties : une "souche" permanente constituée hors-ligne relativement à une large gamme de séquences d'images. De branches ajoutées pour chaque nouveau type de séquences à coder. Notre QV adaptatif prenant place au sein d'un codeur de type MPEG, nous analysons les résultats expérimentaux obtenus lors du codage de sources réelles

Molecular mechanisms of acquired resistance to third-generation EGFR-TKIs in EGFR T790M-mutant lung cancer

International audienceLung cancer represents the leading cause of cancer-related deaths worldwide. Despite great advances in its management with the recent emergence of molecular targeted therapies for non-small-cell lung cancer (NSCLC), relapse of the metastatic disease always occurs within approximately one year. Epidermal growth factor receptor (EGFR) mutant tumours are the prime example of oncogene addiction and clonal evolution in oncology, regarding the emergence of resistance to first- and second-generation EGFR inhibitors. Multiple studies have revealed that the EGFR-T790M gatekeeper mutation is the main cause of tumour escape. Recently, irreversible pyrimidine-based EGFR inhibitors especially designed for this particular setting have shown robust clinical activity. However, similar to first- and second-generation inhibitors, the development of a diversified set of resistance mechanisms in response to these new compounds is an emerging issue. To date, clinical management of this growing number of patients has not been clearly established, even if anecdotal responses to subsequent molecularly guided therapies have been observed. By exhaustively reviewing and classifying all the preclinical and clinical data published on resistance to third-generation EGFR inhibitors in NSCLC, this work reveals the heterogeneity of the mechanisms that a tumour can develop to evade therapeutic pressure. Strategies currently being tested in clinical trials are discussed in light of these findings

Newly identified tumor suppressor functions of ING proteins

International audienceThe INhibitor of Growth (ING) proteins (ING1, ING2, ING3, ING4 and ING5) are a family of epigenetic regulators. Their decreased expression in numerous cancers led to identifying the ING proteins as gatekeeper tumor suppressors as they regulate cell cycle progression, apoptosis and senescence. Subsequently, they were also described as caretaker tumor suppressors through their involvement in DNA replication and the DNA damage response (DDR). Recent studies have identified new interactions of the ING proteins with proteins or pathways implicated in cell proliferation, the maintenance of stem cells pluripotency or the DDR. Furthermore, the ING proteins have been identified as regulators of ribosomal RNA synthesis and of mRNA stability and as regulators of mitochondrial DNA transcription resulting in the regulation of metabolism. These new findings highlight new antitumorigenic activities of the ING proteins that are potential targets for cancer treatment. © 2022 The Author

Molecular mechanisms of acquired resistance to third-generation EGFR-TKIs in EGFR T790M-mutant lung cancer

International audienceLung cancer represents the leading cause of cancer-related deaths worldwide. Despite great advances in its management with the recent emergence of molecular targeted therapies for non-small-cell lung cancer (NSCLC), relapse of the metastatic disease always occurs within approximately one year. Epidermal growth factor receptor (EGFR) mutant tumours are the prime example of oncogene addiction and clonal evolution in oncology, regarding the emergence of resistance to first- and second-generation EGFR inhibitors. Multiple studies have revealed that the EGFR-T790M gatekeeper mutation is the main cause of tumour escape. Recently, irreversible pyrimidine-based EGFR inhibitors especially designed for this particular setting have shown robust clinical activity. However, similar to first- and second-generation inhibitors, the development of a diversified set of resistance mechanisms in response to these new compounds is an emerging issue. To date, clinical management of this growing number of patients has not been clearly established, even if anecdotal responses to subsequent molecularly guided therapies have been observed. By exhaustively reviewing and classifying all the preclinical and clinical data published on resistance to third-generation EGFR inhibitors in NSCLC, this work reveals the heterogeneity of the mechanisms that a tumour can develop to evade therapeutic pressure. Strategies currently being tested in clinical trials are discussed in light of these findings

Spontaneous splenic rupture as a rare complication of G-CSF injection

International audienceSplenic rupture is an infrequent and underdiagnosed side effect of granylocyte colony-stimulating factor (G-CSF). We report the case of a 54-year-old woman with brain and bone metastasis in a lung adenocarcinoma who was admitted for faintness 28 days after a G-CSF injection. Abdominal CT scan confirmed the diagnosis of splenic rupture. A conservative treatment was chosen using a peritoneal cleansing during laparoscopic surgery. Clinicians should be aware of this rare toxicity as it could be severe, but easily reversible using appropriate surgical treatment. Even if prognosis remains poor for patients with lung cancer, invasive procedures could be considered in this rapidly evolving setting, especially in case of reversible adverse event

Large Cell Neuroendocrine Lung Carcinoma Transformation as an Acquired Resistance Mechanism to Osimertinib

International audienceLetter to the Edito